Disposition of enrofloxacin and its metabolite ciprofloxacin after intramuscular injection in juvenile Burmese pythons (Python molurus bivittatus)

Journal of Zoo and Wildlife Medicine

Volumn 28, Issue 1, 1997, Pages 71-79

  Young, Lee A ^a,c   Schumacher, Juergen ^a   Papich, Mark G ^b   Jacobson, Elliott R ^a  

^a University of Florida College of Veterinary Medicine   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c Jacksonville Zoological Park   (United States)

Author keywords

Burmese python; Ciprofloxacin; Enrofloxacin; Pharmacokinetics; Python molurus bivittatus; Reptile

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN; ENROFLOXACIN; QUINOLONE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; FEMALE; HALF LIFE TIME; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; METABOLISM; SNAKE;

ANIMALS; ANTI-INFECTIVE AGENTS; BOIDAE; CIPROFLOXACIN; FEMALE; FLUOROQUINOLONES; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; MALE; QUINOLONES;

EID: 0031090269     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bowser, P. R., G. A. Wooster, and J. G. Babish. 1992. Pharmacokinetics of enrofloxacin in rainbow trout (Oncorhynchus mykiss). J. Vet. Pharmacol. Ther. 15: 62-71.
2. Broome, R. L., D. L. Brooks, J. G. Babish, D. D. Copeland, and G. M. Conzelman. 1991. Pharmacokinetic properties of enrofloxacin in rabbits. Am. J. Vet. Res. 52: 1835-1841.
3. Caligiuri, R., G. V. Kollias, E. Jacobson, B. McNab, C. H. Clark, and R. C. Wilson. 1990. The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises. J. Vet. Pharmacol. Ther. 13: 287-291.
4. Clark, C. H., E. D. Rogers, and J. L. Milton. 1985. Plasma concentrations of chloramphenicol in snakes. Am. J. Vet. Res. 46: 2654-2657.
5. Courvalin, P. 1990. Plasmid-mediated 4-quinolone resistance: a real or apparent absence? Antimicrob. Agents Chemother. 34: 681-684.
6. Draper, C. S., R. D. Walker, and H. E. Lawler. 1981. Patterns of oral bacterial infection in captive snakes. J. Am. Vet. Med. Assoc. 179: 1223-1226.
7. Flammer, K., D. P. Aucoin, and D. A. Whitt. 1991. Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses. J. Vet. Pharmacol. Ther. 14: 359-366.
8. Forrest, A., D. E. Nix, and C. H. Ballow. 1993. Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob. Agents Chemother. 37: 1073-1081.
9. Gilbaldi, M., and D. Perrier. 1982. Noncompartmental analysis based on statistical moment theory. In: Pharmacokinetics, 2nd ed. Marcel Dekker, New York, New York. Pp. 409-417.
10. Hilf, M., D. Swanson, R. Wagner, and V. L. Yu. 1991. A new dosing schedule for gentamicin in blood pythons (Python curtis): a pharmacokinetic study. Res. Vet. Sci. 50: 127-130.
11. Hilf, M., D. Swanson, R. Wagner, and V. L. Yu. 1991. Pharmacokinetics of piperacillin in blood pythons (Python curtis) and in vitro evaluation of efficacy against aerobic gram-negative bacteria. J. Zoo Wildl. Med. 22: 199-203.
12. Hilf, M., R. A. Wagner, and V. L. Yu. 1990. A prospective study of upper airway flora in healthy boid snakes and snakes with pneumonia. J. Zoo Wildl. Med. 21: 318-325.
13. Jacobson, E. R. 1976. Gentamicin-related visceral gout in two boid snakes. Vet. Med. Small Anim. Clin. 71: 361-363.
14. Jacobson, E. R. 1988. Use of chemotheraputics in reptile medicine. In: Jacobson, E. R., and G. V. Kollias (eds.). Exotic Animals. Churchill Livingstone, New York, New York. Pp. 35-48.
15. Jacobson, E. R., and M. Hodge. 1980. Chronic cannulation technique allowing daily blood sampling in water snakes. Lab. Anim. Sci. 30: 249-251.
16. Klingenberg, R. J., and B. Backner. 1991. The use of ciprofloxacin, a new antibiotic, in snakes. Proc. Int. Herpetol. Symp. Captive Propagation Husbandry 15: 127-140.
17. Lawrence, K., P. W. Muggleton, and J. R. Needham. 1984. Preliminary study on the use of ceftazidime, a broad spectrum cephalosporin antibiotic, in snakes. Res. Vet. Sci. 36: 16-20.
18. Lawrence, K., J. R. Needham, G. H. Palmer, and J. C. Lewis. 1984. A preliminary study on the use of carbenicillin in snakes. J. Vet. Pharmacol. Ther. 7: 119-124.
19. Mader, D. R., G. M. Conzelman, and J. D. Baggot. 1985. Effects of ambient temperature on the half-life and dosage regimen of amikacin in the gopher snake. J. Am. Vet. Med. Assoc. 187: 1134-1136.
20. Meinen, J. B., J. T. McClure, and E. Rosin. 1995. Pharmacokinetics of enrofloxacin in clinically normal dogs and mice and drug pharmacodynamics in neutropenic mice with Escherichia coli and staphylococcal infections. Am. J. Vet. Res. 56: 1219-1224.
21. Prescott, J. F., and K. M. Yielding. 1990. In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin, and norfloxacin. Can. J. Vet. Res. 54: 194-197.
22. Prezant, R. M., R. Isaza, and E. R. Jacobson. 1994. Plasma concentrations and disposition kinetics of enrofloxacin in gopher tortoises (Gopherus polyphemus). J. Zoo Wildl. Med. 25: 82-87.
23. Raphael, B. L., M. Papich, and R. A. Cook. 1994. Pharmacokinetics of enrofloxacin after a single intramuscular injection in Indian star tortoises (Geochelone elegans). J. Zoo Wildl. Med. 25: 88-93.
24. Schentag, J. J. 1991. Correlation of pharmacokinetic parameters to efficacy of antibiotics: relationships between serum concentrations, MIC values, and bacterial eradication in patients with gram-negative pneumonia. Scand. J. Infect. Dis. 74(Suppl.): 218-234.
25. Spöle, H., T. Gobel, and B. Schildger. 1991. Blood levels of some antiinfectives in the spur-tailed tortoise (Testudo hermanni). Int. Colloq. Pathol. Med. Reptiles Amphib. 4: 120-128.
26. Tyczkowska, K., K. M. Hedeen, D. P. Aucoin, and A. L. Aronson. 1989. High-performance liquid chromatographic method for the simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in canine serum and prostatic tissue. J. Chromatogr. 493: 337-346.
27. Vancustem, P. M., J. G. Babish, and W. S. Scwark. 1990. The fluoroquinolone antimicrobials: structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Vet. 80: 173-186.
28. Walker, R. C., and A. J. Wright. 1991. The fluoroquinolones. Mayo Clin. Proc. 66: 1249-1259.
29. Walker, R. D., G. E. Stein, J. G. Hauptman, and K. H. MacDonald. 1992. Pharmacokinetic evaluation of enrofloxacin administered orally to healthy dogs. Am. J. Vet. Res. 53: 2315-2319.