Candida infection following severe trauma exacerbates Th2 cytokines and increases mortality

Journal of Surgical Research

Volumn 69, Issue 2, 1997, Pages 399-407

  Mack, Vivian E ^a   McCarter, Martin D ^a   Naama, Hassan A ^a   Calvano, Steve E ^a   Daly, John M ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANDIDIASIS; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; INFECTION; INJURY; KIDNEY HOMOGENATE; LIVER HOMOGENATE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SURVIVAL;

EID: 0031148479     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.5093     Document Type: Conference Paper

References (27)

1. 1. Calvano, S. E. Hormonal mediation of immune dysfunction following thermal and traumatic injury. In J. Galin and A. Fauci (Eds.), Advances in Host Defense Mechanisms. New York: Raven Press, 1986. Pp. 111-142.
2. 2. Baker, C. C., Oppenheimer, L., Stephens, B., Lewis, F. R., and Trunkey, D. D. Epidemiology of trauma deaths. Am. J. Surg. 140: 144, 1980.
3. 3. Schmand, J. F., Ayala, A., and Chaudry, I. H. Effects of trauma, duration of hypotension and resuscitation regimen on cellular immunity after hemorrhagic shock. Crit. Care Med. 22: 1076, 1994.
4. 4. Cech, A. C., Markmann, J. F., Naama, H. A., and Daly, J. M. Inappropriate Th2 response to Candida after hemorrhage correlates with reduced survival. Am. Coll. Surg. Surg. Forum 80th Clin. Congr. 45: 55, 1995.
5. 5. Zellweger, R., Ayala, A., DeMaso, C. M., and Chaudry, I. H. Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock 4: 149, 1995.
6. 6. Lawrence, M. H., de Riesthal, H. F., and Calvano, S. E. Changes in memory and naive CD4+ lymphocytes in lymph nodes and spleen after thermal injury. J. Burn Care Rehabil. 17: 1, 1996.
7. 7. O'Sullivan, S. T., Lederer, J. A., Horgan, A. F., Chin, C. H. L., Mannick, J. A., and Rodrick, M. L. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann. Surg. 222: 482, 1995.
8. 8. Wang, B. S. W., Heacock, E. H., Wu, A. V., and Mannick, J. A. Generation of suppressor cells in mice after surgical trauma. J. Clin. Invest. 66: 200, 1980.
9. 9. Mack, V. E., McCarter, M. D., Naama, H. A., Calvano, S. E., and Daly, J. M. Dominance of Th2-type cytokines following severe injury. Arch. Surg. 131: 1303, 1996.
10. 10. Abraham, E., and Chang, Y. H. Hemorrhage-induced alterations in function and cytokine production of T cells and T cell subpopulations. Clin. Exp. Immunol. 90: 497, 1992.
11. 11. DiPiro, J. T., Howdieshell, T. R., Goddard, J. K., Callaway, D. B., Hamilton, R. G., and Mansberger, A. R. Association of interleukin-4 plasma levels with traumatic injury and clinical course. Arch. Surg. 130: 1159, 1995.
12. 12. Romagnani, S. Induction of Th1 and Th2 responses: A key role for the 'natural' immune response? Immunol. Today 13: 379, 1992.
13. 13. Del Prete, G., Maggi, E., and Romagnani, S. Human Th1 and Th2 cell: Functional properties, mechanisms of regulation, and role in disease. Lab. Invest. 70: 299, 1994.
14. 14. Romagnani, S. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12: 227, 1994.
15. 15. Smith, D. J., Jr., and Thomson, P. D. Changing flora in burn and trauma units: Historical perspective - Experience in the United States. J. Burn Care Rehabil. 13: 276, 1992.
16. 16. Beck-Sague, C., and Jarvis, W. R. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. J. Infect. Dis. 167: 1247, 1993.
17. 17. Mosmann, T. R., and Coffman, R. L. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145, 1989.
18. 18. Del Prete, G., and Romagnani, S. The role of Th1 and Th2 subsets in human infectious diseases. Trends Microbiol. 2: 4, 1994.
19. 19. Gajewski, T. F., Schell, S. R., Nau, G., and Fitch, F. W. Regulation of T-cell activation: Differences among T-cell subsets. Immunol. Rev. 111: 79, 1989.
20. 20. Coffman, R. L., Varkila, K., Scott, P., and Chatelain, R. Role of cytokines in the differentiation of CD4+ T-cell subsets in vivo. Immunol Rev. 23: 189, 1991.
21. 21. Seder, R. A., and Paul, W. E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12: 635, 1994.
22. 22. Kelso, A. Th1 and Th2 subsets: Paradigms lost? Immunol. Today 16: 374, 1995.
23. 23. Ayala, A., Lehman, D. L., Herdon, C. D., and Chaudry, I. H. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Arch. Surg. 129: 1172, 1994.
24. 24. Romani, L., Cenci, E., Mencacci, A., Bistoni, F., and Puccetti, P. T helper cell dichotomy to Candida albicans: Implications for pathology, therapy, and vaccine design. Immunol. Res. 14: 148, 1995.
25. 25. Puccetti, P., Romani, L., and Bistoni, F. A Th1-Th2-like switch in candidiasis: New perspectives for therapy. Trends Microbiol. 240: 237, 1995.
26. 26. Levitz, S. M., and North, E. A. Gamma interferon gene expression and release in human lymphocytes directly activated by Cryptococcus neoformans and Candida albicans. Infect. Immun. 64: 1595, 1996.
27. 27. Ashman, R. B., and Bolitho, E. M. Strain differences in the severity of lesions in murine systemic candidiasis correlate with the production of functional gamma interferon by Candida-activated lymphocytes in vitro. Lymphokine Cytokine Res. 12: 471, 1993.