Some people believe that deontological constraints have a threshold, such that if enough is at stake, it is permissible (or obligatory) to violate a constraint. However, since I shall reject the deontological objections to gene therapy, it doesn't really matter in the present context whether constraints have a threshold.
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Editorial: End-of-the-year potpourri - 1993
Anderson WF. Editorial: end-of-the-year potpourri - 1993. Human Gene Therapy 1993;4:701-2.
For a good discussion of the relation between unnaturalness and morality, see Singer P, Wells D. The Reproduction Revolution: New Ways of Making Babies. Oxford: Oxford University Press, 1984:36-41.
What is morally distinctive about genetic engineering?
For a theological analysis to the effect that gene therapy is not unnatural in any morally problematic sense, see Porter J. What is morally distinctive about genetic engineering? Human Gene Therapy 1990;1:419-24.
Chadwick R, ed. London: Routledge, Also see notes 9 and 10
For discussions of this objection, see Chadwick R. The perfect baby: Introduction. In: Chadwick R, ed. Ethics, Reproduction and Genetic Control. London: Routledge, 1992:110-1. Also see notes 9 and 10.
Laslett P, Fishkin JS, eds. New Haven: Yale University Press
Glover J. Future people, disability and screening. In: Laslett P, Fishkin JS, eds. Justice Between Age Groups and Generations. New Haven: Yale University Press, 1992:133-4.