Activation of acyl-CoA: Cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol

Biochemical Pharmacology

Volumn 53, Issue 1, 1997, Pages 27-34

  Bhuvaneswaran, Chidambaram ^a,b   Synouri Vrettakou, Stella ^a,d   Mitropoulos, Kostas A ^a,c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^d NONE   (Greece)

Author keywords

25 hydroxycholesterol; ACAT; activation; acyl CoA:cholesterol acyltransferase; cholesterol esterification; liver; microsomes; oxysterols

Indexed keywords

25 HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; LIPOSOME; PHOSPHATIDYLCHOLINE; RADIOISOTOPE;

ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; ESTERIFICATION; KINETICS; LIVER CELL MEMBRANE; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHOLESTEROL; ENZYME ACTIVATION; HYDROXYCHOLESTEROLS; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; STEROL O-ACYLTRANSFERASE;

EID: 0031060715     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00649-1     Document Type: Article

References (36)

1. Suckling KE and Stange EF, Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26: 647-671, 1985.
2. Kandutsch AA, Chen HW and Heiniger HJ, Biological activity of some oxygenated sterols. Science 201: 498-501, 1978.
3. Morin RJ, Hu B and Peng S-K, Effects of cholesterol oxides on cholesterol metabolism. In: Biological Effects of Cholesterol Oxides (Eds. Peng S-K and Morin RJ), pp. 103-123. CRC Press, Boca Raton, FL, 1992.
4. Saucier SE, Kandutsch AA, Taylor FR, Spencer TA, Phirwa S and Gayen AK, Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxy-cholesterol, incultured fibroblasts. J Biol Chem 260: 14571-14579, 1985.
5. Brown MS, Dana SE and Goldstein JL, Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols. J Biol Chem 250: 4025-4027, 1975.
6. Chang TY and Limanek JS, Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells. J Biol Chem 255: 7787-7795, 1980.
7. Chen HW, Cavenee WK and Kandutsch AA, Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol and serum. J Biol Chem 254: 715-720, 1979.
8. Kandutsch AA and Shown EP, Assay of oxysterol-binding protein in a mouse fibroblast, cell-free system. Dissociation constant and other properties of the system. J Biol Chem 256: 13068-13073, 1981.
9. Schroepfer GJ Jr, Sterol biosynthesis. Annu Rev Biochem 50: 585-621, 1981.
10. Sinensky M, Duwe G and Pinkerton F, Defective regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant. J Biol Chem 254: 4482-4486, 1979.
11. Miller SC and Melnykovych G, Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone. J Lipid Res 25: 991-999, 1984.
12. Field FJ and Mathur SN, Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells. J Lipid Res 24: 1049-1059, 1983.
13. Drevon CA, Weinstein DB and Steinberg D, Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. J Biol Chem 255: 9128-9137, 1980.
14. Erickson SK, Shrewsbury MA, Brooks C and Meyer DJ, Rat liver acyl-coenzyme A: cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro. J Lipid Res 21: 930-941, 1980.
15. 14 to acids and other products by liver mitochondria. J Biol Chem 222: 109-120, 1956.
16. Bjorkhem I and Gustafsson J, Mitochondrial omega-hydroxylation of cholesterol side chain. J Biol Chem 249: 2528-2535, 1974.
17. Morin RJ and Peng S-K, Cholesterol oxides in plasma and tissues. In: Biological Effects of Cholesterol Oxides (Eds. Peng S-K and Morin RJ), pp. 89-101. CRC Press, Boca Raton, FL, 1992.
18. Johnson KA, Morrow CJ, Knight GD and Scallen TJ, In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge. J Lipid Res 35: 2241-2253, 1994.
19. Lichtenstein AH and Brecher P, Esterification of cholesterol and 25-hydroxycholesterol by rat liver microsomes. Biochim Biophys Acta 751: 340-348, 1983.
20. Swell L, Schwartz CC, Gustafsson J, Danielsson H and Vlahcevic ZR, A quantitative evaluation of the conversion of 25-hydroxycholesterol to bile acids in man. Biochim Biophys Acta 663: 163-168, 1981.
21. Zhang J, Larsson O and Sjovall J, 7α-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. Biochim Biophys Acta 1256: 353-359, 1995.
22. Taylor FR and Kandutsch AA, Metabolism of 25-hydroxycholesterol in mammalian cell cultures. Side-chain scission to pregnenolone in mouse L929 fibroblasts. J Lipid Res 30: 899-905, 1989.
23. Bhuvaneswaran C and Mitropoulos KA, Effect of liposomal phospholipid composition on cholesterol transfer between microsomal and liposomal vesicles. Biochem J 238: 647-652, 1986.
24. Venkatesan S, Gallagher JJ and Mitropoulos KA, Modulation of the activity of 5'-nucleotidase by the transfer of non-esterified cholesterol to rat-liver microsomal fraction and evidence for regulation of the concentration of non-esterified cholesterol in plasma membranes in vivo. Biochim Biophys Acta 756: 72-82, 1983.
25. Synouri-Vrettakou S and Mitropoulos KA, Acyl-coenzyme A: cholesterol acyltransferase. Transfer of cholesterol to its substrate pool and modulation of activity. Eur J Biochem 133: 299-307, 1983.
26. Mitropoulos KA, Venkatesan S, Balasubramaniam S and Peters TJ, The submicrosomal localization of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, cholesterol 7alpha-hydroxylase and cholesterol in rat liver. Eur J Biochem 82: 419-429, 1978.
27. Mitropoulos KA, Venkatesan S, Synouri-Vrettakou S, Reeves BE and Gallagher JJ, The role of plasma membranes in the transfer of non-esterified cholesterol to the acyl-CoA: cholesterol acyltransferse substrate pool in liver microsomal fraction. Biochim Biophys Acta 792: 227-237, 1984.
28. Folch J, Lees M and Sloane-Stanley GH, A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509, 1957.
29. Bartlett GR, Phosphorous assay in column chromatography. J Biol Chem 234: 466-468, 1959.
30. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin-phenol reagent. J Biol Chem 193: 265-275, 1951.
31. Erickson SK, Matsui SM, Shrewsbury MA, Cooper AD and Gould RG, Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes. J Biol Chem 253: 4159-4164, 1978.
32. Lange Y, Strebel F and Steck TL, Role of the plasma membrane in cholesterol esterification in rat hepatoma cells. J Biol Chem 268: 13838-13843, 1993.
33. Balasurbramaniam S, Venkatesan S, Mitropoulos KA and Peters TJ, The submicrosomal localization of acyl-coenzyme A-cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver. Biochem J 174: 863-872, 1978.
34. Balasubramaniam S, Mitropoulos KA and Venkatesan S, Ratliver acyl-CoA: cholesterol acyltransferase. Eur J Biochem 90: 377-383, 1978.
35. Venkatesan S, Mitropoulos KA, Balasubramaniam S and Peters TJ, Biochemical evidence for the heterogeneity of membranes from rat liver endoplasmic reticulum. Studies on the localization of acyl-CoA: cholesterol acyltransferase. Eur J Cell Biol 21: 167-174, 1980.
36. Cheng D, Chang CC, Qu X and Chang TY, Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system. J Biol Chem 270: 685-695, 1995.