Acute Cardiotoxicity of Gadolinium-based Contrast Media: Findings in the Isolated Rat Heart

Academic Radiology

Volumn 4, Issue 4, 1997, Pages 283-291

  Akre, Benedikte Thunes ^a   Dunkel, Jelena Alexandra ^b   Hustvedt, Svein Olaf ^b   Refsum, Helge ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b NYCOMED IMAGING AS   (Norway)

Author keywords

Arrhythmia; Cardiac effects; Gadodiamide injection; Gadopentetate dimeglumine; Gadoteridol injection; Inotropy; Magnetic resonance imaging

Indexed keywords

CONTRAST MEDIUM; DRUG DERIVATIVE; GADODIAMIDE; GADOLINIUM; GADOLINIUM PENTETATE; GADOTERIDOL; HETEROCYCLIC COMPOUND; MEGLUMINE; ORGANOMETALLIC COMPOUND; PENTETIC ACID;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG COMBINATION; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART; HEART ARRHYTHMIA; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART VENTRICLE PRESSURE; IN VITRO STUDY; MALE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ARRHYTHMIA; CONTRAST MEDIA; DRUG COMBINATIONS; ELECTROCARDIOGRAPHY; GADOLINIUM; GADOLINIUM DTPA; HEART; HEART RATE; HETEROCYCLIC COMPOUNDS; MALE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; PENTETIC ACID; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 0031113681     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1076-6332(97)80030-X     Document Type: Article

References (32)

1. Goldstein HA, Kashamian FK, Blumetti RF, Holyoak WI, Hugo FP, Blumsfield DM. Safety assessment of gadopentetate dimeglumine in US clinical trials. Radiology 1990;174:17-23.
2. Ekholm S, Jonsson E, Sandvik L, et al. Tolerance and efficacy of Omniscan (gadodiamide injection) in MR imaging of the central nervous system. Acta Radiol 1996;37:223-228.
3. Niendorf HP, Alhassan A, Geens VR, Clauss W. Safety review of gadopentetate dimeglumine: extended clinical experience after more than five million applications. Invest Radiol 1994;29(suppl 2):179-182.
4. deLange EE. Gadodiamide injection-enhanced MR imaging of the body: results of a multicenter trial. Acad Radiol 1994;1:23-29.
5. Li HT, Saeed M, Wendland MF, Higgins CB. Cardiovascular responses after ionic and nonionic magnetic resonance contrast media in rats with acute myocardial infarction. Invest Radiol 1993;28:11-19.
6. Masui T, Takehara Y, Aoshima R, Kaneko M. Acute hemodynamic effects of non-ionic and ionic magnetic resonance contrast media in intravenous bolus injection in rats. Invest Radiol 1994;29(suppl 2):189-191.
7. Mühler A, Saeed M, Brasch RC, Higgins CB. Hemodynamic effects of bolus injection of gadodiamide injection and gadopentetate dimeglumine as contrast media at MR imaging in rats. Radiology 1992;183: 523-528.
8. Peters JL, Shaw DD. Hemodynamic effects of gadodiamide injection and gadopentetate dimeglumine in anesthetized dogs. Acta Radiol 1993;34:1-7.
9. Bøkenes J, Hustvedt SO, Refsum H. Cardiovascular safety of gadodiamide injection and gadopentetate dimeglumine in dogs. Acad Radiol 1997;4:204-209.
10. Svendsen P, Carter AM. Influence of injectable anesthetic combinations on blood gas tensions and acid-base status in laboratory rats. Acta Pharmacol Toxico/1985;57:1-7.
11. Green CJ. Neuroleptanalgesic drug combinations in the anaesthetic management of small laboratory animals. Lab Anim 1975;9:161-178.
12. Williamson JR, Kobayashi K. Use of the perfused rat heart to study cardiac metabolism: retrospective and prospective views. Basic Res Cardiol 1984;69:283-291.
13. Langendorff O. Untersuchungen am überlebenden säugethierherzen. Pflügers Arch Ges Physiol 1895;61:291-332.
14. Curtis MJ, Macleod BA, Tabrizchi R, Walker MJA. An improved perfusion apparatus for small animal hearts. J Pharmacol Meth 1986;15:87-94.
15. Driscoll P. The normal rat electrocardiogram (ECG). In: Budden R, Detweiler DK, Zbinden G, eds. The rat electrocardiogram in pharmacology and toxicology. New York, NY: Pergamon, 1981;1-14.
16. Walker MJA, Curtis MJ, Hearse DJ, et al. The lambeth conventions: guidelines for the study of arrhythmias in ischemia, infarction, and reperfusion. Cardiovasc Res 1988;22:447-455.
17. Morris TW, Sahler LG, Fisher HW. Calcium binding by radiopaque media. Invest Radiol 1982;17:501-505.
18. Bourdillon PD, Bettmann MA, McCracken S, Poole-Wilson PA, Grossman W. Effects of a new nonionic and a conventional ionic contrast agent on coronary sinus ionized calcium and left ventricular hemodynamics in dogs. J Am Coll Cardiol 1985;6:845-853.
19. Higgins CB. Overview and methods used for the study of the cardiovascular actions of contrast materials. Invest Radiol 1980;15(suppl 6):188-193.
20. Higgins CB, Schmidt W. Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog. Circulation 1978; 58:512-519.
21. Mühler A, Saeed M, Brasch RC, Higgins CB. Amelioration of cardiodepressive effects of gadopentetate dimeglumine with addition of ionic calcium. Cardiac Radiol 1992;184:159-164.
22. Jynge P, Holten T, Øksendal AN. Sodium-calcium balance and cardiac function with isotonic iodixanol: an experimental study in the isolated rat heart. Invest Radiol 1993;28:20-25.
23. Morris TW. The cardiovascular effects of iodinated contrast media injections. Invest Radiol 1988;23(suppl 1):133-136.
24. Chang CA, Sieving PF, Watson AD, Dewey TW, Karpishin TB, Raymond KN. Ionic versus nonionic MR imaging contrast media: operational definitions. JMRI 1992;2:95-98.
25. Wildenthal K, Mierzwiak DS, Mitchell JH. Acute effects of increased serum osmolality on left ventricular performance. Am J Physiol 1969; 216:898-904.
26. Koch-Weser J. Influence of osmolarity of perfusate on contractility of mammalian myocardium. Am J Physiol 1963;204:957-962.
27. Fleetwood G, Bettmann MA, Gordon JL. The effects of radiographic contrast media on myocardial contractility and coronary resistance: osmolality, ionic concentration and viscosity. Invest Radiol 1990;25:254-260.
28. Zipes DP, Fischer JC. fleets of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog. Circ Res 1974;34:184-192.
29. Malécot CO, Feindt P, Trautwein W. Intracellular N-methyl-D-glucamine modifies the kinetics and voltage-dependence of the calcium current in guinea pig ventricular heart cells. Eur J Physiol 1988;411:235-242.
30. Muller RG, Valera M, Carrasco H, et al. Valoración eletrocardiográfica de la cardiotoxicidad del antimoniato de n-metil glucamina (r glucantime) Arch Inst Cardiol Mex 1982;52:155-159.
31. Higgins CB. Effects of contrast media on the conducting system of the heart. Radiology 1977;124:599-606.
32. Higgins CB, Feld GK. Direct chronotropic and dromotropic actions of contrast material: ineffectiveness of atropine in the prevention of bradyarrhythmias and conduction disturbances. Radiology 1976;121:205-209.