Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines

International Journal of Hematology

Volumn 65, Issue 2, 1997, Pages 115-121

  Miyamura, Tomoya ^a   Nishimura, Junji ^a   Yufu, Yuji ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

BCR ABL; pRB; Signal transduction

Indexed keywords

BCR ABL PROTEIN; RETINOBLASTOMA PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031081349     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0925-5710(96)00539-7     Document Type: Article

References (23)

1. [1] Fialkow PJ, Martin PJ, Najfeld V, Penfold GK, Jacobson RJ, Hansen J A. Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 1981;58:158-163.
2. [2] Kurzrock R, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 1988;319:990-998.
3. [3] Witte ON. Role of BCR-ABL oncogene in human leukemia: Fifteenth Richard and Hinda Rosenthal Foundation Award lecture. Cancer Res 1993;53:485-489.
4. [4] Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 1984;37:1035-1042.
5. [5] Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products. Mol Cell Biol 1985;5:3116-3123.
6. [6] Pendergast AM, Muller AJ, Havlik MH, Clark R, McCormick F, Witte ON. Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. Proc Natl Acad Sci USA 1991;88:5927-5931.
7. [7] Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a nonphosphotyrosine-dependent manner. Cell 1991;66:161-171.
8. [8] McWhirter JR, Wang JWJ. Activation of tyrosine kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins. Mol Cell Biol 1991;11:1553-1565.
9. [9] Muller AJ, Young JC, Pendergast AM et al. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 1991;11:1785-1792.
10. [10] Young JC, Witte ON. Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid and myeloid cultures. Mol Cell Biol 1988;8:4079-4087.
11. bcr abl protein. Proc Natl Acad Sci USA 1988;85:9312-9316.
12. bcr abl gene of the Philadelphia chromosome. Science 1990;247:824-830.
13. [13] Laneuville P, Sun G, Timm M, Vekemans M. Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of P210bcr abl. Blood 1992;80:1788-1797.
14. [14] Hamel PL, Phillips RA, Muncaster M, Gallie B J. Speculation of the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression. FASEB J 1993;7:846-854.
15. [15] Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243:934-937.
16. [16] Hu Q, Dyson N, Harlow E. The region of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J 1990;9:1147-1155.
17. [17] Hiebert S W. Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol Cell Biol 1993;13:3384-3391.
18. [18] Lin B TY, Wang JYJ. Cell cycle regulation of retinoblastoma protein phosphorylation. Ciba Foundation Symp 1992;170:227-243.
19. [19] Welch PJ, Wang JYJ. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 1993;75:779-790.
20. + ALL involve GTPase-activating protein, phospholipase C-γl, and phosphatidylinositol 3′-kinase. Leukemia 1994;8:115-120.
21. [21] Puil L, Liu J, Gish G et al. Bcr-Abl oncoproteins bind directory to activators of the Ras signaling pathway. EMBO J 1994;13:764-773.
22. [22] Tauchi T, Boswell HS, Leibovvitz D, Broxmeyer HE. Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to Ras activation pathway. J Exp Med 1994;179:167-175.
23. [23] Qin XQ, Chittenden T, Livingston DM, Kaelin WG. Identification of a growth suppression domain within the retinoblasloma gene product. Genes Dev 1992;6:953-964.