On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells

Journal of Molecular Neuroscience

Volumn 8, Issue 1, 1997, Pages 29-44

  Kontny, Ewa ^a   Ciruela, Francisco ^a,b   Svenningsson, Per ^a   Ibáñez, Carlos F ^c   Fredholm, Bertil B ^a  

^a INSTITUTE OF RHEUMATOLOGY   (Poland)

^b UNIVERSITY OF BARCELONA   (Spain)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Calcium; Neurite outgrowth; Neurotrophins; Phospholipase C; Protein kinase C; Transcription factors

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOTRANSFERASE; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; TRANSCRIPTION FACTOR AP 1;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETIC TRANSFECTION; METABOLISM; NEURITE; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; NERVE GROWTH FACTORS; NEURITES; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0031067491     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02736861     Document Type: Article

References (58)

1. Andrews N. C. and Faller D. V. (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19, 2499.
2. Angel P. and Karin M. (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157.
3. LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13, 203-215.
4. Bartel D. P., Sheng M., Lau L. F., and Greenberg M. (1989) Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Develop. 3, 304-313.
5. Benedetti M., Levi A., and Chao M. V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc. Natl. Acad. Sci. USA 90, 7859-7863.
6. Berg M. M., Sternberg D. W., Parada L. F., and Chao M. V. (1992) K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. Biol. Chem. 267, 13-16.
7. Berridge M. J., Dawson R. M. C., Downes C. P., Helson J. P., and Irvine R. R. (1983) Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem. J. 212, 473-492.
8. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-294.
9. Braselmann S., Bergers G., Wrighton C., Graninger P., Superti-Furga G., and Busslinger M. (1992) Identification of Fos target genes by the use of selective induction systems. J. Cell. Sci. Suppl. 16, 97-109.
10. Chao M. V., Bothwell M. A., Ross A. H., Koprowski H., Lanahan A. A., Buck C. R., and Seghal A. (1986) Gene transfer and molecular cloning of the human NGF receptor. Science 232, 518-521.
11. Chao M. V. (1992) Neurotrophin receptors: a window into neuronal differentiation. Neuron 9, 583-593.
12. Chao C. P., Laulederkind S. J., and Ballou L. R. (1994) Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization. J. Biol. Chem. 269, 5849-5856.
13. Chao M. V. and Hempstead B. L. (1995) p75 and Trk: a two receptor system. Trends Neurosci. 18, 321-326.
14. Chodosh L. A., Baldwin A. S., Carthew R. W., and Sharp P. A. (1988) Human CCAAT-binding proteins have heterologous subunits. Cell 53, 11-24.
15. Contreras M. L. and Guroff G. (1987) Calcium-dependent nerve growth factor-stimulated hydrolysis of phosphoinositides in PC12 cells. J. Neurochem. 48, 1466-1472.
16. Contreras M. L. (1993) Nerve growth factor stimulates the production of inositol 1,3,4- and 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in PC12 cells. J. Neurochem. 61, 1035-1042.
17. Davies A. M., Lee K.-F., and Jaenisch R. (1993) p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11, 565-574.
18. Dobrowsky R. T., Werner M. H., Castellino A. M., Chao M. V., and Hannun Y. A. (1994a) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265, 1596-1599.
19. Dobrowsky R. T., Werner M. H., Castellino A. M., Chao M. V., and Hannun Y. A. (1994b) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265, 1596-1599.
20. Freire-Moar J., Cherwinski H., Huang F., Ransom J., and Webb D. (1991) Expression of protein kinase C isoenzymes in thymocyte subpopulations and their differential regulation. J. Immunol. 147, 405-109.
21. Gerwins P. (1993) Modification of a competitive protein binding assay for determination of inositol 1,4,5-trisphosphate. Anal. Biochem. 210, 45-49.
22. Ginty D. D., Bonni A., and Greenberg M. E. (1994) Nerve growth factor activates a ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77, 713-725.
23. Gold M. R., Duronio V., Saxena S. P., Schrader J. W., and Aebersold R. (1994) Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins. J. Biol. Chem. 269, 5403-5412.
24. Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
25. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
26. Hantzopoulos P. A., Suri C., Glass D. J., Goldfarb M. P., and Yancopoulos G. D. (1994) The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13, 187-201.
27. Hartman D. S., McCormack M., Schnubenel R., and Hertel C. (1992) Multiple trkA proteins in PC12 cells bind NGF with a slow association rate. J. Biol. Chem. 267, 24,515-24,522.
28. NGFR. J. Neurochem. 63, 1261-1270.
29. Ito E., Sonnenberg J. L., and Narayanan R. (1989) Nerve growth factor induced differentiation in PC-12 cells is blocked by fos oncogene. Oncogene 4, 1193-1199.
30. Kahle P., Burton L. E., Schmelzer C. H., and Hertel C. (1992) The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA. J. Biol. Chem. 267, 22,707-22,710.
31. Kaplan D. R., Martin-Zanca D., and Parada L. F. (1991) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.
32. Klein R., Jing S., Nanduri V., O'Rourke E., and Barbacid M. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189-197.
33. 3 responses in PC12 cells. Different pathways. FEBS Lett. 324, 147-152.
34. Kolesnick R. and Golde D. W. (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328.
35. Lee W., Mitchell P., and Tjian R. (1987) Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49, 741-752.
36. Lee K.-F., Li E., Huber L. J., Landis S. C., Sharpe A. H., Chao M. V., and Jaenisch R. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
37. Lee K.-F., Bachman K., Landis S., and Jaenisch R. (1994) Dependence on p75 for innervation of some sympathetic targets. Science 263, 1447-1449.
38. Loeb D. M. and Greene L. A. (1993) Transfection with trk restores "slow" NGF binding, efficient NGF uptake and multiple NGF responses to NGF-non-responsive PC12 cell mutants. J. Neurosci. 13, 2919-2929.
39. Martin-Zanca D., Oskam R., Mitra G., Copeland T., and Barbacid M. (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell Biol. 9, 24-33.
40. Meakin S. O. and Shooter E. M. (1992) The nerve growth factor family of receptors. Trends Neurosci. 15, 323-331.
41. Nakafuku M., Satoh T., and Kaziro Y. (1992) Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras-GTP complex in rat pheochromocytoma PC12 cells. J. Biol. Chem. 267, 19,448-19,454.
42. Qiu M.-S. and Green S. H. (1992) PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity. Neuron 9, 705-717.
43. Radeke M. J., Misko T. P., Hsu C., Herzenberg L. A., and Shooter E. M. (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325, 593-597.
44. trk in PC12 cells. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 269, 255-264.
45. Riabowol K., Schiff J., and Gilman M. Z. (1992) Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc. Natl. Acad. Sci. USA 89, 157-161.
46. Rovelli G., Heller R. A., Canossa M., and Shooter E. M. (1993) Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cells. Proc. Natl. Acad. Sci. USA 90, 8717-8721.
47. Ryden M., Murray-Rust J., Glass D., Ilag L. L., Trupp M., Yancopoulos G. D., McDonald N. Q., and Ibanez C. F. (1995) Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling. EMBO J. 14, 1979-1990.
48. Sheng M. and Greenberg M. E. (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4, 477-485.
49. Smith C. A., Farrah T., and Goodwin R. G. (1994) The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76, 959-962.
50. Stephens R. M., Loeb D. M., Copeland T. D., Pawson T., Greene L. A., and Kaplan D. R. (1994) Trk receptors use redundant signal transduction pathways involving SHC and PLC-gammal to mediate NGF responses. Neuron 12, 691-705.
51. Taylor L. K., Marshak D. R., and Landreth G. E. (1993) Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos. Proc. Natl. Acad. Sci. USA 90, 368-372.
52. Taylor L. K., Swanson K. D., Kerigan J., Mobley W., and Landreth G. E. (1994) Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J. Biol. Chem. 269, 308-318.
53. Varticovski L., Harrison-Findik D., Keeler M. L., and Susa M. (1994) Role of PI 3-kinase in mitogenesis. Biochim. Biophys. Acta 1226, 1-11.
54. LNGFR regulates trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12, 733-745.
55. Vetter M. L., Martin-Zanca D., Parada L. F., Bishop J. M., and Kaplan D. R. (1991) Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. Proc. Natl. Acad. Sci. USA 88, 5650-5654.
56. Volonte C., Angelastro J. M., and Greene L. A. (1993) Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J. Biol. Chem. 268, 21,410-21,415.
57. Wooten M. W., Seibenhener M. L., Soh Y., Ewald S. J., White K. R., Lloyd E. D., Olivier A., and Parker P. J. (1992) Characterization and differential expression of protein kinase C isoforms in PC12 cells. Differentiation parallels an increase in PKC beta II. FEBS Lett. 298, 74-78.
58. Wu Y. Y. and Bradshaw R. A. (1993) Effect of nerve growth factor and fibroblast growth factor on PC12 cells: inhibition by orthovanadate. J. Cell. Biol. 121, 409-422.