TCR Vβ usage by acetylcholine receptor-specific CD4+ T cells in myasthenia gravis

Journal of Autoimmunity

Volumn 10, Issue 2, 1997, Pages 203-217

  Raju, Raghavanpillai ^c   Navaneetham, Duraiswamy ^f   Protti, Maria Pia ^d   Norton, Robert M ^e   Hoppe, Bobbi L ^f   Howard Jr , James ^a   Conti Fine, Bianca M ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF MILAN   (Italy)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NONE

Author keywords

autoimmunity; myasthenia gravis; PCR; preferential TCR V usage; T cell epitopes

Indexed keywords

CHOLINERGIC RECEPTOR; EPITOPE; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MYASTHENIA GRAVIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION;

EID: 0031128368     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0120     Document Type: Article

References (95)

1. 1. Engel A.G. 1984. Myasthenia gravis and myasthenic syndromes. Ann. Neurol. 16: 519-534
2. 2. Lindstrom J.D., Fujii Y. 1988. Myasthenia gravis. Adv. Immunol. 42: 233-284
3. 3. Schonbeck S., Chrestel S., Hohlfeld R. 1990. Myasthenia gravis: prototype of the antireceptor autoimmune diseases. Intl. Rev. Neurobiol. 32: 175-201
4. 4. Protti M.P., Manfredi A.A., Horton R.M., Bellone M., Conti-Tronconi B.M. 1993. Myasthenia gravis: recognition of an autoantigen at the molecular level. Immunol. Today 14: 363-368
5. 5. Drachman D. 1994. Myasthenia gravis. New Engl. J. Med. 330: 1797-1810
6. 6. Conti-Fine B.M., McLane K.E., Raftery M.A., Grando S., Protti M.P. 1994. The nicotinic acetylcholine receptor: structure and autoimmune pathology. Crit. Rev. Biochem. Mol. Biol. 29: 69-123
7. 7. Sakai K., Zamvil S.S., Mitchell D.J., Hodgkinson S., Rothbard J.B., Steinman L. 1989. Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins. Proc. Natl. Acad. Sci. USA 86: 9470-9474
8. 8. Wraith D.C., McDevitt H.O., Steinman L., Acha-Orbea H. 1989. T-cell recognition as the target for immune intervention in autoimmune disease. Cell 57: 709-715
9. 9. Howell M.D., Winters S.T., Olee T., Powell H.C., Carlo D.J., Brostoff S.W. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246: 668-670
10. 10. Vandenbark A.A., Hashim G., Offner H. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341: 541-543
11. 11. Hashim G.A., Vandenbark A.A., Galang A.B., Diamanduros T., Carvalho E., Srinivasan J., Jones R., Vainiene M., Morrison W.J., Offner H. 1990. Antibodies specific for Vβ receptor peptide suppress experimental autoimmune encephalomyelitis. J. Immunol. 144: 4621-4627
12. 12. Gaur A., Wiers B., Liu A., Rothbard J., Fathman C.G. 1992. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258: 1491-1494
13. 13. Vandenbark A.A., Hashim G., Offner H. 1993. TCR peptide therapy in autoimmune diseases. Intl. Rev. Immunol. 9: 251-276
14. 14. Weinberg A.D., Celnik B., Vainiene M., Buenafe A.C., Vandenbark A.A., Offner H. 1994. The effect of TCR Vβ8 peptide protection and therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J. Neuroimmunol. 49: 161-170
15. + epitopes. J. Immunol. 152: 4686-4698
16. 16. Panina-Bordignon P., Tan A., Termijtelen A., Demotz S., Coradin G., Lanzavecchia A. 1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19: 2237-2242
17. 17. Ho P.C., Mutch D.A., Winkel K.D., Saul A.J., Jones G.L., Doran T.J., Rzepczyk C.M. 1990. Identification of two promiscuous T cell epitopes from tetanus toxin. Eur. J. Immunol. 20: 477-483
18. + T cells on diphtheria toxin: structural features of sequence segments forming epitopes recognized by most subjects. Eur. J. Immunol. 25: 3207-3214
19. + T cells on tetanus toxin: identification of immunodominant sequence segments. J. Infec. Diseases 175: 382-391
20. 20. Wiertz E.J., van Gaans-van den Brink J.A.M., Gausepohl H., Prochnicka-Chalufour A., Hoogerhout P., Poolman J.T. 1992. Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis. J. Exp. Med. 176: 79-88
21. 21. Wei S., Charmley P., Robinson M.A., Concannon P. 1994. The extent of the human germline T-cell receptor Vβ gene repertoire. Immunogenetics 40: 27-36
22. 22. Esch T., Clark L., Zhang X.-M., Goldman S., Heber-Katz E. 1992. Observations, legends, and conjectures concerning restricted T-cell receptor usage and autoimmune disease. Crit. Rev. Immunol. 11: 249-264
23. 23. Navarrete C., Bottazzo G.F. 1993. In search of TCR restriction in autoreactive T cell in human autoimmunity: why is it so elusive? Clin. Exp. Immunol. 91: 189-192
24. 24. Casanova J., Maryanski J.L. 1993. Antigen-selected T-cell receptor diversity and self-nonself homology. Immunol. Today 14: 391-394
25. 25. Acha-Orbea H., McDevitt H.O. 1989. T cell receptors in murine autoimmune diseases. Ann. Rev. Immunol. 7: 371-405
26. 26. Wucherpfennig K.W., Weiner H.L., Hafler D.A. 1991. T-cell recognition of myelin basic protein. Immunol. Today 12: 277-282
27. a. J. Immunol. 147: 3303-3305
28. 28. Infante A.J., Levcovitz H., Gordon V., Wall K.A., Thompson P.A., Krolick K.A. 1992. Preferential use of a T cell receptor Vβ gene by acetylcholine receptor reactive T cells from myastyenia gravis-susceptible mice. J. Immunol. 148: 3385-3390
29. bm12 mutation influences susceptibility to experimental myasthenia gravis. A study in homozygous and heterozygous mice. Scand. J. Immunol. 42: 215-225
30. 30. Smith L.R., Kono D.H., Asthana D., Balderas R.S., Fujii Y., Lindstrom J., Theofilopoulos A.N. 1994. T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. J. Immunol. 152: 2596-2600
31. 31. Theofilopoulos A.N., Balderas R.S., Baccala R., Kono D.H. 1993. T-cell receptor genes in autoimmunity. Ann. NY Acad. Sci. 681: 33-46
32. 32. Stamenkovic I., Stegagno M., Wright K.A., Krane S.M., Amento E.P., Colvin R.B., Duquesnoy R.J., Kurnick J.T. 1988. Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc. Natl. Acad. Sci. USA 85: 1179-1183
33. + T cells in the synovial fluid of patients with arthritis. J. Immunol. 149: 295-299
34. 34. Williams W.V., Fang Q., Demarco D., Von Feldt J., Zurier R.B., Weiner D.B. 1992. Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J. Clin. Invest. 90: 326-333
35. 35. Jenkins R.N., Nikaein Z., Zimmermann Z., Meek K., Lipsky PE. 1993. T cell receptor V beta gene bias in rheumatoid arthritis. J. Clin. Invest. 92: 2688-2701
36. + T cells in rheumatoid arthritis. J. Clin. Invest. 94: 2068-2076
37. 37. Li Y., Sun G.R., Tumang J.R., Crow M.K., Friedman S.M. 1994. CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response. J. Clin. Invest. 94: 2525-2531
38. 38. Zwillich S.H., Fang Q., Kieber-Emmons T., Von Feldt J., Monos D., Ramanujam T., Wang B., Weiner D.B., Williams W.V. 1994. V alpha gene usage in rheumatoid compared with osteoarthritic synovial tissue T cells. DNA Cell Biol. 13: 923-931
39. 39. Mima T., Saeki Y., Ohshima S., Nishimoto N., Matsushita M., Shimizu M., Kobayashi Y., Nomura T., Kishimoto T. 1995. Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenic implications of T cell populations oligoclonally expanding in the rheumatoid joints. J. Clin. Invest. 96: 1746-1758
40. 40. Paliard X., West S.G., Lafferty J.A., Clements J.R., Kappler J.W., Marrack P., Kotzin B.L. 1991. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253: 325-329
41. 41. He X.W., Goronzy J., Weyand C. 1992. Selective induction of rheumatoid factors by superantigens and human helper T cells. J. Clin. Invest. 89: 673-680
42. 42. Duby A.D., Sinclair A.K., Osborne-Lawrence S.L., Zeldes W., Kan L., Fox D.A. 1989. Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 86: 6206-6210
43. 43. Uematsu Y., Wege H., Straus A., Ott M., Bannwarth W., Lanchbury J., Panayi G., Steinmetz M. 1991. The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc. Natl. Acad. Sci. USA 88: 8534-8538
44. 44. Wilson K.B., Quayle A.J., Suleyman S., Kjeldsen-Kragh J., Forre O., Natvig J.B., Capra J.D. 1993. Heterogeneity of the TCR repertoire in synovial fluid T lymphocytes responding to BCG in a patient with early rheumatoid arthritis. Scand. J. Immunol. 38: 102-112
45. 45. Ramanujam T., Luchi M., Schumacher H.R., Zwillich S., Chang C.P., Callegari P.E., Von Feldt J.M., Fang Q., Weiner D.B., Williams W.V. 1995. Detection of T cell receptors in early rheumatoid arthritis synovial tissue. Pathobiology 63: 100-108
46. 46. Wucherpfennig K.W, Ota K., Endo N., Seidman J.G., Rosenzweig A., Weiner H.L., Hafler D.A. 1990. Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248: 1016-1019
47. 47. Oksenberg J.R., Stuart S., Begovich A.B., Bell R.B., Erlich H.A., Steinman L., Bernard C.C.A. 1990. Limited heterogeneity of rearranged T-cell receptor Va transcripts in brains of multiple sclerosis patients. Nature 345: 344-346
48. 48. Wucherpfennig K.W., Newcombe J., Li H., Keddy C., Cuzner M.L., Hafler D.A. 1992. T cell receptor Vα-Vβ repertoire and cytokine gene expression in active multiple sclerosis lesions. J. Exp. Med. 175: 993-1002
49. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148: 1359-1368
50. 50. Allegretta M., Albertini R.J., Howell M.D., Smith M.D., Martin R., McFarland H.F., Sriram S., Brostoff S., Steinman L. 1994. Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J. Clin. Invest. 94: 105-109
51. 51. Desai-Mehta A., Mao C., Rajagopalan S., Robinson T., Datta S.K. 1995. DNA autoantibody-inducing T cells in human lupus. J. Clin. Invest. 95: 531-541
52. 52. Matsumoto I., Tsubota K., Satake Y., Kita Y., Matsumura R., Murata H., Namekawa T., Nishioka K., Iwamoto I., Saitoh K., Sumida T. 1996. Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjogren's syndrome. J. Clin. Invest. 97: 1969-1977
53. 53. Mantegazza R., Andretta F., Bernasconi P., Baggi F., Oksenberg J.R., Simoncini O., Mora M., Cornelio F., Steinman L. 1993. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. J. Clin. Invest. 91: 2880-2886
54. 54. Seko Y., Ishiyama S., Nishikawa T., Kasajima T., Hiroe M., Kagawa N., Osada K., Suzuki S., Yagita H., Okumura K., Yazaki Y. 1995. Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. J. Clin. Invest. 96: 1035-1941
55. 55. Gold D.P., 1994. TCR V gene usage in autoimmunity. Curr. Opin. Immunol. 6: 907-912
56. 56. Protti M.P., Manfredi A.A., Straub C., Howard J.F., Conti-Tronconi B.M. 1990. Immunodominant regions for T helper sensitization on the human nicotinic acetylcholine receptor α subunit in myasthenia gravis. Proc. Natl. Acad. Sci. USA 87: 7792-7796
57. + cells of myasthenia gravis patients and healthy subjects. J. Clin. Invest. 93: 1020-1028
58. + epitopes on the embryonic γ subunit of human muscle acetylcholine receptor. J. Clin. Invest. 90: 1558-1567
59. 59. Protti M.P., Manfredi A.A., Wu X.D., Moiola L., Howard J.F., Conti-Tronconi B.M. 1991. Myasthenia gravis. T epitopes of the δ subunit of human muscle acetylcholine receptor. J. Immunol. 146: 2253-2261
60. + T cell response to human acetylcholine receptor α subunit correlates with myasthenia gravis severity. A study with synthetic peptides. J. Immunol. 144: 1276-1281
61. + T epitope repertoire on the human acetylcholine receptor α subunit in severe myasthenia gravis. A study with synthetic peptides. Neurology 42: 1092-1100
62. 62. Manfredi A.A., Protti M.P., Dalton M.W., Howard J.F., Conti-Tronconi B.M. 1993. T helper cell recognition of muscle acetylcholine receptor in myasthenia gravis. Epitopes on the gamma and delta subunits. J. Clin. Invest. 92: 1055-1067
63. 63. Protti M.P., Manfredi A.A., Howard J.F., Conti-Tronconi B.M. 1991. T cells in myasthenia gravis specific for embryonic muscle acetylcholine receptor. Neurology 41: 1809-1814
64. 64. Raju R., Hoppe B.L., Navaneetham D., Conti-Fine B.M. 1995. Rapid method for the elution and analysis of PCR products separated on high resolution acrylamide gels. BioTechniques 18: 33-35
65. 65. Panzara M.A., Gussoni E., Steinman L., Oksenberg J.R. 1992. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. BioTechniques 12: 728-735
66. 66. Horton R.M., Raju R., Conti-Fine B.M. 1996. Designing PCR primers to amplify specific members or subgroups of multigene families. In Methods in Molecular Biology. B.A. White, ed. Humana Press, Inc., Totowa, N.J. Vol. 67, pp. 459-479
67. 67. Horton R.M., Hoppe B., Conti-Tronconi B.M. 1994. AmpliGrease: 'hot start' PCR using petroleum jelly. BioTechniques 16: 42-43
68. 68. Oksenberg J.R., Panzara M.A., Steinman L.1992. The Polymerase Chain Reaction and the Analysis of the T cell Receptor Repertoire. R.G. Landes Company, Austin, Texas, pp. 47-77
69. 69. Chamberlain J.S., Chamberlain J.S. 1994. Optimization of multiplex PCRs. In The Polymerase Chain Reaction. K.B. Mullis, F. Ferré, R.A. Gibbs, eds. Birkhauser, Boston, pp. 38-46
70. 70. Natarajan K., Burstyn D., Zauderer M. 1992. Major histocompatibility complex determinants select T-cell receptor alpha chain variable region dominance in a peptide-specific response. Proc. Natl. Acad. Sci. USA. 89: 8874-8878
71. + subsets of T lymphocytes in monozygotic twins. J. Immunol. 150: 2033-2045
72. 72. Melms A., Oksenberg J.R., Malcherek G., Schoepfer R., Müller C.A., Lindstrom J., Steinman L. 1993. T cell receptor gene usage of acetylcholine receptor-specific T-helper. Ann. NY Acad. Sci. 681: 313-314
73. 73. Grunewald J., Ahlberg R., Lefvert A.-K., Dersimonian H., Wigzell H., Janson C.H. 1991. Abnormal T-cell expansion and V-gene usage in myasthenia gravis patients. Scand. J. Immunol. 34: 161-168
74. 74. Meinl E., Weber F., Drexler K., Morelle G., Ott M., Saruhan-Direskeneli G., Goebels N., Ertl B., Jechart G., Giegerich G., Schonbeck S., Bannwarth N., Wekerle H., Hohlfeld R. 1993. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. J. Clin. Invest. 92: 2633-2643
75. 75. Tesch H., Hohlfeld R., Toyka K.V. 1989. Analysis of immunoglobulin and T cell receptor gene rearrangements in the thymus of myasthenia gravis patients. J. Neuroimmunol. 21: 169-176
76. + lines propagated with tetanus toxoid or with synthetic tetanus toxin sequences. J. Autoimmunity 9: 79-88
77. 77. Matsuo H., Botacchi A-P., Hawke S., Nicolle M., Jacobson L., Vincent A., Newsome-Davis J., Willcox N. 1995. Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor. J. Immunol. 155: 3683-3692
78. 78. Czerskinsky C., Andersson G., Ekre H.-P., Nilsson L.A., Klareskog L., Ouchterlony O. 1988. Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma-interferon secreting cells. J. Immunol. Methods 110: 29-36
79. 79. Wang Z.-Y., Link H., Huang W.-X. 1993. T cell immunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmuine myasthenia gravis. Scand. J. Immunol. 37: 615-622
80. 80. Bellone M., Ostlie N., Lei S., Conti-Tronconi B.M. 1991. Experimental myasthenia gravis in congenic mice strains. Sequence mapping and H-2 restriction of T helper epitopes on the α subunit of Torpedo californica and murine acetylcholine receptors. Eur. J. Immunol. 21: 2303-2310
81. + cells sensitized to nicotinic acetylcholine receptor. J. Immunol. 146: 2253-2261
82. + cells. J. Immunol. 151: 1025-1038
83. 83. Bellone M., Karachunski P., Ostlie N., Lei S., Conti-Tronconi B.M. 1995. Clustering of B and T epitopes within short sequence regions of the nicotinic acetylcholine receptor. Scand. J. Immunol. 41: 135-140
84. 84. Lehmann P.V., Forsthuber T., Miller A., Sercarz E.E. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358: 155-157
85. 85. Lehmann P.V., Sercarz E.E., Forsthuber T., Dayan C.M., Gammon G. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today 14: 203-208
86. 86. Lanzavecchia A. 1995. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181: 1945-1948
87. 87. Infante A.J., Thompson P.A., Krolick K.A., Wall K.A. 1991. Determinant selection in murine experimental autoimmune myasthenia gravis. Effect of the bm12 mutation on T cell recognition of acetylcholine receptor epitopes. J. Immunol. 146: 2977-2982
88. + anti-myelin basic protein rat T lymphocytes inhibit disease induction. J. Immunol. 147: 1208-1213
89. 89. Shenoy M., Oshima M., Atassi M.Z., Christadoss P. 1993. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α146-162 of acetylcholine receptor. Clin. Immunol. Immunopathol. 66: 230-238
90. 90. Acha-Orbea H., Palmer E. 1991. Mls - a retrovirus exploits the immune system. Immunol. Today 12: 356-361
91. 91. Woodland D.L., Blackman M.A. 1992. Retroviral super-antigens and T cells. Intl. Rev. Immunol. 8: 311-325
92. 92. Ruberti G., Gaur A., Fathman G.G., Livingstone A.M. 1991. The T cell receptor repertoire influences Vβ element usage in response to myoglobin. J. Exp. Med. 174: 83-92
93. 93. Perkins D.L., Wang Y.S., Fruman D., Seidman J.G., Rimm I.J. 1991. Immunodominance is altered in T cell receptor (β-chain) transgenic mice without the generation of a hole in the repertoire. J. Immunol. 146: 2960-2964
94. 94. Cibotti R., Cabaniols J.-P., Pannetier C., Delarbre C., Vergnon I., Kannellopoulos J.M., Kourilsky P. 1994. Public and private Vβ T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J. Exp. Med. 180: 861-872
95. 95. Wang Z.-Y., Okita D.K., Howard J. Jr., Conti-Fine B.M. (in press). Th1 epitope repertoire on the α subunit of human muscle acetylcholine receptor in Myasthenia gravis. Neurology.