Gene therapeutic strategies for neuroprotection: Implications for Parkinson's disease

Experimental Neurology

Volumn 144, Issue 1, 1997, Pages 58-68

  Bowers, William J ^a   Howard, Darlene F ^a   Federoff, Howard J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPROTECTIVE AGENT; TYROSINE 3 MONOOXYGENASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0031105553     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.6389     Document Type: Article

References (114)

1. 1. AFIONE, S. A., C. K. CONRAD, W. G. KEARNS, S. CHUNDURU, R. ADAMS, T. C. REYNOLDS, W. G. GUGGINO, G. R. CUTTING, B. J. CARTER, AND T. R. FLOTTE. 1996. In vivo model of adeno-associated virus vector persistence and rescue. J. Virol. 70: 3235-3241.
2. 2. AKLI, S., C. CAILLAUD, E. VIGNE, P. L. STRATFORD, L. POENARU, M. PERRICAUDET, A. KAHN, AND M. PESCHANSKI. 1993. Transfer of a foreign gene into the brain using adenovirus vectors. Nature Genet. 3: 224-228.
3. 3. ALLSOPP, T., S. WYATT, H. PATERSON, AND A. DAVIES. 1993. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73: 295-307.
4. 4. ALTAR, C., C. BOYLAN, M. FRITSCHE, B. JONES, C. JACKSON, S. WIEGAND, R. LINDSAY, AND C. HYMAN. 1994. Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J. Neurochem. 63: 1021-1032.
5. 5. ALTAR, C., R. BOYLAN, M. FRITSCHE, C. JACKSON, C. HYMAN, AND R. LINDSAY. 1994. Neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusion to the substantia nigra. Neurology 130: 31-40.
6. 6. ANDERSEN, J., AND X. BREAKEFIELD. 1995. Gene delivery to neurons on the adult mammalian nervous system using herpes and adenovirus vectors. Pages 135-160 in J. Wolfe, Ed., Somatic Gene Therapy. CRC Press, Boca Raton, FL.
7. 7. ANDERSEN, J., D. GARBER, C. MEANEY, AND X. BREAKEFIELD. 1992. Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial LacZ in neurons using the neuron-specific enolase promoter. Hum. Gene Ther. 3: 487-499.
8. 8. ANGLADE, P., S. VYAS, F. JAVOY-AGID, M. HERRERO, P. MICHEL, J. MARQUEZ, A. MOUATT-PRIGENT, M. RUBERG, E. HIRSH, AND Y. AGID. 1995. Apoptotic degeneration of nigral dopaminergic neurons in parkinson's disease. Soc. Neurosci. Abstr. 21: 1250.
9. 9. ANTON, R., J. KORDOWER, D. KANE, C. MARKHAM, AND D. BREDESEN. 1995. Neural transplantation of cells expressing the anti-apoptotic gene bcl-2. Cell Trans. 4: 49-54.
10. 10. ANTON, R., J. KORDOWER, N. MAIDMENT, J. MANASTER, D. KANE, S. RABIZADEH, S. SCHUELLER, J. YANG, S. RABIZADEH, R. EDWARDS, C. MARKHAM, AND D. BREDESEN. 1994. Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp. Neurol. 127: 207-218.
11. 11. BAJOCCHI, G., S. FELDMAN, R. CRYSTAL, AND A. MASTRANGELI. 1993. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nature Genet. 3: 229-234.
12. 12. BARTLETT, J. S., AND R. J. SAMULSKI. 1995. Genetics and biology of adeno-associated virus. Pages 55-73 in M. G. Kaplitt and A. D. Loewy, Eds., Gene Therapy and Neuroscience Applications. Academic Press, New York.
13. 13. BATISTATOU, A., D. MERRY, S. KORSMEYER, AND L. GREENE. 1993. Bcl-2 affects survival but not neuronal differentiation of PC12 cells. J. Neurosci. 13: 4422-4428.
14. 14. BECK, K., J. VALVERDE, T. ALEXI, K. POULSEN, B. MOFFAT, R. VANDLEN, A. ROSENTHAL, AND F. HEFTI. 1995. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373: 339-341.
15. 15. BENDER, M., N. DELUCA, B. KAPLAN, R. RAMAKRISNAN, M. LEVINE, R. MOORE, W. GOINS, AND J. GLORIOSO. 1993. Herpes simplex virus vector-mediated gene transfer to CNS neurons. Soc. Neurosci. Abstr. 19: 1318.
16. 16. BOISE, L., M. GONZALEZ-GARCIA, C. POSTEMA, L. LING, T. LINDSTEN, L. TURKA, X. MAO, G. NUNEZ, AND C. THOMPSON. 1993. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608.
17. 17. BREAKEFIELD, X., AND N. DELUCA. 1991. Herpes simplex virus for gene delivery to neurons. New Biol. 3: 203-218.
18. 18. BREAKEFIELD, X., Q. HUANG, J. ANDERSEN, M. KRAMER, W. BEBRIN, G. DAVAR, B. Vos, D. GARBER, M. DIFIGLIA, AND D. COEN. 1992. Gene transfer into the nervous system using recombinant herpes virus vectors. Pages 45-48 in Gage, Ed., Gene Transfer and Therapy in the Nervous System. Springer-Verlag, Heidelberg.
19. 19. CHENG, L., P. ZIEGELHOFFER, AND N.-S. YANG. 1993. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. Natl. Acad. Sci. USA 90: 4455-4459.
20. 20. CHOI-LUNDBERG, D., AND M. BOHN. 1995. Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Dev. Brain Res. 85: 80-88.
21. 21. CHOI-LUNDBERG, D. L., O. LIN, H. MOHAJERI, Y. N. CHANG, Y. L. CHIANG, C. M. HAY, B. L. DAVIDSON, AND M. C. BOHN. 1996. GDNF delivered via an adenoviral vector (Ad) protects rat dopaminergic (DA) neurons from degeneration. Soc. Neurosci. Abst. Nov. 22: 16-21.
22. 22. DAVIDSON, B., E. ALLEN, K. KOZARSKY, K. WILSON, AND B. ROESSLER. 1993. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet. 3: 219-223.
23. 23. DAVIDSON, B. L., AND B. J. ROESSLER. 1993. Direct plasmid mediated transfection of adult murine brain cells in vivo using cationic liposomes. Neurosci. Lett. 167: 5-10.
24. 24. DAVIDSON, B. L., AND B. J. ROESSLER. 1995. Adenoviral-mediated gene transfer: potential therapeutic applications. Pages 173-192 in M. G. Kaplitt and A. D. Loewy Eds., Viral Vectors: Gene Therapy and Neuroscience Applications. Academic Press, New York.
25. 25. DELUCA, N., A. MCCARTHY, AND P. SCHAFFER. 1985. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J. Virol. 56: 558-570.
26. 26. DELUCA, N., AND P. SCHAFFER 1987. Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides. Nucleic Acids Res. 15: 4491-4511.
27. 27. DOBSON, A., T. P. MARGOLIS, F. SEDARATI, J. STEVENS, AND L. FELDMAN. 1990. A latent, nonpathogenic HSV-1 derived vector stably expresses β-galactosidase in mouse neurons. Neuron 5: 353-360.
28. 28. DOBSON, A. T., F. SEDARATI, G. DEVI-RAO, W. M. FLANAGAN, M. J. FARRELL, J. G. STEVENS, E. K. WAGNER, AND L. T. FELDMAN. 1989. Identification of the latency-associated transcript promoter by expression of rabbit β-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol. 63: 3844-3851.
29. 29. DURING, M., J. NAEGELE, K. O'MALLEY, AND A. GELLER. 1994. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266: 1399-1403.
30. 30. DUVOISIN, R. 1992. The genetic etiology of parkinson's disease. A review of the evidence. Neurologica 7: 223-229.
31. 31. DUVOISIN, R. 1992. Overview of parkinson's disease. Ann. N.Y. Acad. Sci. 648: 187-193.
32. 32. DUVOISIN, R. 1993. The genetics of parkinson's disease. Pages 306-315 in H. Narabayashi, T. Nagatsu, N. Yanagisawa, and Y. Mizuno, Eds., Advances in Neurology. Raven Press, New York.
33. 33. EDWARDS, S., AND A. TOLKOVSKY. 1994. Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal. J. Cell Biol. 124: 537-546.
34. 34. ENGELHARDT, J., X. YE, B. DORANZ, AND J. WILSON. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91: 6196-6200.
35. 35. ENGELHARDT, J. F., Y. YANG, L. D. STRATFORD-PERRICAUDET, E. D. ALLEN, K. KOZARSKY, M. PERRICAUDET, J. R. YANKASKAS, AND J. M. WILSON. 1993. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nature Genet. 4: 27-34.
36. 36. FEDEROFF, H. In press. Growth of replication defective herpes virus amplicon vectors and their use for gene transfer. In D. Spector, Leinwand, L. and Goldman, R., eds., Cell Biology: A Laboratory Manual. CSH Press, Cold Spring Harbor.
37. 37. FEDEROFF, H., M. GESCHWIND, A. GELLER, AND J. KESSLER. 1992. Expression of nerve growth factor in vivo, from a defective HSV-1 vector prevents effects of axotomy on sympathetic ganglia. Proc. Natl. Acad. Sci. USA 89: 1636-1640.
38. 38. FINK, D., L. STERNBERG, P. WEBER, M. MATA, W GOINS, AND J. GLORIOSO. 1992. In-vivo expression of β-galactosidase in hippocampal neurons by HSV mediated gene transfer. Hum. Gene Ther. 4: 11-19.
39. 39. FRENKEL, N. 1981. Defective interfering herpesviruses. Pages 91-120 in A. Nahmias, W. Dowdle, and R. Scchinazy, Eds., The Human Herpesviruses - An Interdisciplinary Prospective. Elsevier-North-Holland, New York.
40. 40. FRENKEL, N., R. SPAETE, D. VLAZNY, L. DEISS, AND H. LOCKER. 1982. The herpes simplex virus amplicon - A novel animal-virus cloning vector. Pages 205-209 in Y. Gluzman, Ed., Eucaryotic Viral Vectors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. 41. FRIM, D., T. UHLER, W. GALPERN, M. BEAL, X. BREAKFIELD, AND O. ISACSON. 1994. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl 4 phenylpyridiniom toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sci. USA 91: 5104-5108.
42. 42. GARCIA, I., I. MARTINOU, Y. TSUJIMOTO, AND J.-C. MARTINOU. 1992. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 258: 302-304.
43. 43. GASH, D., Z. ZHANG, A. OVADIA, W. CASS, A. YI, L. SIMMERMAN, D. RUSSELL, D. MARTIN, P. LAPCHAK, F. COLLINS, B. HOFFER, AND G. GERHARDT. 1996. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380: 252-255.
44. 44. GELLER, A., AND X. BREAKEFIELD. 1988. A defective HSV-1 vector expresses escherichia coli beta-galactosidase in cultured peripheral neurons. Science 241: 1667-1669.
45. 45. GELLER, A., AND A. FREESE. 1990. Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli β-galactosidase. Proc. Natl. Acad. Sci. USA 87: 1149-1153.
46. 46. GELLER, A., K. KEYOMARSI, J. BRYAN, AND A. PARDEE. 1990. An efficient deletion mutant packaging system for defective herpes simplex vectors: Potential applications to human gene therapy and neuronal physiology. Proc. Natl. Acad. Sci. USA 87: 8950-8954.
47. 47. GESCHWIND, M., C. HARTNICK, W. LIU, J. AMAT, T. VAN DE WATER, AND H. FEDEROFF. 1996. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: Model for treatment of neuron loss following cochlear degeneration. Hum. Gene Ther. 7: 173-182.
48. 48. GESCHWIND, M., J. KESSLER, A. GELLER, AND H. FEDEROFF. 1994. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Mol. Brain Res. 24: 327-335.
49. 49. GLORIOSO, J., W. GOINS, C. MEANEY, D. FINK, AND N. DELUCA. 1994. Gene transfer to brain using herpes simplex virus vectors. Ann. Neurol. 35: S28-S34.
50. 50. GOINS, W. F., L. R. STERNBERG, K. D. COREN, P. R. KRAUSE, R. L. HENDRICKS, D. J. FINK, S. E. STRAUS, M. LEVINE, AND J. C. GLORIOSO. 1994. A novel latency active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J. Virol. 68: 2239-2252.
51. 51. GREENLUND, L., S. KORSMEYER, AND E. J. JOHNSON. 1995. Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15: 649-661.
52. 52. HEFTI, F., E. MELAMED, B. SAHAKIAN, AND R. WURTMAN. 1980. Circling behavior in rats with partial, unilateral nigrostriatal lesions: Effects of amphetamine, apomorphine, and DOPA. Pharmacol. Biochem. Behav. 12: 185-188.
53. 53. Ho, D., AND R. SAPOLSKY. 1995. Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system. Soc. Neurosci. Abstr. 21: 73.
54. 54. HOCKENBERY, D., G. NUNEZ, C. MILLIMAN, R. SCHREIBER, AND S. KORSMEYER 1990. Bcl-2 is an inner mitochondrial membrane protein blocks programmed cell death. Nature 334-336:
55. 55. HOFER, M., S. PAGLIUSI, A. HOHN, J. LEIBROCK, AND Y. BARDE. 1990. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9: 2459-2464.
56. 56. HORELLOU, P., E. VIGNE, M.-N. CASTEL, P. BARNEOUD, P. COLIN, M. PERRICAUDET, P. DELAERE, AND J. MALLET. 1994. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease. Neuroreport 6: 49-53.
57. 57. HYMAN, C., M. HOFER, Y.-A. BARDE, M. JUHASZ, G. YANCOPOULOS, S. SQUINTO, AND R. LINDSAY. 1991. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230-232.
58. 58. HYNES, M., K. POULSEN, M. ARMANINI, L. BERKEMEIER, H. PHILLIPS, AND A. ROSENTHAL. 1994. Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J. Neurosci. Res. 37: 144-154.
59. 59. JIAO, S., G. ACSADI, A. JANI, P. FELGNER, AND J. WOLFF. 1992. Persistence of plasmid DNA and expression in rat brain cells in vivo. Exp. Neurol. 115: 400-413.
60. 60. JIAO, S., L. CHENG, J. WOLFF, AND N.-S. YANG. 1993. Particle bombardment-mediated gene transfer and expression in rat brain tissues. BioTechniques 11: 497-502.
61. 61. JIN, B. K., M. BELLONI, B. CONTI, H. J. FEDEROFF, R. STARR, J. H. SON, H. BAKER, AND T. H. JOH. 1996. Long-term in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Hum. Gene Ther. 7: 2015-2025.
62. 62. JINNAH, H., AND T. FRIEDMANN. 1995. Gene therapy and the brain. Br. Med. Bull. 51(1): 138-148.
63. 63. JOHNSON, P., M. WANG, AND T. FRIEDMANN. 1994. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J. Virol. 68: 6347-6362.
64. 64. JONES, K., C. BOYLAN, AND M. FRITSCHE. 1993. The effects of BDNF and BT-3 in a selective striatal dopamine lesion produced by chronic intrastriatal infusion of 6-OHDA. Soc. Neurosci. Abstr. 19: 662.
65. 65. KANE, D., T. SARAFIAN, R. ANTON, H. HAHN, E. GRALLA, J. VALENTINE, T. ORD, AND D. BREDESEN. 1993. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262: 1274-1277.
66. 66. KAPLITT, M., A. KWONG, S. KLEOPOULOS, C. MOBBS, S. RABKIN, AND D. PFAFF. 1994. Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proc. Natl. Acad. Sci. USA 91: 8979-8983.
67. 67. KAPLITT, M., P. LEONE, A. FREESE, X. XIAO, D. PFAFF, K. O'MALLEY, AND M. DURING. 1994. Adeno-associated virus (AAV) vectors yield safe delivery and long-term expression of potentially therapeutic genes in the adult mammalian brain. Soc. Neurosci. Abstr. 20: 1465.
68. 68. KINEMUCHI, H., C. FOWLER, AND K. TIPTON. 1987. The neurotoxicity of 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its relevance to parkinson's disease. Neurochem. Int. 11: 359-373.
69. 69. KNUSEL, B., J. WINSLOW, K. BECK, A. ROSENTHAL, L. BURTON, H. WIDMER, K. NILOLICS, AND F. HEFTI. 1992. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J. Neurosci. 12: 4391-1402.
70. 70. KOTIN, R. 1994. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum. Gene Ther. 5: 793-801.
71. 71. KRIEGLSTEIN, K., C. SUTER-CRAZZOLARA, W FISCHER, AND K. UNSICKER. 1995. TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. 14: 736-742.
72. 72. LANGE, K., M. YOUDIM, AND P. RIEDERER. 1992. Neurotoxicity and neuroprotection in parkinson's disease. J. Neural Transm. 38: 27-14.
73. 73. LAPCHAK, P., K. BECK, D. RAUJO, I. IRWIN, J. LANGSTON, AND F. HEFTI. 1993. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience 53: 183-194.
74. 74. LAWRENCE, M., D. Ho, R. DASH, AND R. SAPOLSKY. 1995. Herpes simplex virus overexpressing the glucose transporter gene protects against excitotoxic seizures. Proc. Natl. Acad. Sci. USA 92: 7247-7251.
75. 75. LE GAL LA SALLE, G., J. ROBERT, S. BERRARD, V. RIDOUS, L. STRATFORD-PERRICAUDET, M. PERRICAUDET, AND J. MALLET. 1993. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259: 988-990.
76. 76. LIN, L.-F., D. DOHERTY, J. LILE, S. BEKTESH, AND F. COLLINS. 1993. A glial cell lined-derived neurtrophic factor for midbrain dopaminergic neurons. Science 260: 113-1132.
77. 77. LINNIK, M., P. ZAHOS, M. GESCHWIND, AND H. FEDEROFF. 1995. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 26: 1670-1675.
78. 78. LINNIK, M., AND R. ZOBRIST. 1992. Protein synthesis inhibition reduces infarct volume following focal cerebral ischemia: Evidence supporting programmed cell death in stroke. Soc. Neurosci. Abstr. 18: 51.
79. 79. Lu, B., AND H. FEDEROFF. 1995. Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Hum. Gene Ther. 6: 421-130.
80. 80. MAH, S., L. ZHONG, Y. LIU, A. ROGHANI, R. EDWARDS, AND D. BREDESEN. 1993. The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J. Neurochem. 60: 1183-1186.
81. 81. MARGOLIS, T., K. BLOOM, A. DOBSON, L. FELDMAN, AND J. STEVENS. 1993. Decreased gene expression during latent infection with HSV LAT promoter constructs. Neurol. Immunol. 197: 585-592.
82. 82. MARTINOU, J.-C., M. DUBOIS-DAUPHIN, J. STAPLE, I. RODRIGUEZ, H. FRANKOWSKI, M. MISSOTTEN, P. ALBERTINI, D. TALABOT, S. CATSICAS, C. PIETRA, AND J. HUARTE. 1994. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030.
83. 83. NITATORI, T., N. SATO, S. WAGURI, Y. KARASAWA, H. ARAKI, K. SHIBANAI, E. KOMINAMI, AND Y. UCHIYAMA. 1995. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15(2): 1001-1011.
84. 84. OKAZAWA, H., M. MURATA, M. WATANABE, M. KAMEI, AND I. KANAZAWA. 1992. Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotropic factor (BDNF) in the striatum. FEBS Lett. 313: 138-12.
85. 85. ONO, T., Y. FUJINO, T. TSUCHIYA, AND M. TSUDA. 1990. Plasmid DNAs directly injected into mouse brain with lipofectin can be incorporated and expressed by brain cells. Neurosci. Lett. 117: 259-263.
86. 86. PATERSON, T., AND R. EVERETT. 1990. A prominent serine-rich region in Vmw175, the major transcriptional regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture. J. Gen. Virol. 71: 1775-1783.
87. 87. PICCINI, P., N. TURJANSKI, AND D. BROOKS. 1995. Pet studies of the striatal dopaminergic system in parkinson's disease (PD). J. Neural. Transm. 45: 123-131.
88. 88. PLETSCHER, A., AND M. DAPRADA. 1993. Pharmacotherapy of Parkinson's disease: Research from 1960 to 1991. Acta Neurol. Scand. 87: 26-31.
89. 89. ROESSLER, B., AND B. DAVIDSON. 1994. Direct plasmid mediated transfection of adult murine brain cells in vivo using cationic liposomes. Neurosci. Lett. 167: 5-10.
90. 90. SAUER, H., AND W. OERTEL. 1994. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemistry study in the rat. Neuroscience 59(2): 401-115.
91. 91. SCHAAR, D., B.-A. SIEBER, A. SHERWOOD, D. DEAN, G. MENDOZA, L. RAMAKRISHNAN, C. DREYFUS, AND I. BLACK. 1994. Multiple astrocyte transcripts encode nigral trophic factors in rat and human. Exp. Neurol. 130: 387-393.
92. 92. SEROOGY, K., K. LUNDGREN, T. TRAN, K. GUTHRIE, P. ISACCKSON, AND C. GALL. 1994. Dopaminergic neurons in rat ventral midbrain express brain derived neurotrophic factor and neurotrophin 3 mRNAs. J. Comp. Neurol. 342: 321-334.
93. 93. SMITH, G. M., J. HALE, E. M. PASNIKOWSKI, R. M. LINDSAY, V. WONG, AND J. S. RUDGE. 1996. Astrocytes infected with replication-defective adenovirus containing a secreted form of CNTF or NT3 show enhanced support of neuronal populations in vitro. Exp. Neurol. 139: 156-166.
94. 94. SONSALLA, P., A. GIOVANNI, B.-A. SIEBER, K. DELLE DONNE, AND L. MANZINO. 1992. Characteristics of dopaminergic neurotoxicity produced MPTP and methamphetamine. In Neurotoxins and Neurodegenerative Disease. (W. J. Langston and A. B. Young, Eds.), pp. 229-238. New York Acad. Sci., New York.
95. 95. SPAETE, R., AND N. FRENKEL. 1982. The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector. Cell 30: 305-310.
96. 96. SPAETE, R., AND N. FRENKEL. 1985. The herpes simplex virus amplicon: analyses of cis-acting replication functions. Proc. Natl. Acad. Sci. USA 82: 694-698.
97. 97. SPRINGER, F., X. MU, L. BERGMANN, AND J. TROJANOWSKI. 1994. Expression of GDNF mRNA in rat and human nervous tissue. Exp. Neurol. 127: 167-170.
98. 98. STOW, N., AND E. MCMONAGLE. 1982. Propagation of foreign DNA sequences linked to a herpes simplex virus origin of replication. Pages 199-204 in Y. Gluzman, Ed., Eucaryotic Viral Vectors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
99. 99. STROMBERG, I., L. BJORKLUND, M. JOHANSSON, A. TOMAC, F. COLLINS, L. OLSON, B. HOFFER, AND C. HUMPEL. 1993. Glial cell line derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates dopamine neurons in vivo. Exp. Neurol. 124: 401-412.
100. 100. TANNER, C. 1992. Occupational and environmental causes of parkinsonism. Occupational Med. 7(3): 503-513.
101. 101. TOMAC, A., E. LINDQVIST, L. LIN, S. OGREN, D. YOUNG, B. HOFFER, AND L. OLSON. 1995. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373: 335-339.
102. 102. UNGERSTEDT, U., AND G. ARBUTHNOTT. 1970. Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal system. Brain Res. 24: 485-493.
103. 103. VOLPE, B., T. WESSEL, B. MUKHERJEE, AND H. FEDEROFF. 1995. Delayed neuronal death after global ischemia is accompanied by internucleosomal DNA fragmentation. Neurosci. Lett. 186: 157-160.
104. 104. WALKINSHAW, G., AND C. WATERS. 1995. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. J. Clin. Invest. 95: 2458-2464.
105. 105. WINOCOUR, E., L. PUZIS, S. ETKIN, T. KOCH, B. DANOVITCH, E. MENDELSON, E. SHAULIAN, S. KARBY, AND S. LAVI. 1992. Modulation of the cellular phenotype by integrated adeno-associated virus. Virology 190: 316-329.
106. 106. WOLFE, J., S. DESHMANE, AND N. FRASER. 1992. Herpesvirus vector gene transfer and expression of β-glucuronidase in the central nervous system of MPS VII mice. Nature Genet. 1: 379-384.
107. 107. WOLFE, J., L. FISHER, AND L. XU. 1989. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 86: 9011-9014.
108. 108. WYLLIE, A. 1993. Apoptosis (The 1992 Frank Rose Memorial Lecture). Br. J. Cancer 67: 205-208.
109. 109. WYLLIE, A., J. KERR, AND A. CURRIE. 1980. Cell death: The significance of apoptosis. Int. Rev. Cytol. 68: 251-306.
110. 110. WYLLIE, A., R. MORRIS, A. SMITH, AND D. DUNLOP. 1984. Chromatin clevage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142: 67-77.
111. 111. YOSHIMOTO, Y., Q. LIN, T. COLLIER, D. FRIM, X. BREAKEFIELD, AND M. BOHN. 1995. Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of parkinson's disease. Brain Res. 691: 25-36.
112. 112. ZHONG, L.-T., D. KANE, AND D. BREDESEN. 1993. Bcl-2 blocks glutamate toxicity in neural cell lines. Mol. Brain Res. 19: 353-355.
113. 113. ZHONG, L.-T., T. SARAFIAN, D. KANE, A. CHARLES, S. MAH, R. EDWARDS, AND D. BREDESEN. 1993. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA 90: 4533-1537.
114. 114. ZIGMOND, M., T. HASTINGS, AND E. ABERCROMBIE. 1992. Neurochemical responses to 6-hydroxydopamine and L-DOPA therapy: Implications for PD. In Neurotoxins and Neurodegenerative Disease. (W. J. Langston and A. B. Young, Eds.), pp. 71-86. New York Acad. Sci., New York.