Synthetic Trehalose Dicorynomycolate (S-TDCM): Behavioral Effects and Radioprotection

Journal of Radiation Research

Volumn 38, Issue 1, 1997, Pages 45-54

  Landauer, Michael R ^a,b   Mcchesney, Daniel G ^a   Ledney, G David ^a  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Food consumption; Immunomodulator; Locomotor activity; Radiation protection; S TDCM

Indexed keywords

CONTROLLED DRUG DELIVERY; DOSIMETRY; DRUG DOSAGE; FISSION REACTIONS; FOOD SUPPLY; MAMMALS; NEUTRON IRRADIATION; NEUTRONS; RADIATION EFFECTS; RADIATION PROTECTION; TOXICITY;

BEHAVIORAL EFFECTS; BODY WEIGHT; FISSION NEUTRONS; FOOD CONSUMPTION; FOOD INTAKE; IMMUNOMODULATORS; LOCOMOTOR ACTIVITY; RADIOPROTECTION; SYNTHETIC TREHALOSE DICORYNOMYCOLATE; WATER INTAKES;

ANTHROPOMETRY;

6,6' DICORYNOMYCOLYL TREHALOSE; 6,6'-DICORYNOMYCOLYL TREHALOSE; CORD FACTOR; IMMUNOLOGICAL ADJUVANT; RADIOPROTECTIVE AGENT;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DRINKING; DRUG EFFECT; EATING; FEMALE; MOTOR ACTIVITY; MOUSE; RADIATION EXPOSURE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BEHAVIOR, ANIMAL; CORD FACTORS; DRINKING; EATING; FEMALE; MICE; MOTOR ACTIVITY; RADIATION-PROTECTIVE AGENTS;

EID: 0031090455     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.38.45     Document Type: Article

References (35)

1. Lederer, E. (1988) An update un natural and synthetic trehalose diesters. In "Immunomodulators and nonspecific host defense mechanisms against microbial infections," Ed. K. Masihi and W. Lange, pp.73-83, Pergamon Press, Oxford, England.
2. Lemaire, G., Tenu, J.P., Petit, J.F. and Lederer, E. (1986) Natural and synthetic trehalose diesters as immunomudulators. Medicinal Res. Rev. 6: 243-274.
3. Bloch, H. (1950) Studies on the virulence of tubercle bacilli. J. Exp. Med. 2: 197-219.
4. Hayashi, Y., Yamaguchi, I., Kobayashi, M., Shimizu, T., Matsuda, K., Yoshida, M., Kumakura, M. and Hirashima, K. (1990) Effects of Z-100 on mice exposed to -irradiation. J. Radiat. Res. 31: 375-388.
5. Monig , H., Messerschmidt, O. and Streffer, C. (1990) Chemical radioprotection in mammals and man. In "Radiation Exposure and Occupational Risks" Ed. E. Scherer, C. Streffer and K.R. Trott, pp. 97-143, Springer-Verlag, New York.
6. Landauer M.R., Davis, H.D., Dominitz, J.D. and Weiss, J.F. (1988a) Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine. Pharmacol. Ther. 39: 97-100.
7. Landauer, M.R., Davis, H.D., Kumar, K.S. and Weiss, J.F. (1992) Behavioral toxicity of selected radioprotectors. Adv. Space Res. 12: 273-283.
8. McChesney, D.G., Ledney, G.D. and Madonna, G.S. (1990) TDM enhances survival of fission neutron irradiated mice and Klebsiella pneumoniae challenged irradiated mice. Radiat. Res. 121: 71-75.
9. Madonna, G.S., Ledney, G.D., Moore, M.M. and Elliott, T.B. (1991) Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM). J. Trauma. 31: 316-325.
10. Ledney, G.D., Madonna, G.S., Elliott, T.B., Moore, M.M. and Jackson III, W.E. (1991) Therapy of infections in mice irradiated in mixed neutron/photon fields and inflicted with wound trauma: A review of current work. Radiat. Res. 128: S18-S28.
11. Ledney, G.D., Elliott, T.B., Landauer, M.R., Vigneulle, R.M., Henderson, P.L., Harding, R.A. and Tom, Jr., S.P. (1994) Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin. Adv. Space Res. 14 (10): 583-586.
12. Ribi, E., Ulrich, J.T. and Masihi, K.N. (1987) Immunopotentiating activities of monophosphoryl lipid A. In "Immunopharmacology of infectious diseases: vaccine adjuvants and modulators of non-specific resistance," Ed. J. Majde, pp. 101-112, Alan R. Liss, Inc. New York.
13. Ribi, E. (1986) Structure-function relationship of bacterial adjuvants. In "Advances in Carriers and Adjuvants for Veterinary Biologies," Eds. R. Nevig, P., Gough, M. Kaeberle and C. Whetstone, pp. 35-49, Iowa State University Press, Ames, IA.
14. Yarkoni, E., Wang, L. and Bekierkunst, A. (1977) Stimulation of macrophages by cord factor and by heat killer and living BCG. Infect. Immun. 16: 1-7.
15. Peterson, V.M., Adamovicz, J.J., Elliott, T.B., Moore, M.M., Madonna, G.S., Jackson, W.E., Ledney, G.D. and Gause, W.C. (1994) Gene expression of hematoregulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers. J. Immunol. 153: 2321-2330.
16. Silva, C.L., Ekizlerian, S.M. and Fazioli, R.A. (1985) Role of cord factor in the modulation of infection caused by mycobacteria. Am. J. Pathol. 118: 238-247.
17. Seggev, J.S., Goren, M.B., Carr R.I. and Kirkpatrick, C.H. (1982) Interstitial and hemorrhagic pneumonitis induced by mycobacterial trehalose dimycolate. Am. J. Pathol. 106: 348-355.
18. Seggev, J.S., Goren, M.B. and Kirkpatrick, C.H. (1984) The pathogenesis of trehalose dimycolate-induced interstitial pneumonitis. III. Evidence for a role for T lymphocytes. Cell. Immunol. 85: 428-435.
19. Saito, R., Tanaka, A., Sugiyama, K. and Kato, M. (1975) Cord factor not toxic in rats. American Review of Respiratory Disease 112: 578-580.
20. Madonna, G.S., Ledney, G.D., Elliott, T.B., Brook, I., Ulrich, J.T. Meyers, K.B., Patchen, M.L. and Walker, R.I. (1989) Trehalose dimycolate enhances resistance to infection in neutropenic animals. Infect. Immun. 57: 2495-2501.
21. Ferguson, J.L., Kandasamy, S.B., Harris, A.H., Davis, H.D. and Landauer, M.R. (1996) Indomethacin attenuation of radiation-induced hyperthermia does not modify radiation-induced hypoactivity. J. Radiat. Res., 37, 209-215.
22. Maier, D.A. and Landauer, M.R. (1990) Onset of behavioral effects of mice exposed to 10 Gy 60-Co radiation. Aviat. Space Environ. Med. 61: 893-898.
23. Landauer M.R., Davis, H.D., Dominitz, J.D. and Weiss, J.F. (1988b) Long-term effects of radioprotector WR-2721 on locomotor activity and body weight of mice following exposure to ionizing radiation. Toxicology 49: 315-323.
24. McPherson, C.W. (1963) Reduction of Pseudomonas aeruginosa and coliform bacteria in mouse drinking water following treatment with hydrochloric acid or chlorine. Lab. Animal Care 13: 737-744.
25. Elliott, T.B., Ledney, G.D., Harding, R.A., Henderson, P.L., Gerstenberg, H.M., Rotruck, J.R., Verdolin, M.H., Stille, C.M. and Krieger, A.C. (1995) Mixed-field neutrons and γ photons induce different changes in ileal bacteria and correlated sepsis in mice. Int. J. Radiat. Biol. 18: 85-95.
26. Meulders, J.P. (1988) Dosimetry in mixed n + gamma field. In "Ionizing Radiation: Protection and Dosimetry," Ed. G. Paic, pp. 203-214, CRC Press, Boca Raton, FL.
27. Winer, B.J. (1971) Statistical principles in experimental design. McGraw-Hill, New York.
28. Silva, C.L. and Faccioli, L.H. (1988) Tumor necrosis factor (cachectin) mediates induction of cachexia by cord factor from mycobacteria. Infec. Immun. 56: 3067-3071.
29. Conn, C.A., McClellan, J.L., Maassab, H.F., Smitka, C.W., Majde, J.A. and Kluger, M.J. (1995) Cytokines and the acute phase response to influenza virus in mice. Am. J. Physiol. 268: (Pt 2), R78-R84.
30. McCarthy, D.O., Kluger, M.J. and Vander, A.J. (1985) Suppression of food intake during infection: Is interleukin-1 involved? J. Clin. Nutrition 42: 1179-1182.
31. Plata-Salaman, C.R. (1994) Meal patterns in response to intracerebroventricular administration of interleukin-1 beta in rats. Physiol. Behav. 55: 727-733.
32. Cockayne, D.A., Bodine, D.M., Cline, A., Nienhuis, A.W., Dunbar, C.E. (1994) Transgenic mice expressing antisense interleukin-3 RNA develop a B-cell lymphproliferative syndrome or neurologic dysfunction. Blood 84: 2699-2710.
33. Bianchi, M., Sacerdote, P., Ricciardi,-Castagnoli, P., Mantegazza, P. and Panerai, A.E. (1992) Central effects of tumor necrosis factor alpha and interleukin-1 alpha on nociceptive thresholds and spontaneous locomotor activity. Neurosci. Lett. 148: 76-80.
34. Castro, C.A., Hogan, J.B., Benson, K.A., Shehata, C.W. and Landauer, M.R. (1995) Behavioral effects of vehicles: DMSO, Ethanol, Tween-20, Tween-80, and Emulphor-620. Pharmacol. Biochem. Behav. 50: 521-526.
35. Orbach-Arbouys, S., Tenu, J.P. and Petit, J.F. (1967) Enhancement of in vitro and in vivo antitumor activity by cord factor (6-6′-dimycolate of trehalose)administered suspended in saline. Int. Archs. Allergy Appl.Immun. 71: 67-73.