Thermolysin-inhibitor binding: Effect of the His231 → Ala mutation on the relative affinities of thiolate versus phosphoramidate inhibitors - A model theoretical investigation incorporating a continuum reaction field hydration model

Biopolymers

Volumn 41, Issue 2, 1997, Pages 145-164

  Gresh, Nohad ^a   Roques, Bernard Pierre ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSTS; ENZYME INHIBITION; HYDRATION; MODELS; MOLECULES; MUTAGENESIS;

CARBOXYLATE; HYDROXAMATE; MUTATION; PHOSPHORAMIDATE; THERMOLYSIN; THIOLATE;

PROTEINS;

PHOSPHORAMIDATE INHIBITOR; THERMOLYSIN; THERMOLYSIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME INHIBITION; HYDRATION; INHIBITION KINETICS; MATHEMATICAL MODEL; MOLECULAR INTERACTION; PROTEIN BINDING; REACTION ANALYSIS;

EID: 0031081157     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0282(199702)41:2<145::aid-bip3>3.0.co;2-t     Document Type: Article

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