Rat Mesangial Cells and Matrix Metalloproteinase Inhibitor: Inhibition of 72-kD Type IV Collagenase (MMP-2) and of Cell Proliferation

Journal of the American Society of Nephrology

Volumn 8, Issue 3, 1997, Pages 395-405

  Steinmann Niggli, Karin ^a   Lukes, Manuela ^a   Marti, Hans Peter ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COLLAGENASE; GELATINASE B; HYDROXAMIC ACID; METALLOPROTEINASE; N1 [2,2 DIMETHYL 1 [(METHYLAMINO)CARBONYL]PROPYL] N4 HYDROXY 2 (2 METHYLPROPYL)BUTANEDIAMIDE; PROTEINASE INHIBITOR; RO 31-9790;

ANIMAL; ARTICLE; CELL DIVISION; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FLUOROMETRY; MESANGIUM; METABOLISM; OSMOLARITY; RAT; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; CELL DIVISION; CELL SURVIVAL; COLLAGENASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROMETRY; GLOMERULAR MESANGIUM; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MUSCLE, SMOOTH; OSMOLAR CONCENTRATION; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031092147     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Marti HP, McNeil L, Davies M, Martin J, Lovett DH: Homology cloning of rat 72 kDa type IV collagenase: Cytokine and second-messenger inducibility in glomerular mesangial cells. Biochem J 291: 441-446, 1993.
2. Marti HP, McNeil L, Thomas G, Davies M, Lovett DH: Molecular characterization of a low molecular weight matrix metallo-proteinase secreted by glomerular mesangial cells as Pump-1. Biochem J 285: 899-905, 1992.
3. Michael AF, Falk RJ, Platt JL, Melvin T, Yang J: Antigens of the human glomerulus. Adv Nephrol 13: 203-218, 1984.
4. Mene P, Simonson MS, Dunn MJ: Physiology of the mesangial cell. Physiol Rev 69: 1347-1424, 1989.
5. Woessner JF: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5: 2145-2154, 1991.
6. Marti HP, Lee L, Kashgarian M, Lovett DH: Transforming growth factor-β stimulates glomerular mesangial cell synthesis of the 72 kDa type IV collagenase. Am J Pathol 144: 82-94, 1994.
7. Davies M, Martin J, Thomas GJ, Lovett DH: Proteinases and glomerular matrix turnover. Kidney Int 41: 671-678, 1992.
8. Martin J, Davies M, Thomas G, Lovett DH: Human mesangial cells secrete a GBM-degrading neutral proteinase and a specific inhibitor. Kidney Int 36: 790-801, 1989.
9. Davies M, Thomas GJ, Martin J, Lovett DH: The purification and characterization of a glomerular basement membrane-degrading neutral proteinase from rat mesangial cells. Biochem J 251; 419-425, 1988.
10. Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He C, Bauer EA, Goldberg GI: H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloproteinase capable of degrading basement membrane collagen. J Biol Chem 263: 6579-6587, 1988.
11. Brown PD, Levy AT, Margulies I, Liotta LA, Stetler-Stevenson WG: Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res 50: 6184-6191, 1990.
12. Turck J, Pollock AS, Lee LK, Marti HP, Lovett DH: Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. J Biol Chem 271: 15074-15083, 1996.
13. Southgate KM, Davies M, Booth RFG, Newby AC: Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth-muscle cell proliferation. Biochem J 288: 93-99, 1992.
14. Martin J, Lovett DH, Gemsa D, Sterzel RB, Davies M: Enhancement of glomerular mesangial cell neutral proteinase secretion by macrophages: role of interleukin 1. J Immunol 137: 525-529, 1986.
15. Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW: Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies: A sequential histological and ultrastructural study in the rat. Lab Invest 55: 680-687, 1986.
16. Southgate K, Newby AC: Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP. Atherosclerosis 82: 113-123, 1990.
17. Studer H, Gerber H, Zbaeren J, Peter HJ: Histomorphological and immunohistochemical evidence that human nodular goiters grow by episodic replication of multiple clusters of thyroid follicular cells. J Clin Endocrinol Metab 75: 1151-1158, 1992.
18. Mastroianni A, Invernizzi L, Tagliabue E, Fassina G, Albini A, Ménard S, Colnaghi MI: Alteration of laminin production in small-cell lung carcinoma: possible correlation with the absence of the basement membrane. Tumor Biol 14: 279-287, 1993.
19. Van den Dobbelsteen MEA, van der Woude FJ, Schroeijers WEM, van den Wall Bake AWL, van Es LA, Daha MR: Binding of dimeric and polymeric IgA to rat mesangial cells enhances the release of interleukin 6. Kidney Int 46: 512-519, 1994.
20. Sato T, van Dixhoorn MGA, Schroeijers WEM, Huizinga TWJ, Reutelingsperger CPM, van Es LA, Daha MR: Apoptosis of cultured rat glomerular mesangial cells induced by IgG2a monoclonal anti-Thy-1 antibodies. Kidney Int 49: 403-412, 1996.
21. Broestl JA, Emancipator SN: Rat mesangial cell lysis in vitro is induced by cationic polypeptides. Am J Pathol 142: 529-539, 1993.
22. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685, 1970.
23. Kleiner DE, Stetler-Stevenson WG: Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem 218: 325-329, 1994.
24. Gomez DE, Lindsay CK, Cottam DW, Nason AM, Thorgeirsson UP: Expression and characterization of human tissue inhibitor of metalloproteinase-1 in a baculovirus-insect cell system. Biochem Biophys Res Commun 203: 237-243, 1994.
25. Knight CG, Willenbrock F, Murphy G: A novel coumarin-labelled peptide for sensitive continuous assays of the matrx metalloproteinases. FEBS Lett 296: 263-266, 1992.
26. Itoh Y, Binner S, Nagase H: Steps involved in activation of the complex of promatrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP) - 2 by 4-aminophenylmercuric acetate. Biochem J 308: 645-651, 1995.
27. Escher G, Meyer KV, Vishwanath BS, Frey BM, Frey FJ: Furosemide inhibits 11β-hydroxysteroid dehydrogenase in vitro and in vivo. Endocrinology 136: 1759-1765, 1995.
28. Dixon M: The determination of enzyme inhibitor constants. Biochem J 55: 170-171, 1953.
29. Segel IH: Enzyme inhibition. In: Biochemical Calculations, 2nd ed., New York, John Wiley & Sons, 1976, pp. 246-273.
30. Bergmann U, Tuuttila A, Stetler-Stevenson WG, Tryggvason K: Autolytic activation of recombinant human 72 kilodalton type IV collagenase. Biochemistry 34: 2819-2825, 1995.
31. Kleiner DE, Stetler-Stevenson WG: Structural biochemistry and activation of matrix metalloproteinases. Curr Opin Cell Biol 5: 891-897, 1993.
32. Johnson RJ, Iida H, Alpers CE, Majeski MW, Schwartz SM, Pritzl P, Gordon K, Gown AM: Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. J Clin Invest 87: 847-858, 1991.
33. Nixon JS, Bottomley KMK, Broadhurst MJ, Brown PA, Johnson WH, Lawton G, Marley J, Sedgwick AD, Wilkinson SE: Potent collagenase inhibitors prevent interleukin-1-induced cartilage destruction in vitro. Int J Tiss Reac XIII(5): 237-243, 1991.
34. Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W: X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem 228: 830-841, 1995.
35. Vincenti MP, Clark IM, Brinckerhoff CE: Using inhibitors of metalloproteinases to treat arthritis. Arthritis Rheum 8: 1115-1126, 1994.
36. Hill PA, Docherty JP, Bottomley KM, O'Connell JP, Morphy JR, Reynolds JJ, Meikle MC: Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase. Biochem J 308: 167-175, 1995.
37. Gearing AJH, Beckett P, Christodouiou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, Leber TM, Mangan M, Miller K, Nayee P, Owen K, Patel S, Thomas W, Wells G, Wood LM, Wooltley K: Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature (Lond) 370: 555-557, 1994.
38. McGeehan GM, Becherer JD, Bast RC, Boyer CM, Champion B, Connolly KM, Conway JG, Furdon P, Karp S, Kidao S, McElroy AB, Nichols J, Pryzwanski KM, Schoenen F, Sekut S, Truesdale A, Verghese M, Warner J, Ways JP: Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. Nature (Lond) 370: 558-561, 1994.
39. Spirito S, Doughty J, O'Byme E, Ganu V, Goldberg RL: Metalloproteinase inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures. Inflamm Res 44[Suppl 2]: S131-S132, 1995.
40. Kusner DJ, Luebbers EL, Nowinski RJ, Konieczkowski M, King CH, Sedor JR: Cytokine- and LPS-induced synthesis of interleukin-8 from human mesangial cells. Kidney Int 39: 1240-1248, 1991.
41. Abbott F, Ryan JJ, Ceska M, Matsushima K, Sarraf CE, Rees AJ: Interleukin-1 beta stimulates human mesangial cells to synthesize and release interleukins-6 and -8. Kidney Int 40: 597-605, 1991.
42. Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM: Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 54: 4726-4728, 1994.
43. Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 53: 2087-2091, 1993.
44. Chirivi RG, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R: Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58: 460-464, 1994.
45. Naito K, Kanbayashi N, Nakajima S, Murai T, Arakawa K, Nishimura S, Okuyama A: Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor. Int J Cancer 58: 730-735, 1994.
46. Galardy RE, Cassabonne CG, Giese C, Gilbert JH, Lapierre F, Lopez H, Schaefer ME, Stack R, Sullivan M, Summers B, Tressler R, Tyrell D, Wee J, Allen SD, Castellot JJ, Barletta JP, Schultz SG, Fernandez LA, Fisher S, Cui TY, Foellmer DG, Holleran WM: Low molecular weight inhibitors in corneal ulceration. Ann NY Acad Sci 732: 315-323, 1994.
47. Kitamura M, Shirasawa T, Maruyama N: Gene transfer of metalloproteinase transin induces aberrant behavior of cultured mesangial cells. Kidney Int 45: 1580-1586, 1994.
48. Murphy G, Cockett MI, Stephens PE, Smith BJ, Docherty AJP: Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes. Biochem J 248: 265-268, 1987.
49. Nagase H, Suzuki K, Morodomi T, Enghild JJ, Salvesen G: Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. Matrix Suppl 1P: 237-244, 1992.
50. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW II, Coughlin SR, Owens GK: Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 91: 94-98, 1993.
51. Kirchheimer JC, Wojta J, Christ G, Binder BR: Proliferation of a human epidermal tumor cell line stimulated by urokinase. FASEB J 1: 125-128, 1987.
52. Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG: Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am J Pathol 141: 85-98, 1992.