Myelosuppression in the pig (Sus scrofa): Uteroferrin reduces the myelosuppressive effects of 5-fluorouracil in young pigs

Comparative Biochemistry and Physiology - A Physiology

Volumn 116, Issue 4, 1997, Pages 369-377

  Laurenz, Jamie C ^a,b   Hadjisavas, Michael ^a   Chovanic, Greg W ^a   Bazer, Fuller W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

Author keywords

5 fluorouracil; BFU E; CFU GEMM; CFU GM; hematopoiesis; myelosuppression; pigs; type 5 tartrate resistant acid phosphatase

Indexed keywords

FLUOROURACIL; HEMOGLOBIN; UTEROFERRIN;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW SUPPRESSION; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; HEMATOCRIT; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; NONHUMAN; PRIORITY JOURNAL; SWINE;

ACID PHOSPHATASE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BONE MARROW; BONE MARROW CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE COUNT; ERYTHROID PROGENITOR CELLS; FLUOROURACIL; HEMATOCRIT; HEMATOPOIETIC STEM CELLS; ISOENZYMES; LEUKOCYTE COUNT; LEUKOPENIA; MALE; METALLOPROTEINS; SWINE;

EID: 0031128061     PISSN: 03009629     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9629(96)00368-4     Document Type: Article

References (31)

1. Andreani M., De Biagi M., Centis F., Manna M., Agostinelli F., Fillippetti A., Gaudenzi G., Muretto X., Grianti C., Scotti G., Rigon A., Lucarelli G. Fetal liver transplantation. 1985;Alan R. Liss, New York.
2. Bazer F.W., Worthington-White D., Fliss M.F.V., Gross S. Uteroferrin. a progesterone-induced hematopoietic growth factor of uterine origin Exp. Hematol. 19:1991;910-915.
3. Brade W.P., Herdich K. Tegafur-a review of pharmacology and toxicology. Contr. Oncol. 14:1983;2-25.
4. Chen T.T., Bazer F.W., Gebhardt B.M., Roberts R.M. Uterine secretion in mammals. Synthesis and placental transport of purple acid phosphatase in pigs Biol. Reprod. 13:1975;304-313.
5. Ducsay C.A., Buhi W.C., Bazer F.W., Roberts R.M. Role of uteroferrin in iron transport and macromolecular uptake by allantoic epithelium of the porcine conceptus. Biol. Reprod. 26:1982;729-743.
6. Ducsay C.A., Buhi W.C., Bazer F.W., Roberts R.M., Combs G.E. Role of uteroferrin in placental iron transport. effect of maternal iron treatment on fetal iron uteroferrin content and neonatal hemoglobin J. Anim. Sci. 59:1984;1303-1308.
7. Eaves C.J. Peripheral blood stem cells reach new heights. Blood. 82:1993;1957-1959.
8. Friendship R.M., Henry S.C. Cardiovascular system, hematology and clinical chemistry. Leman A.D., Straw B.E., Mengeling W.L., D'Allaire S., Taylor D.J. Diseases of Swine. 1992;1-11 Iowa State University Press, Ames, IA.
9. Harrison D.E., Lerner C.P. Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood. 78:1991;1237-1240.
10. Hodgson G.S., Bradley T.R., Radley J.M. The organization of hematopoietic tissue as inferred from the effects of 5-fluorouracil. Exp. Hematol. 10:1982;26-35.
11. Ketcham C.M., Baumbach G.A., Bazer F.W., Roberts R.M. The type 5, acid phosphatase from spleen of humans with hairy cell leukemia. Purification, properties, immunological characterization, and comparison with porcine uteroferrin J. Biol. Chem. 260:1985;5768-5776.
12. Lerner C., Harrison D.E. 5-Fluorouracil spares hematopoietic stem cells responsible for long term repopulation. Exp. Hematol. 18:1990;114-118.
13. Lieschke G.J., Burgess A.W. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. N. Engl. J. Med. 327:1992;99-106.
14. Malathy P.V., Imakawa K., Simmen R.C.M., Roberts R.M. Molecular cloning of the uteroferrin-associated protein. a major progesterone-induced serpin secreted by the porcine uterus, and expression of its mRNA during pregnancy Mol. Endocrinol. 4:1990;428-440.
15. Marsh J.C. The effects of cancer chemotherapeutic agents on normal hematopoietic precursors cells. A review Cancer Res. 36:1976;1853-1882.
16. Metcalf D. Techniques for clonal culture of hematopoietic cells. Metcalf D. Clonal Culture of hematopoietic Cells. Techniques and Applications:1984;19-72 Elsevier, Amsterdam.
17. Micklem H.S., Anderson N., Ross E. Limited potential of circulating haemopoietic stem cells. Nature. 256:1975;41-43.
18. Moore M.A.S. Clinical implications of positive and negative hematopoietic stem cell regulators. Blood. 78:1991;1-19.
19. Parker W.B., Cheng Y.C. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol. Ther. 48:1990;381-395.
20. Pettengell R., Testa N.G., Swindell R., Crowther D., Dexter T.M. Transplantation potential of hematopoietic cells released into circulation during routine chemotherapy for non-Hodgkins lymphoma. Blood. 82:1993;2239-2248.
21. Pizzo P.A. Granulocytopenia and cancer therapy. Past problems, current solutions, future challenges. Cancer. 54:1984;2649-2661.
22. Radley J.M., Hodgson G.S., Thean L.E., Zangheri O., Levin J. Increased megakaryocytes in the spleen during rebound thrombocytosis following 5-fluorouracil. Exp. Hematol. 8:1980;1129-1138.
23. Renegar R.H., Bazer F.W., Roberts R.M. Placental transport and distribution of uteroferrin in the fetal pig. Biol. Reprod. 27:1982;1247-1260.
24. Rich I.N. The effect of 5-fluorouracil on erythrocytes. Blood. 77:1991;1164-1170.
25. Roberts R.M., Bazer F.W. Uteroferrin. A protein in search of a function Bioessays. 1:1984;8-11.
26. Russell E.S., Bernstein S.E. Blood and Blood cell formation. Green E.L. Biology of the laboratory mouse. 1966;351-372 McGraw-Hill Book Co, New York.
27. SAS SAS/STAT® user's guide (Release 6.04). 1987;SAS Institute Inc, Cary, NC.
28. Saunders P.T.K., Renegar R.H., Raub T.J., Baumbach G.A., Atkinson P.H., Bazer F.W., Roberts R.M. The carbohydrate structure of porcine uteroferrin and the role of the high mannose chains in promoting uptake by the reticulo-endothelial cells of the fetal liver. J. Biol. Chem. 260:1985;3658-3665.
29. Shuey D.L., Zucker R.M., Elstein K.H., Rogers J.M. Fetal anemia following maternal exposure to 5-fluorouracil in the rat. Teratology. 49:1994;311-319.
30. Wintrobe M.M., Lee G.R., Boggs D.R., Bethell T.C., Athens J.W., Foerster J.F. Clinical hematology. 1974;Lea and Febiger, Philadelphia.
31. Yeager A.M., Levin J., Levin F.C. The effects of 5-fluorouracil on hematopoiesis. studies of murine megakaryocyte-CFC, granulocyte-macrophage-CFC, and peripheral blood cell levels Exp. Hematol. 11:1983;944-952.