Children, adolescents and periodontal diseases

Journal of Dentistry

Volumn 25, Issue 2, 1997, Pages 79-89

  Dibart, S ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

Adolescents; Children; Periodontal diseases; Review

Indexed keywords

ADOLESCENT; BACTERIAL PHENOMENA AND FUNCTIONS; CHILD; CHRONIC DISEASE; CLASSIFICATION; DECIDUOUS TOOTH; DISEASE COURSE; GINGIVITIS; HUMAN; MICROBIOLOGY; MOLECULAR BIOLOGY; PATHOPHYSIOLOGY; PERIODONTAL DISEASE; PERIODONTITIS; REVIEW; TOOTH; VINCENT STOMATITIS;

ADOLESCENT; BACTERIAL PHYSIOLOGY; CHILD; CHRONIC DISEASE; DISEASE PROGRESSION; GINGIVITIS; GINGIVITIS, NECROTIZING ULCERATIVE; HUMANS; MOLECULAR BIOLOGY; PERIODONTAL DISEASES; PERIODONTITIS, JUVENILE; TOOTH; TOOTH, DECIDUOUS;

EID: 0031092427     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-5712(96)00019-X     Document Type: Review

References (132)

1. Special issue Periodontal diseases of children and adolescents. Guidelines, 1992. Pediatr Dent 1994; 16: 77-79.
2. Page RC Oral health status in the United States: prevalence of inflammatory periodontal diseases. J Dent Educ 1985; 49: 354-364.
3. Spencer AJ, Beighton D and Higgins TJ Periodontal disease in five and six year old children. J Periodont 1983; 54: 19-22.
4. Holm AK Oral health in five year old Swedish children. Community Dent Oral Epidemiol 1975; 3: 184-189.
5. Kohler L and Holst K Dental health of four year old children. Acta Paediat Scand 1975; 62: 269-278.
6. Parfitt GJ A five year longitudinal study of the gingival conditions of a group of children in England. J Periodont 1957; 28: 26-32.
7. Loe H, Theilade E and Jensen SB Experimental gingivitis in man. J Periodont 1965; 36: 177-187.
8. Theilade E, Wright WH, Jensen SB and Loe H Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation. J Periodont Res 1986; 1: 1-13.
9. Moore LVH, Moore WEC and Cato EP Bacteriology of gingivitis. J Dent Res 1987; 66: 989-995.
10. Ranney RR Discussion: pathogenesis of gingivitis. J Clin Periodont 1986; 13: 356-359.
11. Alcoforado GAP, Kristoffersen T, Johannessen AC and Nilsen R The composition of gingival inflammatory cell infiltrates in children studied by enzyme histochemistry. J Clin Periodont 1990; 17: 335-340.
12. Longhurst P, Gillett R and Johnson NW Electron microscope quantitation of inflammatory infiltrates in childhood gingivitis. J Periodont Res 1980; 15: 255-266.
13. Seymour GJ, Crouch MS and Powell RN The phenotypic characterization of lymphoid cell subpopulation in gingivitis in children. J Periodont Res 1981; 16: 582-592.
14. Lindhe J, Liljenberg B and Listgarten M Some microbiological and histopathological features of periodontal disease in man. J Periodont 1980; 51: 264-269.
15. Page RC and Schroeder HE Pathogenesis of inflammatory periodontal disease. Lab Invest 1976; 33: 235-249.
16. Kopczyk RA and Lenox JA Periodontal health and disease in children: examination and diagnosis. Dent Clin North Am 1973;17: 25-33.
17. Bimstein E and Soskolne WA A radiographic study of interproximal alveolar bone crest between the primary molars in children. J Dent Child 1988; 55: 348-350.
18. Sjodin B and Matsson L Marginal bone level in the normal primary dentition. J Clin Periodont 1992; 19: 672-678.
19. Shapira L, Tarazi E, Rosen L and Bimstein E The relationship between alveolar bone height and age in the primary dentition. J Clin Periodont 1995; 22: 408-412.
20. Mombelli A, Gusberti FA, van Oosten MA and Lang NP Gingival health and gingivitis development during puberty. A 4 year longitudinal study. J Clin Periodont 1989; 16: 451-456.
21. Seymour RA and Heasman PA. In: Seymour RA and Heasman PA, eds. Drugs, Diseases and the Periodontum. Oxford: Oxford Medical Publications, Oxford University Press, 1992.
22. Proceedings of the World Workshop in Clinical Periodontics. Princeton, NJ: American Academy of Periodontology, 1989; I/23-I/31.
23. Gottlieb B Die Diffuse Atrophie des Alveolar knochens. Ztchr. Stomatol. 1923; 21: 195-262.
24. Gottlieb B The formation of the pocket: diffuse atrophy of alveolar bone. J Am Dent Assoc 1928; 15: 462-476.
25. Wisner-Lynch LA and Giannobile WV Current concepts in juvenile periodontitis. Curr Opin Periodont 1993; 28-42.
26. Orban B and Weinman JP Diffuse atrophy of the alveolar bone (periodontosis). J Periodont 1942; 13: 31-35.
27. Ramfjord SP, Ash MM and Kerr DA. World Workshop in Periodontics. Ann Arbor: University of Michigan Press, and 1966.
28. Baer PN The case for periodontosis as a clinical entity. J Periodont 1971; 42: 516-519.
29. Baer PN and Benjamin SD. Periodontal Diseases in Children and Adolescents. Philadelphia, PA: J. B. Lippincott, 1974.
30. Socransky SS and Haffajee AD The bacterial etiology of destructive periodontal disease: current concepts. J Periodont 1992; 63: 322-331.
31. Newman MG, Socransky SS, Savit ED, Propas DA and Crawford A Studies of the microbiology of periodontosis. J Periodont 1976; 47: 373-379.
32. Slots J The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976; 84: 1-10.
33. Tanner ACR, Haffer C, Brathall G, Visconti RA and Socransky SS A study of the bacteria associated with the advancing periodontitis in man. J Clin Periodont 1979; 6: 278-307.
34. Slots J, Reynolds HS and Genco RJ Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect Immunol 1980; 29: 1013-1020.
35. Listgarten MA, Lai CH and Evian CI Comparative antibody titers to Actinobacillus actinomycetemcomitans in juvenile periodontitis, chronic periodontitis and periodontally healthy subjects. J Clin Periodont 1981; 8: 155-164.
36. Haffaje AD, Socransky SS, Ebersole JL and Smith DJ Clinical, microbiological and immunological features associated with treatment of active periodontosis lesions. J Clin Periodont 1984; 11: 600-618.
37. Zambon JJ, Christersson LA and Slots J Actinobacillus actinomycetemcomitans in human periodontal disease: prevalence in patient groups and distribution of biotypes within families. J Periodont 1983; 54: 707-711.
38. van Winkelhoff AJ, de Groot P, Abbas F and de Graaff J Quantitative aspects of the subgingival distribution of Actinobacillus actinomycetemcomitans in a patient with localised juvenile periodontitis. J Clin Periodont 1994; 21: 199-202.
39. Asikainen S, Lai CH, Alaluusua S and Slots J Distribution of Actinobacillus actinomycetemcomitans serotypes in periodontal health and disease. Oral Microbiol Immunol 1991; 6: 115-118.
40. Lu H, Wang M, Gunsolley JC, Scheinken HA and Tew JG Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. Infect Immunol 1994; 62: 1677-1682.
41. Berthold P, Forti D, Kieba IR, Rosebbloom J, Taichman NS and Lally ET Electron immunocytochemical localization of Actinobacillus actinomycetemcomitans leukotoxin. Oral Microbiol Immunol 1992; 7: 24-27.
42. Tsai CC, McArthur WP, Baehni PC, Hammond BF and Taichman NS Extraction and partial characterization of of a leukotoxin from a plaque-derived gram-negative microorganism. Infect Immunol 1979; 25: 427-439.
43. Tsai CC, Shenker BJ, DiRienzo JM, Malamud D and Taichman NS Extraction and isolation of a leukotoxin from Actinobacillus actinomycetemcomitans with polymixin b. Infect Immunol 1984; 43: 700-705.
44. Iwase M, Lally ET, Berthold P, Korchak HM and Taichman NS Effects of cations and osmotic protectant on cytolytic activity of Actinobacillus actinomycetemcomitans leukotoxin. Infect Immunol 1990; 58: 1782-1788.
45. Iiono Y and Hopps RM The bone resorbing activities in tissue culture of lipopolysaccharides from the bacteria Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Capnocytophaga ochracea isolated from human mouths. Archs Oral Biol 1984; 29: 59-64.
46. Ishihara Y, Nichihara T, Maki E, Nogushi T and Koga T Role of interleukin-1 and prostaglandin in in vitro bone resorption induced by Actinobacillus actinomycetemcomitans lipopolysaccharide. J Periodont Res 1991; 26: 155-160.
47. Robertson PB, Lantz M, Marucha PT, Kornman TS, Trummel CL and Holt SC Collagenolytic activity associated with Bacteroides species and Actinobacillus actinomycetemcomitans. J Periodont Res 1982; 17: 275-283.
48. Birkedal-Hansen H, Caufield PW, Wannemeumlar V and Pierce R A sensitive screening assay for epitheliotoxins produced by oral microorganisms (abstract). J Dent Res 1982; 61: 192.
49. Stevens RH and Hammond BF Inhibition of firoblast proliferation by extracts of Capnocytophaga species and Actinobacillus actinomycetemcomitans (abstract). J Dent Res 1982; 61: 347.
50. Miyasaki KT The neutrophil mechanisms of controlling periodontal bacteria. J Periodont 1991; 62: 761-774.
51. Cianciola EJ, Genco RJ, Patters MR, McKenna J and Van Oss CJ Defective polymorphonuclear leukocyte function in human periodontal disease. Nature 1977; 265: 445-447.
52. Van Dyke TE, Horoszewica HU and Genco RJ The polymorphonuclear leukocyte (PMNL) locomotor defect in juvenile periodontitis: study of random migration, chemokinesis and chemotaxis. J Periodont 1982; 53: 682-687.
53. Suzuki JB, Risom L, Falker WA, Collison C and Bowers J Effect of periodontal therapy on spontaneous lymphocyte response and neutrophil chemotaxis in localised and generalised juvenile periodontitis. J Clin Periodont 1985; 12: 124-134.
54. Van Dyke TE, Levine MJ, Tabak LA and Genco RJ Reduced chemotactic peptide binding in juvenile periodontitis: a model for neutrophil function. Biochem Biophys Res Commun 1981; 100: 1278-1284.
55. Perez HD, Kelly E, Elfman F, Armitage G and Winkler J Defective polymorphonuclear leukocyte formyl peptide receptor(s) in juvenile periodontitis. J Clin Invest 1991; 87: 971-976.
56. Van Dyke TE, Wilson-Burroughs C, Offenbacher S and Henson P Association of an abnormality of neutrophil chemotaxis in human periodontal disease with a cell surface protein. Infect Immunol 1987; 55: 2262-2267.
57. Kalmar JR, Arnold RR and Van Dyke TE Direct interaction of Actinobacillus actynomycetemcomitans with normal and defective (LJP) neutrophils. J Periodont Res 1987; 22: 179-181.
58. Nisenguard RJ The role of immunology in periodontal diseases. J Periodont 1977; 48: 505-516.
59. Crossner CG, Carlsson J and Sjodin Periodontitis in the primary dentition associated with Actinobacillus actinomycetemcomitans infection and leukocyte dysfunction. A 3 1/2 year follow-up. J Clin Periodont 1990; 17: 265-267.
60. Gunsolley JC, Ranney RR, Zambon JJ, Burmeister JA and Scheinken HA Actinobacillus actinomycetemcomitans in families afflicted with periodontitis. J Periodont 1990; 61: 643-648.
61. Asikainen S, Chen C and Slots J Actinobacillus actinomycetemcomitans genotypes in relation to serotypes and periodontal status. Oral Microbiol Immunol 1995; 10: 65-68.
62. Moore WEC, Holdeman LV and Cato EP Comparative bacteriology of juvenile periodontitis. Infect Immunol 1985; 48: 507-519.
63. Scheinken HA and Van Dyke TE Early onset periodontitis: systemic aspects of etiology and pathogenesis. Periodont 2000 1984; 6: 7-25.
64. Loe H and Brown LJ Early onset periodontitis in the United States of America. J Periodont 1991; 62: 608-616.
65. Schenkein HA, Best AM and Gunsolley JC The influence of race and periodontal clinical status on neutrophil chemotactic responses. J Periodont Res 1991; 26: 272-275.
66. Schenkein HA, Burmeister HA and Koertge TE The influence of race and gender on periodontal microflora. J Periodont 1993; 64: 292-296.
67. Chapple ILC Periodontal disease diagnosis: current status and future developments. J Dent 1997; 25: 3-15.
68. Hart TC, Marazita ML, Schenkein HA, Brooks CN, Gunsolley JG and Diehl SR No female preponderance in juvenile periodontitis after correction for ascertainment bias. J Periodont 1991; 62: 745-749.
69. Hart TC, Marazita ML, Schenkein HA and Diehl SR Reinterpretation of the evidence for X-linked dominant inheritance of juvenile periodontitis. J Periodont 1992; 63: 169-173.
70. Saxen L and Nevanlinna HR Autosomal recessive inheritance of juvenile periodontitis: test of a hypothesis. Clin Genet 1984; 25: 332-335.
71. Beaty TH, Boughman JA, Yang P, Astemborski JA and Suzuki JB Genetic analysis of juvenile periodontitis in families ascertained through an affected proband. Am J Hum Genet 1987; 40: 443-452.
72. Boughman JA, Beaty TH, Yang P, Goodman SB, Wooten RK and Suzuki JB Problems of genetic model testing in early onset periodontitis. J Periodont 1988; 59: 332-337.
73. Boughman JA, Halloran SL and Roulston D An autosomal-dominant form of juvenile periodontitis: its localization to chromosome 4 and linkage to dentogenesis imperfecta and Gc. J Craniofac Genet Devl Biol 1986; 6: 341-350.
74. Hart TC, Marazita ML, McCanna KM, Schenkein NA and Diehl SR Re-evaluation of the chromosome 4q candidate for early onset periodontitis. Human Genet 1993; 91: 416-422.
75. Page RC, Altman LC and Ebersole JL Rapidly progressing periodontitis. A distinct clinical condition. J. Periodont 1983; 54: 197-209.
76. Spektor MD, Vandesteen GE and Page RC Clinical studies of one family manifesting rapidly progressive, juvenile and prepubertal periodontitis. J Periodont 1985; 56: 93-101
77. Genco RJ, Christersson LA and Zambon JJ Juvenile periodontitis. Int Dent J 1986; 36: 168-176.
78. Gunsolley JC, Califano JV, Koertge TE, Burmeister JA, Cooper LC and Schenkein HA Longitudinal assessment of early onset periodontitis. J Periodont 1995; 66: 321-328.
79. Shapira L, Smidt A and Van Dyke TE Sequential manifestation of different forms of early-onset periodontitis. A case report. J Periodont 1994; 65: 631-635.
80. Marazita ML, Burmeister JA, Gunsolley JC, Koertge TE, Lake K and Schenkein HA Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis. J Periodont 1994; 65: 623-631.
81. Burmeister JA, Best AM, Palcanis KG, Caine FA and Ranney RR Localised juvenile periodontitis and generalised severe periodontitis: clinical findings. J Clin Periodont 1984; 11: 181-192.
82. Caton JG Jr. Periodontal diagnosis and diagnosis aids. In: Nevins M, Becker W, Kornman K, eds. Proceedings of the World Workshop in Clinical Periodontics. Chicago: American Academy of Periodontology, 1989; pp 1-22.
83. Murayama Y, Kurihara H, Nagai A, Dompkowski D and Van Dyke TE Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. Periodont 2000 1994; 6: 116-124.
84. Plaut HC Studien zur bacteriellen diagnostik der diphtheric und der anginen. Dtsch Med Wochenschr 1894; 20: 920-923.
85. Vincent MH Recherches bacteriologiques sur l'angine a bacilles fusiformes. Ann L'Institut Pasteur 1899; 8: 609-620.
86. Monteiro da silva AM, Newman HN and Oakley DA Psychological factors in inflammatory periodontal diseases. A review. J Clin Periodont 1995; 22: 516-526.
87. Shannon IL, Kilgore WG and O'Leary TJ Stress as a predisposing factor in necrotizing ulcerative gingivitis. J Periodont 1969; 40: 240-242.
88. Kowolik MJ and Nisbet T Smoking and acute ulcerative gingivitis: study of 100 patients. Br Dent J 1983; 154: 241-242.
89. Ryan ME, Hopkins K and Wilbur RB Acute necrotizing ulcerative gingivitis in children with cancer. Am J Dis Child 1983; 137: 592-594.
90. Ohishi M Acute gingival necrosis caused by drug-induced agranulocytosis. Oral Sur g Oral Med Oral Path 1988; 66: 194-196.
91. Schiodt M and Pindborg JJ AIDS and the oral cavity: epidemiology and clinical oral manifestations of human immune virus infection: a review. Int J Oral Maxillofac Surg 1987; 16: 1-14.
92. Melnick SL, Roseman JM, Engel D and Cogen RB Epidemiology of acute necrotizing ulcerative gingivitis. Epidemiol Rev 1988; 10: 191-211.
93. Jimenez L and Baer P Necrotizing ulcerative gingivitis in children: a 9 year clinical study. J Periodont 1975; 46: 715-720.
94. Enwonwu CO Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma(cancrum oris) in Nigerian children. Archs Oral Biol 1972; 17: 1357-1371.
95. Pindborg JJ, Bhat M, Devanath KR, Narayana HR and Ramachandra S Occurrence of acute necrotizing gingivitis in south Indian children. J Periodont 1966; 37: 14-19.
96. Cogen RB. Acute necrotizing ulcerative gingivitis. In: Genco RJ, Goldman HM and Cohen DW, eds. Contemporary Periodontics. St Louis: Mosby, 1990; pp 459-465.
97. Hart TC and Shapira L Papillon-Lefevre syndrome. Periodont 2000 1994; 6: 88-100.
98. Baehni PC, Payot P, Tsai CC and Cimasoni G Periodontal status associated with chronic neutropenia. J Clin Periodont 1983; 10: 222-230.
99. Pritchard JF, Ferguson DM, Windmiller J and Hurt WC Prepubertal periodontitis affecting the deciduous and permanent dentition in a patient with with cyclic neutropenia. J Periodont 1984; 55: 114-122.
100. Davey KW and Konchak PA Agranulocytosis. Oral Surg Oral Med Oral Path 1969; 28: 166-171.
101. Awbrey JJ and Hibbard ED Congenital agranulocytosis. Oral Surg Oral Med Oral Path 1973; 35: 526-530.
102. Modeer T, Barr M and Dahllof G Periodontal diseases in children with Down syndrome. Scand J Dent Res 1990; 98: 228-234.
103. Ulseth JO, Hestness A, Stovner LJ and Storhaug K Dental caries and periodontitis in persons with Down syndrome. Special Care Dent 1991; 11: 71-73.
104. Yalda B, Offenbacher S and Collins JG Diabetes as a modifier of periodontal disease expression. Periodont 2000 1994; 6: 37-49.
105. Pinson M, Hoffman WH, Garnick JJ and Litaker MS Periodontal disease and type I diabetes mellitus in children and adolescents. J Clin Periodont 1995; 22: 118-123.
106. Meyle J Leukocyte adhesion deficiency and prepubertal periodontitis. Periodont 1994; 6: 26-36.
107. Chapple ILC Hypophosphatasia: dental aspects and mode of inheritance. J Clin Periodont 1993; 20: 615-622.
108. Obura CW Pink disease. Report of a case. Br Dent J 1965; 119: 273-274.
109. Watanabe K Prepubertal periodontitis: a review of diagnostic criteria, pathogenesis, and differential diagnosis. J Periodont Res 1990; 25: 31-48.
110. Tempel TR, Kimball HR, Kakehashi S and Aman CR Host factors in periodontal disease: periodontal manifestation of Chediak-Higashi syndrome. J Periodont Res 1972; 7: 26-27.
111. Delaney JE and Kornman KS Microbiota of subgingival plaque from children with localized prepubertal periodontitis. Oral Microbiol Immunol 1987; 2: 71-76.
112. Shaw L and Glenwright HD Histiocytosis X: an oral diagnostic problem. J Clin Periodont 1988; 15: 312-315.
113. Rylander H, Ramberg P, Blohme G and Lindhe J Prevalence of periodontal disease in young diabetics. J Clin Periodont 1986; 14: 38-43.
114. De Pommereau V, Dargent-Pare C and Robert JJ Periodontal status in insulin-dependent diabetic adolescents. J Clin Periodont 1992; 19: 628-632.
115. Barnett ML, Baker RL and Kotoyan M Absence of periodontitis in a population of insulin dependent diabetes mellitus (IDDM) patients. J Periodont 1984; 55: 402-405.
116. Hayden P and Buckley A Diabetes mellitus and periodontal disease in an Irish population. J Periodont Res 1989; 24: 298-302.
117. Page RC, Bowen T and Altman L Prepubertal periodontitis. I Definition of a clinical disease entity. J Periodont 1983; 54: 257-271.
118. Bowen TJ, Ochs HD and Altman LC Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophil deficiency in a cell-associated glycoprotein. J Pediatr 1982; 101: 932-940.
119. Page RC, Beatty P and Waldrop TC Molecular basis for the functional abnormality in neutrophils from patients with generalised prepubertal periodontitis. J Periodont Res 1987; 22: 182-183.
120. Waldrop TC, Anderson DC and Hallmon WW Periodontal manifestations of the heritable Mac-1, LFA-1 deficiency syndrome. Clinical, histopathologic and molecular characteristics. J Periodont 1987; 58: 400-416.
121. Kishimoto TK, Larson RS, Corbi AL, Dustin ML, Staunton DE and Springer TA The leukocyte integrins. Adv Immunol 1989; 46: 149-182.
122. Anderson DC and Springer TA Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1 and p150,95 glycoproteins. A Rev Med 1987; 38: 175-194.
123. Anderson DC, Schmalstieg FC and Arnaout MA Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence. J Clin Invest 1984; 74: 536-551.
124. Anderson DC, Miller LJ, Schmalstieg FC, Rothlein R and Springer TA Contributions of the Mac-1 glycoprotein family to adherence dependent granulocyte functions: structure-function assessments employing sub-unit specific monoclonal antibodies. J Immunol 1986; 137: 15-27.
125. Springer TA, Dustin ML, Kishimoto TK and Marlin DS The lymphocyte function associated molecules: LFA-1, CD2 and LFA-3 cell adhesion receptors of the immune system. A Rev Immunol 1987; 5: 223-252.
126. Micklem KJ and Sim RB Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. Biochem J 1985; 231: 233-236.
127. Springer TA, Thomson WS, Miller LJ, Schmalstieg FC and Anderson DC Inherited deficiency of the Mac-1, LFA-1, p 150,95 glycoprotein family and its molecular basis. J Exp Med 1984; 160: 1901-1918.
128. Butler JH A familial pattern of juvenile periodontitis (periodontosis). J Periodont 1969; 40: 115-118.
129. Sjodin B, Matsson L, Unell L and Egelberg J Marginal bone loss in the primary dentition of patients with juvenile periodontitis. J Clin Periodont 1993; 20: 32-36.
130. Hara Y, Aono M and Maeda K Immunohistological study with peroxidase-antiperoxidase staining in a case of generalised prepubertal periodontitis. J Periodont 1986; 57: 100-103.
131. Socransky SS, Smith C, Martin L, Paster BJ, Dewhirst FE and Levin AE Checkerboard DNA-DNA hybridization. Biotechniques 1994; 17: 788-792.
132. Sjodin B, Arnrup K, Matsson L, Wranne L, Carlsson J and Hanstrom L Periodontal and systemic findings in children with marginal bone loss in the primary dentition. J Clin Periodont 1995; 22: 214-224.