Measurement of Lactate Levels in Serum and Bile Using Proton Nuclear Magnetic Resonance in Patients with Hepatobiliary Diseases: Its Utility in Detection of Malignancies

Japanese Journal of Clinical Oncology

Volumn 27, Issue 1, 1997, Pages 13-17

  Nishijima, Tatsushige ^a   Nishina, Masami ^a   Fujiwara, Kenji ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

1H NMR lactate; Carcinoma; Carcinoma of the biliary tract; Hepatocellular

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; DECARBOXYPROTHROMBIN; LACTIC ACID; PROTEIN PRECURSOR; PROTHROMBIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BILE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; BLOOD; CHEMISTRY; CHOLELITHIASIS; FEMALE; GALLBLADDER TUMOR; HUMAN; INTRAHEPATIC BILE DUCT; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY;

ADULT; AGED; ALPHA-FETOPROTEINS; BILE; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; CHOLELITHIASIS; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; LACTIC ACID; LIVER DISEASES; LIVER NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PROTEIN PRECURSORS; PROTHROMBIN; TUMOR MARKERS, BIOLOGICAL;

EID: 0031068623     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/27.1.13     Document Type: Article

References (12)

1. Farrar TC, Becker ED. Pulse and Fourier Transform NMR. New York: Academic Press, 1971
2. Nicholson JK, Sadler PJ, Bales JR, Juul SM, MacLeod AF, Sonken PH. Monitoring metabolic diseases by proton NMR of urine. Lancet 1984;2:751-52.
3. Bell JD, Brown JCC, Nicholson IK, Sadler PJ Assignment of resonance for acute phase glycoproteins in high resolution proton NMR spectra of human blood. FEBS Lett 1987;215:311-5.
4. Rabenstein DL, Millis KK, Strauss EJ. Proton NMR spectroscopy of human blood plasma and red cells. Anal Chem 1988;60:1380A-91A.
5. Con CF, Cori GT. The carbohydrate metabolism tumors. 1. The free sugar, lactic acid, and glycogen content of malignant tumors. J Biol Chem 1925;64:11-22.
6. Haug H, Schramm C. Metabolic pattern of free amino acids, glucose, lactic acid, pyruvic acid, fatty acids, BUN, uric acid. etc. in serum of 21 healthy persons and 24 patients with malignant tumors. Clin Chem 1975;21:1025
7. Bales JR, Higham M, Howe I, Nicholson JK, Sadler PJ. Use of high resolution nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urin. Clin Chem 1984;30:426-32.
8. Hadjivassiliou AG, Pieder SV. The enzymatic assay of pyruvic and lactic acids. A diffinitive procedure. Clin Chim Acta 1968;19:357-61.
9. Nicholson JK, Wilson ID. High resolution proton magnetic resonance spectroscopy of biological fluid. Prog NMR Spectr 1989;21:449-501.
10. Halvorsen RA Jr, Riberio A, Blinder R, Waters C, Thompson WM. Magnetic resonance spectroscopy of bile. In vitro stability over time and component identity. Invest Radiol 1989;24:903-08.
11. Lee H-S, Chung YH, Kim CY. Specificities of serum alphafetoprotein in HBsAg+ and HBsAg- patients in the diagnosis of hepatocellular carcinoma. Hepatology 1991;14:68.
12. Ohsaka A, Yoshikawa K, Matsuhashi T Detection by proton nuclear magnetic resonance of elevated lactate concentration in serums from patients with malignant tumors. Jpn J Med Sci Biol 1979;32:305-9.