A double-blind, a placebo-controlled study of preventive immunotheraphy with E.P.D., in the treatment of seasonal allergic disease

Allergie et Immunologie

Volumn 29, Issue 2, 1997, Pages 39-42

  Di Stanislao, C ^a   Di Berardino, L ^b   Bianchi, I ^b   Bologna, G ^a  

^a ASL 104   (Italy)

^b SARM Research Department   (Italy)

Author keywords

E.P.D.; Preventive immunotherapy Allergy prevention Grass Beta glucuronidase

Indexed keywords

ALLERGEN; BETA GLUCURONIDASE; IMMUNOLOGICAL ADJUVANT;

ADOLESCENT; ADULT; ALLERGIC CONJUNCTIVITIS; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DESENSITIZATION; DOUBLE BLIND PROCEDURE; FEMALE; HAY FEVER; HUMAN; MALE; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; ALLERGENS; CONJUNCTIVITIS, ALLERGIC; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; GLUCURONIDASE; HUMANS; MALE; RHINITIS, ALLERGIC, SEASONAL; TREATMENT OUTCOME;

EID: 0031062698     PISSN: 03979148     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. L.M. MCEWEN, M.A. GANDERTON, C.W.M. WELSON AND J.H.D. BLACK. - Hyaluronidase in the treatment of allergy. Brit. Med. J., 509-530, 1967.
2. L.M. MCEWEN AND M.S. STARR. - Enzyme potentiated hyposensitization I. The effect of pretreatment with beta glucuronidase, hyaluronidase and antigen on anaphylactic sensivity on guinea pigs, rats and mice. Int. Arch. Allerg., 42, 152-158, 1972.
3. L.M. MCEWEN. - Enzyme potentiated hyposensitization II. Effect of glucose, glucosamine, N-acelylamino-sugars and gelatin on the ability of F Beta glucuronidase to block the anamnestic response to antigen in mice. Ann. Allerg., 31, 79-83, 1973.
4. L.M. MCEWEN, M. NICHOLSON, I. KITCHEN AND W. SHEILA. - Enzyme potentiated hyposensitization III. Control by sugars and diols of immunological effect of beta glucuronidase, in mice and patients with hay fever. Ann. Allerg., 31, 543-550, 1973.
5. L.M. MCEWEN, M. NICHOLSON, I. KITCHEN, J. O'GORMAN AND W. SHEILA. - Enzyme potentiated hyposensitization IV. Effect of Protamine on the immunological behavior of beta glucuronidase in mice and patients with hay fever. Ann. Allerg., 34, 290-295, 1975.
6. L.M. MCEWEN. - Enzyme potentiated hyposensitization V. Five case reports of patients with acute food allergy. Ann. Allerg., 35, 99-103, 1975.
7. P. FELL AND J. BROSTOFF. - A single dose desensitization for summer hay fever. Results of a double blind study - 1988. Eur. J. Clin. Pharmacol., 77-79, 1990.
8. J. EGGER, A. STOLLA, L.M. MCEWEN. - Controlled trial of hyposensitization in children with food-induced hyperkinetic syndrome. The Lancet 339, 1150-53, 1992.
9. G.A. VENA, G. CURATOLI, V. D'ARGENTO AND G. ANGELINI. - POLLINOSIS : A new immunotherapeutic methodology. The Med. J. of Surg. and Med. 253-256, 1993.
10. G. CARAMIA, F. FRANCESCHINI, A. CIMARELLI, M.S. CIUCCHI, R. GAGLIARDINI AND E. RUFFINI. - The efficacy of E.P.D., a new immunotherapy in the treatment of allergic diseases in children. Allergie et Immunologie, 28, 70-73, 1996.
11. A. CANTANI, V. RAGNO, M.A. MONTELEONE, P. LUVENTI, L. BUSINCO. - Enzyme-potentiated desensitization in children with asthma and mite allergy : A double-blind study. J. Invest. Allergol. Clin. Immunol., 6 (4), 270-276, 1996.
12. EAACI Immunotherapy position paper. 1993, Weeke HJ and B editors. Allergy, 48, 28, 1993.3.
13. International rhinithis management working group : International consensus report on the diagnosis and management of rhintis. Allergy 49, suppl. 19, 1994.
14. A.H. ENK., J. SALOGA, D. BECKER. - B1P6 madzadeh M. Knop J. - Induction of hapten-specific tolerance by interleukin 10 in vivo. J. Exp. Med. 179 (4), 1397-1402, 1994.