The influence of ultraviolet light on immunological cytotoxicity in the skin

Photochemistry and Photobiology

Volumn 65, Issue 4, 1997, Pages 636-646

  Norris, David A ^a   Whang, Kyu ^b   David Bajar, Kathleen ^c   Bennion, Scott D ^d  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Soonchunhyang University   (South Korea)

^c BROOKE ARMY MEDICAL CENTER   (United States)

^d FITZSIMONS ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031127607     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb01905.x     Document Type: Conference Paper

References (117)

1. Arends, M. J. and A. H. Wyllie (1991) Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32, 223-254.
2. Cohen, J. J. (1993) Apoptosis. Immunol. Today. 14, 126-130.
3. Fadok, V. A., D. R. Voelker, P. A. Campbell, J. J. Cohen, D. L. Bratton and P. M. Henson (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specifie recognition and removal by macrophages. J. Immunol. 148, 2207-2216.
4. Norris, D. A. (1995) Editorial: differential control of cell death in the skin. Arch. Dermatol. 131, 945-948.
5. Arends, M. J., A. H. McGregor and A. H. Wyllie (1994) Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am. J. Pathol. 144, 1045-1057.
6. Dive, C., C. D. Gregory, D. J. Phipps, D. L. Evans, A. E. Milner and A. H. Wyllie (1992) Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim. Biophvs. Acta 1133, 275-285.
7. Norris, D. A. (1989) Immune Mechanisms in Cutaneous Disease. Marcel Dekker, New York, NY.
8. Muller-Eberhard, H. J. (1986) The membrane attack complex of complement. Annu. Rev. Immunol. 4, 503-528.
9. Young, J. D. E., E. R. Podack and Z. A. Cohn (1986) Properties of a purified pore-forming protein (perforin 1) isolated from H-2 restricted T cell granules. J. Exp. Med. 164, 144-155.
10. Irmler, M., S. Hertig, H. R. MacDonald, R. Sadoul, J. D. Becherer, A. Proudfoot, R. Solari and J. Tschopp (1995) Granzyme a is an interleukin 1 beta-converting enzyme. J. Exp. Med. 181, 1917-1922.
11. Peitsch, M. C. and J. Tschopp (1994) Granzyme b. Methods Enzymol. 244, 80-87.
12. Duke, R. C., P. M. Persechini, S. Chang, C. C. Liu, J. J. Cohen and J. D. Young (1989) Purified perforin induces target cell lysis but not DNA fragmentation. J. Exp. Med. 170, 1451-1456.
13. Taylor, M. K. and J. J. Cohen (1992) Cell-mediated cytotoxicity. Curr. Opin. Immunol. 4, 338-343.
14. Lowin, B., F. Beermann, A. Schmidt and J. Tschopp (1994) A null mutation in the perforin gene impairs cytolytic T lymphocyte-and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA 91, 11571-11575.
15. Lowin, B., M. Hahne, C. Mattmann and J. Tschopp (1994) Cytolytic T-cell cytotoxicity is mediated through perforin and fas lytic pathways. Nature 370, 650-652.
16. Wright, S. C., P. Kumar, A. W. Tam, N. Shen, M. Varma and J. W. Larrick (1992) Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. J. Cell. Biochem. 48, 344-355.
17. + T cell-mediated cytotoxicity. J. Immunol. 152, 1127-1133.
18. Suda, T., T. Takahashi, P. Golstein and S. Nagata (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169-1178.
19. Duke, R. C., D. M. Ojcius and J. D.-E. Young (1996) Cell suicide in health and disease. Sci. Am. December, 80-87.
20. Duke, R. C., R. Z. Witter, P. B. Nash, J. D. Young and D. M. Ojcius (1994) Cytolysis mediated by ionophores and poreforming agents: role of intracellular calcium in apoptosis. FASEB J. 8, 237-246.
21. Arends, J., A. H. McGregor, N. J. Toft, E. J. Brown and A. H. Wyllie (1993) Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br. J. Cancer 68, 1127-1133.
22. Rak, J. W., Y. Mitsuhashi, V. Erdos, J. Filmus, H. Jamal, L. Bayko, T. Sasazuki and R. S. Kerbel (1995) Activated ras oncogene expression is essential for growth and survival of intestinal epithelial cells under three-dimensional culture conditions. Proc. Annu. Meet. Am. Assoc. Cancer Res. 36, A44.
23. Kinoshita, T., T. Yokota, K. Arai and A. Miyajima (1995) Regulation of bcl-2 expression by oncogenic ras protein in hematopoietic cells. Oncogene 10, 2207-2212.
24. Korsmeyer, S. J., J. R. Shutter, D. J. Veis, D. E. Merry and Z. N. Oltvai (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol. 4, 327-332.
25. Yang, E., J. Zha, J. Jockel, L. H. Boise, C. B. Thompson and S. J. Korsmeyer (1995) Bad, a heterodimeric partner for bcl-xl and bcl-2, displaces bax and promotes cell death. Cell 80, 285-291.
26. Yin, X. M., Z. N. Oltvai and S. J. Korsmeyer (1995) Heterodimerization with bax is required for bcl-2 to repress cell death. Curr. Top. Microbiol. Immunol. 194, 331-338.
27. Miyashita, T., S. Krajewski, M. Krajewska, H. G. Wang, H. K. Lin, D. A. Liebermann, B. Hoffman and J. C. Reed (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9, 1799-1805.
28. Kumar, S. (1995) Ice-like proteases in apoptosis. Trends Biochem. Sci. 20, 198-202.
29. Wilson, K. P., J. A. Black, J. A. Thomson, E. E. Kim, J. P. Griffith, M. A. Navia, M. A. Murcko, S. P. Chambers, R. A. Aldape and S. A. Raybuck (1995) Structure and mechanism of interleukin-1 beta converting enzyme. Nature 370, 270-275.
30. Norris, D. A. (1995) Photoimmunology of lupus erythematosus. In Photoimmunology (Edited by C. E. Elmets and J. Krutmann). Blackwell Science, Oxford, pp. 209-230.
31. Herrlich, P., C. Sachsenmaier, A. Radler-Pohl, S. Gebel, C. Blattner and H. J. Rahmsdorf (1994) The mammalian UV response: mechanism of DNA damage induced gene expression. Adv. Enzyme Regul. 34, 381-395.
32. Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne and T. Jacks (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
33. Canman, C. E., T. M. Gilmer, S. B. Coutts and M. B. Kastan (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes & Dev. 9, 600-611.
34. Norris, D. A. (1997). Differentiation pathways and cutaneous carcinogenesis: alterations in differentiation, in control of the cell cycle, and in induction of apoptosis in skin cancer. In Cutaneous Oncology (Edited by S. Miller and D. Maloney). Blackwell Science, Boston, MA. (In press)
35. Nicholson, D. W., A. Ali, N. A. Thornberry, J. P. Vaillancourt, C. K. Ding, M. Gallant, Y. Gareau, P. R. Griffin, M. Labelle and Y. A. Lazebnik (1995) Identification and inhibition of the ice/ced-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
36. Lazebnik, Y. A., S. H. Kaufmann, S. Desnoyers, G. G. Poirier and W. C. Earnshaw (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ice. Nature 371, 346-347.
37. Sen, S. (1993) Programmed cell death: concept, mechanism and control. Biol. Rev. 67, 287-319.
38. Duke, R. C. (1992) Apoptosis in cytotoxic T lymphocytes and their targets. Semin. Immunol. 4, 407-412.
39. te Velde, A. A. and C. G. Figdor (1992) Monocyte mediated cytotoxic activity against melanoma. [review]. Melanoma Res. 1, 303-309.
40. Norris, D. A. (1990) Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets. J. Invest. Dermatol. 95, 111S-120S.
41. Cohen, J. J. (1993) Programmed cell death and apoptosis in lymphocyte development and function. Chest 103, 99S-101S.
42. Watanabe Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins and S. Nagata (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
43. Norris, D. A., T. Horikawa and J. G. Morelli (1994) Melanocyte destruction and repopulation in vitiligo. Pigment Cell Res. 7, 193-203.
44. Koh, J. Y., B. J. Gwag, D. Lobner and D. W. Choi (1995) Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268, 573-575.
45. Allsopp, T. E., S. Wyatt, H. F. Paterson and A. M. Davies (1993) The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73, 295-307.
46. Brooks, P. C., A. M. Montgomery, M. Rosenfeld, R. A. Reisfeld, T. Hu, G. Klier and D. A. Cheresh (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
47. Montgomery, A. M., R. A. Reisfeld and D. A. Cheresh (1994) Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA 91, 8856-8860.
48. Zhang, Z., K. Vuori, J. C. Reed and E. Ruoslahti (1995) The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates bcl-2 expression. Proc. Natl. Acad. Sci. USA 92, 6161-6165.
49. Meredith, J. E., Jr., B. Fazeli and M. A. Schwartz (1993) The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
50. Re, F., A. Zanetti, M. Sironi, N. Polentarutti, L. Lanfrancone, E. Dejana and F. Colotta (1994) Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol. 127, 537-546.
51. Clark, E. A. and R. O. Hynes (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase a2 but not for cytoskeletal organization. J. Biol. Chem. 271, 14814-14818.
52. Fujita, M., W. Robinson, M. Lemon, S. Bennion, and D. Norris (1996) Ras mutations in human melanoma activate migration, survival and proliferation pathways essential for tumor formation. J. Invest. Dermatol. 107, 472a.
53. Plettenberg, A., C. Ballaun, J. Pammer, M. Mildner, D. Strunk, W. Weninger and E. Tschachler (1995) Human melanocytes and melanoma cells constitutively express the bcl-2 proto-oncogene in situ and in cell culture. Am. J. Pathol. 146, 651-659.
54. Yaar, M., S. Zhai, C. Pincelli and B. A. Gilchrest (1995) A dual role for p75 nerve growth factor receptor in melanocyte survival and apoptosis. J. Invest. Dermatol. 104, 585A.
55. Zhai, S., C. Pincelli, M. Yaar, J. Gonsalves and B. Gilchrest (1995) The role of nerve growth factor in preventing keratinocyte apoptosis. Invest. Dermatol. 104, 572a.
56. Archambault, M., M. Yaar and B. A. Gilchrest (1995) Keratinocytes and fibroblasts in a human skin equivalent model enhance melanocyte survival and melanin synthesis after ultraviolet irradiation. J. Invest. Dermatol. 104, 859-867.
57. Aberer, W., G. Schuler, G. Stingl, H. Honigsmann and K. Wolff (1981) Ultraviolet light depletes surface markers of Langerhans cells. J. Invest. Dermatol. 76, 202-210.
58. Takashima, A. (1995) UVB-dependent modulation of epidermal cytokine network: roles in UVB-induced depletion of Langerhans cells and dendritic epidermal T cells. J. Dermatol. 22, 876-887.
59. Krueger, J. G., J. T. Wolfe, R. T. Nabeya, V. P. Vallat, P. Gilleaudeau, N. S. Heftler, L. M. Austin and A. B. Gottlieb (1995) Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. J. Exp. Med. 182, 2057-2068.
60. Black, A. K., N. Fincham, M. W. Greaves and C. N. Hensby (1980) Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation. Br. J. Clin. Pharmacol. 10, 453-457.
61. Greaves, M. W. and J. Sondergaard (1970) Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion. J. Invest. Dermatol. 54, 365-367.
62. Hensby, C. N., N. A. Plummer, A. K. Black, N. Fincham and M. W. Greaves (1980) Time-course of arachidonic acid, prostaglandins E2 and F2 alpha production in human abdominal skin, following irradiation with ultraviolet wavelengths (290-320 nm). Adv. Prostaglandin Thromboxane Res. 7, 857-860.
63. Kurimoto, I. and J. W. Streilein (1992) Deleterious effects of cis-urocanic acid and UVB radiation on Langerhans cells and on induction of contact hypersensitivity are mediated by tumor necrosis factor-alpha. J. Invest. Dermatol. 99, 69S-70S.
64. Kupper, T. S., A. O. Chua, P. Flood, J. McGuire and U. Gubler (1987) Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J. Clin. Invest. 80, 430-436.
65. Granstein, R. D. and D. N. Sauder (1987) Whole-body exposure to ultraviolet radiation results in increased serum interleukin-1 activity in humans. Lymphokine Res. 6, 187-193.
66. Mizutani, H., R. Black and T. S. Kupper (1991) Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J. Clin. Invest. 87, 1066-1071.
67. Mizutani, H., N. Schechter, G. Lazarus, R. A. Black and T. S. Kupper (1991) Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174, 821-825.
68. Bigler, C. F., D. A. Norris, W. L. Weston and W. P. Arend (1992) Interleukin-1 receptor antagonist production by human keratinocytes. J. Invest. Dermatol. 98, 38-44.
69. Kupper, T. S. and R. W. Groves (1995) The interleukin-1 axis and cutaneous inflammation. J. Invest. Dermatol. 105, 62S-66S.
70. Kock, A., T. Schwarz, R. Kirnbauer, A. Urbanski, P. Perry, J. C. Ansel and T. A. Luger (1990) Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med. 172, 1609-1614.
71. Middleton, M. H. and D. A. Norris (1995) Cytokine-induced icam-1 expression in human keratinocytes is highly variable in keratinocyte strains from different donors. J. Invest. Dermatol. 104, 489-496.
72. Kurimoto, I. and J. W. Streilein (1992) Cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha. J. Immunol. 148, 3072-3078.
73. Ansel, J., P. Perry, J. Brown, D. Damm, T. Phan, C. Hart, T. Luger and S. Hefeneider (1990) Cytokine modulation of keratinocyte cytokines. J. Invest. Dermatol. 94, 101S-107S.
74. Kupper, T. S. (1989) Mechanisms of cutaneous inflammation. Arch. Dermatol. 125, 1406-1412.
75. Chouaib, S., D. Branellec and W. A. Buurman (1991) More insights into the complex physiology of TNF. Immunol. Today 12, 141-142.
76. Jacob, C. O. (1992) Studies on the role of tumor necrosis factor in murine and human autoimmunity. J. Autoimmun. 5, 133-143.
77. Luger, T. A. and T. Schwarz (1990) Evidence for an epidermal cytokine network. J. Invest. Dermatol. 95, 100S-104S.
78. Schroeder, J. M. (1995) Cytokine networks in the skin. J. Invest. Dermatol. 105, 20S-24S.
79. Kirnbauer, R., A. Kock, T. Schwarz, A. Urbanski, J. Krutmann, W. Borth, D. Damm, G. Shipley, J. C. Ansel and T. A. Luger (1989) IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J. Immunol. 142, 1922-1928.
80. Urbanski, A., T. Schwarz, P. Neuner, J. Krutmann, K. Kirnbauer, K. Kock and T. A. Luger (1990) Ultraviolet light induces increased circulating interleukin-6 in humans. J. Invest. Dermatol. 94, 808-811.
81. Turksen, K., T. Kupper, L. Degenstein, I. Williams and E. Fuchs (1992) Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc. Natl. Acad. Sci. USA 89, 5068-5072.
82. Yoshikawa, T., I. Kurimoto and J. W. Streilein (1992) Tumour necrosis factor-alpha mediates ultraviolet light B-enhanced expression of contact hypersensitivity. Immunology 76, 264-271.
83. Beissert, S., S. E. Ullrich, J. Hosoi and R. D. Granstein (1995) Supernatants from UVB radiation-exposed keratinocytes inhibit Langerhans cell presentation of tumor-associated antigens via IL-10 content. J. Leukocyte Biol. 58, 234-240.
84. Ullrich, S. E. (1994) Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J. Immunol. 152, 3410-3416.
85. Makgoba, M. W., M. E. Sanders, G. E. Ginther Luce, M. L. Dustin, T. A. Springer, E. A. Clark, P. Mannori and S. Shaw (1988) ICAM-1 a ligand for LFA-1-dependent adhesion by B, T and myeloid cells. Nature 331, 86-91.
86. Dustin, M. L., K. H. Singer, D. T. Tuck and T. A. Springer (1988) Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon-gamma and is mediated by intercellular adhesion molecule-1 (ICAM-1). J. Exp. Med. 167, 1323-1340.
87. Kashihara Sawami, M. and D. A. Norris (1992) The state of differentiation of cultured human keratinocytes determines the level of intercellular adhesion molecule-1 (ICAM-1 ) expression induced by gamma interferon. J. Invest. Dermatol. 98, 741-747.
88. Norris, D. A., M. B. Lyons, M. H. Middleton, J. J. Yohn and M. Kashihara Sawami (1990) Ultraviolet radiation can either suppress or induce expression of intercellular adhesion molecule 1 (ICAM-1) on the surface of cultured human keratinocytes. J. Invest. Dermatol. 95, 132-138.
89. Bennion, S. D., M. H. Middleton, K. M. David-Bajar, S. Brice and D. A. Norris (1995) In three types of interface dermatitis, different patterns of expression of intercellular adhesion molecule-1 (ICAM-1) indicate different triggers of disease. J. Invest. Dermatol. 105, 71S-79S.
90. Lawrence, M. B. and T. A. Springer (1993) Neutrophils roll on E-selectin. J. Immunol. 151, 6338-6346.
91. Springer, T. A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
92. Sauder, D. N., D. Wong and C. Laskin (1993) Epidermal cytokines in murine lupus. J. Invest. Dermatol. 100, 42S-46S.
93. Norris, D. A. and L. A. Lee (1985) Antibody-dependent cellular cytotoxicity and skin disease. J. Invest. Dermatol. 85, 165s-175s.
94. Bangert, J. L., R. G. Freeman, R. D. Sontheimer and J. N. Gilliam (1984) Subacute cutaneous lupus erythematosus and discoid lupus erythematosus. Comparative histopathologic findings. Arch. Dermatol. 120, 332-337.
95. Sontheimer, D., P. J. Maddison, M. Reichlin, R. E. Jordon, P. Stasyny and J. N. Gilliam (1982) Serologic and HLA associations in subacute cutaneous lupus erythematosus: a clinical subset of lupus erythematosus. Ann. Int. Med. 97, 664-671.
96. Weston, W. L., C. Harmon and C. Peebles (1982) A serologic marker for neonatal lupus. Br. J. Dermatol. 107, 377-382.
97. Mond, C. B., M. G. Peterson and N. F. Rothfield (1989) Correlation of anti-Ro antibody with photosensitivity rash in systemic lupus erythematosus patients. Arthritis Rheum. 32, 202-204.
98. Sontheimer, R. D. (1987) Questions pertaining to the true frequencies with which anti-Ro/SS-A autoantibody and the HLA-DR3 phenotype occur in subacute cutaneous lupus erythematosus patients. J. Am. Acad. Dermatol. 16, 130-134.
99. Lehmann, P., E. Holzle, P. Kind, G. Goerz and G. Plewig (1990) Experimental reproduction of skin lesions in lupus erythematosus by UVA and UVB radiation. J. Am. Acad. Dermatol. 22, 181-187.
100. Kind, P., P. Lehmann and G. Plewig (1993) Phototesting in lupus erythematosus. J. Invest. Dermatol. 100, 53S-57S.
101. Lee, L. A. and K. M. David (1989) Cutaneous lupus erythematosus. Curr. Prob. Dermatol. 1, 161-210.
102. David-Bajar, K. M., S. D. Bennion, J. D. DeSpain, L. E. Golitz and L. A. Lee (1992) Clinical, histologic, and immunofluorescent distinctions between subacute cutaneous lupus erythematosus and discoid lupus erythematosus. J. Invest. Dermatol. 99, 251-257.
103. Norris, D. A., S. R. Ryan, K. A. Fritz, M. Kubo, E. M. Tan, J. S. Deng and W. L. Weston (1984) The role of RNP, Sm, and SS-A/Ro-specific antisera from patients with lupus erythematosus in inducing antibody-dependent cellular cytotoxicity (ADCC) of targets coated with nonhistone nuclear antigens. Clin. Immunol. Immunopathol. 31, 311-320.
104. Norris, D. A. and L. A. Lee (1985) Pathogenesis of cutaneous lupus erythematosus. Clin. Dermatol. 3, 20-35.
105. Furukawa, F., H. Kanauchi and S. Imamura (1994) Susceptibility to UVB light in cultured keratinocytes of cutaneous lupus erythematosus. Dermatology 189 Suppl 1, 18-23.
106. Weedon, D. (1980) Apoptosis in lichen planus. Clin. Exp. Dermatol. 5, 425-430.
107. Norris, D. A. (1993) Pathomechanisms of photosensitive lupus erythematosus. J. Invest. Dermatol. 100, 58S-68S.
108. LeFeber, W. P., D. A. Norris, S. R. Ryan, J. C. Huff, L. A. Lee, M. Kubo, S. T. Boyce, B. L. Kotzin and W. L. Weston (1984) Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J. Clin. Invest. 74, 1545-1551.
109. Furukawa, F., M. Kashihara Sawami, M. B. Lyons and D. A. Norris (1990) Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J. Invest. Dermatol. 94, 77-85.
110. Jones, S. K. (1992) The effects of hormonal and other stimuli on cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: their possible role in the induction of cutaneous lupus lesions. Br. J. Dermatol. 126, 554-560.
111. Jones, S. K. (1992) Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions. Br. J. Dermatol. 126, 546-553.
112. Golan, T. D., K. B. Elkon, A. E. Gharavi and J. G. Krueger (1992) Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythemtosus patients after ultravioletB/ultraviolet A radiation. J. Clin. Invest. 90, 1067-1076.
113. Casciola-Rosen, L. A., G. Anhalt and A. Rosen (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes [see comments]. J. Exp. Med. 179, 1317-1330.
114. Golan, T. D., A. E. Gharavi and K. B. Elkon (1993) Penetration of autoantibodies into living epithelial cells. J. Invest. Dermatol. 100, 316-322.
115. Rosen, A., L. Casciola-Rosen and J. Ahearn (1995) Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med. 181, 1557-1561.
116. Casciola-Rosen, L. A., D. K. Miller, G. J. Anhalt and A. Rosen (1994) Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem. 269, 30757-30760.
117. Lee, L. A., C. M. Roberts, M. B. Frank, V. R. McCubbin and M. Reichlin (1994) The autoantibody response to Ro/SSA in cutaneous lupus erythematosus. Arch. Dermatol. 130, 1262-1268.