Linomide Administration to Mice Attenuates the Induction of Nitric Oxide Synthase Elicited by Lipopolysaccharide-Activated Macrophages and Prevents Nephritis in MRL/Mp-lpr/lpr Mice

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1402-1408

  Hortelano, Sonsoles ^a   Díaz Guerra, María J M ^a   Gonzalez García, Ana ^c   Leonardo, Esther ^c   Gamallo, Carlos ^b   Boscá, Lisardo ^a   Martínez A , Carlos ^c  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGICAL ADJUVANT; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; QUINOLINOL DERIVATIVE; ROQUINIMEX;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; IMMUNOLOGY; KIDNEY; MACROPHAGE ACTIVATION; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NEPHRITIS; PATHOLOGY; SEPTIC SHOCK; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ENZYME INDUCTION; HYDROXYQUINOLINES; KIDNEY; LIPOPOLYSACCHARIDES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGE ACTIVATION; MICE; MICE, INBRED MRL LPR; NEPHRITIS; NITRIC OXIDE SYNTHASE; SHOCK, SEPTIC;

EID: 0031066657     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Wanders, A., and H. Ekberg. 1993. New immunosuppressants: testing and development in animal models and the clinic with special reference to DSG. Immunol. Rev. 136:99.
2. Slavin, S., H. Sidi, L. Weiss, E. Rosenman, T. Kalland, and G. D. Gross. 1993. Linomide, a new treatment for autoimmune diseases: the potential in type 1 diabetes. Diabetes Metab. Rev. 9:311.
3. Johnsson, C., and G. Tufveson. 1994. The immunomodulator LS-2616 (linomide) more effectively than sensitization of the donor enhances graft-versus-host reaction after small bowel transplantation. Transplant. Immunol. 2:56.
4. Wanders, A., P. Vogt, A. Karlsson-Parra, K. Wonigkeit, B. Gerdin, and G. Tufveson. 1991. Evidence that LS-2616 (linomide) causes acute rejection of rat allografts protected by cyclosporine but not of long-term surviving allografts. Transplantation 52:234.
5. Wanders, A., E. Larsson, B. Gerdin, and G. Tufveson. 1989. Abolition of the effect of cyclosporine A on rat cardiac allograft rejection by the new immunomodulator LS2616 (linomide). Transplantation 47:216.
6. Kalland, T. 1986. Effects of the immunomodulator LS 2616 on growth and metastasis of the murine melanoma. Cancer Res. 46:3018.
7. Vukanovic, J., and J. T. Isaacs. 1995. Linomide inhibits angiogenesis, growth, metastasis and macrophage infiltration within rat prostatic cancers. Cancer Res. 55:1499.
8. Gonzalo, J. A., A. González-García, T. Kalland, G. Hedlung, C. Martínez-A., and G. Kroemer. 1994. Linomide inhibits programmed cell death in peripheral T cells in vivo. Eur. J. Immunol. 24:48.
9. Gonzalo, J. A., A. González-García, T. Kalland, G. Hedlung, C. Martínez-A., and G. Kroemer. 1993. Linomide, a novel immunomodulator that prevents death in four models of septic shock. Eur. J. Immunol. 23:2372.
10. Bengtsson, M., B. Somonsson, B. Carlsson, B. Nilsson, B. Smedmyr, B. Termander, G. Oberg, and T. H. Totterman. 1992. Stimulation of NK cell, T cell and monocyte functions by the novel immunomodulator linomide after autologous bone marrow transplantation: a pilot study in patients with acute myeloid leukemia. Transplantation 53:882.
11. Rowe, J., D. Ryan, J. Dipersio, A. Gaspari, B. Nilsson, L. Larsson, J. Liesveld, P. Kouides, and B. Simonsson. 1993. Autografting in chronic myelogenous leukemia followed by immunotherapy. Stem Cells 11:34.
12. Theofilopoulos, A., and F. J. Dixon. 1985. Murine models of SLE. Adv. Immunol. 37:289.
13. Theofilopoulos, A. N., R. Kofler, P. A. Sinfer, and F. J. Dixon. 1989. Molecular genetics of murine lupus model. Adv. Immunol. 46:61.
14. 1 hybrid mice. Immunology 5:589.
15. Spetz-Hagberg, A.-L., T. J. Goldschmidt, T. Stalhandske, and E.-L. Larsson-Sciard. 1990. Amelioration of intrathymic T cell development and peripheral T cell reactivities in autoimmune mice undergoing therapy with a novel immunomodulator. Int. Immunol. 2:645.
16. Gross, D. J., H. Sidi, L. Weiss, T. Kalland, E. Rosenmann, and S. Slavin. 1995. Prevention of diabetes mellitus in non-obese diabetic mice by linomide, a novel immunomodulating drug. Diabetologia 37:1195.
17. Borgstrom, P., I. P. Torres-Filho, P. Vajkoczy, K. Strandgarden, J. Polacek, and B. Hartley. 1994. The quinoline-3-carboxamide linomide inhibits angiogenesis in vivo. Cancer Chemother. Pharmacol. 34:280.
18. Kuvanovic, J., A. Passaniti, T. Hirata, R. J. Traystman, B. Hartley, and J. T. Isaacs. 1992. Antitumor effects of the quinoline-3-carboxamide linomide on Dunning R-3327 rat prostatic cancers. Cancer Res. 52:3022.
19. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
20. Zhang, X., and D. C. Morrison. 1993. LPS-induced selective priming effects on tumor necrosis factor-α and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 177:511.
21. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FEBS J. 6:3051.
22. G-monomethyl-L-arginine. J. Exp. Med. 179:651.
23. Terenzi, F., M. J. M. Díaz-Guerra, M. Casado, S. Hortelano, S. Leoni, and L. Boscá. 1995. Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages. J. Biol. Chem. 270:6017.
24. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
25. Xie, Q-w., R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177:1779.
26. Möller, G., ed. 1990. Models of autoimmunity. Immunol. Rev. 118:5.
27. Wick, G., Y. Hu, S. Schwarz, and G. Kroemer. 1993. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocr. Rev. 14:539.
28. Cohen, P. L., and R. A. Eisenberg. 1991. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
29. Garchon, H.-J., P. Bedossam, L. Eloy, and J.-F. Bach. 1991. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulinitis in nonobese diabetic mice. Nature 353:260.
30. Prins, J. B., J. A. Todd, N. R. Rodrigues, S. Ghosh, P. M. Hogarth, L. S. Wicker, E. Gaffney, P. L. Podolin, P. A. Fischer, A. Sirotina, and L. B. Peterson. 1993. Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice. Science 260:695.
31. Moreno de Alboran, I., G. Kroemer, J. L. Andreu, E. Leonardo, M. A. R. Marcos, J. C. Gutierrez, and C. Martinez-A. 1992. Attenuation of autoimmune diseases and lymphocyte accumulation in MRL/lpr mice by treatment with anti Vb antibodies. Eur. J. Immunol. 22:2153.
32. Gutierrez-Ramos, J. C., J. L. Andreu, I. Moreno de Alboran, J. Rodriguez, E. Leonardo, G. Kroemer, M. A. R. Marcos, and C. Martinez-A. 1990. Insights into autoimmunity: from classical models to current perspectives. Immunol. Rev. 118:73.
33. Gutierrez-Ramos, J. C., J. L. Andreu, Y. Revilla, E. Viñuela, and C. Martínez-A. 1990. Recovery of autoimmune MRL/lpr with a recombinant IL-2-vaccinia virus infection. Nature 346:271.
34. Moreno de Alboran, I., J. C. Gutierrez, J. A. Gonzalo, J. L. Andreu, M. A. R. Marcos, G. Kroemer, and C. Martinez-A. 1992. lpr T cells vaccinate against lupus in MRL/lpr mice. Eur. J. Immunol. 22:1089.
35. Gonzalo, J. A., H. J. Schuurman, F. Uytdehaag, G. Wick, C. Martinez-A., and G. Kroemer. 1994. A single injection of SEB reduces autoimmunity in MRL/lpr mice. Clin. Immunol. Immunopathol. 71:106.
36. Nathan, C., and Q-W. Xie. 1994. Nitric oxide synthase: roles, tolls and control. Cell 78:915.
37. Huang, F.-P., G.-J. Feng, G. Lindop, D. L. Stott, and F. Y. Liew. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/Mp-lpr/lpr mice. J. Exp. Med. 183:1447.
38. McCartney-Francis, N., J. B. Allen, D. E. Mizel, J. E. Albina, Q.-W. Xie, C. F. Nathan, and S. M. Wahl. 1994. Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178:749.
39. Murray, L. J., R. Lee, and C. Martens. 1990. In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur. J. Immunol. 20:163.
40. Dang-vu, A. P., D. S. Pisetsky, and J. B. Weinberg. 1987. Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. J. Immunol. 138:1757.
41. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury of nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620.
42. Ischiropoulos, H. L., L. Zhu, and J. S. Beckman. 1992. Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys. 298:446.