Lack of influence of cyclosporin a on levels of gingival procollagen types I and III mRNAs in rats of different ages

Archives of Oral Biology

Volumn 42, Issue 4, 1997, Pages 277-282

  Redlich, Meir ^a   Greenfeld, Ziv ^a   Cooperman, Helena ^a   Pisanty, Sara ^a   Shoshan, Shumel ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Ageing; Cyclosporin A. collagen mRNA; Interstitial collagen

Indexed keywords

ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COMPLEMENTARY DNA; CYCLOSPORIN; CYCLOSPORIN A; MESSENGER RNA; PROCOLLAGEN;

ADOLESCENT; AGE; AGED; ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA PROBE; DNA RNA HYBRIDIZATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GINGIVA; GINGIVA HYPERPLASIA; GINGIVA OVERGROWTH; IATROGENIC DISEASE; INTERSTITIUM; MALE; METABOLISM; NONHUMAN; NORTHERN BLOTTING; RAT; RAT STRAIN; STATISTICS; STROMA; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSLATION REGULATION;

AGE FACTORS; ANIMALS; CYCLOSPORINE; DNA PROBES; GENE EXPRESSION REGULATION; GINGIVA; GINGIVAL OVERGROWTH; MALE; PROCOLLAGEN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0031128399     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(97)00015-0     Document Type: Article

References (40)

1. Amstad-Jossi M. and Schroeder H. E. (1987) Age related alterations of periodontal structure around the cemento-enamel junction and of the gingival connective tissue composition in germ-free rats. J. Periodont. Res. 13, 76-90.
2. Ashcroft G. S., Horan M. A. and Ferguson M. W. J. (1995) The effects of ageing on cutaneus wound healing in mammals. J. Anat. 187, 1-26.
3. Barber M. T., Savage N. W. and Seymour G. J. (1992) The effect of cyclosporin and lipopolysaccharide on fibroblasts: Implications for cyclosporin induced gingival overgrowth. J. Periodontal. 63, 397-404.
4. Bartold P. M. (1987) Cyclosporin and gingival overgrowth. J. oral. Pathol. Med. 16, 463-468.
5. Belazi M., Thomopoulos G. N., Markopoulos A. K. and Papanayoton P. (1993) Cyclosporin-A induced gingival hyperplasia: an ultrastructural study of the oral epithelial prickle cells. J. Submicrosc. Cytol. Pathol. 25, 591-601.
6. Bellon G., Wegrowski J. and Perreau C.et al. (1978) A parallel between two techniques of extraction of connective tissue macromolecules. Anal. Biochem. 75, 263-273.
7. Birkedal-Hansen H. (1993) Role of matrix metalloproteinases in human periodontal diseases. J. Periodontol. 64, 474-484.
8. Bonnaure-Mallet M., Tricot-Doleux S. and Godeau G. J. (1995) Changes in extracellular matrix macromolecules in human gingiva after treatment with drugs inducing gingival overgrowth. Archs. oral Biol. 40, 393-400.
9. Bradford M. (1976) A rapid and sensitive method for the determination of microgram quantities of protein utilizing the principle of dye binding. Anal. Biochem. 72, 242-254.
10. Burke E. M., Horton W. E., Pearson J. D., Crow M. T. and Martin G. R. (1994) Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors. Exp. Gerontol. 29, 37-53.
11. Burton K. (1968) Determination of DNA concentration with diphenylamine. Meth. Enzymol. XII-B, 163-166.
12. Calne R. Y., Rolles K., White D. J. G., Thiru S., Evans D. B. and Henderson R. (1981) Cyclosporin-A in clinical organ grafting. Transplant Proc. 13, 349-358.
13. Chomczynsky P. and Sacchi N. (1987) Single-step method of RNA isolation by acid quanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
14. Deliliers G. L., Santoro F., Polli N., Bruno E., Fumagalli L. and Risciotti E. (1986) Light and electron microscopic study of cyclosporin A-induced gingival hyperplasia. J. Periodontal. 57, 771-775.
15. Feutren G. (1989) Cyclosporin A: Recent developments in the mechanism of action and clinical application. Curr. Opin. Immunol. 2, 239-245.
16. Fu E., Nieh S., Chang H. L. and Wang S. L. (1995) Dose-dependent gingival overgrowth induced by cyclosporin in rats. J. Periodontol. 66, 594-598.
17. Furth J. J. (1991) The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts. J. Gerontol. 46B, 122-124.
18. Granelli-Piperno A., Keane M. and Steinmann R. (1988) Evidence that cyclosporin inhibits cell mediated immunity primarily at the level of the T lymphocyte rather than accessory cell. Transplantation 46 (Suppl.. 535 605.
19. James J. A., Irwin C. R. and Linden G. J. (1995) The effects of culture environment on the response of human gingival fibroblasts to cyclosporin A. J. Periodontol. 66, 339-344.
20. Johnson B. D., Page R. C., Narayanan S. and Pieters H. P. (1986) Effects of donor age on protein and collagen synthesis in vitro by human diploid fibroblasts. Lab. Invest. 55, 490-496.
21. Karring T. and Loe H. (1973) The effect of age on mitotic activity in rat oral epithelium. J. Periodont. Res. 8, 164-170.
22. Klausen B. (1991) Microbiological and immunological aspects of experimental periodontal disease in rats: A review article. J. Periodontol. 62, 59-73.
23. Marian G., Calastrini C., Carinci F., Marzola R. and Calura G. (1993) Ultrastructural features of cyclosporin-A induced gingival hyperplasia. J. Periodontol. 64, 1092-1097.
24. Mariotti A., Hassell T. and Kaminker P. (1993) The influence of age on collagen and non-collagen protein production by human gingival epithelial cells. Archs oral Biol. 38, 635-640.
25. Mays P. K., McAnulty R. J., Campa J. S. and Laurent G. (1991) Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesised collagen in regulating collagen production. Biochem. J. 276, 307-313.
26. McGaw W. T. and Porter H. (1988) Cyclosporin-induced gingival overgrowth: An ultrastructural stereologic study. Oral. Surg. Oral Med. Oral Pathol. 65, 186-190.
27. McGaw W. T., Lam S. and Coates J. (1987) Cyclosporin-induced gingival overgrowth: Correlation with dental plaque scores, gingivitis scores and cyclosporin levels in serum and saliva. Oral Surg. Oral Med. Oral Pathol. 64, 293-297.
28. Neuman R. E. and Logan M. A. (1950) The determination of collagen and elastin in tissue. J. Biol. Chem. 186, 549-556.
29. Nudel U., Zakut R., Shani M., Neuman S., Levy Z. and Yaffe D. (1983) The nucleotide sequence of the rat cytoplasmatic β-actin gene. Nucl. Acid Res. 11, 1759-1771.
30. Olbricht C. J., Steinker M., Auch-Schwelk W., Bossaller C., Haas J. and Kock K. M. (1994) Effect of cyclosporin on kidney proteolytic enzymes in men and rats. Nephrol. Dial. Transplant. 9, 22-26.
31. Page E. H., Wexler D. M. and Guenther L. C. (1986) Cyclosporin A. J. Am. Acad. Dermat. 14, 785-791.
32. Pisanty S., Rahamim E., Ben-Ezra D. and Shoshan S. (1990) Prolonged systemic administration of cyclosporin A affects gingival epithelium. J. Periodontol. 61, 138-141.
33. Pisanty S., Shoshan S., Chajek T., Maftsir G., Sacks B. and Ben-Ezra D. (1988) The effect of cyclosporin A (CsA) treatment on gingival tissue of patients with Behçet's disease. J. Periodontol. 59, 599-603.
34. Redlich M., Peleg I., Cooperman H. and Shoshan S. (1994) Topological differences in the expression of collagen type I and collagen type III mRNAs in the rat gingiva. J. Periodontol. 65, 776-780.
35. Rostock M. H., Fry H. R. and Turner J. E. (1986) Severe gingival overgrowth associated with cyclosporin therapy. J. Periodontol. 57, 294-299.
36. Siegel S. (1956) Non-Parametric Statistics for the Behavioral Sciences (Ed. Siegel S.) p. 116. McGraw-Hill, New York.
37. Schincaglia G. P., Forniti F., Cavallini R., Piva R., Calura G. and del-Senno L. (1992) Cyclosporin A increases type I procollagen production and mRNA level in human gingival fibroblasts in vitro. J. Oral Pathol. Med. 21, 181-185.
38. Stegemann H. and Stalder K. (1967) Determination of hydroxyproline. Clin. Chim. Acta. 18, 267-273.30.
39. Tipton D. A., Stricklin G. P. and Dabbous M. K. (1991) Fibroblast heterogeneity in collagenolytic response to cyclosporine. J. Cell Biochem. 46, 152-165.
40. Takeda K., Gosiewska A. and Peterkofsky B. (1992) Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblasts. J. Cell Physiol. 153, 450-459.