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Volumn 83, Issue 1, 1997, Pages 15-17

Extrapolation of experimental safety data to humans: The interleukin-6 case

(2)  Kammuller M a   Ryffel, B a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 6;

EID: 0031127540     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.4305     Document Type: Conference Paper
Times cited : (8)

References (16)
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  • 2
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    • Interleukin-6 family of cytokines and gp130
    • 2. Kishimoto, T., Akira, S., Narazaki, M., and Taga, T., Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254, 1995.
    • (1995) Blood , vol.86 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 3
    • 0025226107 scopus 로고
    • Biological and clinical aspects of interleukin 6
    • 3. Hirano, T., Akira, S., Taga, T., and Kishimoto, T., Biological and clinical aspects of interleukin 6. Immunol. Today 11, 443-449, 1990.
    • (1990) Immunol. Today , vol.11 , pp. 443-449
    • Hirano, T.1    Akira, S.2    Taga, T.3    Kishimoto, T.4
  • 4
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • 4. Van Snick, J., Interleukin-6: An overview. Annu. Rev. Immunol. 8, 253-278, 1990.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 5
    • 0024814903 scopus 로고
    • Interleukin 6: A multifunctional cytokine regulating immune reactions and the acute-phase protein response
    • 5. Le, J., and Vilcek, J., Interleukin 6: A multifunctional cytokine regulating immune reactions and the acute-phase protein response. Lab. Invest. 61, 588-602, 1989.
    • (1989) Lab. Invest. , vol.61 , pp. 588-602
    • Le, J.1    Vilcek, J.2
  • 9
    • 0029609110 scopus 로고
    • Recombinant human interleukin-6: Safety issues of a pleiotropic growth factor
    • 9. Kammüller, M. E., Recombinant human interleukin-6: Safety issues of a pleiotropic growth factor. Toxicology 105, 91-107, 1995.
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    • Kammüller, M.E.1
  • 10
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    • The tolerability and pharmacology of interleukin-6 administered in combination with GM-CSF or G-CSF in the rhesus monkey
    • 11. Myers, L. A., Boyce, J. T., and Robison, R. L., The tolerability and pharmacology of interleukin-6 administered in combination with GM-CSF or G-CSF in the rhesus monkey. Toxicology 101, 157-166, 1995.
    • (1995) Toxicology , vol.101 , pp. 157-166
    • Myers, L.A.1    Boyce, J.T.2    Robison, R.L.3
  • 12
    • 0028090534 scopus 로고
    • Effects of recombinant human interleukin 6 (rhIL-6) in marmosets (Callithrix jacchus). 1. General toxicity and hematological changes
    • 12. Klug, S., Neubert, R., Stahlmann, R., Thiel, R., Ryffel, B., Car, B. D., and Neubert, D., Effects of recombinant human interleukin 6 (rhIL-6) in marmosets (Callithrix jacchus). 1. General toxicity and hematological changes. Arch. Toxicol. 68, 619-631, 1994.
    • (1994) Arch. Toxicol. , vol.68 , pp. 619-631
    • Klug, S.1    Neubert, R.2    Stahlmann, R.3    Thiel, R.4    Ryffel, B.5    Car, B.D.6    Neubert, D.7
  • 13
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    • Long-term interleukin-6 administration stimulates sustained thrombopoiesis and acute-phase protein synthesis in a small primate -the marmoset
    • 13. Ryffel, B., Car, B. D., Woerly, G., Weber, M., DiPadova, F., Kammuller, M., Klug, S., Neubert, R., and Neubert, D., Long-term interleukin-6 administration stimulates sustained thrombopoiesis and acute-phase protein synthesis in a small primate -the marmoset. Blood 83, 2093-2102, 1994.
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    • Ryffel, B.1    Car, B.D.2    Woerly, G.3    Weber, M.4    DiPadova, F.5    Kammuller, M.6    Klug, S.7    Neubert, R.8    Neubert, D.9
  • 14
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    • Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: Induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity
    • 14. Scheid, C., Young, R., McDermott, R., Fitzsimmons, L., Scarffe, J. H., and Stern, P. L., Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: Induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity. Cancer Immunol. Immunother. 38, 119-126, 1994.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.