Synthesis and β-lactamase inhibitory activity of 2β-Carboxamide penicillanic acid sulfones

Journal of Antibiotics

Volumn 50, Issue 3, 1997, Pages 276-278

  Reddy, Narender A V ^a   Setti, Eduardo L ^a   Phillips, Oludotun A ^a   Czajkowski, David P ^a   Atwal, Harninder ^a   Atchison, Kevin ^a   Micetich, Ronald G ^a   Maiti, Samarendra N ^a   Kunugita, Chieko ^b   Hyodo, Akio ^b  

^a NAEJA Pharmaceutical Inc   (Canada)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CEFTAZIDIME; PIPERACILLIN; SULBACTAM; TAZOBACTAM; ENZYME INHIBITOR; SULFONE;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; DRUG ANTAGONISM; SYNTHESIS;

BETA-LACTAMASES; CEFTAZIDIME; DRUG SYNERGISM; ENZYME INHIBITORS; SULFONES;

EID: 0031085986     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.276     Document Type: Article

References (5)

1. RICHTER, H. G. F.; P. ANGEHRN, C. HUBSCHWERLEN, M. KANIA, M. G. P. PAGE, J.-L. SPECKLIN & F. K. WINKLER: Design, synthesis and evaluation of 2β-alkenyl penam sulfone acids as inhibitors of β-lactamascs. J. Med. Chem. 39: 3712-3722, 1996
2. PFLIEGER, P.; P. ANGEHRN, M. BOHRINGER, C. HUBSCHWERLEN, M. G. P. PAGE, F.-P. THEIL & F. WINKLER: Bridged carbacephems as β-lactamase inhibitors: Synthesis and structure-activity relationships. 36th Intersci. Conf. on Antimicrob. Agents Chemother. Poster No. F-158, New Orleans, Sept. 15∼18, 1996
3. HUBSCHWERLLN, C.; P. ANGEHRN, M. BOHRINGER, M. KANSY, M. G. P. PAGE, J.-L. SPECKLIN & R. THEN: Bridged isooxa- and iso-cephems as β-lactamase inhibitors and antibacterial: Synthesis and structure-activity relationships. 36th Intersci. Conf. on Antimicrob. Agents Chemother. Poster No. F-157, New Orleans, Sept. 15∼ 18, 1996
4. ANGEHRN, P.; K. GUBERNATOR, E. -M. GUTKNECHT, I. H. KRAUSS, C. HUBSCHWERLEN, M. KANIA, M. G. P. PAGE & J.-L. SPECKLIN: Bridged β-lactams: A new class of β-lactamase inhibitors, synthesis and structure-activity relationships. 35th Intersci. Conf. on Antimicrob. Agents Chemother. Poster No. F-147, San Francisco, Sept. 17∼ 20, 1995
5. SETTI, E. L.; N. A. V. REDDY, O. A. PHILLIPS, D. P. CZAJKOWSKI, H. ATWAL, R. G. MICETICH, S. N. MAITI, C. KUNUGITA & A. HYODO: Studies on penam sulfones I: Synthesis and β-lactamase inhibitory activity of 2β-alkoxycarbonyl penicillanic acid sulfones. J. Antibiotics 49: 944-946, 1996