The synthesis of no-carrier-added [11C]urea from [11C]carbon dioxide and application to [11C]uracil synthesis

Applied Radiation and Isotopes

Volumn 48, Issue 5, 1997, Pages 619-621

  Chakraborty, P K ^a   Mangner, T J ^a   Chugani, H T ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CONDENSATION; CYCLOTRONS; HYDROLYSIS; NOBELIUM; SULFURIC ACID; SYNTHESIS (CHEMICAL);

RADIOCHEMICAL YIELD; URACIL SYNTHESIS;

UREA;

CARBON DIOXIDE C 11; UNCLASSIFIED DRUG; URACIL C 11; UREA C 11;

ARTICLE; CONTROLLED STUDY; ISOTOPE LABELING; PRIORITY JOURNAL; SYNTHESIS;

EID: 0031149744     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(97)00007-9     Document Type: Article

References (10)

1. Chakraborty, P. K., Mangner, T. J. and Chugani, H. T. (1996) The synthesis of no-carrier-added [C-11]urea from [C-11]carbon dioxide. J. Nucl. Med. 37, 51P.
2. Davidson, D. and Baudish, O. (1926) The preparation of uracil from urea. J. Am. Chem. Soc. 48, 2379-2383.
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4. 11C]urea. Int. J. Appl. Radiat. Isot. 36, 739-740.
5. Hart, D. J., Kanai, K., Thomas, D. G. and Yang, T. K. (1983) Preparation of primary amines and 2-azetidones via N-trimethylsilyl imines. J. Org. Chem. 48, 289-294.
6. Kruger, C. R. and Rochow, E. G. (1964) O-silyl-substituted enols. J. Organometal. Chem. 1, 476-483.
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9. 11C] thymidine for quantification of cellular proliferation with PET. Appl. Radiat. Isot. 42, 103-104.
10. Wannagat, V. U., Kuckertz, H., Kruger, C. and Pump, J. (1964) Reaktionen des Natrium-bis-[trimethylsilyl]-amids mit Kohlenstoffchalkogeniden und Kohlenstoffhalogeniden. (This reference was provided by Dr L. R. Sita, University of Chicago in a personal communication after the manuscript had been submitted.). Z. Anorg. Allge. Chem. 333, 54-60.