Dissociation of apoptosis and activation of IL-1β-converting enzyme/ced-3 proteases by ALG-2 and the truncated Alzheimer's gene ALG-3

Journal of Immunology

Volumn 158, Issue 11, 1997, Pages 5129-5135

  Lacanà, Emanuela ^a   Ganjei, J Kelly ^a   Vito, Pasquale ^a   D'Adamio, Luciano ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; CALCIUM BINDING PROTEIN; CASPASE; CED 3 PROTEIN, C ELEGANS; CED-3 PROTEIN, C ELEGANS; CYSTEINE PROTEINASE; MEMBRANE PROTEIN; PDCD6 PROTEIN, HUMAN; PDCD6 PROTEIN, MOUSE; PRESENILIN 2; PSEN2 PROTEIN, HUMAN; PSEN2 PROTEIN, MOUSE;

ANIMAL; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYBRIDOMA; LEUKEMIA CELL LINE; MOUSE; PATHOLOGY; T LYMPHOCYTE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-BINDING PROTEINS; CASPASES; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; HYBRIDOMAS; JURKAT CELLS; MEMBRANE PROTEINS; MICE; PRESENILIN-2; T-LYMPHOCYTES;

EID: 0031154753     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Kerr, J. F. R., A. H. Wyllie, and A. R. Currie. 1972. Apoplosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26:239.
2. Martin, S. J., and D. R. Green. 1995. Protease activation during apoptosis: death by a thousand cuts? Cell 82:349.
3. Yuan, J., S. Shaham, S. Ledoux, H. M. Ellis, and H. R. Horvitz. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641.
4. Henkart, P. 1996. ICE family proteases: mediators of all apoptotic cell death? Immunity 4:195.
5. Muzio, M., A. M. Chinnaiyan, F. C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/ Ced-3-like protease, is recruited to the CD95 (Fas/APO-1) death inducing signaling complex. Cell 85:817.
6. Boldin, M. P., T. M. Goncharov, Y. V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803.
7. Duan, H., K. Orth, A. M. Chinnaiyan, G. G. Poirier, C. J. Froelich, W-W. He, and V. M. Dixit. 1996. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271:16720.
8. Schlegel, J., I. Peters, S. Orrenius, D. K. Miller, N. A. Thornberry, T-T. Yamin, and D. W. Nicholson. 1996. CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas mediated apoptosis. J. Biol. Chem. 271: 1841.
9. Duan, H., A. M. Chinnaiyan, P. L. Hudson, J. P. Wing, W-W. He, and V. M. Dixit. 1996. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 271:1621.
10. Chinnaiyan, A. M., K. Orth, K. O'Rourke, H. Duan, G. G. Poirier, and V. M. Dixit. 1996. Molecular ordering of the cell death pathway. J. Biol. Chem. 271: 4573.
11. Fernandes-Alnemri, T., G. Litwack, and E. S. Alnemri. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme. J. Biol. Chem. 269:30761.
12. Nicholson, D. W., A. Ali, N. A. Thornberry, J. P. Vaillancourt, C. K. Ding, M. Gallant, Y. Gareau, P. R. Griffin, M. Labelle, Y. A. Lazebnik, N. A. Munday, S. M. Raju, M. E. Smulson, T-T. Yamin, V. L. Yu, and D. K. Miller. 1995. Identification and inhibition of the ICE/Ced-3 protease necessary for mammalian apoptosis. Nature 376:37.
13. Lazebnik, Y. A., S. H. Kaufmann, S. Desnoyers, G. G. Poirier, and W. C. Earnshaw. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371:346.
14. Tewari, M., L. T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salveson, and V. M. Dixit. 1995. Yama/CPP32β, a mammalian homolog of Ced-3, is a CrmA-inhibitable prolease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81:801.
15. Casciola-Rosen, L., D. W. Nicholson, T. Chong, K. R. Rowan, N. A. Thornberry, D. K. Miller, and A. Rosen. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair a fundamental principle of apoptotic death. J. Exp. Med. 183:1957.
16. Femandes-Alnemri, T., A. Takahashi, R. Armstrong, J. Krebs, L. Fritz, K. J. Tomaselli, L. Wang, C. M. Croce, G. Salveson, W. C. Earnshaw, G. Litwack, and E. S. Alnemri. 1995. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55:6045.
17. Shi, Y., M. G. Szalay, L. Paskar, M. Boyer, B. Singh, and D. R. Green. 1990. Activation-induced cell death in T cell hybridomas is due to apoptosis. J. Immunol. 144:3326.