Large-scale production of peptides using the solid-phase continuous flow method. Preparative synthesis of the novel tachykinin antagonist MEN 10627

Journal of Peptide Science

Volumn 3, Issue 3, 1997, Pages 224-230

  Caciagli, Valerio ^a   Cardinali, Franco ^a   Hänsicke, Andre ^b   Tuchalski, Gisbert ^b   Lombardi, Paolo ^a  

^a Menarini Ricerche SpA   (Italy)

^b Berlin Chemie Menarini   (Germany)

Author keywords

Continuous flow; Large scale peptide synthesis; Macrosorb; Neurokinin A receptor antagonist; SPPS

Indexed keywords

CYCLOPEPTIDE; MEN 10627; TACHYKININ;

ARTICLE; CHEMICAL MODEL; DRUG ANTAGONISM; PROTEIN ENGINEERING; SYNTHESIS;

MODELS, CHEMICAL; PEPTIDES, CYCLIC; PROTEIN ENGINEERING; TACHYKININS;

EID: 0031135556     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1387(199705)3:3<224::aid-psc104>3.0.co;2-z     Document Type: Article

References (11)

1. J. Meienhofer in: Peptides 1984 (Proceedings of the 18th European Peptide Symposium, U. Ragnarsson, Ed., p. 19-34, Almqvist & Viksell, Stockholm 1984.
2. C. Groginski (1986). Automated large scale, solid phase peptide synthesis. Am. Biotechnol Lab. 4, 38-52.
3. M. Edelstein, P. E. Scott, M. Sherlund, A. L. Hansen and J. L. Hughes (1986). Design considerations for pilot scale solid phase peptide synthesis reactors. Chem. Eng. Sci. 41, 617-624.
4. C. Birr in: Innovation and Perspectives in Solid Phase Synthesis, R. Epton, Ed., p. 84-94, Mayflower, Birmingham 1994.
5. V. Caciagli, M. G. Longobardi and A. Pessi in: Peptides (Proceedings of the 12th American Peptide Symposium), J. A. Smith and J. E. Rivier, Eds., p. 672-673, ESCOM, Leiden 1992.
6. A. Dryland and R. C. Sheppard (1986). Peptide synthesis. Part 8. A system for solid-phase synthesis under low pressure continuous flow conditions. J. Chem. Soc. Perkin Trans. I, 125-137.
7. K. Nokihara, M. Kiffe, Y. Yokomizo, S. Nakamura and T. Nishine (1994). Large-scale continuous-flow peptide synthesis with solvent and acyl component recovery. J. Am. Lab. 8, 41-45.
8. V. Pavone, A. Lombardi, C. Pedone, L. Quartara and C. A. Maggi in: Peptides (Proceedings of the 13th American Peptide Symposium), R. S. Hodges and J. A. Smith, Eds., p. 487-489, ESCOM, Leiden 1994.
9. V. Pavone, A. Lombardi, C. A. Maggi, L. Quartara and C. Pedone (1995). Conformationally rigidity versus flexibility in a novel peptidic Neurokinin A receptor antagonist. J. Peptide Sci. 1, 236-240.
10. 6-) cyclo(2b-5b). J. Chem. Soc. Perkin Trans. 2, 987-983,
11. D. P. Gregory, N. Bhaskar, R. C. Sheppard and S. Singleton in: Innovation and Perspectives in Solid Phase Synthesis, R. Epton, Ed., p. 391-396, Intercept Ltd, Andover 1992.