Pharmacokinetics of dexamethasone and its relationship to dexamethasone suppression test outcome in depressed patients and healthy control subjects

Biological Psychiatry

Volumn 41, Issue 5, 1997, Pages 574-584

  O'Sullivan, Brendan T ^a,b   Cutler, David J ^a   Hunt, Glenn E ^a   Walters, Craig ^a   Johnson, Gordon F ^a   Caterson, Ian D ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

controls; depression; dexamethasone; dexamethasone suppression test; pharmacokinetics

Indexed keywords

DEXAMETHASONE;

ADULT; ARTICLE; BIOAVAILABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MELANCHOLIA; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; TIME;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DEPRESSIVE DISORDER; DEXAMETHASONE; FEMALE; HALF-LIFE; HUMANS; INDIVIDUALITY; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PERSONALITY INVENTORY; REFERENCE VALUES;

EID: 0031105949     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00094-7     Document Type: Article

References (44)

1. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed rev. Washington, DC: American Psychiatric Press.
2. American Psychiatric Association Task Force on Laboratory Tests in Psychiatry (1987): The dexamethasone suppression test: An overview of its current status in psychiatry. Am J Psychiatry 144:1253-1262.
3. Arana GW, Workman RJ, Baldessarini RJ (1984): Association between low plasma levels of dexamethasone and elevated levels of cortisol in psychiatric patients given dexamethasone. Am J Psychiatry 141:1619-1620.
4. Arana GW, Baldessarini RJ, Ornsteen M (1985): The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Arch Gen Psychiatry 42:1193-1204.
5. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1976): An inventory for measuring depression. Arch Gen Psychiatry 4:561-571.
6. Carroll BJ, Schroeder K, Mukhopadhyay S, Greden JF, Feinberg M, Ritchie J, Tarika J (1980): Plasma dexamethasone concentrations and cortisol suppression response in patients with endogenous depression. J Clin Endocrinol Metab 51:433-437.
7. Carroll BJ, Feinberg M, Greden JF, et al (1981a): A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38:15-22.
8. Carroll BJ, Feinberg M, Smouse P, Rawson S, Greden J (1981b): The Carroll rating scale for depression: I. Development, reliability and validation. Br J Psychiatry 18:194-200.
9. Duggan DE, Yeh KC, Matalia N, Ditzler CA, McMahon FG (1975): Bioavailability of oral dexamethasone. Clin Pharmacol Ther 18:205-209.
10. Endicott J, Spitzer RL (1978): A diagnostic interview. The schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844.
11. English J, Chakroborty J, Marks V, Parke A (1975): A radioimmunoassay procedure for dexamethasone - Plasma and urine levels in man. Eur J Clin Pharmacol 9:239-244.
12. Gastpar M, Gilsdorf U, Abousaleh MT, Ngokhac T (1992): Clinical correlates of response to DST - The dexamethasone suppression test in depression - A World-Health-Organization collaborative study. J Affect Disord 26:17-24.
13. Gibaldi M, Perrier D (1982): Pharmacokinetics, 2nd ed rev. New York: Marcel Dekker Inc.
14. Gupta SK, Ritchie JC, Wiedemann K, Holsboer F (1992): Modeling the pharmacokinetics and pharmacodynamics of dexamethasone in depressed patients. Eur J Clin Pharmacol 43:51-55.
15. Guthrie S (1991): The impact of dexamethasone pharmacokinetics on the DST - A review. Psychopharmacol Bull 27:565-576.
16. Guthrie SK, Heidt M, Pande A, Grunhaus L, Haskett RF, Hariharan M (1992): A longitudinal evaluation of dexamethasone pharmacokinetics in depressed patients and normal controls. J Clin Psychopharmacol 12:191-196.
17. Hamilton M (1960): A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62.
18. Hitchens M, Hogans AF (1974): Radioimmunoassay for dexamethasone in plasma. Clin Chem 20:266-271.
19. Holsboer F, Haack D, Gerken A, Vecsei P (1984): Plasma dexamethasone concentrations and differential suppression response of cortisol and corticosterone in depressives and controls. Biol Psychiatry 19:281-291.
20. Holsboer F, Wiedemann K, Boll E (1986a): Shortened dexamethasone half-life in depressed dexamethasone nonsuppressors. Arch Gen Psychiatry 43:813-815.
21. Holsboer F, Wiedemann K, Gerken A, Boll E (1986b): The plasma dexamethasone variable in depression: Test-retest studies and early biophase kinetics. Psychiatry Res 17:97-103.
22. Hunt GE, O'Sullivan BT, Johnson GFS, Caterson ID (1991): The effect of high plasma dexamethasone levels on DST sensitivity: A dose-response study in depressed patients and controls. Psychiatry Res 36:209-222.
23. Johnson GF, Hunt G, Kerr K, Caterson I (1984): Dexamethasone suppression test (DST) and plasma dexamethasone levels in depressed patients. Psychiatry Res 13:305-313.
24. Johnson GF, Hunt G, Kerr K, Caterson I (1987): The plasma dexamethasone "window" and the dexamethasone suppression test in depression. Biol Psychiatry 22:1035-1039.
25. Johnson GF, Hunt GE, Caterson I (1988): Plasma dexamethasone and the dexamethasone suppression test. Initial and follow-up tests in depressed patients. J Affect Disord 15:93-100.
26. Kawai S, Ichikawa Y, Homma M (1985): Differences in metabolic properties among cortisol, prednisolone, and dexamethasone in liver and renal diseases: Accelerated metabolism of dexamethasone in renal failure. J Clin Endocrinol Metab 60:848-854.
27. Loew C, Schuster O, Graul EH (1986): Dose-dependent pharmacokinetics of dexamethasone. Eur J Clin Pharmacol 30: 225-230.
28. Lowy T, Meltzer HY (1987): Dexamethasone bioavailability: Implications for DST research. Biol Psychiatry 22:373-385.
29. Maguire KP, Tuckwell VM, Schweitzer I, Tiller JW, Davies BM (1990): Dexamethasone kinetics in depressed patients before and after clinical response. Psychoneuroendocrinology 15: 113-123.
30. Morris J, Carr V, Gilliland J, Hooper M (1986): Dexamethasone concentrations and the dexamethasone suppression test in psychiatric disorders. Br J Psychiatry 148:66-69.
31. Norusis MJ (1985): SPSS-X. Advanced Statistics Guide. New York: McGraw Hill.
32. O'Sullivan BT, Hunt GE, Johnson GF, Caterson ID (1989): The plasma dexamethasone window: Evidence supporting its usefulness to validate dexamethasone suppression test results. Biol Psychiatry 25:739-754.
33. Poland RE, Rubin RT, Lesser IM, Lane LA, Hart PJ (1987): Neuroendocrine aspects of primary endogenous depression: II. Serum dexamethasone concentrations and hypothalamopituitary-adrenal cortical activity as determinants of the dexamethasone suppression test response. Arch Gen Psychiatry 44:790-795.
34. Ribeiro SCM, Tandon R, Grunhaus L, Greden JF (1993): The DST as a predictor of outcome in depression: A meta-analysis. Am J Psychiatry 150:1618-1629.
35. Ritchie JC, Belkin BM, Krishnan KR, Nemeroff CB, Carroll BJ (1990): Plasma dexamethasone concentrations and the dexamethasone suppression test. Biol Psychiatry 27:159-173.
36. Rose JQ, Yurchak AM, Meikle AW, Jusko WJ (1981): Effect of smoking on prednisone, prednisolone, and dexamethasone pharmacokinetics. J Pharmacokinet Biopharm 9:1-14.
37. Sachar EJ, Hellman L, Roffwarg HP, Halpern FS, Fukushima DK, Gallagher TF (1973): Disrupted 24 hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry 28:19-24.
38. Speilberger CD, Gorswuch RL, Lushene RE (1970): STAI Manual for the State-Trait-Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
39. Spitzer RL, Endiocott J, Robbins E (1978): Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd ed. New York: New York State Psychiatric Institute.
40. Tabachnick BG, Fidell LS (1989): Using Multivariate Statistics, 2nd ed. New York: Harper & Row, pp 123-191.
41. Wartak J (1983): Clinical Pharmacokinetics. New York: Praeger Scientific Press.
42. Wiedemann K, Holsboer F (1987): Plasma dexamethasone kinetics during the DST after oral and intravenous administration of the test drug. Biol Psychiatry 22:1340-1348.
43. Wilkinson L (1988): SYSTAT: The System for Statistics. Evanston, IL: SYSTAT Inc.
44. Zimmerman M, Coryell W (1987): The dexamethasone suppression test in healthy controls. Psychoneuroendocrinology 12: 245-251.