Neoglycopeptide synthesis and purification in multi-gram scale: Preparation of O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-N α-fluoren-9-yl-methoxycarbonyl-hydroxyproline and its use in the pilot-scale synthesis of the potent analgesic glycopeptide O 1.5-β-D-galactopyranosyl [DMet2,Hyp5]enkephalinamide

Journal of Peptide Science

Volumn 3, Issue 2, 1997, Pages 99-109

  Torres, Josep Lluís ^a   Clapés, Pere ^a  

^a DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

Analgesic glycopeptides; Neoglycopeptides; Pilot scale; Preparative purification; Solid phase peptide synthesis

Indexed keywords

DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENKEPHALIN; ENKEPHALINAMIDE, MET(2) HYP(5)GALACTOPYRANOSYL; ENKEPHALINAMIDE, MET(2)-HYP(5)GALACTOPYRANOSYL-; GALACTOSIDE; GLYCOPEPTIDE; HYDROXYPROLINE; METENKEPHALIN; NARCOTIC ANALGESIC AGENT; O (2,3,4,6 TETRA O ACETYL GALACTOPYRANOSYL) N FLUOREN 9 YL METHOXYCARBONYLHYDROXYPROLINE; O-(2,3,4,6-TETRA-O-ACETYL-GALACTOPYRANOSYL)-N-FLUOREN-9-YL-METHOXYCARBONYLHYDROXYPROLINE;

ARTICLE; CHEMISTRY; GLYCOSYLATION; ISOLATION AND PURIFICATION; PILOT STUDY; SYNTHESIS;

ANALGESICS, OPIOID; ENKEPHALIN, METHIONINE; ENKEPHALINS; GALACTOSIDES; GLYCOPEPTIDES; GLYCOSYLATION; HYDROXYPROLINE; INDICATORS AND REAGENTS; PILOT PROJECTS;

EID: 0031087994     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1387(199703)3:2<99::AID-PSC89>3.0.CO;2-F     Document Type: Article

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