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Volumn 1, Issue 1, 1997, Pages 10-16

The joys of in vitro selection: Chemically dressing oligonucleotides to satiate protein targets

Author keywords

[No Author keywords available]

Indexed keywords

BIOPOLYMER; NUCLEOSIDE; OLIGONUCLEOTIDE; PROTEIN;

EID: 0031151974     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1367-5931(97)80103-2     Document Type: Article
Times cited : (99)

References (65)
  • 1
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C, Gold L: Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249:505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 2
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington AD, Szostak JW: In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346:818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 3
    • 0029040284 scopus 로고
    • Searching for strategies for applied molecular evolution
    • Kauffman SA, Macready WG: Searching for strategies for applied molecular evolution. J Theor Biol 1995, 173:427-440.
    • (1995) J Theor Biol , vol.173 , pp. 427-440
    • Kauffman, S.A.1    Macready, W.G.2
  • 4
    • 0029361782 scopus 로고
    • Adaptive walks with noisy fitness measurements
    • Levitan B, Kauffman S: Adaptive walks with noisy fitness measurements. Mol Divers 1995, 1:53-68.
    • (1995) Mol Divers , vol.1 , pp. 53-68
    • Levitan, B.1    Kauffman, S.2
  • 5
    • 0028869690 scopus 로고
    • Diversity of oligonucleotide functions
    • A historic account of oligonucleotide in vitro selections
    • Gold L, Polisky B, Uhlenbeck O, Yarus M: Diversity of oligonucleotide functions. Annu Rev Biochem 1995, 64:763-797. A historic account of oligonucleotide in vitro selections.
    • (1995) Annu Rev Biochem , vol.64 , pp. 763-797
    • Gold, L.1    Polisky, B.2    Uhlenbeck, O.3    Yarus, M.4
  • 6
    • 0029891450 scopus 로고    scopus 로고
    • In vitro selection of aptamers: The dearth of pure reason
    • Uphoff, KW, Bell SD, Ellington AD: In vitro selection of aptamers: the dearth of pure reason. Curr Biol 1996, 6:281-287. A recent review of aptamers and their use both as therapeutics and as tools for molecular recognition.
    • (1996) Curr Biol , vol.6 , pp. 281-287
    • Uphoff, K.W.1    Bell, S.D.2    Ellington, A.D.3
  • 7
    • 0029031094 scopus 로고
    • Oligonucleotides as research, diagnostic, and therapeutic agents
    • Gold L: Oligonucleotides as research, diagnostic, and therapeutic agents. J Biol Chem 1995, 270:13581-13584. A concise review that contrasts Oligonucleotides to other combinatorial libraries and describes their potential uses.
    • (1995) J Biol Chem , vol.270 , pp. 13581-13584
    • Gold, L.1
  • 8
    • 0030072640 scopus 로고    scopus 로고
    • Chance and necessity in the selection of nucleic acid catalysts
    • Lorsch JR, Szostak JW: Chance and necessity in the selection of nucleic acid catalysts. Accounts Chem Res 1996, 29:103-110. An excellent review of the state of nucleic acid catalysts discovered by in vitro selection.
    • (1996) Accounts Chem Res , vol.29 , pp. 103-110
    • Lorsch, J.R.1    Szostak, J.W.2
  • 9
    • 0029119820 scopus 로고
    • Artificial evolution and natural ribozymes
    • Kumar PKR, Ellington AD: Artificial evolution and natural ribozymes. FASEB J 1995, 9:1183-1185.
    • (1995) FASEB J , vol.9 , pp. 1183-1185
    • Kumar, P.K.R.1    Ellington, A.D.2
  • 10
    • 0029956108 scopus 로고    scopus 로고
    • Ribozyme-catalysed amino-acid transfer reactions
    • Lohse PA, Szostak JW: Ribozyme-catalysed amino-acid transfer reactions. Nature 1996, 381:442-444. This paper describes the first amide bond formation catalyzed by RNA and demonstrates how powerful substrate alignment by duplex formation with the selected catalytic nucleic acid can be.
    • (1996) Nature , vol.381 , pp. 442-444
    • Lohse, P.A.1    Szostak, J.W.2
  • 11
    • 0028969534 scopus 로고
    • Aminoacyl-RNA synthesis catalyzed by an RNA
    • Illangasekare M, Sanchez G, Nickles T, Yarus M: Aminoacyl-RNA synthesis catalyzed by an RNA. Science 1995, 267:643-647. The first example of ester bond formation is described as well as HPLC partitioning of RNA catalysts.
    • (1995) Science , vol.267 , pp. 643-647
    • Illangasekare, M.1    Sanchez, G.2    Nickles, T.3    Yarus, M.4
  • 12
    • 0030582393 scopus 로고    scopus 로고
    • Specialization of the DNA-cleaving activity of a Group I ribozyme through in vitro evolution
    • Tsang J, Joyce GF: Specialization of the DNA-cleaving activity of a Group I ribozyme through in vitro evolution. J Mol Biol 1996, 262:31-42. A powerful example of how in vitro evolution can be used to identify specialized ribozymes, which are perhaps superior to those found naturally.
    • (1996) J Mol Biol , vol.262 , pp. 31-42
    • Tsang, J.1    Joyce, G.F.2
  • 13
    • 0028911845 scopus 로고
    • In vitro evolution of a self-alkylating ribozyme
    • Wilson C, Szostak JW: In vitro evolution of a self-alkylating ribozyme. Nature 1995, 374:777-782.
    • (1995) Nature , vol.374 , pp. 777-782
    • Wilson, C.1    Szostak, J.W.2
  • 14
    • 0029903899 scopus 로고    scopus 로고
    • In vitro selection of a novel catalytic RNA: Characterization of a sulfur alkylation reaction and interaction with a small peptide
    • Wecker M, Smith D, Gold L: In vitro selection of a novel catalytic RNA: characterization of a sulfur alkylation reaction and interaction with a small peptide. RNA 1996, 2:982-994.
    • (1996) RNA , vol.2 , pp. 982-994
    • Wecker, M.1    Smith, D.2    Gold, L.3
  • 15
    • 0029147392 scopus 로고
    • Structurally complex and highly active RNA ligases derived from random RNA sequences
    • Ekland EH, Szostak JW, Bartel DP: Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 1995, 269:364-370. This paper demonstrates how nucleic acid selection can identify nucleic acids catalysts that rival proteins for related chemical transformations.
    • (1995) Science , vol.269 , pp. 364-370
    • Ekland, E.H.1    Szostak, J.W.2    Bartel, D.P.3
  • 16
    • 0029037713 scopus 로고
    • A DNA metalloenzyme with DNA ligase activity
    • Cuenoud B, Szostak JW: A DNA metalloenzyme with DNA ligase activity. Nature 1995, 375:611-614.
    • (1995) Nature , vol.375 , pp. 611-614
    • Cuenoud, B.1    Szostak, J.W.2
  • 17
    • 0028842989 scopus 로고
    • Synthetic ribozymes and the first deoxyribozyme
    • Burgstaller P, Famulok M: Synthetic ribozymes and the first deoxyribozyme. Angew Chem Int Ed 1995, 34:1189-1192.
    • (1995) Angew Chem Int Ed , vol.34 , pp. 1189-1192
    • Burgstaller, P.1    Famulok, M.2
  • 18
    • 0008451711 scopus 로고    scopus 로고
    • Porphyrin metalation catalyzed by a small RNa molecule
    • Conn MM, Prudent JR, Schultz PG: Porphyrin metalation catalyzed by a small RNA molecule. J Am Chem Soc 1996, 118:7012-7013. An excellent example of how the transition-state analog approach, used so successfully in the catalytic antibody field, can be employed for the selection of RNA catalysts.
    • (1996) J Am Chem Soc , vol.118 , pp. 7012-7013
    • Conn, M.M.1    Prudent, J.R.2    Schultz, P.G.3
  • 19
    • 0030003509 scopus 로고    scopus 로고
    • Kinetic and mechanistic analysis of nonenzymatic, template-directed oligonucleotide ligation
    • Rohatgi R, Bartel DP, Szostak JW: Kinetic and mechanistic analysis of nonenzymatic, template-directed oligonucleotide ligation. J Am Chem Soc 1996, 118:3332-3339.
    • (1996) J am Chem Soc , vol.118 , pp. 3332-3339
    • Rohatgi, R.1    Bartel, D.P.2    Szostak, J.W.3
  • 20
    • 0029832218 scopus 로고    scopus 로고
    • RNA-catalyzed RNA polymerization using nucleoside triphosphates
    • Ekland EH, Bartel DP: RNA-catalyzed RNA polymerization using nucleoside triphosphates. Nature 1996, 382:373-376.
    • (1996) Nature , vol.382 , pp. 373-376
    • Ekland, E.H.1    Bartel, D.P.2
  • 21
    • 0029915714 scopus 로고    scopus 로고
    • Nonenzymatic, template-directed ligation of oligonucleotides is a highly regioselective for the formation of 3′→5′ phosphosphodiester bonds
    • Rohatgi R, Bartel DP, Szostak JW: Nonenzymatic, template-directed ligation of oligonucleotides is a highly regioselective for the formation of 3′→5′ phosphosphodiester bonds. J Am Chem Soc 1996, 118:3340-3344.
    • (1996) J Am Chem Soc , vol.118 , pp. 3340-3344
    • Rohatgi, R.1    Bartel, D.P.2    Szostak, J.W.3
  • 22
    • 0029766901 scopus 로고    scopus 로고
    • RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities
    • Wang Y, Killian J, Hamasaki K, Rando R: RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities. Biochemistry 1996, 35:12338-12346. This paper describes the use of fluorescence depolarization to map aminoglycoside binding to selected aptamers.
    • (1996) Biochemistry , vol.35 , pp. 12338-12346
    • Wang, Y.1    Killian, J.2    Hamasaki, K.3    Rando, R.4
  • 23
    • 0029347016 scopus 로고
    • A novel RNA motif for neomycin recognition
    • Wallis MG, von Ahsen U, Schroeder R, Famulok M: A novel RNA motif for neomycin recognition. Chem Biol 1995, 2:543-552. Comprehensive characterization of aminoglycoside binding aptamers demonstrating how exquisite aptamer recognition can be for small molecules.
    • (1995) Chem Biol , vol.2 , pp. 543-552
    • Wallis, M.G.1    Von Ahsen, U.2    Schroeder, R.3    Famulok, M.4
  • 24
    • 0029294539 scopus 로고
    • Specific binding of aminoglycoside antibiotics to RNA
    • Wang Y, Rando RR: Specific binding of aminoglycoside antibiotics to RNA. Chem Biol 1995, 2:281-290.
    • (1995) Chem Biol , vol.2 , pp. 281-290
    • Wang, Y.1    Rando, R.R.2
  • 25
    • 0028874701 scopus 로고
    • Structural probing and damage selection of citrulline- And arginine-specific RNA aptamers identify base positions required for binding
    • Burgstaller P, Kochoyan M, Famulok M: Structural probing and damage selection of citrulline- and arginine-specific RNA aptamers identify base positions required for binding. Nucleic Acids Res 1995, 23:4769-4776.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4769-4776
    • Burgstaller, P.1    Kochoyan, M.2    Famulok, M.3
  • 26
    • 0028965943 scopus 로고
    • A DNA aptamer that binds adenosine and ATP
    • Huizenga DE, Szostak JW: A DNA aptamer that binds adenosine and ATP. Biochemistry 1995, 34:656-665.
    • (1995) Biochemistry , vol.34 , pp. 656-665
    • De Huizenga1    Szostak, J.W.2
  • 27
    • 0029138009 scopus 로고
    • RNA aptamers that bind flavin and nicotinamide redox cofactors
    • Lauhon CT, Szostak JW: RNA aptamers that bind flavin and nicotinamide redox cofactors. J Am Chem Soc 1995, 117:1246-1257. A remarkable demonstration of how specific aptamers to small molecules can be. NAD can be distinguished from NADH by the selected aptamers.
    • (1995) J am Chem Soc , vol.117 , pp. 1246-1257
    • Lauhon, C.T.1    Szostak, J.W.2
  • 29
    • 0030025648 scopus 로고    scopus 로고
    • Arginine-binding RNAs resembling TAR identified by in vitro selection
    • Tao J, Frankel AD: Arginine-binding RNAs resembling TAR identified by in vitro selection. Biochemistry 1996, 35:2229-2238.
    • (1996) Biochemistry , vol.35 , pp. 2229-2238
    • Tao, J.1    Frankel, A.D.2
  • 30
    • 0029361759 scopus 로고
    • In vitro selection methodologies to probe RNA function and structure
    • Conrad RC, Baskerville S, Ellington AD: In vitro selection methodologies to probe RNA function and structure. Mol Divers 1995, 1:69-78.
    • (1995) Mol Divers , vol.1 , pp. 69-78
    • Conrad, R.C.1    Baskerville, S.2    Ellington, A.D.3
  • 31
    • 0029295966 scopus 로고
    • Dissecting protein:protein interactions between transcription factors with an RNA aptamer
    • Tian Y, Adya N, Wagner S, Giam C, Green M, Ellington AD: Dissecting protein:protein interactions between transcription factors with an RNA aptamer. RNA 1995, 1:317-326. This paper provides an illustration of how aptamers can be used as molecular tools to investigate complex biological interactions.
    • (1995) RNA , vol.1 , pp. 317-326
    • Tian, Y.1    Adya, N.2    Wagner, S.3    Giam, C.4    Green, M.5    Ellington, A.D.6
  • 32
    • 0028801335 scopus 로고
    • In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr Virus expressed RNA by using randomized and cDNA-derived RNA libraries
    • Dobbelstein M, Shenk T: In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr Virus expressed RNA by using randomized and cDNA-derived RNA libraries. J Virol 1995, 69:8027-8034.
    • (1995) J Virol , vol.69 , pp. 8027-8034
    • Dobbelstein, M.1    Shenk, T.2
  • 34
    • 0029379767 scopus 로고
    • Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor
    • Green LS, Jellinek D, Bell C, Beebe LA, Feistner BD, Gill SC, Jucker FM, Janjic N: Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor. Chem Biol 1995, 2:683-695. Examples of exhaustive post-SELEX modification to improve the therapeutic potential of aptamers.
    • (1995) Chem Biol , vol.2 , pp. 683-695
    • Green, L.S.1    Jellinek, D.2    Bell, C.3    Beebe, L.A.4    Feistner, B.D.5    Gill, S.C.6    Jucker, F.M.7    Janjic, N.8
  • 35
    • 0028923775 scopus 로고
    • High-affinity RNA ligands to Escherichia coli ribosomes and ribosomal protein S1: Comparison of natural and unnatural binding sites
    • Ringquist S, Jones T, Snyder EE, Gibson T, Boni I, Gold L: High-affinity RNA ligands to Escherichia coli ribosomes and ribosomal protein S1: comparison of natural and unnatural binding sites. Biochemistry 1995, 34:3640-3648.
    • (1995) Biochemistry , vol.34 , pp. 3640-3648
    • Ringquist, S.1    Jones, T.2    Snyder, E.E.3    Gibson, T.4    Boni, I.5    Gold, L.6
  • 36
    • 0028808340 scopus 로고
    • Selection and characterization of RNAs replicated by Q replicase
    • Brown D, Gold L: Selection and characterization of RNAs replicated by Q replicase. Biochemistry 1995, 34:14775-14782.
    • (1995) Biochemistry , vol.34 , pp. 14775-14782
    • Brown, D.1    Gold, L.2
  • 37
    • 0029165745 scopus 로고
    • High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus
    • Schneider DJ, Feigon J, Hostomsky Z, Gold L: High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus. Biochemistry 1995, 34:9599-9610.
    • (1995) Biochemistry , vol.34 , pp. 9599-9610
    • Schneider, D.J.1    Feigon, J.2    Hostomsky, Z.3    Gold, L.4
  • 38
    • 0028960472 scopus 로고
    • Comprehensive chemical modification interference and nucleotide substitution analysis of an RNA pseudoknot inhibitor to HIV-1 reverse transcriptase
    • Green L, Waugh S, Binkley JP, Hostomska Z, Hostomsky Z, Tuerk C: Comprehensive chemical modification interference and nucleotide substitution analysis of an RNA pseudoknot inhibitor to HIV-1 reverse transcriptase. J Mol Biol 1995, 247:60-68.
    • (1995) J Mol Biol , vol.247 , pp. 60-68
    • Green, L.1    Waugh, S.2    Binkley, J.P.3    Hostomska, Z.4    Hostomsky, Z.5    Tuerk, C.6
  • 40
    • 0029062420 scopus 로고
    • In vitro selection of RNA ligands to substance P
    • Nieuwlandt D, Wecker M, Gold L: In vitro selection of RNA ligands to substance P. Biochemistry 1995, 34:5651-5659.
    • (1995) Biochemistry , vol.34 , pp. 5651-5659
    • Nieuwlandt, D.1    Wecker, M.2    Gold, L.3
  • 41
    • 0029931691 scopus 로고    scopus 로고
    • Characterization of antibody-binding RNAs selected from structurally constrained libraries
    • Hamm J: Characterization of antibody-binding RNAs selected from structurally constrained libraries. Nucleic Acids Res 1996, 24:2220-2227.
    • (1996) Nucleic Acids Res , vol.24 , pp. 2220-2227
    • Hamm, J.1
  • 42
    • 0029379551 scopus 로고
    • Let's get specific: The relationship between specificity and affinity
    • Eaton BE, Gold L, Zichi DA: Let's get specific: the relationship between specificity and affinity. Chem Biol 1995, 2:633-638. A discussion provoking review of aptamers and how their affinities and specificities seem to be correlated despite the fact that there is no theoretical basis.
    • (1995) Chem Biol , vol.2 , pp. 633-638
    • Eaton, B.E.1    Gold, L.2    Zichi, D.A.3
  • 43
    • 0029557118 scopus 로고
    • Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands
    • Jensen KB, Atkinson BL, Willis MC, Koch TH, Gold L: Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands. Proc Natl Acad Sci USA 1995, 92:12220-12224. An example of how the aptamer/target interface can drive chemical reactions.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12220-12224
    • Jensen, K.B.1    Atkinson, B.L.2    Willis, M.C.3    Koch, T.H.4    Gold, L.5
  • 44
    • 0029004235 scopus 로고
    • Ribonucleosides and RNA
    • Eaton BE, Pieken WA: Ribonucleosides and RNA. Annu Rev Biochem 1995, 64:837-863. A review of modified ribonucleosides and RNA including examples of chemistries that impart nuclease resistance and cross-linking.
    • (1995) Annu Rev Biochem , vol.64 , pp. 837-863
    • Eaton, B.E.1    Pieken, W.A.2
  • 45
    • 0030200945 scopus 로고    scopus 로고
    • Interpretation of oligonucleotide mass spectra for determination of sequence using electrospray ionization and tandem mass spectrometry
    • Ni J, Pomerantz SC, Rozenski J, Zhang Y, McCloskey JA: Interpretation of oligonucleotide mass spectra for determination of sequence using electrospray ionization and tandem mass spectrometry. Anal Chem 1996, 68:1989-1999. With some imagination this paper can serve as the basis for structural deconvolution of aptamers derived from post-SELEX combinatorial libraries.
    • (1996) Anal Chem , vol.68 , pp. 1989-1999
    • Ni, J.1    Pomerantz, S.C.2    Rozenski, J.3    Zhang, Y.4    McCloskey, J.A.5
  • 46
    • 0028982469 scopus 로고
    • N7-cyanoborane-2′-deoxyguanosine 5′-triphosphate is a good substrate for DNa polymerase
    • Porter KW, Tomasz J, Huang F, Sood A, Ramsay-Shaw B: N7-cyanoborane-2′-deoxyguanosine 5′-triphosphate is a good substrate for DNA polymerase. Biochemistry 1995, 34:11963-11969.
    • (1995) Biochemistry , vol.34 , pp. 11963-11969
    • Porter, K.W.1    Tomasz, J.2    Huang, F.3    Sood, A.4    Ramsay-Shaw, B.5
  • 47
    • 0028331830 scopus 로고
    • Synthesis of 2′-deoxyuridine nucleosides with appended 5-position carbonyl cross-linking groups
    • Crouch GJ, Eaton BE: Synthesis of 2′-deoxyuridine nucleosides with appended 5-position carbonyl cross-linking groups. Nucleosides Nucleotides 1994, 13:939-944.
    • (1994) Nucleosides Nucleotides , vol.13 , pp. 939-944
    • Crouch, G.J.1    Eaton, B.E.2
  • 48
    • 0029161984 scopus 로고
    • New uridine derivatives for use in systematic evolution of RNA ligands by exponential enrichment
    • Dewey TM, Mundt A, Crouch GJ, Zyzniewski MC, Eaton BE: New uridine derivatives for use in systematic evolution of RNA ligands by exponential enrichment J Am Chem Soc 1995, 117:8474-8475. The facile synthesis of 5-position modified UTPs and testing of modified UTPs as T7 RNA polymerase substrates is described.
    • (1995) J Am Chem Soc , vol.117 , pp. 8474-8475
    • Dewey, T.M.1    Mundt, A.2    Crouch, G.J.3    Zyzniewski, M.C.4    Eaton, B.E.5
  • 49
    • 0029962713 scopus 로고    scopus 로고
    • The RNa world: Functional diversity in a nucleoside by carboxyamidation of uridine
    • Dewey TM, Zyzniewski MC, Eaton BE: The RNA world: functional diversity in a nucleoside by carboxyamidation of uridine. Nucleosides Nucleotides 1996, 15:1611-1617. A generic methodology for the streamlined synthesis of modified uridines is described.
    • (1996) Nucleosides Nucleotides , vol.15 , pp. 1611-1617
    • Dewey, T.M.1    Zyzniewski, M.C.2    Eaton, B.E.3
  • 50
    • 0028829020 scopus 로고
    • Palladium catalysis in the synthesis of 8-position modified adenosine, 2′-deoxyadenosine and guanosine
    • Tu C, Keane C, Eaton BE: Palladium catalysis in the synthesis of 8-position modified adenosine, 2′-deoxyadenosine and guanosine. Nucleosides Nucleotides 1995, 14:1631-1638.
    • (1995) Nucleosides Nucleotides , vol.14 , pp. 1631-1638
    • Tu, C.1    Keane, C.2    Eaton, B.E.3
  • 51
    • 0030973840 scopus 로고    scopus 로고
    • Carboxyamidation of purine nucleosides: New secondary 8-carboxamid-purine nucleosides
    • in press
    • Tu C, Keane C, Eaton BE: Carboxyamidation of purine nucleosides: new secondary 8-carboxamid-purine nucleosides. Nucleosides Nucleotides 1997, in press.
    • (1997) Nucleosides Nucleotides
    • Tu, C.1    Keane, C.2    Eaton, B.E.3
  • 52
    • 0030580438 scopus 로고    scopus 로고
    • 2′-deoxy-2′-alkoxylaminouridines: Novel 2′-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2′-O-anhydrouridines
    • Sebesta DP, O'Rourke SS, Martinez RL, Pieken WA, McGee DPC: 2′-deoxy-2′-alkoxylaminouridines: novel 2′-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2′-O-anhydrouridines. Tetrahedron 1996,52:14385-14402. Stereoselective and generic methodology for the modification of the 2′-position of uridine is described.
    • (1996) Tetrahedron , vol.52 , pp. 14385-14402
    • Sebesta, D.P.1    O'Rourke, S.S.2    Martinez, R.L.3    Pieken, W.A.4    McGee, D.P.C.5
  • 54
    • 0030049806 scopus 로고    scopus 로고
    • 2′-amino-2′-deoxyuridine via an intramolecular cyclization of a trichloroacetimidate
    • McGee DPC, Vaughn-Settle A, Vargeese C, Zhai Y: 2′-amino-2′-deoxyuridine via an intramolecular cyclization of a trichloroacetimidate. J Org Chem 1996, 61:781-785.
    • (1996) J Org Chem , vol.61 , pp. 781-785
    • McGee, D.P.C.1    Vaughn-Settle, A.2    Vargeese, C.3    Zhai, Y.4
  • 56
    • 0030977566 scopus 로고    scopus 로고
    • Deconvolution of oligonucleotide libraries by electrospray ionization tandem mass spectrometry
    • in press
    • Pomerantz SC, McCloskey JA, Tarasow TM, Eaton BE: Deconvolution of oligonucleotide libraries by electrospray ionization tandem mass spectrometry. J Am Chem Soc 1997, in press.
    • (1997) J am Chem Soc
    • Pomerantz, S.C.1    McCloskey, J.A.2    Tarasow, T.M.3    Eaton, B.E.4
  • 57
    • 0030209142 scopus 로고    scopus 로고
    • Ribozymes: Building the RNA world
    • Joyce GF: Ribozymes: building the RNA world. Curr Biol 1996, 6:965-967. An insightful and thought provoking discussion of the catalytic necessities of an RNA world and what remains to be proven.
    • (1996) Curr Biol , vol.6 , pp. 965-967
    • Joyce, G.F.1
  • 58
    • 0025828122 scopus 로고
    • The rise and fall of the RNA world
    • Joyce GF: The rise and fall of the RNA world. New Biol 1991, 3:399-407.
    • (1991) New Biol , vol.3 , pp. 399-407
    • Joyce, G.F.1
  • 59
    • 0029414939 scopus 로고
    • The search for missing links between self-replicating nucleic acids and the RNA world
    • James KD, Ellington AD: The search for missing links between self-replicating nucleic acids and the RNA world. Orig Life Evol Biosphere 1995, 25:515-530.
    • (1995) Orig Life Evol Biosphere , vol.25 , pp. 515-530
    • James, K.D.1    Ellington, A.D.2
  • 60
    • 0029360503 scopus 로고
    • Re-creating the RNA world
    • Ichiro H, Ellington AD: Re-creating the RNA world. Curr Biol 1995,5:1017-1022. A description of how in vitro selection of RNA can be used to interpret molecular evolution.
    • (1995) Curr Biol , vol.5 , pp. 1017-1022
    • Ichiro, H.1    Ellington, A.D.2
  • 61
    • 0030133325 scopus 로고    scopus 로고
    • Some biochemical thoughts on the RNA world
    • Bloch K: Some biochemical thoughts on the RNA world. Chem Biol 1996, 3:405-407.
    • (1996) Chem Biol , vol.3 , pp. 405-407
    • Bloch, K.1
  • 62
    • 0029844445 scopus 로고    scopus 로고
    • Molecular paleontology: Understanding catalytic mechanisms in the RNa world by excavating clues from a ribozyme three-dimensional structure
    • Scott WG: Molecular paleontology: understanding catalytic mechanisms in the RNA world by excavating clues from a ribozyme three-dimensional structure. Biochemistry 1996, 24:604-608.
    • (1996) Biochemistry , vol.24 , pp. 604-608
    • Scott, W.G.1
  • 63
    • 0028234664 scopus 로고
    • Alternative bases in the RNA world: The prebiotic synthesis of urazole and its ribosides
    • Kolb VM, Dworkin JP, Miller SL: Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides. J Mol Evol 1994, 38:549-557.
    • (1994) J Mol Evol , vol.38 , pp. 549-557
    • Kolb, V.M.1    Dworkin, J.P.2    Miller, S.L.3
  • 64
    • 0028989062 scopus 로고
    • Prebiotic synthesis of 5-substituted uracils: A bridge between the RNa world and the DNA-protein world
    • Robertson MP, Miller S: Prebiotic synthesis of 5-substituted uracils: a bridge between the RNA world and the DNA-protein world. Science 1995, 268:702-705. An example of a spontaneous chemistry that could have occurred in an RNA world which would lead to the modification of uracils is described.
    • (1995) Science , vol.268 , pp. 702-705
    • Robertson, M.P.1    Miller, S.2
  • 65
    • 0029905462 scopus 로고    scopus 로고
    • The origin and early evolution of life: Prebiotic chemistry, the pre-RNA world, and time
    • Lazcano A, Miller S: The origin and early evolution of life: prebiotic chemistry, the pre-RNA world, and time. Cell 1996, 85:793-798.
    • (1996) Cell , vol.85 , pp. 793-798
    • Lazcano, A.1    Miller, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.