The development of lymphocytes

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 11-13

  Melchers, Fritz ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

Allelic exclusion; Immature and mature B cells; Positive and negative selection; Pre B receptor; Surrogate light L chain; S S switching

Indexed keywords

ANIMAL; B LYMPHOCYTE; GENE REARRANGEMENT; HUMAN; LYMPHOCYTE; PHYSIOLOGY; REVIEW; CELL MATURATION; CONFERENCE PAPER; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; LYMPHOCYTES;

EID: 0031134838     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237496     Document Type: Article

References (19)

1. Melchers F: Introduction to the Annual Report of the Basel Institute for Immunology 1995., pp 12-28.
2. Rolink A, Melchers F: Generation and regeneration of cells of the B-lymphocyte lineage. Curr Opin Immunol 1993:5:207-217.
3. Grawunder U, Rolink A, Melchers F: Induction of sterile transcription from the T. chain gene locus in V(D)J-recombinase deficient progenitor B cells. Int Immunol 1995:7:1915-1925.
4. Rolink A, Haasner D, Nishikawa SI, Melchers F: Changes in frequencies of clonable preB cells during life in different lymphoid organs of mice. Blood 1993:81:2290-2300.
5. Rolink AG, Melchers F, Andersson J: The SCID but not the RAG2 gene product is required for Sp-Ss-heavy chain class switching. Immunity, in press.
6. Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F: 1L-2 receptor chain (CD25. TAC) expression defines a crucial stage in preB cell development. Int Immunol 1994:6: 1257-1264.
7. Ten Boekel E, Melchers F, Rolink A: The status of Ig loci rearrangements in single cells from different stages of B cell development. Int Immunol 1995:7:1013-1019.
8. Rolink A, Kudo A, Karasuyama H, Kikuchi Y, Melchers F: Long-term proliferating early prc B cell lines and clones with the potential to develop to surfacc-Ig positive mitogen-reactive Beells in vitro and in vivo. EMBO J 1991:10: 327-336.
9. Rolink A, Streb M, Nishikawa SI, Melchers F: The c-kii encoded tyrosine kinase regulates the proliferation of early pre-B cells. F.ur J Immunol 1991;21:2609-2612.
10. Winkler TH, Melchers F, Rolink AG: Interleu-kin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Blood 1994:85:2045-2051.
11. Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A: The surrogate light chain in B-cell development. Immunol Today 1993; 14:60-68.
12. Rolink A, Ten Boekel E, Melchers F, Fearon DT, Krop I, Andersson J: A subpopulation of B220+ cells in murine bone marrow docs not express CD 19 and contains NK cell-progenitors. J Exp Med 1996:183:187-194.
13. Melchers F, Rolink A, Grawunder U, Winkler Til, Karasuyama H, Ghia P, Andersson J: Positive and negative selection events during B lymphopoiesis. Curr Opin Immunol 1995:7:214-227.
14. Grawunder U, Leu TMJ, Schatz DG, Werner A, Rolink AG, Melchers F, Winkler TH: Down-regulation of RAG I and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 1995;3: 601-608.
15. Rolink A, Grawunder U, Haasner D, Strasser A, Melchers F: Immature surface lg+ B cells can continue to rearrange v. and X L chain gene loci. J Exp Med 1993; 178:1263-1270.
16. Ghia P, Gratwohl A, Signer E. Winkler TH, Melchers F, Relink AG: immature B cells from human and mouse bone marrow can change their surface light chain expression. Bur J Immunol 1995;25:3108-3114.
17. Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A. Melchers F. Alt FW: Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev 1994:8:1043-1057.
18. Andersson J, Melchers F, Rolink A: Stimulation by Tcell independent antigens can relieve the arrest of differentiation of immature auto-reactive B cells in the bone marrow. Scand J Immunol 1995:42:21-33.
19. Oka Y, Rolink AG, Andersson J, Kamanaka M, Uchida J, Yasui T, Kishimoto T, Kikutani H, Melchers F: Profound reduction of mature B cell numbers, reactivities and serum immunoglobulin levels in mice which simultaneously carry the XID and CD40-deftciency genes. Int Immunol, in press