Immunohistochemical study of cathepsin G and medullasin in inflamed gingival tissues from periodontal patients

Journal of Periodontal Research

Volumn 32, Issue 2, 1997, Pages 264-270

  Kunimatsu, K ^a   Ozaki, Y ^a   Hara, Y ^a   Aoki, Y ^b   Yamamoto, K ^c   Kato, I ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Cathepsin G; Immunohistochemistry; Medullasin; Periodontal disease; Serine proteinase

Indexed keywords

ANTIBODY; CATHEPSIN; CATHEPSIN G; DIAGNOSTIC AGENT; MEDULLASIN; SERINE PROTEINASE;

ADULT; ARTICLE; CELL GRANULE; CONNECTIVE TISSUE; ENZYME IMMUNOASSAY; ENZYMOLOGY; EPITHELIUM; FEMALE; FIBROBLAST; GINGIVA; GINGIVITIS; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MIDDLE AGED; NEUTROPHIL; PATHOLOGY; PERIODONTITIS; PERIODONTIUM; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM;

ADULT; ANTIBODIES; CATHEPSINS; CONNECTIVE TISSUE; CYTOPLASMIC GRANULES; ENDOTHELIUM, VASCULAR; EPITHELIAL ATTACHMENT; EPITHELIUM; FEMALE; FIBROBLASTS; GINGIVA; GINGIVITIS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MIDDLE AGED; NEUTROPHILS; PERIODONTAL POCKET; PERIODONTITIS; SERINE ENDOPEPTIDASES;

EID: 0031063446     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1997.tb00533.x     Document Type: Article

References (25)

1. Cimasoni G. Crevicular fluid updated. In: Myers HM, ed. Monographs in oral sciences. Basel: Karger, 1983; 1-152.
2. Curtis MA, Gillett IR, Griffiths GS, et al. Detection of high-risk groups and individuals for periodontal diseases. Laboratory markers from analysis of gingival crevicular fluid. J Clin Periodont 1989; 16: 1-11.
3. Fine DH, Mandel ID. Indicators of periodontal disease activity: an evaluation. J Clin Periodont 1986: 13: 533-546.
4. Uitto V-J. Human gingival proteases. I. Extraction and preliminary characterization of trypsin-like and elastaselike enzymes. J Periodont Res 1987; 22: 58-63.
5. Kennett CN, Cox SW, Eley BM. Comparative histochemical, biochemical and immunocytochemical studies of cathepsin B in human gingiva. J Periodont Res 1994; 29: 203-213.
6. Starkey PM, Barrett AJ, Burleigh MC. The degradation of articular collagen by neutrophil proteinases. Biochim Biophys Acta 1977; 483: 386-397.
7. Odeberg H, Ohlsson I. Antibacterial activity of cationic proteins from human granulocytes. J Clin Invest 1975; 56: 1118-1124.
8. Shafer WM, Onunka VC, Martin LE. Antigonococcal activity of human neutrophil cathepsin G. Infect Immun 1986; 54: 184-188.
9. Bangalore N, Travis J, Onunka VC, Pohl J, Shafer WM. Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J Biol Chem 1990; 265: 13584-13588.
10. Aoki Y, Sumiya M, Oshimi K. Medullasin enhances human natural killer cell activity. J Clin Invest 1982; 69: 1223-1230.
11. Aoki Y, Machinami R. Medullasin in inflammation (part II). Asian Med J 1983; 26: 15-37.
12. Aoki Y, Fukuchi K. Medullasin enhances human natural killer cell activity by a mechanism other than the induction of interferons or interleukin-2. Jpn J Cancer Res (Gann) 1987; 78: 74-79.
13. Kunimatsu K, Ichimaru E, Kato I, et al. Granulocyte medullasin levels in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects. J Periodont Res 1990; 25: 352-357.
14. Kunimatsu K, Mine N, Kato I, Hase T, Aoki Y, Yamamoto K. Possible functions of human neutrophil serine proteinases, medullasin and cathepsin G, in periodontal tissue breakdown. J Periodont Res 1993; 28: 547-549.
15. Kunimatsu K, Mine N, Muraoka Y, et al. Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects. J Periodont Res 1995; 30: 51-57.
16. Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967; 38: 610-616.
17. Hase-Yamazaki T, Aoki Y. Stimulation of human lymphocyte by cathepsin G. Cell Immunol 1995; 160: 24-32.
18. Aoki Y. Crystallization and characterization of a new protease in mitochondria of bone marrow cells. J Biol Chem 1978; 253: 2026-2032.
19. Senior RM, Campbell EJ. Cathepsin G in human mononuclear phagocytes: comparisons between monocytes and U937 monocyte-like cells. J Immunol 1984; 132: 2547-2551.
20. Starkey PM. Elastase and cathepsin G, the serine proteinases of human neutrophil leukocytes and spleen. In: Barrett AJ, ed. Proteinases in mammalian cells and tissues. Amsterdam: North-Holland, 1977; 57-89.
21. Watorek W, Farley D, Salvesen G, Travis J. Neutrophil elastase and cathepsin G: structure, function, and biological control. Adv Exp Med Biol 1988; 240: 23-31.
22. Baici A, Knöpfel M, Fehr K. Cathepsin G from human polymorphonuclear leukocytes cleaves human IgM. Mol Immunol 1982; 19: 719-727.
23. Baici A, Knöpfel, Fehr K. Cleavage of the four human IgG subclasses with cathepsin G. Scand J Immunol 1982; 16: 487-498.
24. Wintroub BU, Coblyn JS, Kaempfer CE, Austen KF. Cleavage of flbrinogen by the human neutrophil neutral peptide-generating protease. Proc Nail Acad Sci USA 1980; 77: 5448-5452.
25. Schmidt W. Differential release of elastase and chymotrypsin from polymorphonuclear leukocytes. In: Haveman K, Janoff A, eds. Neutral proteases of human polymorphonuclear leukocytes. Baltimore: Urban and Schwarzenberg, 1978; 77.