Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 2, 1997, Pages 393-396

  Kerdesky, Francis A J ^a   Brooks, Clint D W ^a   Hulkower, Keren I ^a   Bouska, Jennifer B ^a   Bell, Randy L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTIBUFEN; IBUFENAC; IBUPROFEN; LIPOXYGENASE INHIBITOR; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; THIAZOLE DERIVATIVE; ZILEUTON;

ARTICLE; BLOOD; CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUTROPHIL; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS;

EID: 0031081773     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00255-6     Document Type: Article

References (12)

1. 1. Lombardino, J. G. Nonsteroidal Antiinflammatory Drugs; Wiley-Interscience: New York, 1985.
2. 2. Vane, J. R. Nature (Lond.) 1971, 231, 232.
3. 3. Samuelsson, B. Science 1983, 220, 568.
4. 4. (a) Lewis, R. A.; Austen, K. F.; Soberman, R. J. New Engl. J. Med. 1990, 323, 645.
5. (b) Henderson, W. R. Ann. Intern. Med. 1994, 121, 684.
6. 5. Brooks, D. W.; Carter, G. W. In The Search for Anti-Inflammatory Drugs; Merluzzi, V. J.; Adams, J., Eds.; Birkhauser: Boston, 1995; Chapter 5, pp 129-160.
7. 6. Carter, G. W.; Young, P. R.; Albert, D. H.; Bouska, J.; Dyer, R.; Bell, R. L.; Summers, J. B.; Brooks, D. W. J. Pharmacol. Exp. Ther. 1991, 256, 929.
8. 7. Israel, E.; Rubin, P.; Kemp, J. P.; Grossman, J.; Pierson, W.; Siegel, S. C.; Tinkelman, D.; Murray, J. J.; Busse, W.; Segal, A. T.; Fish, J.; Kaiser, H. B.; Ledford, D.; Wenzel, S.; Rosenthal, R.; Cohn, J.; Lanni, C.; Perlman, H.; Karahalios, P.; Drasen, J. M. Ann. Intern. Med. 1993, 119, 1059.
9. 8. Walsh, D. A.; Lo, Y. S.; Shamblee, D. A.; Welstead, W. J.; Nolan, J. C.; Graff, G. J. Med. Chem. 1990, 33, 2070.
10. 9. Musser, J. H.; Kreft, A. F. J. Med. Chem. 1992, 35, 2502.
11. 10. Kerdesky, F. A. J.; Holms, J. H.; Moore, J. L.; Bell, R. L.; Dyer, R. D.; Carter, G. W.; Brooks, D. W. J. Med. Chem. 1991, 34, 2158.
12. 11. Brooks, D. W.; Kerdesky, F. A. J. U.S. Patent 5,032,588, 16 July 1991.