Composite poly(2-hydroxyethyl methacrylate) membranes as rate-controlling barriers for transdermal applications

Biomaterials

Volumn 18, Issue 7, 1997, Pages 527-533

  Sun, Yi Ming ^a   Huang, Jan Jan ^b   Lin, Fung Ching ^b   Lai, Juin Yih ^b  

^a YUAN ZE UNIVERSITY   (Taiwan)

^b CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Membranes; Poly(2 hydroxyethyl methacrylate) composite; Rate controlling barriers; Transdermal drug delivery

Indexed keywords

BIOMATERIALS; COMPOSITION EFFECTS; CROSSLINKING; ETHANOL; MECHANICAL PERMEABILITY; MOLECULAR WEIGHT; SOLUTIONS; SWELLING;

PERMEATION FLUX; RATE CONTROLLING BARRIERS; TRANSDERMAL DRUG DELIVERY;

POLYMERIC MEMBRANES;

2 HYDROXYETHYL METHACRYLATE; ALCOHOL; GLYCERYL TRINITRATE; POLYESTER; WATER;

ARTICLE; CROSS LINKING; DRUG DELIVERY SYSTEM; MOLECULAR WEIGHT; PERMEABILITY; PRIORITY JOURNAL; THICKNESS;

ADMINISTRATION, CUTANEOUS; BIOPOLYMERS; CROSS-LINKING REAGENTS; CYANATES; INDICATORS AND REAGENTS; KINETICS; MATERIALS TESTING; METHACRYLATES; MOLECULAR WEIGHT; NITROGLYCERIN; POLYHYDROXYETHYL METHACRYLATE;

EID: 0031128051     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(96)00166-4     Document Type: Article

References (13)

1. 1. Montheard, J.-P., Chatzopoulos, M. and Chappard, D., 2-Hydroxyethyl methacrylate (HEMA): chemical properties and application in biomedical fields. JMS-Rev. Macromol. Chem. Phys., 1992, C32, 1-34.
2. 2. Gehrke, S. H. and Lee, P. I., Hydrogels for drug delivery systems. In Specialized Drug Delivery Systems, ed. P. Tyle. Marcel Dekker, New York, USA, 1990, pp. 333-392.
3. 3. Peppas, N. A., ed., Hydrogels in Medicine and Pharmacy, Vols I-III. CRC Press, Boca Raton, Florida, 1987.
4. 4. Andrade, J. D., ed., Hydrogels for Medical and Related Applications. ACS Symposium Series 31, American Chemical Society, Washington DC, USA, 1976.
5. 5. Roorda, W. E., Bouwstra, J. A., de Vries, M. A. and Junginger, H. E., Thermal behavior of poly(hydroxyethyl methacrylate) (pHEMA) hydrogels. Pharm. Res., 1988, 5, 722-725.
6. 6. Sun, Y. M. and Chang, J. N., Solute transport in poly(2-hydroxyethyl methacrylate) hydrogel membranes. J. Polym. Res., 1995, 2, 71-82.
7. 7. Chien, Y. W., ed., Transdermal Controlled Systemic Medications. Marcel Dekker, New York, USA, 1987.
8. 8. Berner, B., Otte, J. H., Mazzenga, G. C., Steffens, R. J. and Ebert, C. D., Ethanol-water mutually enhanced transdermal therapeutic system. I. Nitroglycerin solution properties and membrane transport. J. Pharm. Sci., 1989, 78, 314-318.
9. 9. Berner, B., Mazzenga, G. C., Otte, J. H., Steffens, R. J., Juang, R. H. and Ebert, C. D., Ethanol-water mutually enhanced transdermal therapeutic system. II. Skin permeation of ethanol and nitroglycerin. J. Pharm. Sci., 1989, 78, 402-407.
10. 10. Jeon, S. I. and Jhon, M. S., Dilute solution properties of tactic poly(2-hydroxyethyl methacrylate). J. Polym. Sci. Polym. Chem. Edn, 1984, 22, 3555-3561.
11. 11. Yasuda, H., Lamaze, C. E. and Ikenberry, L. D., Permeability of solutes through hydrated polymer membranes. I: Diffusion of sodium chloride. Makromol. Chem., 1968, 118, 19-35.
12. 12. Yasuda, H., Ikenberry, L. D. and Lamaze, C. E., Permeability of solutes through hydrated polymer membranes. II: Permeability of water soluble organic solutes. Makromol. Chem., 1969, 125, 108-118.
13. 13. Fujita, H., Organic vapors above the glass transition temperature. In Diffusion in Polymers, ed. J. Crank and G. S. Park. Academic Press, London, UK, 1968, pp. 75-105.