Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: An immunohistochemical analysis

Journal of Oral Pathology and Medicine

Volumn 26, Issue 3, 1997, Pages 124-128

  Norberg, Lena ^a   Stratis, Michael ^b   Dardick, Irving ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

myoepithelioma; pleomorphic adenoma; proliferating cell nuclear antigen; proliferation; salivary gland

Indexed keywords

EID: 0031105830     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0714.1997.tb00034.x     Document Type: Article

References (36)

1. TAKEICHI N, HIROSE F, YAMAMOTO H, et al. Salivary gland tumors in atomic bomb survivors, Hiroshima, Japan. Cancer 1983; 52: 377-85.
2. HAMILTON-DUTOIT SJ, THERKILDSEN MH, NEILSEN NH, JENSEN H, HANSON JPH, PALLESEN G. Undifferentiated carcinoma of the salivary gland in Greenlandic Eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Hum Pathol 1991; 22: 811-5.
3. GALLO O, SANTUCCI M, CALZOLARI A, STORCHI OF. Epstein-Barr virus (EBV) infection and un differentiated carcinoma of the parotid gland in Caucasian patients. Acta Oto-Laryngol 1994; 114: 572-5.
4. CHRISTIANSEN MS, MOURAD WA, HALES ML, OLDRING DJ. Spindle cell malignant lymphoepithelial lesion of the parotid gland: clinical, light microscopic, ultrastructural, and in situ hybridization findings in one case. Mod Pathol 1995; 8: 711-5.
5. FONESCA I, SOARES J. Proliferating cell nuclear antigen immunohistochemistry in epithelial-myoepithelial carcinoma of the salivary glands. Arch Pathol Lab Med 1993; 117: 93-5.
6. YANG L, HASHIMURA K, QIN C, SHRESTHA P, SUMITOMO S, MORI M. Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumours: an assessment of growth potential. Virchows Archiv A Pathol Anat 1993; 422: 481-6.
7. SKALOVA A, LEIVO I, VON BOGUSLAWSKY K, SAKSELA E. Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin: immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections. J Pathol 1994; 173: 13-21.
8. SKALOVA A, LEHTONEN H, VON BOGUSLAWSKY K, LEIVO I. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol 1994; 25: 929-35.
9. MARTIN AR, MANTRAVADI J, KOTYLO PK, MULLINS R, WALKER S, ROTH LM. Proliferative activity and aneuploidy in pleomorphic adenomas of the salivary glands. Arch Pathol Lab Med 1994; 118: 252-9.
10. OGAWA I, MIYAUCHI M, TAKATA T, VUHAHULA E, IJUHIN N, NIKAI H. Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). J Oral Pathol Med 1993; 22: 447-50.
11. YANG L, LIU B, QIN C, HASHIMURA K, YAMADA T, SUMITOMO S, MORI M. Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma. Oral Oncol Eur J Cancer 1994; 30B: 56-60.
12. CHO KJA, EL-NAGGAR AK, ORDONEZ NG, LUNA MA, AUSTIN J, BATSAKIS JG. Epithelial-myoepithelial carcinoma of salivary glands: a clinicopathologic, DNA flow cytometric, and imnumohistochemica! study of Ki-67 and Her-2/ neu oncogene. Am J Clin Pathol 1995; 103: 432-7.
13. Ross DA, HUAMAN JA, BARSKY SH. A study of the heterogeneity of the mucoepidermoid tumor and the implication for future therapies. Arch Otolaryngol Head Neck Surg 1992; 118: 1172-8.
14. GARCIA RL, COLTERA MD, GOWN AM. Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed embedded tissues. Am J Pathol 1990; 134: 733-9.
15. BURFORD-MASON AP, MACKAY AJ, CUMMINS M, DARDICK I. Detection of proliferating cell nuclear antigen in paraffin-embedded specimens is dependent on preembedding tissue handling and fixation. Arch Pathol Lab Med 1994; 118: 1007-13.
16. HUNTER T, PINES J. Cyclins and cancer. Cell 1991; 66: 1071-4.
17. FENOGLIO-PREISER CM. Selection of appropriate cellular and molecular tests in evaluation of cancer. Cancer 1992; 69. 1607-32.
18. FENOGLIO-PREISER CM, NOFFSINGER AE, MILLER MA, DAVIS BB, HEFFELFINGER SC. "Imaging" the cell through its markers: insights into cell growth, cell death and cancer. Annals RCPSC 1995; 28: 341-7.
19. WALKER NI, GOBÉ GC. Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction. J Pathol 1987; 153: 333-44.
20. DARDICK I, BURFORD-MASON AP. Current status of histogenetic and morphogenetic concepts of salivary gland tumorigenesis. Curr Rev Oral Biol Med 1993; 4: 639-77.
21. DENNY PC, CHAI Y, KLAUSER DK, DENNY PA. Parenchymal cell proliferation and mechanisms for maintenance of granular duct and acinar cell populations in adult male mouse submandibular gland. Anat Rec 1993: 235; 475-85.
22. BURFORD-MASON AP, CUMMINS MM, BROWN DH, MACKAY AJ, DARDICK I. Immunohistochemical analysis of the proliferative capacity of duct and acinar cells during ligation-induced atrophy and subsequent regeneration of rat parotid gland. J Oral Pathol Med 1993; 22: 440-6.
23. DARDICK I, DARDICK AM, MACKAY AJ, PASTOLERO GC, GULLANE PJ, BURFORD-MASON AP. The pathobiology of salivary glands. IV. Histogenetic concepts and cycling cells in human parotid and submandibular glands cultured in floating gels. Oral Surg Oral Med Oral Pathol 1993; 76: 307-18.
24. REDMAN RS. Myoepithelium of salivary glands. Microsc Res Techn 1994; 27: 25-45.
25. BURGESS K, DARDICK I, BURFORD-MASON A, MACKAY A. Myoepithelial cells: another possible progenitor cell for neoplastic induction of salivary gland tumors? Oral Surg Oral Med Oral Pathol 1994; 78: 780-1.
26. BALLAGH RH, KUDRYK KG, LAMPE HB, et al. The pathobiology of salivary gland. III. PCNA-localization of cycling cells induced in rat submandibular gland by low-dose x-radiation. Oral Surg Oral Med Oral Pathol 1994; 77: 27-53.
27. BASSETT RE, DARDICK I, BURFORD-MASON AP, MACKAY A, BURGESS K, GULLANE PJ. Post-irradiation human submandibular gland: potential model to study salivary gland radioprotection and tumorigenesis. J Otolaryngol 1995; 24: 184-90.
28. MILLS SE, COOPER PH. An ultrastructural study of cartilaginous zones and surrounding epithelium in mixed tumors of salivary glands and skin. Lab Invest 1981; 44: 6-12.
29. DARDICK I, VAN NOSTRAND AWP, JEANS MTD, RIPPSTEIN P, EDWARDS V. Pleomorphic adenoma. I. Ultrastructural organization of "epithelial" regions. Hum Pathol 1983; 14 780-97.
30. DARDICK I, VAN NOSTRAND AWP, JEANS MTD, RIPPSTEIN P, EDWARDS V. Pleomorphic adenoma. II. Ultrastructural organization of "stromal" regions. Hum Pathol 1983; 14: 798-809.
31. ERLANDSON RA, CORDON-CARDO C, HIGGINS PJ. Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands: an ultrastructural and immunohistochemical study. Am J Surg Pathol 1984; 8: 803-20.
32. LAM RMK. An electron microscopic histochemical study of the histogenesis of major salivary gland pleomorphic adenoma. Ultrastruct Pathol 1984; 8: 207-23.
33. BURGESS KL. Myoepithelial cell proliferation in rat parotid gland. MSc thesis. University of Toronto, 1995.
34. BRAVO R, MAC-DONALD-BRAVO H. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987; 105: 1549-54.
35. HALL PA, WOODS AL. Immunohistochemical markers of cellular proliferation: achievements, problems, and perspectives. Cell Tiss Kinet 1990; 23: 505-22.
36. MCCORMICK D, HALL PA. The complexities of proliferating cell nuclear antigen. Histopathology 1992; 21: 591-4.