Genomic organization of the human integrin β4 gene

Mammalian Genome

Volumn 8, Issue 6, 1997, Pages 448-450

  Iacovacci, Silvia ^a   Gagnoux Palacios, Laurent ^b   Zambruno, Giovanna ^a   Meneguzzi, Guerrino ^b   D'Alessio, Marina ^a  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA4 INTEGRIN; LEUKOCYTE ANTIGEN;

ARTICLE; CHROMOSOME MAP; CYTOPLASM; DNA SEQUENCE; EPIDERMOLYSIS BULLOSA; EXON; GENETICS; HUMAN; INTRON; METABOLISM; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN SYNTHESIS; RNA SPLICING;

ANTIGENS, CD; BASE SEQUENCE; CHROMOSOME MAPPING; CLONING, MOLECULAR; CYTOPLASM; EPIDERMOLYSIS BULLOSA, JUNCTIONAL; EVOLUTION, MOLECULAR; EXONS; HUMANS; INTEGRIN BETA4; INTRONS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; RNA SPLICING; SEQUENCE ANALYSIS, DNA;

EID: 0031153949     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900467     Document Type: Article

References (19)

1. Borradori L, Sonnenberg A (1996) Hemidesomosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol 8, 647-656
2. Breathnach R, Chambon P (1981) Organization and expression of eukaryotic split genes coding for proteins. Annu Rev Biochem 50, 349-383
3. Brown T, Gil S, Sybert V, Lestringant G, Tadini G, Caputo R, Carter W (1996) Defective integrin α6β4 expression in the skin of patients with junctional epidermolysis bullosa and pyloric atresia. J Invest Dermatol 107, 384-391
4. Clarke AS, Lotz MM, Mercurio AM (1994) A novel structural variant of the human β4 integrin cDNA. Cell Adh Comm 2. 1-6
5. Davis GC (1990) The many faces of epidermal growth factor repeats. New Biologist 2, 410-419
6. De Luca M, Tamura R, Kajiji S, Bondanza S, Cancedda R, Rossino P, Marchisio PC, and Quaranta V (1990) Polarized integrin mediates human keratinocyte adhesion to basal lamina. Proc Natl Acad Sci USA 87, 6888-6892
7. Dowling J, Yu QC, Fuchs E (1996) β4 integrin is required for hemidesomosome formation, cell adhesion and cell survival. J Cell Biol 134, 559-572
8. Giancotti FG (1996) Signal transduction by the α6β4 integrin: charting the path between laminin binding and nuclear events. J Cell Sci 109, 1165-1172
9. Hogervost F, Kuikman I, von dem Borne A, Sonnenberg A (1990) Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 Kd cytoplasmic domain. EMBO J 9, 765-770
10. Hogervost F, Kuikman I, Van Kessel AG, Sonnenberg A (1991) Molecular cloning of the human α6 integrin subunit: alternative splicing and chromosomal localization of the α6 and β4 genes. Eur J Biochem 199, 425-433
11. Hynes RO (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell 69, 11-25
12. Niessen C, van der Raaij-Helmer L, Hulsman E, van der Neut R, Jonkman M, Sonnenberg A (1996) Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci 109, 1695-1706
13. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, ArtavanisTsakonas S (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687-699
14. 4 protein complexes: tissue distribution and biochemical properties. J Cell Biol 96, 207-217
15. Spinardi L, Ren Y, Sanders R, Giancotti FG (1993) The β4 subunit cytoplasmic domain mediates the interaction of α6β integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell 4, 871-884
16. Suzuki S, Naitoh Y (1990) Amino acid sequence of a novel integrin subunit and primary expression of the mRNA in epithelial cells. EMBO J 9, 757-763
17. Tamura R, Rozzo C, Starr L, Chambers J, Reichardt L, Cooper H, Quaranta V (1990) Epithelial integrin α6β4: complete primary structure of the α6 and variant forms of β4. J Cell Biol 111, 1593-1604
18. van der Neut R, Krimpenfort P, Calafat J, Niessen C, Sonnenber A (1996) Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice. Nature Genet 13, 366-369
19. Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G (1995) Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nature Genet 10, 229-234