Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum

Behavioural Brain Research

Volumn 83, Issue 1-2, 1997, Pages 201-204

  Nitta, Atsumi ^a,b   Ogihara, Yoshiko ^a   Onishi, Joji ^a   Hasegawa, Takaaki ^a   Furukawa, Shoei ^b   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

choline acetyltransferase; dementia model; learning and memory; nerve growth factor (NGF); propentofylline; rat

Indexed keywords

CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; NERVE GROWTH FACTOR ANTIBODY; PROPENTOFYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DEMENTIA; LEARNING; MALE; MEMORY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0031081103     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)86069-X     Document Type: Conference Paper

References (19)

1. [1] Banati, R.B., Gehrmann, J., Schubert, P. and Kreutzberg, G.W., Cytotoxicity of microglia, Glia, 7 (1993) 111-115.
2. [2] Bartus, R.T., Dean, R.L., Beer, B. and Lippa, A.S., The cholinergic hypothesis of geriatric memory dysfunction, Science, 217 (1982) 408-417.
3. [3] Ellman, G.L., Courtney, K.D., Andres, V.A., Jr. and Featherstone, R.M., A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem. PharmacoL., 7 (1961) 88-95.
4. [4] Hefti, F., Dravid, A. and Hartikka, J., Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions, Brain Res., 293 (1984) 305-311.
5. [5] Friden, P.M., Walus, L.R., Watson, P., Doctrow, S.R., Kozarich, J.W., Backman, C., Bergman, H., Hoffer, B., Bloom, F. and Granholm, A.C., Blood-brain barrier penetration and in vivo activity of an NGF conjugate, Science, 259 (1993) 373-377.
6. [6] Fuji, K., Hiramatsu, M., Kameyama, T. and Nabeshima, T., Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats, Eur. J. Pharmacol., 236 (1993) 411-417.
7. [7] Honegger, P. and Lenoir, D., Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures, Dev. Brain Res., 3 (1982) 229-238.
8. [8] Kaneda, N. and Nagatsu, T., Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electrochemical detection, J. Chromatogr., 341 (1985) 23-30.
9. [9] Mrsulja, B.B., Micic, D.V. and Djuricic, B.M., Gerbil stroke model: an approach to the study of therapeutic aspects of post-ischemic brain edema, Adv. Biosci., 43 (1983) 45-62.
10. [10] Nabeshima, T., Nitta, A. and Hasegawa, T., Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (3): oral administration of propentofylline produces recovery of reduced NGF content in the brain of aged rats, Jpn. J. Psychopharmaco., 13 (1993) 89-95.
11. [11] Nitta, A., Hayashi, K., Hasegawa, T. and Nabeshima, T., Development of plasticity of brain function with repeated trainings and passage of time after basal forebrain lesions in rats, J. Neural Transm. Gen. Sect., 93 (1993) 37-46.
12. [12] Nitta, A., Murakami, Y., Furukawa, Y., Kawatsura, W., Hayashi, K., Yamada, K., Hasegawa, T. and Nabeshima, T., Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats, Naunyn-Schmiedeberg's Arch. Pharmacol., 349 (1994) 401-407.
13. [13] Nitta, A., Murase, K., Furukawa, Y., Hayashi, K., Hasegawa, T. and Nabeshima, T., Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats, Neuroscience, 57 (1993) 495-499.
14. 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report), J. Neural Transm. Parkinson's Dis. Dementia Sect., 4 (1992) 79-95.
15. [15] Paxinos, G. and Watson, C., The Rat Brain in the Stereotaxic Coordinates, Academic Press, North Ryde, 1986.
16. [16] Shinoda, I., Furukawam, Y. and Furukawa, S., Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells, Biochem. Pharmacol., 49 (1990) 1813-1816.
17. [17] Sims, N.R., Bowen, D.M., Allen, S.J., Smith, C.C.T., Neary, D., Thomas, D.J. and Davison, A.N., Presynaptic cholinergic dysfunction in patients with dementia, J. Neurochem., 40 (1983) 503-509.
18. [18] Stefanovich, V. and Nagata, K., Effects of propentofylline and cinepazide on cerebral energy metabolism in nitrogen breathing rats, IRCS Med. Sci., 11 (1983) 972.
19. [19] Winkler, J., Suhr, S.T., Gage, F.H., Thai, L.J. and Fisher, L.J., Essential role of neocortical acetylcholine in spatial memory, Nature, 375 (1995) 484-487.