The yellow fever 17D vaccine virus: Molecular basis of viral attenuation and its use as an expression vector

Brazilian Journal of Medical and Biological Research

Volumn 30, Issue 2, 1997, Pages 157-168

  Galler, R ^a,b   Freire, M S ^a   Jabor, A V ^a   Mann, G F ^a  

^a Instituto de Tecnologia em Imunobiologicos   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Attenuation; Flavivirus; Gene expression; Vaccine; Yellow fever virus

Indexed keywords

FLAVIVIRUS; YELLOW FEVER VIRUS;

VIRUS VACCINE;

GENE VECTOR; GENETICS; IMMUNOLOGY; REVIEW; ULTRASTRUCTURE; VIROLOGY; YELLOW FEVER; YELLOW FEVER FLAVIVIRUS;

GENETIC VECTORS; VIRAL VACCINES; YELLOW FEVER; YELLOW FEVER VIRUS;

EID: 0031062778     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0100-879X1997000200002     Document Type: Article

References (66)

1. Monath TP (1987). Yellow Fever: a medically neglected disease. Reviews of Infectious Diseases, 9: 165-175.
2. Halstead SB (1988). Pathogenesis of dengue: challenges to molecular biology. Science, 239: 476-481.
3. Monath TP (1988). Japanese encephalitis: a plague of the Orient. New England Journal of Medicine, 319: 641-645.
4. Sawyer WA, Kitchen SF, Frobisher MM & Lloid W (1930). Relationship of yellow fever of Western hemisphere to that of Africa and leptospiral jaundice. Journal of Experimental Medicine, 51: 493-517.
5. Stokes A, Bauer JH & Hudson NP (1928). The transmission of yellow fever to Macacus rhesus, preliminary note. Journal of the American Medical Association, 90: 253-254.
6. Mathis C, Sellards AW & Laigret J (1928) Sensibilité du Macaca rhesus au virus de la fièvre Jaune. Comptes Rendus de L'Academie des Sciences, 188: 604-606.
7. Lloyd W, Theiler M & Ricci NI (1936). Modification of the virulence of yellow fever virus by cultivation in tissues. Transactions of the Royal Society of Tropical Medicine and Hygiene, 29: 481-529
8. Theiler M & Smith HH (1937). The effect of prolonged cultivation in vitro upon the pathogenicity of yellow fever virus. Journal of Experimental Medicine, 65: 767-786.
9. Theiler M & Smith HH (1937). The use of yellow fever virus modified by in vitro cultivation for human immunization. Journal of Experimental Medicine, 65: 787-800
10. Smith HH, Penna H & Paolielolo A (1938). Yellow fever vaccination with cultured virus (17D) without immune serum. American Journal of Tropical Medicine and Hygiene, 18: 437-468.
11. Soper FL & Smith HH (1938). Vaccination with virus 17D in the control of jungle yellow fever in Brazil. Transactions of the Third International Congress of Tropical Medicine and Malaria, Amsterdam, 1: 295-313.
12. Rice CM, Lenches E, Eddy SR, Shin SJ, Sheets RL & Strauss JH (1985). Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science, 229: 726-733.
13. Wengler G, Castle E, Leidner U, Nowak T & Wengler G (1985). Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene. Virology, 147: 264-274.
14. Chambers TJ, Hahn CS, Galler R & Rice CM (1990). Flavivirus genome organization, expression and evolution. Annual Review of Microbiology, 44: 649-688.
15. Cahour A, Pletnev A, Vazeille-Falcoz M, Rosen L & Lai C-J (1995). Growth-restricted dengue virus mutants containing deletions in the 5′ noncoding region of the RNA genome. Virology, 207: 68-76.
16. Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick RJ & Rice CM (1990). Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proceedings of the National Academy of Sciences, USA, 87: 8898-8902.
17. Preugshat F, Yao CW & Strauss JH (1990). In vitro processing of dengue 2 nonstructural proteins NS2A, NS2B and NS3. Journal of Virology, 64: 4364-4374.
18. Falgout B, Pethel M, Zhang YM & Lai CJ (1991). Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. Journal of Virology. 65: 2467-2475.
19. Yamshihikov VF & Compans RW (1995). Formation of the flavivirus envelope: role of the viral NS2B-NS3 protease. Journal of Virology, 69: 1995-2003.
20. Gorbalenya AE, Koonin EV, Donchenko AP & Blinov VM (1989). Two related superfamilies of putative helicases involved in replication, recombination repair and expression of DNA and RNA genomes. Nucleic Acids Research, 17: 4713-4730.
21. Wengler G & Wengler G (1993). The NS3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity. Virology, 197: 265-273.
22. Falgout B, Channock R & Lai CJ (1989). Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2A. Journal of Virology, 63: 1852-1860.
23. Preugshat F & Strauss JH (1991). Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo. Virology, 185: 689-697.
24. Jan L-R, Yang C-Z, Trent DW, Falgout B & Lai C-J (1995). Processing of Japanese encephalitis virus nonstructural proteins: NS2B-NS3 complex and heterologous proteases. Journal of General Virology, 76: 573-580,
25. Racaniello VR & Baltimore D (1981). Cloned poliovirus complementary DNA is infectious in mammalian cells. Science, 214: 916-919.
26. Melton DA, Krieg PA, Rabagliati MR, Maniatis T, Zinn K & Green MR (1984). Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research, 12: 7035-7056.
27. Monath TP, Brinker KR, Chandler FW, Kemp GE & Cropp CB (1981). Pathophysiologic correlations in a Rhesus monkey model of yellow fever. American Journal of Tropical Medicine and Hygiene, 30: 431-443.
28. Hahn CS, Dalrymple JM, Strauss JH & Rice CM (1987). Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it. Proceedings of the National Academy of Sciences, USA, 84: 2029-2033.
29. Post PR, Santos CND, Carvalho R, Cruz ACR, Rice CM & Galler R (1992). Heterogeneity in envelope protein sequence and N-linked glycosylation among yellow fever virus vaccine strains. Virology, 188: 160-167.
30. Duarte dos Santos CND, Post PR, Carvalho R, Ferreira II, Rice CM & Galler R (1995). Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213. Virus Research, 35: 35-41.
31. Rice CM, Grakoui A, Galler R & Chambers TJ (1989). Transcription of infectious yellow fever RNA from full-length templates produced by in vitro ligation. The New Biologist, 1: 285-296.
32. Marchevsky RS, Mariano J, Ferreira VS, Almeida E, Cerqueira MJ, Carvalho R, Pissurno JW, Travassos da Rosa APA, Simōes MC, Santos CND, Ferreira II, Muylaert IR, Mann GF, Rice CM & Galler R (1995). Phenotypic analysis of yellow fever virus derived from complementary DNA. American Journal of Tropical Medicine and Hygiene, 52: 75-80.
33. Rey FA, Heinz FX, Mandl C, Kunz C & Harrison SC (1995). The envelope glycoprotein from tick-borne encephalitis virus at 2Å resolution. Nature, 375: 291-298.
34. Mandl CW, Guirakhoo F, Holzmann H, Heinz FX & Kunz C (1989). Antigenic structure of the flavivirus envelope E protein at the molecular level using tick-borne encephalitis virus as a model. Journal of Virology, 63: 564-571.
35. Ruoshlati E & Pierschbacher MD (1987). New perspectives in cell adhesion: RGD and integrins. Science, 238: 491-497.
36. Lepiniec L, Dalgarno L, Huong VTQ, Monath TP, Digoutte JP & Deubel V (1994). Geographic distribution and evolution of yellow fever viruses based on direct sequencing of genomic DNA fragments. Journal of General Virology, 75: 417-423.
37. Lobigs M, Usha R, Nesterowicz A, Marschall ID, Weir RC & Dalgarno L (1990). Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse neurovirulence. Virology, 176: 587-595.
38. Sumiyoshi H, Hoke CH & Trent DW (1992). Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates. Journal of Virology, 66: 5425-5431.
39. Sumiyoshi H, Tignor GH & Shope RE (1995). Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA. Journal of Infectious Diseases, 171: 1144-1151).
40. Schlesinger JJ, Brandriss MW, Putnak JR & Walsh EE (1990). Cell-surface expression of yellow fever virus nonstructural glycoprotein NS1: consequences for the interaction with antibody. Journal of General Virology, 71: 593-599.
41. Post PR, Carvalho R & Galler R (1990). Glycosylation and secretion of yellow fever virus nonstructural protein NS1. Virus Research, 18: 291-302.
42. Smith GW & Wright PJ (1985). Synthesis of proteins and glycoproteins in dengue type 2 virus-infected Vero and Ae. albopictus cells. Journal of General Virology, 66: 559-571.
43. Schlesinger JJ, Brandriss MW, Bruce Cropp C & Monath TP (1986). Protection against yellow fever in monkeys immunized with yellow fever virus nonstructural protein NS1. Journal of Virology, 60: 1153-1155.
44. Muylaert IR, Chambers TJ, Galler R & Rice CM (1996). Mutational analysis of the YF 17D virus NS1 protein N-linked glycosylation sites. Virology, 222: 159-168.
45. Holland J, Spindler K, Horodyski H, Grabau E, Nichol S & Van de Pol S (1982). Rapid evolution of RNA genomes. Science, 215: 1577-1585.
46. Kohara M, Abe S, Shusuke K, Semler BL, Toshihiko K, Arita M, Itoh H & Nomoto A (1986). An infectious cDNA clone of the poliovirus Sabin strain could be used as stable repository and inoculum for the oral polio live vaccine. Virology, 151: 21-30.
47. Schoub BD, Dommann CJ, Johnson S, Downie C & Patel PL (1990). Encephalitis in a 13-year old boy following 17D YF vaccine. Journal of Infection, 21: 105-106.
48. Merlo C, Steffen R, Landis T, Tsai T & Karabatsos N (1993). Possible association of encephalitis and a 17D YF vaccination in a 29-year old traveller. Vaccine, 11: 691.
49. Fox JP & Penna HA (1943). Behavior of 17D yellow fever virus in Rhesus monkeys. American Journal of Hygiene, 38: 152-172.
50. Fox JP, Lennette EH, Manso C & Souza Aguiar JR (1942). Encephalitis in man following vaccination with 17D yellow fever virus. American Journal of Hygiene, 36: 117-142.
51. Bray M & Lai C-J (1991). Construction of chimeric dengue virus by substitution of structural protein genes. Proceedings of the National Academy of Sciences, USA, 88: 10342-10346.
52. Chen W, Kawano H, Men R, Clark D & Lai C-J (1993). Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for mice. Journal of Virology, 69: 5186-5190.
53. Pletnev A, Bray M, Huggins J & Lai C-J. (1992). Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses. Proceedings of the National Academy of Sciences, USA, 89: 10532-10536.
54. Pletnev AG, Bray M & Lai C-J (1993). Chimeric tick-borne encephalitis/dengue type 4 viruses: effects of mutations on neurovirulence in mice. Journal of Virology, 67: 4956-4963.
55. Kawano H, Rostapshov V, Rosen L & Lai C-J (1993). Genetic determinants of dengue type 4 virus mouse neurovirulence. Journal of Virology, 67: 6567-6575.
56. Hogle JM, Chow M & Filman DJ (1985). Three-dimensional structure of poliovirus at 2.9 resolution. Science, 229: 1358-1365.
57. Murray MG, Kuhn RJ, Arita M, Kawamura N, Nomoto A & Wimmer E (1988). Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys. Proceedings of the National Academy of Sciences, USA, 85: 3203-3207.
58. Lemon SM, Barclay W, Ferguson M, Murphy P, Jing L, Burke K, Wood D, Katrak K, Sangar D, Minor PD & Almond JW (1992). Immunogenicity and antigenicity of chimeric picornaviruses which express hepatitis A virus (HAV) peptide sequences: evidence for a neutralization domain near the amino terminus of VP1 of HAV. Virology, 188: 285-295.
59. London SD, Schmaljohn AL, Dalrymple JM & Rice CM (1992). Infectious enveloped RNA virus antigenic chimeras. Proceedings of the National Academy of Sciences, USA, 89: 207-211.
60. - cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones. Journal of Virology, 65: 1823-1828.
61. - cytotoxic T-cell clone. Journal of Virology, 67: 6285-6288.
62. - cytotoxic T lymphocyte clones. Journal of General Virology, 76: 2243-2249.
63. Lobigs M, Arthur CE, Múllbacher A & Blanden RV (1994). The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinants. Virology, 202: 195-201.
64. + cytotoxic T lymphocyte (CTL) clones: recognition of NS3 amino acids 500-508 by CTL clones of two different serotype specificities. Journal of Immunology, 154: 1287-1295.
65. Despres P, Cahour A, Dupuy A, Deubel V, Bouloy M, Digoutte JP & Girard M (1987). High genetic stability of the coding region for the structural proteins of yellow fever virus strain 17D. Journal of General Virology, 68: 2245-2247.
66. Hahn Y, Galler R, Hunkapillar T, Dalrymple JM, Strauss JH & Strauss EG (1988). Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology, 162: 167-180.