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Volumn 144, Issue 1, 1997, Pages 160-167

Gene therapy approaches to Parkinson's disease: Preclinical to clinical trials, or what steps to take to get there from here?

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE THERAPY; MONKEY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0031106276     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.6403     Document Type: Article
Times cited : (1)

References (72)
  • 3
    • 0021988433 scopus 로고
    • Transplantation of adrenal medullary tissue to striatum in parkinsonism: First clinical trials
    • 3. BACKLUND, E. O., B. GRANBERG, E. HAMBERGER, A. KNUTSSON, G. MÅRTENSSON, G. SEDVALL, et al. 1985. Transplantation of adrenal medullary tissue to striatum in parkinsonism: First clinical trials. J. Neurosurg. 62: 169-173.
    • (1985) J. Neurosurg. , vol.62 , pp. 169-173
    • Backlund, E.O.1    Granberg, B.2    Hamberger, E.3    Knutsson, A.4    Mårtensson, G.5    Sedvall, G.6
  • 4
    • 0023634115 scopus 로고
    • Biochemical and behavioral correction of MPTP Parkinson-like syndrome by fetal cell transplantation
    • 4. BAKAY, R. A. E., D. L. BARROW, M. S. FIANDACA, P. M. IUVONE, A. SCHIFF, AND D. C. COLLINS. 1987. Biochemical and behavioral correction of MPTP Parkinson-like syndrome by fetal cell transplantation. Ann. N. Y. Acad. Sci. 495: 623-640.
    • (1987) Ann. N. Y. Acad. Sci. , vol.495 , pp. 623-640
    • Bakay, R.A.E.1    Barrow, D.L.2    Fiandaca, M.S.3    Iuvone, P.M.4    Schiff, A.5    Collins, D.C.6
  • 5
    • 0025004324 scopus 로고
    • Behavioral recovery from MPTP-induced parkinsonism in monkeys after intracerebral tissue implants is not related to CSF concentrations of dopamine metabolites
    • 5. BANKIEWICZ, K. S., R. J. PLUNKETT, I. MEFFORD, I. J. KOPIN, AND E. H. OLDFIELD. 1990. Behavioral recovery from MPTP-induced parkinsonism in monkeys after intracerebral tissue implants is not related to CSF concentrations of dopamine metabolites. Prog. Brain Res. 82: 561-571.
    • (1990) Prog. Brain Res. , vol.82 , pp. 561-571
    • Bankiewicz, K.S.1    Plunkett, R.J.2    Mefford, I.3    Kopin, I.J.4    Oldfield, E.H.5
  • 6
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington: Clinical, morphological and neurochemical correlations
    • 6. BERNHEIMER, H., W. BIRKMAYER, O. HORNYKIEWICZ, K. JELLINGER, AND F. SEITELBERGER 1973. Brain dopamine and the syndromes of Parkinson and Huntington: Clinical, morphological and neurochemical correlations. J. Neurosci. 20: 415-4155.
    • (1973) J. Neurosci. , vol.20 , pp. 415-4155
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 7
    • 0018695489 scopus 로고
    • Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants
    • 7. BJÖRKLUND, A., AND U. STENEVI. 1979. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177: 555-560.
    • (1979) Brain Res. , vol.177 , pp. 555-560
    • Björklund, A.1    Stenevi, U.2
  • 8
    • 0023623403 scopus 로고
    • Intracerebral grafting of dopamine neurons: Experimental basis for clinical trials in patients with Parkinson's disease
    • 8. BRUNDIN, P., R. E. STRECKER, O. LINDVALL, O. ISACSON, O. G. NILSSON, G. BARBIN, et al. 1987. Intracerebral grafting of dopamine neurons: Experimental basis for clinical trials in patients with Parkinson's disease. Ann. N. Y. Acad. Sci. 495: 473-496.
    • (1987) Ann. N. Y. Acad. Sci. , vol.495 , pp. 473-496
    • Brundin, P.1    Strecker, R.E.2    Lindvall, O.3    Isacson, O.4    Nilsson, O.G.5    Barbin, G.6
  • 9
    • 0001496694 scopus 로고
    • Aprimate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • 9. BURNS, R. S., C. C. CHIUEH, S. P. MARKEY, M. H. EBERT, D. M. JACOBOWITZ, AND I. J. KOPIN. 1983. Aprimate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Nat. Acad. Sci. USA 80: 4546-4550.
    • (1983) Proc. Nat. Acad. Sci. USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 11
    • 0014208039 scopus 로고
    • Aromatic amino acids and modification of parkinsonism
    • 11. COTZIAS, G. C., M. H. VAN WOERT, AND L. M. SCHIFFER. 1967. Aromatic amino acids and modification of parkinsonism. N. Engl. J. Med. 276: 374-379.
    • (1967) N. Engl. J. Med. , vol.276 , pp. 374-379
    • Cotzias, G.C.1    Van Woert, M.H.2    Schiffer, L.M.3
  • 12
    • 0022446672 scopus 로고
    • Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • 12. DEUTCH, A. Y., J. D. ELSWORTH, M. GOLDSTEIN, K. FUXE, D. E. REDMOND, JR., J. R. SLADEK, JR., AND R. H. ROTH. 1986. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neurosci. Lett. 68: 51-56.
    • (1986) Neurosci. Lett. , vol.68 , pp. 51-56
    • Deutch, A.Y.1    Elsworth, J.D.2    Goldstein, M.3    Fuxe, K.4    Redmond D.E., Jr.5    Sladek, J.R.6    Roth, R.H.7
  • 13
    • 0001073023 scopus 로고
    • Primary and secondary findings in a series of attempts to transplant cerebral cortex in the albino rat
    • 13. DUNN, E. H. 1917. Primary and secondary findings in a series of attempts to transplant cerebral cortex in the albino rat. J. Comp. Neurol. 27: 565-582.
    • (1917) J. Comp. Neurol. , vol.27 , pp. 565-582
    • Dunn, E.H.1
  • 14
    • 0000819366 scopus 로고
    • AAV-mediated transfer of tyrosine hydroxylase and aromatic amino acid decarboxylase genes into the primate brain: A direct gene therapy approach to Parkinson's disease
    • 14. DURING, M. J., M. G. KAPLITT, JR., P. LEONE, X. XIAO, J. D. ELSWORTH, R. H. ROTH, J. R. SLADEK, JR., D. E. REDMOND, JR., AND K. L. O'MALLEY. 1994. AAV-mediated transfer of tyrosine hydroxylase and aromatic amino acid decarboxylase genes into the primate brain: A direct gene therapy approach to Parkinson's disease. Neurosci. Abstr. 20: 1465.
    • (1994) Neurosci. Abstr. , vol.20 , pp. 1465
    • During, M.J.1    Kaplitt M.G., Jr.2    Leone, P.3    Xiao, X.4    Elsworth, J.D.5    Roth, R.H.6    Sladek J.R., Jr.7    Redmond D.E., Jr.8    O'Malley, K.L.9
  • 15
    • 0028303386 scopus 로고
    • Novel radioligands for the dopamine transporter demonstrate the presence of intrastriatal nigral grafts in the MPTP-treated monkey: Correlation with improved behavioral function
    • 15. ELSWORTH, J. D., M. D. AL-TIKRITI, J. R. SLADEK, JR., J. R. TAYLOR, R. B. INNIS, D. E. REDMOND, JR., AND R. H. ROTH. 1994. Novel radioligands for the dopamine transporter demonstrate the presence of intrastriatal nigral grafts in the MPTP-treated monkey: Correlation with improved behavioral function. Exp. Neurol. 126: 300-304.
    • (1994) Exp. Neurol. , vol.126 , pp. 300-304
    • Elsworth, J.D.1    Al-Tikriti, M.D.2    Sladek J.R., Jr.3    Taylor, J.R.4    Innis, R.B.5    Redmond D.E., Jr.6    Roth, R.H.7
  • 16
    • 0023254841 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF
    • 16. ELSWORTH, J. D., A. Y. DEUTCH, D. E. REDMOND, JR., J. R. SLADEK, AND R. H. ROTH. 1987. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Res. 415: 293-299.
    • (1987) Brain Res. , vol.415 , pp. 293-299
    • Elsworth, J.D.1    Deutch, A.Y.2    Redmond D.E., Jr.3    Sladek, J.R.4    Roth, R.H.5
  • 17
    • 0025374307 scopus 로고
    • MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
    • 17. ELSWORTH, J. D., A. Y. DEUTCH, D. E. REDMOND, JR., J. R. SLADEK, JR., AND R. H. ROTH. 1990. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neurosci. Lett. 114: 316-322.
    • (1990) Neurosci. Lett. , vol.114 , pp. 316-322
    • Elsworth, J.D.1    Deutch, A.Y.2    Redmond D.E., Jr.3    Sladek J.R., Jr.4    Roth, R.H.5
  • 18
    • 0024850382 scopus 로고
    • Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated primates: Biochemical changes in striatal regions
    • 18. ELSWORTH, J. D., A. Y. DEUTCH, D. E. REDMOND, JR., J. R. TAYLOR, J. R. SLADEK, JR., AND R. H. ROTH. 1989. Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated primates: Biochemical changes in striatal regions. Neuroscience 33: 323-331.
    • (1989) Neuroscience , vol.33 , pp. 323-331
    • Elsworth, J.D.1    Deutch, A.Y.2    Redmond D.E., Jr.3    Taylor, J.R.4    Sladek J.R., Jr.5    Roth, R.H.6
  • 19
    • 0002674619 scopus 로고
    • Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates
    • 19. ELSWORTH, J. D., D. J. LEAHY, R. H. ROTH, AND D. E. REDMOND, JR. 1987. Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates. J. Neurol Transm. 68: 51-62.
    • (1987) J. Neurol Transm. , vol.68 , pp. 51-62
    • Elsworth, J.D.1    Leahy, D.J.2    Roth, R.H.3    Redmond D.E., Jr.4
  • 20
    • 0027170730 scopus 로고
    • Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens, and striatum
    • 20. ELSWORTH, J. D., J. R. TAYLOR, P. BERGER, AND R. H. ROTH. 1993. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens, and striatum. Neurochem. Int. 23:61-69.
    • (1993) Neurochem. Int. , vol.23 , pp. 61-69
    • Elsworth, J.D.1    Taylor, J.R.2    Berger, P.3    Roth, R.H.4
  • 21
    • 0026218077 scopus 로고
    • Regulatory concerns in human gene therapy
    • 21. EPSTEIN, S. 1991. Regulatory concerns in human gene therapy. Hum. Gene Ther. 2: 243-249.
    • (1991) Hum. Gene Ther. , vol.2 , pp. 243-249
    • Epstein, S.1
  • 22
    • 0000224448 scopus 로고
    • Unified Parkinson's disease rating scale
    • S. Fahn, C. Marsden, M. Goldstein, and C. Calne, Eds., Macmillan, Florham Park, NJ
    • 22. FAHN, S., R. ELTON, AND MEMBERS OF THE UPDRS DEVELOPMENT COMMITTEE. 1987. Unified Parkinson's disease rating scale. Pages 153-163 in S. Fahn, C. Marsden, M. Goldstein, and C. Calne, Eds., Recent Developments in Parkinson's Disease. Macmillan, Florham Park, NJ.
    • (1987) Recent Developments in Parkinson's Disease , pp. 153-163
    • Fahn, S.1    Elton, R.2
  • 24
    • 85030295458 scopus 로고    scopus 로고
    • C. F. B. E. A. Research, Ed. Congressional, Consumer and International Affairs Staff (HFB-142), Rockville, MD
    • 24. FOOD AND DRUG ADMINISTRATION. 1996. Addendum to the points to consider in human somatic cell therapy and gene therapy. Pages 2-18 in C. F. B. E. A. Research, Ed. Congressional, Consumer and International Affairs Staff (HFB-142), Rockville, MD.
    • (1996) Addendum to the Points to Consider in Human Somatic Cell Therapy and Gene Therapy , pp. 2-18
  • 25
    • 0002538260 scopus 로고
    • Neuropathology of MPTP-treated monkeys: Comparison with the neuropathology of human idiopathic Parkinson's disease
    • S. P. Markey, Ed., Academic Press, Orlando
    • 25. FORNO, L. S., L. E. DELANNEY, I. IRWIN, AND J. W. LANGSTON. 1986. Neuropathology of MPTP-treated monkeys: Comparison with the neuropathology of human idiopathic Parkinson's disease. Pages 119-140 in S. P. Markey, Ed., MPTP: A Neurotoxin Producing a Parkinsonian Syndrome. Academic Press, Orlando.
    • (1986) MPTP: A Neurotoxin Producing a Parkinsonian Syndrome , pp. 119-140
    • Forno, L.S.1    Delanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 26
    • 0027343340 scopus 로고
    • Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease: Neuropathologic considerations
    • 26. FORNO, L. S., L. E. DELANNEY, I. IRWIN, AND J. W. LANGSTON. 1993. Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease: Neuropathologic considerations. Adv. Neurol. 60: 600-608.
    • (1993) Adv. Neurol. , vol.60 , pp. 600-608
    • Forno, L.S.1    DeLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 27
    • 0026443974 scopus 로고
    • Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease
    • 27. FREED, C. R., R. E. BREEZE, N. L. ROSENBERG, S. A. SCHNECK, E. KRIEK, J. X. QI, T. LONE, Y. B. ZHANG, J. A. SNYDER, T. H. WELLS, et al. 1992. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease [see comments]. N. Engl. J. Med. 327: 1549-1555.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 1549-1555
    • Freed, C.R.1    Breeze, R.E.2    Rosenberg, N.L.3    Schneck, S.A.4    Kriek, E.5    Qi, J.X.6    Lone, T.7    Zhang, Y.B.8    Snyder, J.A.9    Wells, T.H.10
  • 29
    • 0025702616 scopus 로고
    • Fetal brain grafts and Parkinson's disease
    • 29. FREED, W. J. 1990. Fetal brain grafts and Parkinson's disease. Science 250: 1434.
    • (1990) Science , vol.250 , pp. 1434
    • Freed, W.J.1
  • 30
    • 0025912187 scopus 로고
    • Substantia nigra grafts and Parkinson's disease: From animal experiments to human therapeutic trials
    • 30. FREED, W. J. 1991. Substantia nigra grafts and Parkinson's disease: From animal experiments to human therapeutic trials. Restor. Neurol. Neurosci. 3: 109-134.
    • (1991) Restor. Neurol. Neurosci. , vol.3 , pp. 109-134
    • Freed, W.J.1
  • 31
    • 0027500644 scopus 로고
    • Neural transplantation: Prospects for clinical use
    • 31. FREED, W. J. 1993. Neural transplantation: Prospects for clinical use. Cell Transplant. 2: 13-31.
    • (1993) Cell Transplant. , vol.2 , pp. 13-31
    • Freed, W.J.1
  • 32
    • 0019124289 scopus 로고
    • Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long-term behavioral, biochemical and histochemical studies
    • 32. FREED, W. J., M. J. PERLOW, F. KAROUIM, A. SEIGER, L. OLSON, B. J. HOFFER, AND R. J. WYATT. 1980. Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long-term behavioral, biochemical and histochemical studies. Ann. Neurol. 8: 510-519.
    • (1980) Ann. Neurol. , vol.8 , pp. 510-519
    • Freed, W.J.1    Perlow, M.J.2    Karouim, F.3    Seiger, A.4    Olson, L.5    Hoffer, B.J.6    Wyatt, R.J.7
  • 33
    • 0025241320 scopus 로고
    • Intracerebral adrenal medulla grafts: A review
    • 33. FREED, W. J., M. POLTORAK, AND J. B. BECKER. 1990. Intracerebral adrenal medulla grafts: A review. Exp. Neurol. 110: 139-166.
    • (1990) Exp. Neurol. , vol.110 , pp. 139-166
    • Freed, W.J.1    Poltorak, M.2    Becker, J.B.3
  • 34
    • 0026445783 scopus 로고
    • Repeated measures in clinical trials: Analysis using mean summary statistics and its implications for design
    • 34. FRISON, L., AND S. J. POCOCK. 1992. Repeated measures in clinical trials: Analysis using mean summary statistics and its implications for design. Stat. Med. 11: 1685-1704.
    • (1992) Stat. Med. , vol.11 , pp. 1685-1704
    • Frison, L.1    Pocock, S.J.2
  • 35
    • 0025147442 scopus 로고
    • Intracerebral grafting of genetically modified cells acting as biological pumps
    • 35. GAGE, F. H. 1990. Intracerebral grafting of genetically modified cells acting as biological pumps. Trends Pharmacol. Sci. 11: 437-439.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 437-439
    • Gage, F.H.1
  • 39
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression, and mortality
    • 39. HOEHN, M. M., AND M. D. YAHR 1967. Parkinsonism: Onset, progression, and mortality. Neurology 17: 427-442.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 40
    • 0025818158 scopus 로고
    • Ethical issues in brain-cell transplantation
    • 40. HOFFER, B. J., AND L. OLSON. 1991. Ethical issues in brain-cell transplantation. Trends Neurosci. 14: 384-388.
    • (1991) Trends Neurosci. , vol.14 , pp. 384-388
    • Hoffer, B.J.1    Olson, L.2
  • 41
    • 0003096328 scopus 로고
    • Brain neurotransmitter changes in Parkinson's disease
    • D. Marsden and S. Fahn, Eds., Butterworth, London
    • 41. HORNYKIEWICZ, O. 1982. Brain neurotransmitter changes in Parkinson's disease. Pages 41-58 in D. Marsden and S. Fahn, Eds., Movement Disorders. Butterworth, London.
    • (1982) Movement Disorders , pp. 41-58
    • Hornykiewicz, O.1
  • 44
    • 0027517610 scopus 로고
    • Regulation of somatic-cell therapy and gene therapy by the Food and Drug Administration
    • 44. KESSLER, D. A., J. P. SIEGAL, P. D. NOGUCHI, K. C. ZOON, K. L. FEIDEN, AND J. WOODCOCK. 1993. Regulation of somatic-cell therapy and gene therapy by the Food and Drug Administration. N. Engl. J. Med. 329: 1169-1173.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1169-1173
    • Kessler, D.A.1    Siegal, J.P.2    Noguchi, P.D.3    Zoon, K.C.4    Feiden, K.L.5    Woodcock, J.6
  • 45
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • 45. LANGSTON, J. W., P. BALLARD, J. W. TETRUD, AND I. IRWIN. 1983. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 47
    • 0024362054 scopus 로고
    • Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: A detailed account of methodology and a 6-month follow-up
    • 47. LINDVALL, O., S. REHNCRONA, P. BRUNDIN, B. GUSTAVII, B. ASTEDT, H. WIDNER, et al. 1989. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: A detailed account of methodology and a 6-month follow-up. Arch. Neurol. 46: 615-631.
    • (1989) Arch. Neurol. , vol.46 , pp. 615-631
    • Lindvall, O.1    Rehncrona, S.2    Brundin, P.3    Gustavii, B.4    Astedt, B.5    Widner, H.6
  • 49
    • 0023152420 scopus 로고
    • Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease
    • 49. MADRAZO, I., R. DRUCKER-COLIN, V. DIAZ, J. MARTINEZ-MATA, C. TORRES, AND J. J. BECERRIL. 1987. Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N. Engl. J. Med. 316: 831-834.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 831-834
    • Madrazo, I.1    Drucker-Colin, R.2    Diaz, V.3    Martinez-Mata, J.4    Torres, C.5    Becerril, J.J.6
  • 51
    • 0021190231 scopus 로고
    • Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain
    • 51. MORIHISA, J. M., R. K. NAKAMURA, W. J. FREED, M. MISHKIN, AND R. J. WYATT. 1984. Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain. Exp. Neurol. 84: 643-653.
    • (1984) Exp. Neurol. , vol.84 , pp. 643-653
    • Morihisa, J.M.1    Nakamura, R.K.2    Freed, W.J.3    Mishkin, M.4    Wyatt, R.J.5
  • 56
    • 0018778418 scopus 로고
    • Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
    • 56. PERLOW, M. J., W. J. FREED, B. J. HOFFER, A. SEIGER, L. OLSON, AND R. J. WYATT. 1979. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204: 643-653.
    • (1979) Science , vol.204 , pp. 643-653
    • Perlow, M.J.1    Freed, W.J.2    Hoffer, B.J.3    Seiger, A.4    Olson, L.5    Wyatt, R.J.6
  • 57
    • 0027786845 scopus 로고
    • IVth International Symposium on Neural Transplantation transcript of the closing discussion
    • 57. REDMOND, D. E., JR., B. J. HOFFER, et al. 1992. IVth International Symposium on Neural Transplantation transcript of the closing discussion. J. Neural Transplant. Plast. 4: 113-125.
    • (1992) J. Neural Transplant. Plast. , vol.4 , pp. 113-125
    • Redmond D.E., Jr.1    Hoffer, B.J.2
  • 63
    • 0026667562 scopus 로고
    • In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodin-123 labeled RTI-55
    • 63. SHAYA, E., U. SCHEFFEL, R. DANNALS, G. RICAURTE, F. CARROL, H. WAGNER, JR., AND D. WONG. 1992. In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodin-123 labeled RTI-55. Synapse 10: 169-172.
    • (1992) Synapse , vol.10 , pp. 169-172
    • Shaya, E.1    Scheffel, U.2    Dannals, R.3    Ricaurte, G.4    Carrol, F.5    Wagner H., Jr.6    Wong, D.7
  • 65
    • 0022971670 scopus 로고
    • Survival and growth of fetal catecholamine neurons transplanted into primate brain
    • 65. SLADEK, J. R., JR., T. J. COLLIER, S. N. HABER, R. H. ROTH, AND D. E. REDMOND, JR. 1986. Survival and growth of fetal catecholamine neurons transplanted into primate brain. Brain Res. Bull. 17: 809-818.
    • (1986) Brain Res. Bull. , vol.17 , pp. 809-818
    • Sladek J.R., Jr.1    Collier, T.J.2    Haber, S.N.3    Roth, R.H.4    Redmond D.E., Jr.5
  • 67
    • 0025003032 scopus 로고
    • Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys
    • S. J. Richards and S. B. Dunnett, Eds., Elsevier, Amsterdam
    • 67. TAYLOR, J. R., J. D. ELSWORTH, R. H. ROTH, T. J. COLLIER, J. R. SLADEK, AND D. E. REDMOND, JR. 1990. Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. Pages 543-559 in S. J. Richards and S. B. Dunnett, Eds., Progress in Brain Research, Vol. 82. Elsevier, Amsterdam.
    • (1990) Progress in Brain Research , vol.82 , pp. 543-559
    • Taylor, J.R.1    Elsworth, J.D.2    Roth, R.H.3    Collier, T.J.4    Sladek, J.R.5    Redmond D.E., Jr.6
  • 68
    • 0002269237 scopus 로고
    • Behavioral effects of MPTP administration in the vervet monkey: A primate model of Parkinson's disease
    • M. L. Woodruff and A. J. Nonneman, Eds., Plenum Press, New York
    • 68. TAYLOR, J. R., J. D. ELSWORTH, J. R. SLADEK, JR., R. H. ROTH, AND D. E. REDMOND, JR. 1994. Behavioral effects of MPTP administration in the vervet monkey: A primate model of Parkinson's disease. Pages 139-174 in M. L. Woodruff and A. J. Nonneman, Eds., Toxin-Induced Models of Neurological Disorders. Plenum Press, New York.
    • (1994) Toxin-induced Models of Neurological Disorders , pp. 139-174
    • Taylor, J.R.1    Elsworth, J.D.2    Sladek J.R., Jr.3    Roth, R.H.4    Redmond D.E., Jr.5
  • 70
    • 0004008508 scopus 로고
    • U.S. Gov. Printing Office, Public Health Service, Washington, DC
    • 70. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH. 1988. Report of the Human Fetal Tissue Transplantation Research Panel. U.S. Gov. Printing Office, Public Health Service, Washington, DC.
    • (1988) Report of the Human Fetal Tissue Transplantation Research Panel
  • 71
    • 0028314615 scopus 로고
    • NIH neural transplantation funding
    • 71. WIDNER, H. 1994. NIH neural transplantation funding [letter]. Science 263: 737.
    • (1994) Science , vol.263 , pp. 737
    • Widner, H.1
  • 72
    • 0026458624 scopus 로고
    • Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • 72. WIDNER, H., J. TETRUD, S. REHNCRONA, B. SNOW, P. BRUNDIN, B. GUSTAVII, A. BJÖRKLUND, O. LINDVALL, AND J. W. LANGSTON. 1992. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). N. Engl. J. Med. 327: 1556-1563.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 1556-1563
    • Widner, H.1    Tetrud, J.2    Rehncrona, S.3    Snow, B.4    Brundin, P.5    Gustavii, B.6    Björklund, A.7    Lindvall, O.8    Langston, J.W.9


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