Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits

Magnesium Research

Volumn 10, Issue 2, 1997, Pages 127-133

  Soldatovic, D ^a   Vujanovic, D ^a   Matovic, V ^a   Plamenac, Z ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Blood; Calcium disodium edetate; Lead intoxication; Magnesium; Protoporphyrin IX; Rabbits; Urine; Zinc protoporphyrin; aminolevulinic acid

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

AMINOLEVULINIC ACID; CHELATING AGENT; EDETIC ACID; LEAD; MAGNESIUM; PROTOPORPHYRIN; PROTOPORPHYRIN ZINC;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; CHRONIC DISEASE; COMPARATIVE STUDY; DIET SUPPLEMENTATION; FEMALE; LEAD POISONING; ORAL DRUG ADMINISTRATION; RABBIT; URINE;

ADMINISTRATION, ORAL; AMINOLEVULINIC ACID; ANALYSIS OF VARIANCE; ANIMALS; CHELATING AGENTS; CHRONIC DISEASE; DIETARY SUPPLEMENTS; EDETIC ACID; FEMALE; LEAD; LEAD POISONING; MAGNESIUM; PROTOPORPHYRINS; RABBITS;

EID: 0031151183     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hardy, H.L., Elkins, H.B., Ruotolo, B.P., Quinby, J. & Baker, W.H. (1954): Use of monocalcium disodium ethylene tetraacetate in lead poisoning. J. Am. Med. Assoc. 154, 1171-1175.
2. Foreman, J., Finnegan, C. & Lushnbaugh, C.C. (1956): Nephrotoxic hazard from uncontrolled edathamil calcium-disodium therapy. J. Am. Med. Assoc. 160, 1042-1047.
3. Tsuchiya, K. (1979): Lead. In: Handbook on the toxicology of metals, eds. L.Friberg, G.F. Norberg & V.B. Vouk, pp. 451-500. New York: Elsevier/ North-Holland Biomed. Press.
4. Goyer, R.A. (1971): Lead and kidneys: current topics in pathology Ergenbnissee Pathol. 55, 147-176.
5. Graziano, J.H., Siris, E., Lolacono, N. Silverberg S.J. & Turgeon L. (1985): 2,3-Dimercaptosuccinic acid as an antidote for lead intoxication. Clin. Pharmacol. Ther. 37, 431-438.
6. Graziano, J.H. (1993): Conceptual and practical advances in the measurement and clinical management of lead toxicity. Neuro Toxicology 14(2-3), 219-224.
7. Perry, H.M. & Perry E.F. (1959): Normal concentrations of some trace metals in human urine: change produced by ethylenediaminetetraacetate. J. Clin. Invest. 246, 1452-1463.
8. Klaasen, C.D. (1980): Heavy metals and heavy-metal antagonists. In: The Pharmacological basis of therapeutics. eds. A.G. Gilman & A. Gilman, pp. 1615-1673. New-York: MacMillan Publishing Co.
9. Soldatovic, D., Bresjanac, M. & Petrovic, C. (1965): Changement du taux du calcium et du magnésium dans le serum des animaux soumis aux condition d'intoxication chronique par le plomb. Arh Farm 1, 1-6.
10. er Symp. Inter. Defic. Magn. Path. Hum. II Vol. des Communications et Discussions. ed. Durlach J, pp. 569-572. SGEMV ed Vittel.
11. Soldatovic, D., Nedeljkovic, M. & Farah, G. (1980): Changes in the quantity of Mg in organs of rabbits submitted to chronic intoxication by some mineral poisons (saturnism, fluorosis and manganism). In: Magnesium in health and disease, eds. M. Cantin & M.S. Seeling, pp. 961-965. New York: Spectrum Press.
12. Singh, N.P., Thind, I.S., Vitale, L.F. & Pawlow, M. (1979): Intake of magnesium and toxicity of lead: an experimental model. Arch. Environ. Health 34, 168-173.
13. Krall, A.R., McLean, W.S., Gamble, H.F., Rogers, J.R., Reigart, E.W. & Collawn, S.S. (1980): Effects of magnesium infusions on the metabolism of calcium and lead. In: Magnesium in health and disease, eds. M. Cantin & M.S. Seelig, pp. 941-948. New York: Spectrum Press.
14. Guiet-Bara, A., Bara, M. & Durlach, J. (1985): Magnesium: a competitive inhibitor of lead. Study on the isolated human amnion. In: Magnesium deficiency, eds. M.J. Halpern & J. Durlach. pp. 38-45. Basel: Karger.
15. Guiet-Bara, A., Bara, M. & Durlach, J. (1990): Magnesium: a competitive inhibitor of lead and cadmium. Ultrastructural studies of the human amniotic epithelial cell. Magnes. Res. 3, 31-36.
16. Guiet-Bara, A., Bara, M. & Durlach, J. (1991): Toxic metals and human amniotic ion permeability. II. Ultrastructural study and relationship with magnesium. Magnes. Res. 4, 2, 77-81.
17. Matovic, V. (1991): Antagonism of lead and magnesium in saturnism. Doctoral dissertation. University of Belgrade, Yugoslavia.
18. Soldatovic, D., Matovic, V. & Vujanovic, D. (1993): Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes. Res. 6,2. 145-148.
19. Matovic, V., Vujanovic, D. & Soldatovic, D. (1994): Effect of increased intake of Mg on urinary Cu and Zn elimination in rabbits exposed to prolonged lead intoxication. Arch. Toxicol. Kinet. Xenobiot. Metab. 2,2, 427-428.
20. Matovic, V., Soldatovic, D. & Vujanovic, D. (1995): Magnesium against lead: new approach to prophylaxis and therapy of chronic lead intoxication. In: Aspects on environmental toxicology, eds. V.-P. Kotsaki-Kovatsi & A.J. Vafiadu, pp. 78-82. Thessaloniki: Tecnika Studio.
21. Piomelli, S., Dovidow, B., Guinee, V.F. et al. (1973): The FEP (free erythrocyte porphyrins) test: a screening micromethod for lead poisoning. Pediatrics 51, 254-259.
22. Grabecki, J., Habuch, T. & Urbanowicz, H. (1967): Die einfachen Bestimmungsmethoden der delta-aminolevulinsäure im Harn. Int. Arch. Gewerbepath. Gewerbehyg. 23, 226-240.
23. 2 EDTA on normal Pb in rabbits. Arch. Toxicol. Xenobiot. Metab. 2,2. 479-480.
24. Schlegel, H. & Kufner, G. (1979): Long-term observation of biochemical effects of lead in human experiments. J. Clin. Chem. Clin. Biochem. 17, 225-233.