Mechanisms of in vitro cardioprotective action of magnesium on the aging myocardium

Magnesium Research

Volumn 10, Issue 2, 1997, Pages 157-168

  McCully, James D ^a   Levitsky, Sidney ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Calcium; Calcium channels; Cardioplegia; DNA; High energy phosphates; Ischemia; Magnesium; Mitochondria; Myocardium; Nucleus; RNA

Indexed keywords

MAGNESIUM; POTASSIUM;

ADAPTATION; AGING; ANIMAL; CARDIOMYOPATHY; CELL NUCLEUS; DRUG EFFECT; HEART ARREST; HEART MITOCHONDRION; HUMAN; METABOLISM; METHODOLOGY; REVIEW;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; CARDIOMYOPATHIES; CELL NUCLEUS; HEART ARREST, INDUCED; HUMANS; MAGNESIUM; MITOCHONDRIA, HEART; POTASSIUM;

EID: 0031151469     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Jennings, R.B. & Reimer, K. A. (1981): Lethal myocardial ischemic injury. Am. J. Pathol. 102, 241-255.
2. Jennings, R.B. & Steenbergen, C. (1985): Nucleotide metabolism and cellular damage in myocardial ischemia. Am. Rev. Physiol. 47, 727-749.
3. Nayler, W.G. (1981):The role of calcium in the ischemic myocardium. Am. J. Pathol. 102, 262-270.
4. Steenbergen, C., Murphy, E., Watts, J.A. & London, RE. (1990): Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ. Res. 66, 135-146.
5. Piper, H.M., Siegmund, B., Ladilov, Y.V. & Schluter, K.D. (1996): Myocardial protection during reperfusion. Thorac. Cardiovasc. Surg. 44, 15-9.
6. Barry, W.H. & Bridge, J.H. (1993): Intracellular calcium homeostasis in cardiac myocytes. Circulation 87, 1806-1815.
7. Kojima, S., Wu, S.T., Waters, T.A., Parmley, W.W., & Wikman-Coffelt, J.(1993): Effects of perfusion pressure on intracellular calcium, energetics, and function in perfused rat hearts. Am. J. Physiol. 264 (Heart Circ. Physiol 33). H183-H189.
8. Opie, L.H. (1991): Myocardial contraction and relaxation. In: The heart, physiology and metabolism. 2nd edition. ed. L.H. Opie, pp. 176-194. New York: Raven Press.
9. Ataka, K., Chen, D., McCully, J D., Levitsky, S. & Feinberg, H. (1993): Magnesium cardioplegia prevents accumulation of cytosolic calcium in the ischemic myocardium. J. Mol. Cell. Cardiol. 25, 1387-1390.
10. Tsukube, T., McCully, J.D., Faulk, E., Federman, M., LoCicero, J., Krukenkamp, I.B. & Levitsky, S. (1994): Magnesium cardioplegia reduces cytosolic and nuclear calcium and DNA fragmentation in the senescent myocardium. Ann. Thorac. Surg. 58, 1005-1015.
11. Gay, W.A. (1994): Crystalloid potassium cardioplegia: concepts and early studies. Ann. Thorac. Surg. 58, 1285-1286.
12. Burkhoff, D., Kalil-Filho, R. & Gerstenblith, G. (1990): Oxygen consumption is less in rat hearts arrested by low calcium than by high potassium at fixed flow. Am. J. Physiol. 259, H1142-H1147.
13. Hearse, D.J., Garlick, P.B. & Humphrey, S.M (1977): Ischemic contracture of the myocardium. Mechanism and prevention. Am. J Cardiol. 39, 986-993.
14. Sternbergh, W.C., Brunsting, L.A., Abd-Elfattah, A.S. & Weehsler, A.S. (1989): Basal metabolic energy requirements of polarized and depolarized arrest in rat heart. Am. J. Physiol. 256, H846-H851.
15. Shine, K.I. & Douglas, A.M. (1975): Magnesium effects in rabbit ventricle. Am. J. Physiol. 288, 1545-1554.
16. Meissner, G. & Henderson, J.S. (1987): Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on calcium and is modulated by magnesium, adenine nucleotide, and calmodulin. J. Biol. Chem. 262, 3065-3073.
17. Shine, K.I. (1979): Myocardial effects of magnesium. Am. J. Physiol. (Heart Circ.Physiol.) 237, H413-H423.
18. Ishide, N. (1996): Intracellular calcium modulators for cardiac muscle in pathological conditions. Jpn. Heart J. 37, 1-17.
19. 31P nuclear magnetic resonance spectroscopy Magnes. Trace. Elem. 10, 99-116.
20. Murphy, E. (1991): Cellular magnesium and Na/Mg exchange in heart cells. Ann. Rev. Physiol. 53, 273-287.
21. Murphy, E., Steenbergen, C., Levy, L., Raju, B. & London, R. (1989): Cytosolic free magnesium levels in ischemic rat heart. J. Biol. Chem. 264, 5622-5627.
22. 2+, pHi, and contractility during ischemia and reperfusion. Circulation 86, II371-II376.
23. Tsukube, T., McCully, J.D., Faulk, E., Federman, M., LoCicero, J., Krukenkamp, I.B. & Levitsky, S. (1994): Warm magnesium cardioplegia reduces cytosolic and nuclear calcium and DNA fragmentation in the senescent myocardium. Ann. Thorac. Surg. 58, 1005-1011.
24. Tsukube, T., McCully, J.D., Federman, M., Krukenkamp, I.B. & Levitsky, S. (1996): Developmental differences in cytosolic calcium accumulation associated with surgically induced global ischemia: Optimization of cardioplegic protection and mechanism of action. J. Thorac. Cardiovasc. Surg. 112, 175-184.
25. Faulk, E.A., McCully, J.D., Hadlow, N.C., Tsukube, T., Krukenkamp, I.B., Federman, M. & Levitsky, S. (1995): Magnesium cardioplegia enhances mRNA levels and the maximal velocity of cytochrome oxidase I in the senescent myocardium during global ischemia. Circulation 92, 405-412.
26. McCully, J.D., Tsukube, T., Ataka, K., Krukenkamp, I.B., Feinberg, H. & Levitsky S. (1994): Myocardial cytosolic calcium accumulation during ischemia/reperfusion: The effects of aging and cardioplegia. J.Cardiothorac. Surg. 9, 449-52.
27. Tsukube, T., McCully, J.D., Metz, R.M., Cook, C.U. & Levitsky S. (in press) Amelioration of ischemic calcium overload correlates with preserved high energy phosphates in the senescent myocardium. Am. J. Physiol. (Heart Circ. Physiol.)
28. Faulk, E.A., McCully, J.D., Tsukube, T., Hadlow, N.C., Krukenkamp, I.B. & Levitsky, S.(1995): Myocardial mitochondrial calcium accumulation modulates nuclear.
29. 2+ buffering through a Ca-dependent mechanism in cardiomyocytes. Am. J. Physiol. 267, C633-C641.
30. 2+ channels. Circ. Res. 76, 1049-1056.
31. 2+ channels. Circ. Res. 74, 271-280.
32. Lakatta, E.G. (1993): Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73, 413-467.
33. Moschella, M.C. & Marks AR. (1993): Inositol 1,4,5 triphosphate receptor expression in cardiac myocytes. J.Cell. Biol. 120, 1137-1146.
34. Matsuda, H., McCully, J.D. & Levitsky S. (in press): Developmental differences in cytosolic calcium accumulation associated with global ischemia: Evidence for differential intracellular calcium channel receptor activity. Circulation.
35. Brown, E.M., Vassilev, P.M. & Herbert, S.C. (1995): Calcium ions as extracellular messengers. Cell 83, 679-682.
36. 2+ and phosphorylation. Science 265, 1997-2000.
37. Paradies, G., Ruggiero, P.M., Petrosillo, G. & Quagliariello, E.(1996): Age-dependent impairment of mitochondrial function in rat heart tissue. Effect of pharmacological agents. Ann. N.Y. Acad. Sci. 786, 252-263.
38. Chen, J., Warshaw, J. & Sanadi, D. (1972): Regulation of mitochondrial respiration in senescence. J. Cell Physiol. 80, 141-148.
39. Nishimura, M., Takami, H., Kaneko, M. et al., (1993): Mechanism of mitochondrial enzyme leakage during reoxygenation of the rat heart. Cardiovasc. Res. 27, 1116-1122.
40. 2 release as a byproduct of respiration. Free Rad. Res. Comm. 18, 127-137.
41. Nayler, W., Panagiotopoulos, S. & Elz, J. (1988): Calcium mediated damage during post-ischemic reperfusion. J. Mol. Cell. Cardiol. 20, 41 S11.
42. Jimenez, E., del Nido, P. & Feinberg,H. (1993): Redistribution of myocardial calcium during ischemia. Relation to onset of contracture. J. Thorac. Cardiovasc. Surg. 105, 988-994.
43. Peng, C.F., Kane, J.J. , Murphy, M.L. & Straub, K.D. (1977): Abnomal mitochondrial oxidative phosphorylation of ischemic myocardium by calcium chelating agents. J. Mol. Cell. Cardiol. 9, 897-908.
44. 2+ transport system of myocardium in ageing. Gerontology. 34, 64-74.
45. Pieri,C.,Recchioni, R. & Moroni, F. (1993): Age-dependent modifications of mitochondrial transmembrane potential and mass in rat splenic lymphocytes during proliferation. Mech. Ageing Dev. 70, 201-212.
46. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinazawa- Itoh, K., Nakashima, R., Yaono, R. & Yoshikawa S. (1995): Structures of the metal sites of oxidized bovine heart cytochrome-c oxidase at 2.8 Ȧ. Science 269, 1069-1074.
47. Lin, J., Pan, L.P. & Chan, SI. (1996): The subunit location of magnesium in cytochrome-c oxidase. J. Biol. Chem. 268, 22210-22214.
48. Ferrari, R., Pedersini, P., Bongrazio, M., Gaia, G., Bernocchi, P., DiLisa, F. & Visioli, O. (1993): Mitochondrial energy production and cation control in myocardial ischaemia and reperfusion. Basic. Res.Cardiol. 88, 495-512.
49. 31P-NMR spectroscopy. Biochim. Biophys. Acta. 885, 1-11.
50. 31P NMR chemical shifts of ATP. Anal. Biochem, 214, 458-467.
51. Bak, M. & Ingwall, J. (1992): NMR-invisible ATP in heart: fact or function? Am. J. Physiol. 262, E943-E947.
52. Gevers, W. (1977): Generation of protons by metabolic processes In heart cells. J. Mol. Cell. Cardiol. 9, 867-874.
53. Shattock M.J., Hearse D.J. & Fry C.H. (1987): The ionic basis of the anti-ischemic and anti-arrhythmic properties of magnesium in the heart. J. Am. Col. Nutri. 6, 27-33.
54. Mazzanti, M., DeFelice, L.J., Cohen, J. & Malter, H. (1990): Ion channels in the nuclear envelope. Nature 343, 764-67
55. 2+ concentration in isolated rat liver nuclei. Proc. Natl. Acad. Sci. USA 86, 453-57.
56. 2+ concentration measured with specifically targeted recombinant aequorin. EMBO J. 12, 4813-19.
57. Benzi, R.H. & Lerch, R. (1992): Dissociation between contractile function and oxidative metabolism in post-ischemic myocardium. Circ. Res. 71, 567-76.
58. 2+ as a second messenger within mitochondria of the heart and other tissues. Ann. Rev. Physiol. 52, 451-466.
59. Shmookler-Reis, R.J & Goldstein, S. (1980): Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts. Cell 21, 739-746.
60. Claycomb, W.C. (1979): DNA synthesis and DNA enzymes in terminally differentiating cardiac muscle cells. Exp. Cell Res. 118, 111-114.
61. McCully, J.D., Malby, J.D., Sole, M. J. & Liew,C. C. (1991): RNA transcription and translation in the normal and cardiomyopathic Syrian hamster during the temporal development of the myocardium. Biochem. Cell Biol. 69, 88-92.
62. Matsuda, H., McCully, J.D.,Hadlow, N.C., Krukenkamp, I.B & Levitsky, S. (1995): Evidence that cardioplegia enhances functional recovery in the senescent myocardium through an RNA dependent mechanism. Surg. Forum 46, 651-654.
63. Myrmel, T., McCully, J.D., Krukenkamp, I.B & Levitsky, S. (1994): Warm ischemia triggers cardioprotective heat shock protein mRNA by anaerobic metabolism. Circulation 90, 299-305.
64. McCully, J.D., Myrmel, T., Lotz, M.M., Krukenkamp, I.B & Levitsky, S. (1995). The rapid expression of myocardial Hsp 70 mRNA and the heat shock 70 kD protein can be achieved after only a brief period of retrograde hyperthermic perfusion. J. Mol. Cell. Cardiol. 27, 873-882.
65. Entwistle, J.W.C.,Graham, L.J., Jakoi, E.R. & Wechler, A.S. (1995): Myocardial stunning: Changes in cardiac gene expression after global ischemia and reperfusion. Surg. Forum 46, 209-211.
66. Thornton, J., Striplin, S., Liu, G.S., Swafford, A., Stanley, A.W.H., Van Winkle,D.M. & Downey, J.M.(1990): Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. Am. J. Physiol. 259, H1822-H1825.