Influence of the energy relationships of organic compounds on their specificity toward aquatic organisms

Ecotoxicology and Environmental Safety

Volumn 36, Issue 2, 1997, Pages 99-108

  Genoni, Giulio P ^a  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUND;

AQUATIC FLORA; ARTICLE; BEHAVIOR; BIOACCUMULATION; BIOTRANSFORMATION; ECOSYSTEM; ECOTOXICOLOGY; ENERGY METABOLISM; LIFESPAN; NONHUMAN; TOXICITY TESTING;

ENERGY RELATIONSHIP; ORGANIC COMPOUND; SPECIFICITY; TOXICITY; TRANSFORMITY;

EID: 0031082107     PISSN: 01476513     EISSN: None     Source Type: Journal    
DOI: 10.1006/eesa.1996.1490     Document Type: Article

References (122)

1. Abernethy S., Bobra A. M., Shiu W. Y., Wells P. G., Mackay D. Acute lethal toxicity of hydrocarbons and chlorinated hydrocarbons to two planktonic crustaceans: the key role of organism-water partitioning. Aquat. Toxicol. 8:1986;163-174.
2. Abernethy S. G., Mackay D., McCarthy L. S. Volume fraction correlation for narcosis in aquatic organisms: the key role of partitioning. Environ. Toxicol. Chem. 7:1988;469-481.
3. Adema D. M. M., Vink G. J. A comparative study of the toxicity of 1,1,2-trichloroethane, dieldrin, pentachlorophenol and 3,4-dichloroaniline for marine and fresh water organisms. Chemosphere. 10:1981;553-554.
4. Bengtsson B.-E., Tarkpea M. The acute aquatic toxicity of some substances carried by ships. Mar. Poll. Bull. 14:1983;213-214.
5. Bobra A., Shiu W. Y., Mackay D. A predictive correlation for the acute toxicity of hydrocarbons and chlorinated hydrocarbons to the water flea (Daphnia magna. Chemosphere. 12:1983;1121-1129.
6. Bobra A., Shiu W. Y., Mackay D. Quantitative structure-activity relationships for the acute toxicity of chlorobenezenes toDaphnia magna. Environ. Toxicol. Chem. 4:1985;297-305.
7. Broderius S., Kahl M. Acute toxicity of organic chemical mixtures to the fathead minnow. Aquat. Toxicol. 6:1985;307-322.
8. Brown V. M., Jordan D. H. M., Tiller B. A. The effect of temperature on the acute toxicity of phenol to rainbow trout in hard water. Water Res. 1:1967;587-594.
9. Brungs W. A., McCormick J. H., Neiheisel T. W., Spehar R. L., Stephan C. E., Stokes G. N. Effects of pollution on freshwater fish. J. Water Pollut. Control Fed. 49:1977;1425-1493.
10. Bryson J. W., Betz S. F., Lu H. S., Suich D. J., Zhou H. X., O'Neil K. T., DeGrado W. F. Protein design: a hierarchic approach. Science. 270:1995;935-941.
11. BUA Stoffbericht 3. Beratungsgremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker. 1986;VCH, Weinheim.
12. BUA Stoffbericht 24. Beratungsgremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker. 1988;VCH, Weinheim.
13. BUA Stoffbericht 31. Beratungsgremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker. 1989a;VCH, Weinheim.
14. BUA Stoffbericht 34. Beratungsgremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker. 1989b;VCH, Weinheim.
15. Buccafusco R. J., Ells S. J., LeBlanc G. A. Acute toxicity of priority pollutants to bluegill (Lepomis macrochirus. Bull. Environ. Contam. Toxicol. 26:1981;446-452.
16. Buikema A. L. Jr., Benfield E. F. Effects of pollution on freshwater invertebrates. J. Water Pollut. Control Fed. 52:1980;1675-1686.
17. Buikema A. L. Jr., McGinnis M. J., Cairns J. Jr. Phenolics in aquatic ecosystems: A selective review of recent literature. Mar. Env. Res. 2:1979;87-181.
18. Cairns J. Jr., Scheier A. A comparison of the toxicity of some common industrial wastes tested individually and combined. Prog. Fish. Cult. 30:1968;3-8.
19. Calamari D., Galassi S., Setti F., Vighi M. Toxicity of selected chlorobenzenes to aquatic organisms. Chemosphere. 12:1983;253-262.
20. Canton J. H., Adema D. M. M. Reproducibility of short-term and reproduction toxicity experiments withDaphnia magnaDaphnia magnaDaphnia pulexDaphnia cucullata. Hydrobiologia. 59:1978;135-140.
21. Chang J. C., Taylor P. B., Leach F. R. Use of the Microtox assay system for environmental samples. Bull. Environ. Contam. Toxicol. 26:1981;150-156.
22. Cleveland L., Buckler D. R., Mayer F. L., Branson D. R. Toxicity of three preparations of pentachlorophenol to fathead minnows - A comparative study. Environ. Toxicol. Chem. 1:1982;205-222.
23. Cowgill U. M., Milazzo D. P. The sensitivity ofCeriodaphnia dubiaDaphnia magna. Arch. Environ. Contam. Toxicol. 20:1991;211-217.
24. Cowgill U. M., Takahashi I. T., Applegath S. L. A comparison of the effect of four benchmark chemicals onDaphnia magnaCeriodaphnia dubia-affinis. Environ. Toxicol. Chem. 4:1985;415-422.
25. Davis J. C., Hoos R. A. W. Use of sodium pentachlorophenate and dehydroabietic acid as reference toxicants for salmonid bioassays. J. Fish. Res. Board Can. 32:1974;411-416.
26. Dawson G. W., Jennings A. L., Drozdowski D., Rider E. The acute toxicity of 47 industrial chemicals to fresh and saltwater fishes. J. Hazard. Mater. 1:1975/1977;303-318.
27. De Graeve G. M., Geiger D. L., Meyer J. S., Bergman H. L. Acute and embryo-larval toxicity of phenolic compounds to aquatic biota. Arch. Environ. Contam. Toxicol. 9:1980;557-568.
28. Dietz F., Traud J. Geruchs- und Geschmacks-Schwellenkonzen-trationen von Phenolkörpern. Gsf-Wasser/Abw. 119:1978;318-325.
29. Dolfing J., Harrison B. K. Gibbs free energies of formation of halogenated aromatic compounds and their potential role as electron acceptors in anaerobic environments. Environ. Sci. Technol. 26:1992;2213-2218.
30. Dolfing J., Janssen D. B. Estimates of Gibbs free energies of formation of chlorinated aliphatic compounds. Biodegradation. 5:1994;21-28.
31. 50. Aquat. Toxicol. 8:1986;243-249.
32. Dowden B. F., Bennett H. J. Toxicity of selected chemicals to certain animals. J. Water Pollut. Control Fed. 37:1965;1308-1316.
33. Elnabarawy M. T., Welter A. N., Robideau R. R. Relative sensitivity of three daphnid species to selected organic and inorganic chemicals. Environ. Toxicol. Chem. 5:1986;393-398.
34. Methanol: Environmental and Technical Information for Problem Spills. 1985a;Environmental Protection Service, Ottawa.
35. Phenol: Environmental and Technical Information for Problem Spills. 1985b;Environmental Protection Service, Ottawa.
36. Ewell W. S., Gorsuch J. W., Kringle R. O., Robillard K. A., Spiegel R. C. Simultaneous evaluation of the acute effects of chemicals on seven aquatic species. Environ. Toxicol. Chem. 5:1986;831-840.
37. Feldman D. S., Gagnon J., Hofmann R., Simpson J. StatView II. 9187;Abacus Concepts, Berkeley.
38. Fogels A., Sprague J. B. Comparative short-term tolerance of zebrafish, flagfish, and rainbow trout to five poisons including potential reference toxicants. Water Res. 11:1977;811-817.
39. Genoni G. P., Montague C. L. Influence of the energy relationships of trophic levels and of elements on bioaccumulation. Ecotoxicol. Environ. Saf. 30:1995;203-218.
40. Genoni G. P. Influence of the energy relationships of organic compounds on toxicity to the cladoceranDaphnia magnaPimephales promelas. Ecotoxicol. Environ. Saf. 36:1997.
41. Gersich F. M., Blanchard F. A., Applegath S. L., Park C. N. The precision of daphnid (Daphnia magna. Arch. Environ. Contam. Toxicol. 15:1986;741-749.
42. Geyer H., Scheunert I., Korte F. The effect of organic environmental chemicals on the growth of the algaScenedesmus subspicatus: Chemosphere. 14:1985;1355-1369.
43. Gupta P. K., Rao P. S. Toxicity of phenol, pentachlorophenol and sodium pentachlorophenate to a freshwater pulmonate,Lymnaea acuminata. Arch. Hydrobiol. 94:1982;210-217.
44. Halfon E., Reggiani M. G. On ranking chemicals for environmental hazard. Environ. Sci. Technol. 20:1986;1173-1179.
45. Hall L. H., Kier L. B. Molecular connectivity of phenols and their toxicity to fish. Bull. Environ. Contam. Toxicol. 32:1984;354-362.
46. Hall L. H., Kier L. B. Structure-activity relationship studies on the toxicity of benzene derivatives. II. An analysis of benzene substituent effects on toxicity. Environ. Toxicol. Chem. 5:1986;333-337.
47. Hall L. H., Kier L. B., Phipps G. Structure-activity relationship studies on the toxicity of benzene derivatives. I. An additivity model. Environ. Toxicol. Chem. 3:1984;355-365.
48. Hedtke S. F., Arthur J. W. Evaluation of a site-specific water quality criterion for pentachlorophenol using outdoor experimental streams. Aquatic Toxicology and Hazard Assessment: Seventh Symposium. 1985;American Society for Testing and Materials, Philadelphia. p. 551-564.
49. Hedtke S. F., West C. W., Allen K. N., Norberg-King T. J., Mount D. I. Toxicity of pentachlorophenol to aquatic organisms under naturally varying and controlled environmental conditions. Environ. Toxicol. Chem. 5:1986;531-542.
50. Heitmüller P. T., Hollister T. A., Parrish P. R. Acute toxicity of 54 industrial chemicals to sheepshead minnows (Cyprinodon variegatus). Bull. Environ. Contam. Toxicol. 27:1981;596-604.
51. Hermens J. L. M. Quantitative structure-activity relationships for predicting fish toxicity. Karcher W., Devillers J. Practical Applications of Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology and Toxicology. 1990;263-280 ECSC, Brussels.
52. Hermens J., Canton H., Janssen P., De Jong R. Quantitative structure-activity relationships and toxicity studies of mixtures of chemicals with anaesthetic potency: Acute lethal and sublethal toxicity toDaphnia magna. Aquat. Toxicol. 5:1984a;143-154.
53. Hermens J., Canton H., Steyger N., Wegman R. Joint effects of a mixture of 14 chemicals on mortality and inhibition of reproduction ofDaphnia magna. Aquat. Toxicol. 5:1984b;315-322.
54. Hodson P. V., Dixon D. G., Kaiser K. L. E. Estimating the acute toxicity of waterborne chemicals in trout from measurements of median lethal dose and the octanol-water partition coefficient. Environ. Toxicol. Chem. 7:1988;443-454.
55. Holcombe G. W., Phipps G., Sulaiman A. H., Hoffmann A. D. Simultaneous multiple species testing: acute toxicity of 13 chemicals to 12 diverse freshwater amphibian, fish, and invertebrate families. Bull. Environ. Contam. Toxicol. 16:1987;697-710.
56. Hollander M., Wolfe D. A. Nonparametric Statistical Methods. 1973;Wiley, New York.
57. Holmes D. A., Harrison B. K., Dolfing J. Estimation of free Gibbs free energies of formation for polychlorinated biphenyls. Environ. Sci. Technol. 27:1993;725-731.
58. Janardan S. K., Olson C. S., Schaeffert D. J. Quantitative comparisons of acute toxicity of organic chemicals to rat and fish. Ecotox. Environ. Saf. 8:1984;531-539.
59. Juhnke I., Lüdemann D. Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit dem Goldenorfentest. Z. Wasser Abw. Forsch. 11:1978;161-164.
60. Kaiser K. L. E., Ribo J. M. Photobacterium phosphoreum. Toxic. Assess. 3:1988;195-237.
61. Keen R., Baillod C. R. Toxicity toDaphnia. Water Res. 19:1985;767-772.
62. Knie J., Hälka A., Juhnke I., Schiller W. Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests. Dtsch. Gewässerk. Mitt. 27:1983;77-79.
63. Kühn R., Pattard M. Results of the harmful effects of water pollutants to green algae (Scenedesmus subspicatus. Water Res. 24:1990;31-38.
64. Kühn R., Pattard M., Pernak K.-D., Winter A. Results of the harmful effects of selected water pollutants (anilines, phenols, aliphatic compounds) toDaphnia magna. Water Res. 4:1989;495-499.
65. Kukkonen J., Oikari A. Effects of aquatic humus on accumulation and acute toxicity of some organic micropollutants. Sci. Total Environ. 62:1987;399-402.
66. LeBlanc G. A. Acute toxicity of priority pollutants to water flea (Daphnia magna. Bull. Environ. Contam. Toxicol. 24:1980;684-691.
67. Malle K.-G. Die Bedeutung der 120 Stoffe der EG-Liste für den Gewässerschutz. Z. Wasser Abw. Forsch. 17:1984;75-81.
68. F. L. Mayer, Jr. M. R. Ellersieck, 1986, Manual of Acute Toxicity: Interpretation and Data Base for 410 Chemicals and 66 Species of Freshwater Animals, Fish and Wildlife Science, U.S. Department of the Interior, Washington, DC.
69. Mayes M. A., Alexander H. C., Dill D. C. A study to assess the influence of age on the response of fathead minnows in static acute toxicity tests. Bull. Environ. Contam. Toxicol. 31:1983;139-147.
70. McCarthy L. Relationship between toxicity and bioconcentration for some organic chemicals. II. Application of the relationship. Kaiser K. L. E. QSAR in Environmental Toxicology. 1987;221-229 Reidel, Dordrecht.
71. McCarty L. S., Hodson P. V., Craig G. R., Kaiser K. L. E. The use of quantitative structure-analysis relationships to predict the acute and chronic toxicities of organic chemicals to fish. Environ. Toxicol. Chem. 4:1985;595-606.
72. McKim J. M. Evaluation of tests with early life stages of fish for predicting long-term toxicity. J. Fish. Res. Board Can. 34:1977;1148-1154.
73. Millemann R. E., Birge W. J., Black J. A., Cushman R. M., Daniels K. L., Franco P. J., Giddings J. M., McCarthy J. F., Stewart A. J. Comparative acute toxicity to aquatic organisms of components of coal-derived synthetic fuels. Trans. Am. Fish. Soc. 113:1984;74-85.
74. D. R. J. Moore, S. L. Walker, R. Ansari, 1991a, Canadian Water Quality Guidelines for Trichloroethylene, Inland Waters Directorate, Ottawa.
75. D. R. J. Moore, S. L. Walker, D. Kopniecki, 1991b, Canadian Water Quality Guidelines for Chlorinated Ethanes, Inland Waters Directorate, Ottawa.
76. Mount D. I., Norberg T. J. A seven-day life-cycle cladoceran toxicity test. Environ. Toxicol. Chem. 23:1984;425-434.
77. Odum H. T. Systems Ecology: An Introduction. 1983;Wiley, New York.
78. Odum H. T. Enmergy in ecosystems. Polunin N. Ecosystem Theory and Application. 1986;337-369 Wiley, New York.
79. H. T. Odum, 1991, Emergy and biogeochemical cycles, Ecological Physical Chemistry, C. RossiE. Tiezzi, 25, 56, Elsevier, Amsterdam.
80. v.d. Okkerman P. C., Plassche E. J., Sloof W., van Leeuwen C. J., Canton J. H. Ecotoxicological effects assessment: A comparison of several extrapolation procedures. Ecotoxicol. Environ. Saf. 21:1991;182-193.
81. Phipps G. L., Holcombe G. W. A method for aquatic multiple species toxicant testing: Acute toxicity of 10 chemicals to 5 vertebrates and 2 invertebrates. Environ. Pollut. Ser. A. 38:1985;141-157.
82. Phipps G. L., Holcombe G. W., Fiandt J. T. Acute toxicity of phenols and substituted phenols to the fathead minnow. Bull. Environ. Contam. Toxicol. 26:1981;585-593.
83. Phipps G. L., Harden M. J., Leonard E. N., Roush T. H., Spehar D. L., Stephan C. E., Pickering Q. H., Buikema A. L. Jr. Effects of pollution on freshwater organisms. J. Water Pollut. Control. Fed. 56:1984;725-758.
84. Pickering Q. H., Henderson C. Acute toxicity of some important petrochemicals to fish. J. Water Pollut Control Fed. 38:1966;1419-1429.
85. Pickering Q., Carle D. O., Pilli A., Willingham T., Lazorchak J. M. Effects of pollution on freshwater organisms. J. Water Pollut. Control Fed. 61:1989;998-1042.
86. Pickering Q. H., Hunt E. P., Phipps G. L., Roush T. H., Smith W. E., Spehar D. L., Stephan C. E., Tanner D. K. Effects of pollution on freshwater fish and amphibians. J. Water Pollut. Control Fed. 55:1983;840-863.
87. Poirier S. H., Knuth M. L., Anderson-Buchou C. D., Brooke L. T., Lima A. R., Shubat P. J. Comparative toxicity of methanol andN,N, Bull. Environ. Contam. Toxicol. 37:1986;615-621.
88. Qureshi A. A., Coleman R. N., Paran J. H. Evaluation and refinement of the Microtox test for use in toxic screening. Liu D., Dutka B. J. Toxicity Screening Procedures Using Bacterial Systems. 1984;Dekker, New York.
89. A. A. Qureshi, K. W. Flood, S. K. Thompson, S. M. Janhurst, C. S. Inniss, D. A. Rokosh, 1982, Comparison of a luminescent bacterial test with other bioassays for determining toxicity of pure compounds and complex effluents, Aquatic Toxicology and Hazard Assessment: Fifth Conference, J. G. PearsonR. B. FosterW. E. Bishop, 179, 195, American Society for Testing and Materials, Philadelphia, PA.
90. Ribo J. M., Kaiser K. L. E. Effects of selected chemicals to photoluminescent bacteria and their correlations with acute and sublethal effects on other organisms. Chemosphere. 12:1983;1421-1442.
91. Richter J. E., Peterson S. F., Kleiner C. F. Acute and chronic toxicity of some chlorinated benzenes, chlorinated ethanes, and tetrachloroethylene toDaphnia magna. Arch Environ. Contam. Toxicol. 12:1983;679-684.
92. Rippen G. Handbuch Umweltchemikalien. 1993;Ecomed, Landsberg/Lech.
93. Saarikoski J., Viluksela M. Influence of pH on the toxicity of substituted phenols to fish. Arch. Environ. Contam Toxicol. 10:1982a;747-753.
94. Saarikoski J., Viluksela M. Relation between physiochemical properties of phenols and their toxicity and accumulation in fish. Ecotoxicol. Environ. Saf. 6:1982b;501-512.
95. Sletten O., Burbank N. C. A respirometric screening test for toxic substances. Eng. Bull. Purdue Univ. Eng. Ext. Ser. 141:1972;24-32.
96. Sloof W. Benthic macroinvertebrates and water quality assessment: Some toxicological considerations. Aquat. Toxicol. 4:1983;73-82.
97. Sloof W., Canton J. H., Hermens J. L. M. Comparison of the susceptibility of 22 freshwater species to 15 chemical compounds. I. Subacute toxicity tests. Aquat. Toxicol. 4:1983;113-128.
98. Smith A. D., Bharath A., Mallard C., Orr D., Smith K., Sutton J. A., Vukmanich J., McCarty L. S., Ozburn G. W. The acute and chronic toxicity of ten chlorinated organic compounds to the American flagfish (Jordanella floridae. Arch. Environ. Contam. Toxicol. 20:1991;94-102.
99. Spehar R. L., Lemke A. E., Pickering Q. H., Roush T. H., Russo R. C., Yount J. D. Effects of pollution of freshwater fish. J. Water Pollut. Control Fed. 53:1981;1028-1077.
100. Spehar R. L., Nelson H. P., Swanson M. J., Renoos J. W. Pentachlorophenol toxicity to amphipods and fathead minnows at different test pH values. Environ. Toxicol. Chem. 4:1985;389-397.
101. Stephenson G. L., Kaushik N. K., Solomon K. R. Acute toxicity of pure pentachlorophenol and a technical formulation to three species ofDaphnia. Arch. Environ. Contam. Toxicol. 20:1991;73-80.
102. Streit B. Lexikon Toxikologie. 1991;VCH Verlagsgesellschaft, Weinheim. p. 731-731.
103. Suter G. W., Rosen A. E. Comparative toxicology for risk assessment of marine fishes and crustaceans. Environ. Sci. Technol. 22:1988;548-556.
104. Takahashi I. T., Cowgill U. M., Murphy P. G. Comparison of ethanol toxicity toDaphnia magnaCeriodaphnia dubia. Bull. Environ. Contam. Toxicol. 39:1987;229-236.
105. 50Nitocra spinipes. Ecotoxicol. Environ. Saf. 11:1986;127-143.
106. Thurston r. V., Gilfoil T. A., Meyn E. L., Zajdel R. K., Aoki T. I., Veith G. D. Comparative toxicity of ten organic chemicals to ten common aquatic species. Water Res. 19:1985;1145-1155.
107. Vaishnav D. D., Korthals E. T. Comparative toxicities of selected industrial chemicals to microorganisms and other aquatic organisms. Arch. Environ. Contam. Toxicol. 19:1990;624-628.
108. Veith G. D., Call D. J., Brooke L. T. Structure-toxicity relationships for the fathead minnow.Pimephales promelas: Can. J. Fish. Aquat. Sci. 40:1983a;743-748.
109. Veith G. D., Call D. J., Brooke L. T. Estimating the acute toxicity of narcotic industrial chemicals to fathead minnows. Bishop W. E., Cardwell R. D., Heidolph B. B. Aquatic Toxicology and Hazard Assessment: Sixth Symposium. 1983b;90-97 American Society for Testing and Materials, Philadelphia.
110. Verschueren K. Handbook of Environmental Data on Organic Chemicals. 1983;Van Nostrand Reinhold, New York.
111. Walbridge C. T., Fiandt J. T., Phipps G. L., Holcombe G. W. Acute toxicity of ten chlorinated aliphatic hydrocarbons to the fathead minnow (Pimephales promelas. Arch. Environ. Contam. Toxicol. 12:1983;661-666.
112. Walker J. D. Relative sensitivity of algae, bacteria, invertebrates, and fish to phenol: Analysis of 234 tests conducted for more than 149 species. Toxic. Assess. 3:1988;415-447.
113. Walker J. D. Effects of chemicals on microorganisms. J. Water Pollut. Control Fed. 61:1989;1077-1097.
114. Ward G. S., Tolmsoff A. S., Petrocelli S. R. Acute toxicity of trichlorethylene to saltwater organisms. Bull. Environ. Contam. Toxicol. 37:1986;830-836.
115. Wellens H. Vergleich der Empfindlichkeit vonBrachydanio rarioLeuciscus idus. Z. Wasser Abw. Forsch. 15:1982;49-52.
116. WHO, 1985, Trichloroethylene, World Health Organisation, Geneva.
117. WHO, 1990a, Vinylidene Chloride, World Health Organisation, Geneva.
118. WHO, 1990b, 1-Propanol, World Health Organisation, Geneva.
119. WHO, 1991, Chlorobenzenes Other than Hexachlorobenzene, World Health Organisation, Geneva.
120. Yoshioka Y., Mizuno T., Ose Y., Sato T. Correlation of five test methods to assess chemical toxicity and relation to chemical properties. Ecotoxicol. Environ. Safety. 12:1986;15-21.
121. Zar J. H. Biostatistical Analysis. 1984;Prentice-Hall, Englewood Cliffs.
122. Ziegenfuss P. S., Renaudette W. J., Adams W. J. Methodology for assessing the acute toxicity of chemicals sorbed to sediments: Testing the equilibrium partitioning theory. Poston T. M., Purdy R. Aquatic Toxicology and Environmental Fate. 1986;479-493 American Society for Testing and Materials, Philadelphia.