Exogenously Provided Peptides Fail to Complex with Intracellular Class II Molecules for Presentation by Antigen-Presenting Cells

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3155-3164

  Monji, Tatsue ^a,c   Pious, Donald ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Cell Pro Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HLA ANTIGEN CLASS 2; PEPTIDE; PROTEINASE; TETANUS TOXOID; TUBERCULIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL LINE; EXOCYTOSIS; HUMAN; HYDROLYSIS; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; SYNTHESIS;

ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CELL LINE; ENDOPEPTIDASES; EXOCYTOSIS; HEPATITIS B SURFACE ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYDROLYSIS; PEPTIDES; PROTEIN BINDING; TETANUS TOXOID; TUBERCULIN;

EID: 0031110364     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Brodsky, F. M., and L. E. Guagliardi. 1991. The cell biology of antigen processing and presentation. Annu. Rev. Immunol. 9:707.
2. Rudensky, A. Y., P. Preston-Hurlburt, S. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.
3. d. Science 256:1817.
4. Chicz, R. M., R. G. Urban, J. C. Gorga, D. A. A. Vignali, W. S. Lane, and J. L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27.
5. Harding, C. V., E. R. Unanue, J. W. Slot, A. L. Schwartz, and H. J. Geuze. 1990. Functional and ultrastructural evidence for intracellular formation for major histocompatibility complex class II-peptide complexes during antigen processing. Proc. Natl. Acad. Sci. USA 87:5553.
6. Neefjes, J. J., V. Stollorz, P. J. Peters, H. J. Geuze, and H. L. Ploegh. 1990. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell 61:171.
7. Sette, A., L. Adorini, S. M. Colon, S. Buus, and H. M. Grey. 1989. Capacity of intact proteins to bind to MHC class II molecules. J. Immunol. 143:1265.
8. Jensen, P. E. 1993. Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC. J. Immunol. 150:3347.
9. Streicher, H. Z., I. J. Berkower, M. Busch, F. R. N. Gurd, and J. A. Berzofsky. 1984. Antigen conformation determines processing requirements for T-cell activation. Proc. Natl. Acad. Sci. USA 81:6831.
10. Peri, J., P. Lonai, and V. Friedmar. 1986. Antigen-Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecules of the major histocompatibility complex. Eur. J. Immunol. 16:1093.
11. Takahashi, H., K. B. Cease, and J. A. Berzofsky. 1989. Identification of proteases that process distinct epitopes on the same protein. J. Immunol. 142:2221.
12. Davidson, H. W., P. A. Reid, A. Lanzavecchia, and C. Watts. 1991. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell 67:105.
13. Qiu, Y., X. Xu, A. Wandinger-Ness, D. P. Dalke, and S. K. Pierce. 1994. Separation of subcellular compartments containing distinct functional forms of MHC class II. J. Cell Biol. 125:595.
14. Amigorena, S., J. R. Drake, P. Webster, and I. Mellman. 1994. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 369:113.
15. Tulp, A., D. Verwoerd, B. Dobberstein, H. L. Ploegh, and J. Pieters. 1994. Isolation and characterisation of the intracellular MHC class II compartment. Nature 169:120.
16. West, M. A., J. M. Lucocq, and C. Watts. 1994. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells. Nature 369:147.
17. Kelly, A. P., J. J. Monaco, S. Cho, and J. Trowsdale. 1991. A new human HLA class II-related locus, DM. Nature 353:571.
18. Sanderson, F., M. J. Kleijmeer, A. Kelly, D. Verwoerd, A. Tulp, J. J. Neefjes, H. J. Geuze, and J. Trowsdale. 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266:1566.
19. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. M. Zaller. 1995. HLA-DM induces the dissociation of a subset of peptides from HLA-DR. Nature 375:802.
20. Sherman, M. A., D. A. Weber, and P. E. Jensen. 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 3:197.
21. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induced CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
22. Shimonkevitz, R., S. Colon, J. W. Kappler, P. C. Marrack, and H. M. Grey. 1984. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067.
23. Babbitt, B. P., P. M. Allen, G. Matsueda, E. Haber, and E. R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359.
24. Buus, S., S. Colon, C. Smith, J. H. Freed, C. Miles, and H. M. Grey. 1986. Interaction between a "processed" ovalbumin peptide and Ia molecules. Proc. Natl. Acad. Sci. USA 83:3968.
25. Shimonkevitz, R., J. Kappler, P. Marrack, and H. Grey. 1983. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 158: 303.
26. Gladstone, P., and D. Pious. 1978. Stable variants affecting B cell alloantigens in human lymphoid cells. Nature 271:459.
27. Pious, D., L. Dixon, F. Levine, T. Cotner, and R. Johnson. 1985. HLA class II regulation and structure: analysis with HLA-DR3 and HLA-DP point mutants. J. Exp. Med. 162:1193.
28. Gladstone, P., L. Fueresz, and D. Pious. 1982. Gene dosage and gene expression in HLA region: evidence from deletion variants. Proc. Natl. Acad. Sci. USA 79:1235.
29. Van Schooten, W. C. A., D. G. Elferink, J. Van Embden, D. C. Anderson, and R. R. P. DeVries. 1989. DR3-restricted T cells from different HLA-DR3-positive individuals recognize the same peptide (amino acids 2-12) of the mycobacterial 65-kDa heat-shock protein. Eur. J. Immunol. 19:2075.
30. Demotz, S., P. Matricardi, A. Lanzavecchia, and G. Corradin. 1989. A novel and simple procedure for determining T cell epitopes in protein antigens. J. Immunol. Methods 122:67.
31. Monji, T., E. Mellins, T. Cotner, and D. Pious. 1990. Further characterization of tetanus toxin T cell antigenic peptides restricted by the DR3, DQ2 haplotype. FASEB J. 4:608a (Abstr.).
32. Demotz, S., A. Lanzavecchia, V. Eisel, H. Niemann, C. Widmann, and Corradin, G. 1989. Delineation of several DR-restricted tetanus toxin T cell epitopes. J. Immunol. 142:394.
33. Celis, E., D. Ou, and L. Otvos, Jr. 1988. Recognition of hepatitis B surface antigen by human T lymphocytes. J. Immunol. 140:1808.
34. Ottenhoff, T. H. M., S. Neuteboom, D. G. Elferink, and R. R. P. De Vries. 1986. Molecular localization and polymorphism of HLA class II restriction determinants defined by Mycobacterium leprae-reactive helper T cell clones from leprosy patients. J. Exp. Med. 164:1923.
35. Mellins, E., M. Woelfel, and D. Pious. 1987. Importance of HLA-DQ and -DP restriction elements in T cell responses to soluble antigens: mutational analysis. Hum. Immunol. 18:211.
36. Mellins, E., L. Smith, B. Arp, T. Cotner, E. Celis, and D. Pious. 1990. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71.
37. Geluk, A., W. Bloemhoff, R. R. P. De Vries, and T. H. M. Ottenhoff. 1992. Binding of a major T cell epitope of mycobacteria to a specific pocket within HLA-DRw17(DR3) molecules. Eur. J. Immunol. 22:107.
38. Unanue, E. R., and J.-C. Cerottini. 1970. The immunogenicity of antigen bound to the plasma membrane of macrophages. J. Exp. Med. 131:711.
39. Tanaka, T., O. Saiki, S. Doi, M. Fuji, K. Sugamura, H. Kara, S. Negoro, and S. Kishimoto. 1988. Novel receptor-mediated internalization of interleukin 2 in B cells. J. Immunol. 140:866.
40. Harding, C. V., R. W. Roof, and E. R. Unanue. 1989. Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange. Proc. Natl. Acad. Sci. USA 86:4230.
41. Adorini, L., E. Appella, G. Doria, F. Cardinaux, and Z. Nagy. 1989. Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules. Nature 342:800.
42. Reid, P. A., and C. Watts. 1990. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments. Nature 346:655.
43. Pinet, V., M. Vergelli, R. Martin, O. Bakke, and E. O. Long. 1995. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 375: 603.
44. Davis, J. E., and P. Cresswell. 1990. Lack of detectable endocytosis of B lymphocyte MHC class II antigens using an antibody-independent technique. J. Immunol. 144:990.
45. Lanzavecchia, A., P. A. Reid, and C. Watts. 1992. Irreversible association of peptides with class II MHC molecules in living cells. Nature 357:249.
46. Nelson, C. A., S. J. Petzold, and E. R. Unanue. 1994. Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature 371: 250.
47. Cotner, T. 1992. Unassembled HLA-DRβ monomers are degraded rapidly by a nonlysosomal mechanism. J. Immunol. 148:2163.
48. Germain, R. N., and A. G. Rinker, Jr. 1993. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes selective cell surface expression of occupied molecules. Nature 363:725.
49. Kuismanen, E., and J. Saraste. 1989. Low temperature-induced transport blocks as tools to manipulate membrane traffic. Methods Cell Biol. 32:257.
50. Roosnek, E., S. Demotz, G. Corradin, and A. Lanzavecchia. 1988. Kinetics of MHC-antigen complex formation on antigen-presenting cells. J. Immunol. 140: 4079.
51. d. Proc. Natl. Acad. Sci. USA 88:4661.
52. Roche, P. A., and P. Cresswell. 1990. High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR. J. Immunol. 144:1849.
53. k. Nature 337:274.
54. Sadegh-Nasseri, S., L. J. Stern, D. C. Wiley, and R. N. Germain. 1994. MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature 370:647.
55. Vanbuskirk, A., B. L. Crump, E. Margoliash, and S. K. Pierce. 1989. A peptide binding protein having a role in antigen presentation is a member of the Hsp 70 heat shock family. J. Exp. Med. 170:1799.
56. Roof, R. W., I. F. Leuscher, and E. R. Unanue. 1990. Phospholipids enhance the binding of peptides to class II major histocompatibility molecules. Proc. Natl. Acad. Sci. USA 87:1735.
57. Lakey, E. K., L. A. Casten, W. L. Niebling, E. Margoliash, and S. K. Pierce. 1988. The dependence of B cell processing and presentation of peptide and native protein antigens. J. Immunol. 140:3309.
58. Sherman, M. A., S. M. Tompkins, H. A. Runnels, J. C. Moore, and P. E. Jensen. 1993. Different peptide-binding behavior of purified and membrane HLA-DR1. In Proceedings of FASEB 77th Annual Meeting. Anaheim, CA, p. 42A.
59. Fraser, J. D. 1989. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339:221.
60. Harding, C. V., and E. R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T cell stimulation. Nature 346: 574.
61. Demotz, S., H. M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 249:1028.
62. Adams, C. J., K. M. Maurey, and B. Storrie. 1982. Exocytosis of pinocytic contents by Chinese hamster ovary cells. J. Cell Biol. 93:632.
63. Swanson, J., B. D. Yirinic, and S. C. Silverstein. 1985. Phorbol esters and horse-radish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages. J. Cell Biol. 100:851.
64. Besterman, J. M., J. A. Airhart, R. C. Woodworth, and R. B. Low. 1981. Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation. J. Cell Biol. 91:716.
65. Blum, J. S., and P. Cresswell. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl. Acad. Sci. USA 85: 3975.
66. Monji, T. 1994. The role of HLA-DM molecules in class II-restricted antigen presentation. Doctoral dissertation, University of Washington, Seattle.
67. Roche, P. A., and P, Cresswell. 1990. Invariant chain associaton with HLA-DR molecules inhibits immunogenic peptide binding. Nature 345:615.
68. Steinman, R. M., S. E. Brodie, and Z. A. Cohn. 1976. Membrane flow during pinocytosis: a stereologic analysis. J. Cell Biol. 68:665.
69. Selby, D. M., D. F. Singer, R. W. Anderson, J. E. Coligan, J. J. Linderman, and R. Nairn. 1995. Antigen-presenting cell lines internalize peptide antigens via fluid-phase endocytosis. Cell Immunol. 163:47.
70. Von Figura, K., and H. Kresse. 1974. Quantitative aspects of pinocytosis and the intracellular fate of N-acetyl-α-D-glucosaminidase in Sanfilippo fibroblasts. J. Clin. Invest. 53:85.
71. Berthiaume, E. P., C. Medina, and J. A. Swanson. 1995. Molecular size-fractionation during endocytosis in macrophages. J. Cell Biol. 129:989.
72. Buckmaster, M. J., D. L. Braico, Jr., A. L. Ferris, and B. Storrie. 1987. Retention of pinocytized solute by CHO cell lysosomes correlates with molecular weight. Cell Biol. Int. Rep. 11:501.
73. Rudensky, A. Y., Maric, M., Eastman, S., Shoemaker, L., DeRoos, P. C., and Blum, J. 1994. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1:585.
74. Sela, M., and R. Arnon. 1992. Synthetic approaches to vaccines for infectious and autoimmune diseases. Vaccine 10:991.
75. Adorini, L., J.-C. Guéry, G. Rodriguez-Tarduchy, and S. Trembleau, 1993. Selective immunosuppression. Immunol. Today 14:285.