Specific inhibition of IL-6 signalling with monoclonal antibodies against the gp130 receptor

Cytokine

Volumn 9, Issue 4, 1997, Pages 233-241

  Liautard, Janny ^a   Sun, Ren Xiao ^c   Cotte, Nathalie ^a   Gaillard, Jean Philippe ^a   Mani, Jean Claude ^b   Klein, Bernard ^c   Brochier, Jean ^a  

^a INSERM   (France)

^b CNRS   (France)

^c INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

gp130; Human; IL 6; IL 6 receptor; Monoclonal antibody

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LEUKEMIA INHIBITORY FACTOR; MONOCLONAL ANTIBODY; ONCOSTATIN M; PROTEIN TYROSINE KINASE;

ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0031128317     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0159     Document Type: Article

References (27)

1. 1. Kishimoto T, Akira S, Taga T (1992) Interleukin-6 and its receptor: a paradigm for cytokines. Science 258:593-597.
2. 2. Kishimoto T, Akira S, Narazaki M, Taga T (1995) Interleukin-6 family of cytokines and gp130. Blood 86:1243-1254.
3. 3. Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, Darbonne WC, Knutzon DS, Yen R, Chien KR, Baker JB, Wood WI (1995) Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci USA 92:1142-1146.
4. 4. Kawano M, Irano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe H, Tanaka H, Kuramoto A, Kishimoto T (1988) Autocrine generation and requirement of BSF/2/IL-6 for human Multiple Myeloma. Nature 332:83-85.
5. 5. Klein B, Zhang XG, Jourdan M, Boiron JM, Portier M, Lu ZY, Wijdenes J, Brochier J, Bataille R (1990) Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma. Eur Cytokine Network 1:193-201.
6. 6. Bataille R, Barlogie B, Lu ZY, Rossi JF, Lavabre-Bertrand T, Beck T, Wijdenes J, Brochier J, Klein B (1995) Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86:685-691.
7. 7. Klein B, Wijdenes J, Zhang XG, Jourdan M, Boiron JM, Brochier J, Liautard J, Merlin M, Clement C, Morel-Fournier B, Lu ZY, Mannoni P, Sany J, Bataille R (1991) Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78:1198-1204.
8. 8. Emilie D, Wijdenes J, Gisselbrecht C, Jarousse B, Billaud E, Blay JY, Gabarre J, Gaillard JP, Prochier J, Raphaël M, Boué F, Galanaud P (1994) Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma. Blood 84:2472-2479.
9. 9. Miles SA, Rezai AR, Salazar-Gonzales JF, Meyden MV, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O (1990) AIDS Kaposi sarcoma-derived cells produce and respond to interleukin-6. Proc Natl Acad Sci USA 87:4068-4072.
10. 10. Miki S, Iwano M, Miki Y, Yamamoto M, Tang B, Yokokawa K, Sonoda T, Hirano T, Kishimoto T (1989) Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett 250:607-610.
11. 11. Kishimoto T (1992) Interleukin-6 and its receptor in autoimmunity. J Autoimmunity 5 (Suppl. A):123-132.
12. 12. Wendung D, Racadot E, Wijdenes J (1993) Treatment of severe Rheumatoid Arthritis by anti-Interleukin-6 monoclonal antibody. J Rheumatol 20:259-262.
13. 13. Grau GE, Frei K, Piguet PF, Fontana A, Heremans H, Billiau A, Vassali P, Lambert PH (1990) Interleukin-6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia. J Exp Med 172:1505-1508.
14. 14. Narazaki M, Yasukawa K, Saito T, Oshugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T (1993) Soluble forms of the interleukin-6 signal transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82:1120-1126.
15. 15. Saito T, Taga T, Miki D, Futatsugi K, Yawata H, Kishimoto T, Yasukawa K (1993) Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions. J Immunol Methods 163:217-223.
16. 16. Chevalier S, Fourcin M, Robledo O, Wijdenes J, Pouplard-Barthelaix A, Gascan H (1996) Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. J Biol Chem 271:14764-14772.
17. 17. Wijdenes J, Heinrich PC, Müller-Newen G, Roche C, Gu ZJ, Clement C, Klein B. (1995) Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur J Immunol 25:3474-3481.
18. 18. Fourcin M, Chevalier S, Guillet C, Robledo O, Froger J, Pouplard-Barthelaix A, Gascan H (1996) gp130 transducing receptor cross-linking is sufficient to induce Interleukin-6 type response. J Biol Chem 271:11756-11760.
19. 19. Manolagas SC, Jilka RL (1995) Bone marrow, cytokines and bone remodeling. N Engl J Med 332:305-311.
20. 20. Zhang XG, Gaillard JP, Robillard N, Lu ZY, Gu ZJ, Jourdan M, Boiron JM, Bataille R, Klein B (1994) Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 83:3654-3663.
21. 21. Liautard J, Gaillard JP, Mani JC, Montero-Julian F, Duperray C, Lu ZY, Jourdan M, Klein B, Brailly H, Brochier J (1994) Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies. Eur Cytokine Network 5:293-300.
22. 22. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149-1157.
23. 23. Fagerstam LG, O'Shannessy DJ (1993) Surface plasmon resonance detection in affinity technologies. In Kline T, ed., Handbook of Affinity Chromatography, 63. Marcel Dekker Inc. pp. 229-252.
24. 24. Fagerstam LG, Karlsson R (1993) Biosensor techniques. Immunochemistry, In Van Oss VRM, ed., Marcel Dekker Inc. pp. 949-970.
25. 25. Malmqvist M (1993) Biospecific interaction analysis using biosensor technology. Nature 361:186-187.
26. 26. Malmqvist M (1993) Surface plasmon resonance for detection and measurement of antibody-antigen affinity and kinetics. Curr Opin Immunol 5:282-286.
27. 27. Gu ZJ, Zhang XG, Hallet MM, Lu ZY, Wijdenes J, Rossi JF, Klein B (1996) A ciliary neurotrophic factor sensitive human myeloma cell line. Exp Haematol 24:1195-1200.