Closed-loop drug infusion for control of heart-rate trajectory in pharmacological stress tests

IEEE Transactions on Biomedical Engineering

Volumn 44, Issue 3, 1997, Pages 185-195

  Valcke, Christian P ^a   Chizeck, Howard Jay ^b  

^a Gensia Inc   (United States)

^b Case Western Reserve University   (United States)

Author keywords

Cardiovascular systems; digital control; drug delivery systems

Indexed keywords

ALGORITHMS; CLOSED LOOP CONTROL SYSTEMS; COMPUTER SIMULATION; CONTROLLED DRUG DELIVERY; DIAGNOSIS; DIGITAL CONTROL SYSTEMS; DISEASES; DRUG INFUSION; KNOWLEDGE BASED SYSTEMS; MATHEMATICAL MODELS; PARAMETER ESTIMATION; PHARMACODYNAMICS;

CORONARY ARTERY DISEASE; EXERCISE STRESS TESTING; HEART RATE; HEART RATE TRAJECTORY;

CARDIOVASCULAR SYSTEM;

ARTICLE; CARDIOVASCULAR SYSTEM; COMPUTER ASSISTED THERAPY; CORONARY ARTERY DISEASE; DRUG DELIVERY SYSTEM; MODEL;

ALGORITHMS; ANIMALS; CARDIOTONIC AGENTS; CATECHOLAMINES; CORONARY DISEASE; CROSS-OVER STUDIES; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXERCISE TEST; FEASIBILITY STUDIES; HAPLORHINI; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MODELS, CARDIOVASCULAR; MULTICENTER STUDIES; REFERENCE VALUES;

EID: 0031106773     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/10.554765     Document Type: Article

References (17)

1. American Heart Association, AHA Cardiovascular Statistics. Dallas, TX: National Center, 1993.
2. R. A. Bruce, T. A. DeRouen, and K. F. Hossack, Value of maximal exercise tests in risk assessment of primary coronary heart disease events in healthy men: Five years' experience of the Seattle Heart Watch Study, Amer. J. Cardiol., vol. 46, pp. 371-378, 1980.
3. L. Gibbons, S. N. Blair, H. W. Kohl, and K. Cooper, The safety of maximal exercise testing, Circ., vol. 80, no. 4, pp. 846-852, 1989.
4. S. Severi and C. Michelassi, Prognostic impact of stress testing in coronary artery disease, Circ., vol. 83 (suppl III), pp. 82-88, 1991.
5. P. F. van Rugge, E. E. van der Wall, and A. V. G. Bruschke, New developments in pharmacologie stress imaging, Amer. Heart J., vol. 124, no. 2, pp. 468-485, 1992.
6. M. Young, C. Valcke, K. Mullane, and P. Gardiner, Arbutamine: A novel catecholamine for pharmacologie diagnosis of coronary disease, Cardiovasc. Drug Rev., vol. 13, no. 4, pp. 379-398, 1995.
7. K. T. Olkkola and H. Schwindlen, Adaptive closed-loop feedback control of vecuronium-induced neuromuscular relaxation, Eur. J. Aneaesthesiol, vol. 8, no. 1, pp. 7-12, 1991.
8. H. Schwindlen and H. Stoeckel, Closed-loop feedback controlled administration of alfentanil during alfentanil-nitrous oxide anaesthesia, Er. J. Anaesthesia, vol. 70, pp. 389-393, 1993.
9. G. I. Voss, P. G. Katona, and H. J. Chizeck, Adaptive multivariable drug delivery: Control of arterial pressure and cardiac output in anesthetized dogs, IEEE Trans. Biomed. Eng., vol. BME-34, pp. 617-623, 1987.
10. T. C. Jannett, P. W. Sanders, N. Shanklin, and M. G. Wise, Adaptive control of anticoagulation during hemodialysis, Kidney Int., vol. 45, pp. 912-915, 1994.
11. W. R. Chitwood et al., Multicenter trial of automated nitroprusside infusion for postoperative hypertension, Ann. Thorac. Surg., vol. 54, pp. 517-522, 1992.
12. L. Ljung, System Identification: Theory for the User. Englewood Cliffs, NJ: Prentice Hall, 1987.
13. The MathWorks Inc. Matlab User's Guide. Natick MA, 1992.
14. R. C. Schlant et al.. Guidelines for exercise testing, JACC. vol. 8, no. 3, pp. 725-738, 1986.
15. C. A. Dennis et al., Stress testing with closed-loop arbutamine as an alternative to exercise, JACC. vol. 26, no. 5, pp. 1151-1158, 1995.
16. H. Kiat et al, Arbutamine stress thallium-201 single-photon emission computed tomography using a computarized closed-loop delivery system, JACC, vol 26, no. 5, pp 1159-1167, 1995.
17. J. L. Cohen et al.. Arbutamine echocardiography: Efficacy and safety of a new pharmacologie stress agent to induce myocardial ischemia and detect coronary artery disease, JACC, vol. 26, no. 5, pp. 1168-1175, 1995.