Structural organization of the human vesicular monoamine transporter type-2 gene and promoter analysis using the jelly fish green fluorescent protein as a reporter

Molecular Brain Research

Volumn 45, Issue 1, 1997, Pages 41-49

  Xu, Weiming ^a,b   Liu, Lizhi ^a,b   Mooslehner, Katrin ^a   Emson, Piers C ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

16 exon; Cyclic AMP response element; Genomic structure; Green fluorescent protein; Human VMAT2; Promoter analysis

Indexed keywords

CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; HUMAN VESICULAR MONOAMINE TRANSPORTER; MONOAMINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL SELECTION; CONTROLLED STUDY; COSMID; DNA TRANSFECTION; EXON; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE STRUCTURE; HUMAN; HUMAN CELL; INTRON; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DNA BINDING; REPORTER GENE; RESTRICTION MAPPING; TRANSLATION INITIATION; TRANSLATION REGULATION;

EID: 0031127603     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00218-5     Document Type: Article

References (27)

1. [1] Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W. and Prasher, D.C., Green fluorescent protein as a marker for gene expression, Science, 263 (1994) 802-805.
2. [2] Desnos, C., Laran, M.-P., Langley, K., Annis, D. and Henry, J.P., Long-term stimulation changes the vesicular monoamine transporter content of chromaffin granules, J. Bio. Chem., 270 (1995) 16030-16038.
3. [3] Donovan, D.M., Vandenberg, D., Perry, M.P., Bird, G.S., Ingersoll, R., Nanthakumar, E. and Uhl, G.R., Human and mouse dopamine transporter genes: conservation of the 5′-flanking sequence elements and gene structures, Mol. Brain Res., 30 (1995) 327-335.
4. [4] Erickson, J.D., Eiden, L.E. and Hoffman, B., Expression cloning of a reserpine sensitive vesicular monoamine transporter, Proc. Natl. Acad. Sci. USA, 89 (1992) 10,993-10,997.
5. [5] Erickson, J.D. and Eiden, L.E., Functional identification and molecular cloning of a human brain vesicle monoamine transporter, J. Neurochem., 61 (1993) 2314-2317.
6. [6] Faisst, S. and Meyer, S., Compilation of vertebrate-encoded transcription factors, Nucleic Acids Res., 20 (1992) 3-26.
7. [7] Gonzalez, G. and Montminy, M.R., Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133, Cell, 59 (1989) 675-680.
8. [8] Hawkins, M.D., A survey on intron and exon lengths, Nucleic Acids Res., 16 (1988) 9893-9903.
9. [9] Herzenberg, L.A., Sweet, R.G. and Herzenberg, L.A., Fluorescence-activated cell sorting, Sci. Am., 234 (1976) 108-117.
10. [10] Howell, M., Shirvan, A., Stern-Bach, Y., Steiner-Mordorch, S., Strasser, J.E., Dean, G.E. et al., Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules, FEBS Lett., 338 (1994) 16-22.
11. [11] Ishiguro, H., Kim, K.T., Joh, T.H. and Kim, K.S., Neuron-specific expression of the human dopamine β-hydroxylase gene requires both the cAMP-response element and a silencer region, J. Biol. Chem., 266 (1993) 17987-17994.
12. [12] Kim, K.S., Lee, M.K., Carrol, J. and Joh, T.H., Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element, J. Biol. Chem., 268 (1993) 15689-15695.
13. [13] Langsten, J.W., Balliar, P., Tetrud, J.M. and Irwin, I., Parkinsonism in human due to a product of meperidine analog synthesis, Science, 219 (1983) 979-980.
14. [14] Liu, L., Xu, W., Harrington, K.A. and Emson, P.C., The molecular cloning and expression of a human synaptic vesicle amine transporter that supresses MPP+ toxicity, Mol. Brain Res., 25 (1994), 90-96.
15. [15] Liu, Y., Peter, D., Roghani, D., Schuldiner, S., Prive, G.G., Eisenberg, D., Brecha, N. and Edward, R.H., A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter, Cell, 70 (1992), 539-551.
16. [16] Montminy, M.R. and Bilezikjian, L.M., Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene, Nature, 328 (1987), 175-178.
17. [17] Mount, S.M.A., A catalogue of splice junction sequences, Nucleic Acids Res., 10 (1982), 459-472.
18. [18] Nakanishi, N., Onozawa, S., Matsumoto, R., Hasegawa, H. and Yamada, S., Cyclic AMP-dependent modulation of vesiclar monoamine transport in pheochromocytoma cells, J. Neurochem., 64 (1995) 600-607.
19. [19] Peter, D., Jimenez, J., Liu, Y., Kim, J. and Edward, R.H., The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors, J. Biol. Chem., 269 (1994) 7231-7237.
20. [20] Peter, D., Liu, Y., Sternini, C., Giorgio, R., Brecha, N., and Edward, R., Differential expression of two vesicular monoamine transporters, J. Neurosci., 15 (1995), 6179-6188.
21. [21] Sambrook, J., Fritchs E. and Maniatis, T., Molecular Cloning, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
22. [22] Schuldiner, S., A molecular glimpse of vesicular monoamine transporters, J. Neurochem., 62 (1994) 2067-2078.
23. [23] Smith, M.W., Structure of vertebrate genes: a statistical analysis implication selection, J. Mol. Evol.. 21 (1988) 45-55.
24. [24] Surrat, C.K., Persico, A., Yang, X.D., Edgar, S.R., Bird, G.S., Hawhins, A.L., Griffin, C.A., Ethylin, X.L., Jabs, W. and Uhl, G.R., A human synaptic vesicle monoamine transporter cDNA predicts posttranscriptional modifications, reveals chromosome 10 localization and identifies Taq 1 RFLPs, FEBS Lett., 318 (1993) 330.
25. [25] Usdin, T.B., Eiden, L.E., Bonner, T.I. and Erickson, J., Molecular biology of the vesicular ACh transporter, Trends Neurosci., 18 (1995) 218-224.
26. [26] Yagle, M.K., Parruti G., Xu W., Ponder B.A.J. and Solomon, E., Genetic and physical map of the Von Recklinghausen neurofibromatosis (NF1) region of human chromosome 17, Proc. Natl. Acad. Sci. USA, 87 (1990) 7255-7259.
27. [27] Zhu, Q.S., Grimby, J., Chen, K. and Shih, J.C., Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J. Neurosci., 12 (1992) 4437-4446.