Modulation of Hepatitis C Virus quasispecies heterogeneity by interferon-α and ribavirin therapy

Journal of Viral Hepatitis

Volumn 4, Issue 2, 1997, Pages 99-106

  Gonzalez Peralta R P ^a,b,c   Liu, W Z ^a,b   Davis, G L ^b   Qian, K P ^b   Lau, J Y N ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

HCV; Heterogeneity; Interferon; Quasispecies; Ribavirin; SSCP

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ANTIVIRUS AGENT; GLYCOPROTEIN E2, HEPATITIS C VIRUS; RIBAVIRIN; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; GENETIC HETEROGENEITY; GENETICS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SINGLE STRAND CONFORMATION POLYMORPHISM; VIROLOGY;

ADULT; AGED; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; FEMALE; FOLLOW-UP STUDIES; GENETIC HETEROGENEITY; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RIBAVIRIN; RNA, VIRAL; VIRAL ENVELOPE PROTEINS;

EID: 0031088282     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2893.1997.tb00211.x     Document Type: Article

References (25)

1. Martell M, Esteban JI, Quer J et al. Hepatitis C virus circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution. Virology 1992; 66: 3225-3229.
2. Davis GL, Balart LA, Schiff ER et al. and the Hepatitis Interventional Therapy Group. Treatment of chronic hepatitis C with recombinant interferon alpha. N Engl J Med 1989; 321: 1501-1506.
3. Koskinas J, Tibbs C, Saleh MG, Pereira LM, McFarlane IG, Williams R. Effects of ribavirin on intrahepatic and extrahepatic expression of hepatitis C virus in interferon non-responsive patients. J Med Virol 1995; 45: 29-34.
4. Reichard O, Yun ZB, Sonnerborg A, Weiland O. Hepatitis C viral RNA titers in serum prior to, during, and after oral treatments with ribavirin for chronic hepatitis C. J Med Virol 1993; 41: 99-102.
5. Shindo M, DiBisceglic AM, Cheung L et al. Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C. Ann Intern Med 1991; 115: 700-704.
6. Okada S, Akahane Y, Suzuki H, Okamoto H, Mishiro S. The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlated with responsiveness to interferon therapy in viremic patients. Hepatology 1992; 16: 619-624.
7. Higashi Y, Kakumu S, Yoshika K et al. Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo. Virology 1993; 197: 659-668.
8. Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformational polymorphism analysis. J Gen Virol 1994; 75: 1361-1369.
9. Kanasawa Y, Hayashi N, Mita E et al. Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients. Hepatology 1994; 20: 1121-1130.
10. Moribe T, Hayashi N, Kanazawa Y et al. Hepatitis C viral complexity detected by single-strand conformational polymorphism and response to interferon therapy. Gastroenterology 1995; 108: 789-795.
11. Koizimi K, Enomoto N, Kurosaki M et al. Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 1995; 22: 30-35.
12. Lau JYN, Ohno T, Ohba K et al. Interferon-α therapy exerts selective pressure on hepatitis C virus quasispecies. Hepatology 1994; 20: 167A (abstr).
13. Gonzalez-Peralta RP, Qian K, She JY et al. Clinical significance of viral quasispecies heterogeneity in chronic hepatitis C. J Med Virol 1996; 49: 242-247.
14. Lau JYN, Mizokami M, Kolberg JA et al. Application of six hepatitis C virus genotyping systems to sera from chronic hepatitis C patients in the United States. J Infect Dis 1995; 171: 281-289.
15. Davis GL, Lau JYN, Urdea MS et al. Quantitative detection of hepatitis C virus RNA by solid phase branched DNA amplification method: definition and optimal conditions for specimen collection and clinical application in interferon-treated patients. Hepatology 1994; 19: 1337-1341.
16. Collins ML, Zayati C, Detmer JJ et al. Preparation and characterization of RNA standards for use in branched DNA hybridization assays. Ann Biochem 1995; 226: 120-129.
17. Detmer J, Lagier R, Flynn J et al. Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched-DNA technology. J Clin Microbiol 1996; 34: 901-907.
18. Lau JYN, Simmonds P, Urdea MS. Implications of variations of 'conserved' regions of hepatitis C virus genome. Lancet 1995; 346: 425-426.
19. Simmonds P, Alberti A, Bonino F et al. A proposed system for nomenclature of genotypes for hepatitis C virus. Hepatology 1994; 19: 1321-1324.
20. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-435.
21. Okamoto H, Okada S, Sugiyama Y et al. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates from conserved and divergent regions. J Gen Virol 1991; 72: 2697-2704.
22. Enomoto N, Sakuma I, Asahina Y et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b: sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224-230.
23. Lanford RE, Sureau C, Jacob JR, White R, Fuerst TR. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR. Virology 1994; 202: 606-614.
24. Shimizu YK, Iwamoto A, Hijikata M, Purcell RH, Yoshikura H. Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. Proc Natl Acad Sci USA 1992; 89: 5477-5481.
25. 5 DiBisceglie AM, Krawczynski K, Brazzeal D, Hoofnagle JH. Hepatitis C viral antigen in the liver: effect of antiviral therapy. Gastroenterology 1993; 105: 858-862.