Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus

Clinical Immunology and Immunopathology

Volumn 82, Issue 3, 1997, Pages 243-249

  Togun, Rachel A ^a   Resetkova, Erika ^a   Kawai, Keisuke ^a   Enomoto, Tetsuya ^a   Volpé, Robert ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD8 ANTIGEN; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TETANUS TOXOID;

ADULT; ARTICLE; AUTOIMMUNITY; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031104629     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.4295     Document Type: Article

References (30)

1. 1. Powers, A. C., and Eisenberth, G. S., Autoimmunity to islet cells in diabetes mellitus. Annu. Rev. Med. 36, 533-544, 1985.
2. 2. Silverstein, J. H., Interventions in newly diagnosed diabetes. Int. Diabetes Monit. 6(1), 3-5, 1994.
3. 3. Vandewalle, C. L., Falorni, A., Svanholm, S., Lernmark, A., Pipeleers, D. A., and Gorus, F. K., High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. J. Clin. Endocrinol. Metab. 80, 846-851, 1995.
4. 4. Kaufman, D. L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G. S., Robinson, P., Atkinson, M. A., Sercarz, E. E., Tobin, A. J., and Lehmann, P. V., Spontaneous loss of T cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-71, 1993.
5. 5. Tisch, R., Yang, X., Singer, S. M., Liblau, R. S., Fugger, L., and McDevitt, H. O., Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75, 1993.
6. 6. Atkinson, M. A., Kaufman, D. L., Campbell, L., Gibbs, K. A., Shah, S. C., Bu, D. F., Erlander, M. G., Tobin, A. J., and Maclaren, N. K., Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339, 458-459, 1992.
7. 7. Bach, J. F., Insulin-dependent-diabetes mellitus as an autoimmune disease. Endocrinol. Rev. 15, 516-542, 1994.
8. 8. Seissler, J., Amann, J., Mauch, L., Haubruch, H., Wolfahrt, S., Bieg, S., Richter, W., Holl, R., Heinze, E., Northemann, W., and Scherbaum, W. A., Prevalence of autoantibodies to the 65 and 67 kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J. Clin. Invest. 92, 1394-1399, 1993.
9. 9. Karjalainen, J., Martin, J. M., Knip, M., et al., A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus (IDDM). N. Engl. J. Med. 327, 302-307, 1992.
10. 10. Atkinson, M. A., Bowman, M. A., Kao, K. J., Campbell, L., Dush, P. J., and Shah, S. C., Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N. Engl. J. Med. 329, 1853-1858, 1993.
11. 11. Topliss, D., How, J., Lewis, M., Row, V., and Volpé, R., Evidence for cell-mediated immunity and specific suppressor T lymphocyte dysfunction in Graves' disease and diabetes mellitus. J. Clin. Endocrinol. Metab. 57, 700-705, 1983.
12. 12. Boitard, C., Larger, E., Timsit, J., Sempe, P., and Bach, J. F., IDDM: An islet or an immune disease? Diabetologia 3, S90-S98, 1994.
13. 13. Yoshikawa, N., Arreaza, G., Morita, T., Mukuta, T., Resetkova, E., Akasu, F., Miller, N., Jamieson, C., and Volpé, R., Effect of removing human Graves' thyroid xenografts after eight weeks in nude mice and rexenografting them into SCID mice. J. Clin. Endocrinol. Metab. 78, 367-374, 1994.
14. 14. Yoshikawa, N., Morita, T., Arreaza, G., Resetkova, E., Mukuta, T., Volpé, R., The effect of interleukin-2 on suppressor T lymphocytes in autoimmune thyroid disease. Clin. Invest. Med. 18, 91-98, 1995.
15. 15. Mukuta, T., Yoshikawa, N., Arreaza, G., Resetkova, E., Leshner, J., Song, Y., Akasu, F., Onaya, T., and Volpé, R., Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin dependent diabetes. J. Clin. Endocrinol. Metab. 80, 1264-1272, 1995.
16. 16. Cheung, R., Karjalainen, J., VanderMeulen, J., Singal, D. P., and Dosch, H. M., T cells of children with insulin-dependent diabetes are sensitized to bovine serum albumin. Scand. J. Immunol. 40, 623-628, 1994.
17. 17. Miyazaki, I., Gaedigk, R., Hui, M. F., Cheung, R. K., Morkowski, J., Rajotte, R. V., and Dosch, H. M., Cloning of human and rat P69 cDNA, a candidate autoimmune target in type 1 diabetes. Biochim. Biophys. Acta 1227, 101-104, 1994.
18. 18. Miyazaki, I., Cheung, R. K., Gaedigk, R., Hui, M. F., Meulen, J. V., Rajotte, R. V., and Dosch, H. M., T cell activation and anergy to islet cell antigen in type 1 diabetes. J. Immunol. 154, 1461-1469, 1995.
19. 19. Nicol, P. D., Matsueda, G. R., Haber, E., and Khaw, B. A., Synthetic peptide immunogens for the development of a cardiac myosin light chain-1 specific radioimmunoassay. J. Nucl. Med. 34, 2144-2151, 1993.
20. 20. Yoshikawa, N., Morita, T., Resetkova, E., Arreaza, G., and Volpé, R., Reduced activation of suppressor T lymphocyte by specific antigen in autoimmune thyroid disease. J. Endocrinol. Invest. 15, 609-617, 1993.
21. 21. Diaz-Gallo, C., Moscovitch-Lopatin, M., Strom, T. B., Kelley, V. R., An anergic islet-infiltrating T-cell clone that suppresses murine diabetes secrets a factor that blocks interleukin 2/interleukin 4-dependent proliferation. Proc. Natl. Acad. Sci. USA 89, 8656-8660, 1992.
22. + regulatory T cells in the non-obese diabetic male mouse. Diabetologia 37, 337-343, 1994.
23. + T cell clone, I.S.2.15, has in vitro immunosuppressive properties. Eur. J. Immunol. 22, 2017-2023, 1992.
24. 24. Rashba, E. J., Reich, E. P., Janeway, C. A., and Sherwin, R. S., Type 1 diabetes mellitus: An imbalance between effector and regulatory T cells? Acta Diabetol. 30, 61-69, 1993.
25. 25. Taguchi, O., Kontari, K., Ikeda, H., Kezuka, T., Takeuchi, M., and Takahashi, T., Tissue specific suppressor T cells involved in self-tolerance are activated extrathymically by self antigens. Immunology 82, 365-369, 1994.
26. + suppressor cells. J. Clin. Immunol. 4, 395-402, 1984.
27. 27. Batchelor, J. R., Lombardi, G., and Lechler, R. I., Speculations on the specificity of suppression. Immunol. Today 10, 37-40, 1989.
28. 28. Iitaka, M., Aguayo, J. F., Iwatani, Y., Row, V. V., and Volpé, R., Studies of the effect of suppressor T lymphocytes on the induction of antithyroid microsomal antibody-secreting cells in autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 67, 749-754, 1988.
29. + T cells to xenografts of autoimmune thyroid disease in SCID mice. Thyroid 6, 429-436, 1996.
30. 30. Chen, X., Shelton, J., and McCullagh, P., Suppression of thyrocyte autoreactivity by the lymphocytes of normal fetal lambs. J. Autoimmun. 8, 539-559, 1995.