Gemfibrozil Reduces Elevated Lipoprotein (a) Levels in Hypercholesterolemic Patients;O Gemfibrozil Reduz Níveis Elevados de Lipoproteina (a) em Pacientes Hipercolesterolêmicos

Arquivos Brasileiros de Cardiologia

Volumn 68, Issue 4, 1997, Pages 257-260

  Ramires, José Antonio F ^a   Spósito, Andrei C ^a   Mansur, Antonio P ^a   Solimene, Maria C ^a   Chamone, Dalton ^a   Da Luz, Protásio L ^a   Pileggi, Fúlvio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Gemfibrozil; Lipoprotein (a); Lovastatin

Indexed keywords

ANTILIPEMIC AGENT; GEMFIBROZIL; HYPOCHOLESTEROLEMIC AGENT; LIPOPROTEIN A; MEVINOLIN;

ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; COMPARATIVE STUDY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; ADULT; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; ORAL DRUG ADMINISTRATION;

ANALYSIS OF VARIANCE; ANTICHOLESTEREMIC AGENTS; ANTILIPEMIC AGENTS; CHI-SQUARE DISTRIBUTION; FEMALE; GEMFIBROZIL; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEIN(A); LOVASTATIN; MALE; MIDDLE AGED;

EID: 0031107852     PISSN: 0066782X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Dahlën GH -Lp(a)lipoprotein in cardiovascular disease Atherosclerosis 1994, 108 111-26.
2. Mc Lean JW, Tomlinson WJE, Kuang DL el al - cDNA sequence of human apolipoprotein(a) is homologus to plasminogen Nature 1987; 330 132-7
3. Hajjar KA, Gavish D, Breslow JL, Nachman RL - Lipoprotein(a) modulation of endotelial cell surface fibrinolysis and its potential role in atherosclerosis Nature 1989, 339. 303-5.
4. Marcovina SM, Zhang ZH, Gaur VP, Albers JJ - Identification of 34 apolipoprotein (a) isoforms : differential expression apolipoprotein (a) alleles between American blacks and whites Biochem Bhiophys Res Commun 1993, 191 1192-6.
5. Maianhäo RC, Pileggi F - Lipoproteína(a), um potente fator de risco na aterosclerose Arq Bras Cardiol 1990; 54 337-42.
6. Heam JA. Donohue BC, Ba'aalbaki J et al - Usefulness of serum lipoprotein(a) as a predictor of restenosis after percutaneous transluminal coronary angioplasty Am J Cardiol 1992,69: 736-9
7. Maeda S, Abe A, Seishima M, Makino K, Noma A, Kawade M - Transient changes of serum lipoprotein(a) as an acute phase protein. Atherosclerosis 1989. 78 145-50
8. Bruckert E. Davidoff P, Grimaldi A et al - Increased serum levels of lipoprotein(a) in diabetes mellitus and their reduction with glycemic control JAMA 1990, 263 35-6.
9. Heiman P, Josephson MA, Fellner SK, Thistlerhwaite JR Jr. Stuart FP, Desgupta A - Elevated lipoprotein(a) levels in renal transplantation and hemodyalisis patients Am J Nephrol 1991, 11. 470-4
10. Karadi I, Romics L, Palos G et al - Lp(a) lipoprotein concentration in serum of patients with heavy proteinuria of different origin. Clin Chem 1989, 35 2121-3
11. Boiba E, Santos RD, Bonfa E et al - Lipoprotein(a) levels in systemic lupus erythematosus J Rheumatol 1994, 21 : 220-3
12. Burnstein M, Scolnick HR, Morfin R - Rapid methods for the isolation of lipoproteins from human serum by precipitation with polyanions J Lipid Res 1970, 11 583-95
13. Friedwald WT, Levy RI, Fredrickison DS- Estimation of the concentration of low density lipoprotein cholesterol in plasma, without the use of preparative ultracentrifugue. Clin Chem 1972, 18: 499-52.
14. Corsetti JP, Sterry JA, Sparks JD, Sparks CE. Weintraub M - Effect of weight loss on serum lipoprotein(a) concentrations in an obese population Clin Chem 1991 , 37 1191-5
15. Vessby B, Kostner G, Lithell H, Thomis J - Diverging effects of cholestirarninine on apolipoprotein B and lipoprotein Lp(a) Atherosclerosis 1982; 44 61-71
16. Kostner GM, Gavish D, Leopold D, Bolzano K Weintraub MS, Breslow JL -HMGCo-A reductase inhibitors lower low-density lipoprotein cholesterol without reducing lipoprotein(a) levels Circulation 1989, 80 1313-19
17. Guiakar A, Hoeg JM, Kostner G, Papadopoulus NM, Brewer HB - Levels of lipoprotein(a) decline with neomycin and niacin treatment. Atherosclerosis 1985; 57: 293-301
18. Carlson LA, Hamstern A, Asplund A - Pronounced lowering of serum levels of lipoprotein lipoprotein(a) in hyperlipidemic subjects treated with nicotinic acid J Intern Med 1989, 226 271-6
19. Soma M, Fumagalli R, Paoletti R, Meschia M, Carena M et al - Plasma Lp(a) concentration after estrogen and progestogen in postmenopausal women Lancet 1991; 37 617.
20. Albers JJ, Taggart HMCA, Applebaum-Bowden D, Haffner S, Chestnutt CH, Hazzard WR - Reduction of lechitihin-cholesterol acyl transferase, apohpoprotein A and Lp(a) lipoprotein with the anabolic steroid stanozolol. Biochim Biophys Acta 1984; 795: 293-303.
21. Crook D. Sidhu M, Seed M, O'Donnel M, Stevenson JC - Lipoprotein lipoprotein(a) levels are reduced by danazol , an anabolic steroid. Atherosclerosis 1992; 92: 41-7
22. Jones PH, Gotto AM Jr, Pownal HJ et al - Effect of gemfibrozil on plasma lipoprotein(a) levels in type 11 a hyperlipoprotememic subjects. Circulation 1991, 84: 483.
23. Bimmermann AC. Boerschmann C, ScwartzckopfW, Von Baeyer H, Schleicher J-Effective therapeutic measures for reducing lipoprotein(a) in patients with dyslipidemia Curr Ther Res 1991; 49: 635-43.
24. Windier E, Kovanem PT, Chao YS, Brown MS, Havel RJ, Goldstein JL -The estradiol-stimulated lipoprotein receptor of rat liver J Biol Chem 1980, 255 10464-71
25. Grundy SM - HMGCo-A reductase inhibitors for treatment of hypercholesterolemia. N Eng J Med 1988; 319: 24-33
26. Shepherd J - Fibrates in clinical practice focus on micronised fenofibrate Atherosclerosis 1994; 110(suppl): S55-S63
27. Sandholzer C, Feussner G, Bruznel J, Uterman G - Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a) J Clin Invest 1992, 90 1958-65
28. Santos RD, Vinagre C, Maranhão RC - Lipoprolein lipase does not affect lipoprotein(a) levels in normotriglyceridemic patients. Int J Cardiol 1995; 50. 79-81
29. Krempler F,Kostner GM, Bolzano K,Sandhofer F-Turnover of lipoprotein(a) in man J Clin Invest 1980,65. 1483-90.
30. Knight BL, Perombelon AK, Soutar AK, Wade DP, Seed M - Catabolism of lipoprotein(a) in familial hypercholesterolemic subjects Atherosclerosis 1991 ; 87: 227-37.
31. Ramharack R, Spahr MA, Hicks GW et al - Gemfibrozil significantly lowers cynomolgus monkey plasma lipoprotein(a)-protein and liver apolipoprotein(a) mRNA levels J Lipid Res 1995; 36: 1294-304