Morphine pharmacokinetics during continuous infusion of morphine sulfate for infants receiving extracorporeal membrane oxygenation

Critical Care Medicine

Volumn 25, Issue 2, 1997, Pages 350-364

  Geiduschek, Jeremy M ^a,c   Lynn, Anne M ^a   Bratton, Susan L ^a   Sanders, John C ^a   Levy, Fiona H ^b   Haberkern, Charles M ^a   O'Rourke, P Pearl ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

analgesics; dr ug metabolism; extracorporeal membrane oxygenation; infants; morphine; opioid; pediatrics; pharmacokinetics; pulmonary hypertension

Indexed keywords

MORPHINE SULFATE; MORPHINE;

ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; EXTRACORPOREAL OXYGENATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NEWBORN; NEWBORN INTENSIVE CARE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; TREATMENT OUTCOME; BLOOD; GESTATIONAL AGE; METABOLIC CLEARANCE RATE; METABOLISM; PROSPECTIVE STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXTRACORPOREAL MEMBRANE OXYGENATION; GESTATIONAL AGE; HUMANS; HYPERTENSION, PULMONARY; INFANT, NEWBORN; INFUSIONS, INTRAVENOUS; INTENSIVE CARE UNITS, NEONATAL; METABOLIC CLEARANCE RATE; MORPHINE; PROSPECTIVE STUDIES;

EID: 0031068258     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199702000-00027     Document Type: Article

References (19)

1. Levy FH, O'Rourke PP, Crone RK: Extracorporeal membrane oxygenation. Anesth Analg 1992; 75:1053-1062
2. Rosen D, Rosen K, Davidson B, et al: Fentanyl uptake by the Scimed membrane oxygenator. J Cardiothor Anesth 1988; 2:619-626
3. Green TP, Isham-Schopf B, Irmiter RJ, et al: Inactivation of heparin during extracorporeal circulation in infants. Clin Pharmacol Ther 1990; 48:148-154
4. Cohen P, Collart L, Prober CG, et al: Gentamicin pharmacokinetics in neonates undergoing extracorporeal membrane oxygenation. Pediatr Infect Dis J 1990; 9:562-566
5. Hoie EB, Swigart SA, Leuschen MP, et al: Vancomycin pharmacokinetics in infants undergoing extracorporeal membrane oxygenation. Clinical Pharmacy 1990; 9:711-715
6. Munzenberger PJ, Massoud N: Pharmacokinetics of gentamicin in neonatal patients supported with extracorporeal membrane oxygenation. ASAIO Transactions 1991; 37:16-18
7. Möller JC, Gilman JT, Kearns GL, et al: Effect of extracorporeal membrane oxygenation on tobramycin pharmacokinetics in sheep. Crit Care Med 1992; 20:1454-1458
8. Bhatt-Mehta V, Johnson CE, Shumacher RE: Gentamicin pharmacokinetics in term neonates receiving extracorporeal membrane oxygenation. Pharmacotherapy 1992; 12:28-32
9. Wells TG, Fasules JW, Taylor BJ, et al: Pharmacokinetics and pharmacodynamics of bumetanide in neonates treated with extracorporeal membrane oxygenation. J Pediatr 1992; 121: 974-980
10. Leuschen MP, Willett LD, Hoie EB, et al: Plasma fentanyl levels in infants undergoing extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 1993; 105:885-891
11. Dagan O, Klein J, Gruenwald C, et al: Preliminary studies of the effects of extracorporeal membrane oxygenator on the disposition of common pediatric drugs. Ther Drug Monit 1993; 15: 263-266
12. McRorie TI, Lynn AM, Nespeca MK, et al: The maturation of morphine clearance and metabolism. American Journal of Diseases in Children 1992; 146: 972-976
13. Pokela M-L, Olkkola KT, Seppälä T, et al: Age-related morphine kinetics in infants. Developmental Pharmacology and Therapeutics 1993; 20:26-34
14. Lynn AM, Opheim KE, Tyler DC: Morphine infusion after pediatric cardiac surgery. Crit Care Med 1984; 12: 863-866
15. Arnold JH, Truog RD, Orav EJ, et al: Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology 1990; 73:1136-1140
16. Dagan O, Klein J, Bohn D, et al: Effects of extracorporeal membrane oxygenation on morphine pharmacokinetics in infants. Crit Care Med 1994; 22: 1099-1101
17. Vanderberghe H, Macleod S, Chinyanga H, et al: Pharmacokinetics of intravenous morphine in balanced anesthesia: Studies in children. Drug Metab Rev 1983; 14:887-903
18. Choonara IA, McKay P, Hain R, et al: Morphine metabolism in children. Br J Clin Pharmacol 1989; 28:599-604
19. Osborne R, Joel S, Trew D, et al: Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther 1990; 47:12-19