Failure of cannabinoid compounds to stimulate estrogen receptors

Biochemical Pharmacology

Volumn 53, Issue 1, 1997, Pages 35-41

  Ruh, Mary F ^a   Taylor, Julia A ^b   Howlett, Allyn C ^a   Welshons, Wade V ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

breast cancer cells; cannabinoid analgesics; cannabinoid receptors; environmental estrogens; gene regulatory response elements; phytoestrogens; steroid hormone receptors; tetrahydrocannabinols

Indexed keywords

ANTIESTROGEN; CANNABIDIOL; CANNABINOID DERIVATIVE; DEACETYLLEVONANTRADOL; DRONABINOL; ESTRADIOL; ESTROGEN RECEPTOR; FORMONONETIN; PHYTOESTROGEN; RALOXIFENE;

ARTICLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; REPORTER GENE;

BREAST NEOPLASMS; CANNABINOIDS; CELL DIVISION; ESTROGENS; HUMANS; PHENANTHRIDINES; PIPERIDINES; RALOXIFENE; RECEPTORS, ESTROGEN; TETRAHYDROCANNABINOL; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0031060674     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00659-4     Document Type: Article

References (50)

1. Smith CG and Asch RH, Drug abuse and reproduction. Fertil Steril 48: 355-373, 1987.
2. Murphy LL, Steger RW and Bartke A, Psychoactive and non-psychoactive cannabinoids and their effects on reproductive neuroendocrine parameters. In: Biochemistry and Physiology of Substance Abuse (Ed. Watson RR), pp. 73-93. CRC Press, Boca Raton, 1990.
3. 9-tetrahydrocannabinol on pregnancy, puberty, and the neuroendocrine system. In: Marijuana/Cannabinoids. Neurobiology and Neurophysiology (Eds. Murphy L and Bartke A), pp. 539-560. CRC Press, Boca Raton, 1992.
4. Gerard CM, Mollereau C, Vassart G and Parmentier M, Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279: 129-134, 1991.
5. Das SK, Paria BC, Chakraborty I and Dey SK, Cannabinoid ligand-receptor signaling in the mouse uterus. Proc Natl Acad Sci USA 92: 4332-4336, 1995.
6. Galiegue S, Sophie M, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, LeFur G and Casellas P, Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232: 54-61, 1995.
7. Abood ME and Martin BR, Neurobiology of marijuana abuse. Trends Pharmacol Sci 13: 201-206, 1992.
8. Howlett AC, Cannabinoid compounds and signal transduction mechanisms. In: Cannabinoid Receptors: Molecular Biology and Pharmacology (Ed. Pertwee RG), pp. 167-204. Academic Press, London, 1995.
9. Howlett AC, Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35: 607-634, 1995.
10. 9-tetrahydrocannabinol with estrogen in rat uterine estrogen receptor binding. Science 197: 1189-1191, 1977.
11. Okey AB and Bondy GP, Is delta-9-tetrahydrocannabinol estrogenic? Science 195: 904-906, 1977.
12. Chakravarty I and Naik VK, Action of delta-9-tetrahydrocannabinol on the binding of estradiol to uterine and other tissues in rats. Biochem Pharmacol 32: 253-256, 1983.
13. Sauer MA, Rifka SM, Hawks RL, Cutler GB Jr and Loriaux DL, Marijuana: Interaction with the estrogen receptor. J Pharmacol Exp Ther 224: 404-407, 1983.
14. Okey AB and Truant GS, Cannabis demasculinizes rats but is not estrogenic. Life Sci 17: 1113-1118, 1975.
15. Solomon J, Cocchia MA, Gray R, Shattuck D and Vossmer A, Uterotrophic effect of delta-9-tetrahydrocannabinol in ovariectomized rats. Science 192: 559-561, 1976.
16. Virgo BB, The estrogenicity of delta-9-tetrahydrocannabinol (THC): THC neither blocks nor induces ovum implantation, nor does it effect uterine growth. Res Commun Chem Pathol Pharmacol 25: 65-77, 1979.
17. Grady LH, Nonneman DJ, Rottinghaus GE and Welshons WV, pH-Dependent cytotoxicity of contaminants of phenol red for MCF-7 breast cancer cells. Endocrinology 129: 3321-3330, 1991.
18. Read LD, Greene GL and Katzenellenbogen BS, Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors. Mol Endocrinol 3: 295-304, 1989.
19. Welshons WV, Rottinghaus GE, Nonneman DJ, Dolan-Timpe M and Ross PF, A sensitive bioassay for detection of dietary estrogens in animal feeds. J Vet Diag Invest 2: 268-273, 1990.
20. Labarca C and Paigen K, A simple, rapid and sensitive DNA assay procedure. Anal Biochem 102: 344-352, 1980.
21. Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai M-J and O'Malley BW, Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol 9: 43-49, 1989.
22. Chen C and Okayama H, High efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752, 1987.
23. Gorman CM, Moffat LF and Howard BH, Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2: 1044-1051, 1982.
24. Shutt DA, The effects of plant oestrogens on animal reproduction. Endeavour 35: 110-113, 1976.
25. Bennets HW, Underwood EJ and Shier EL, A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust Vet J 22: 2-12, 1946.
26. Black LJ, Jones CD and Falcone JF, Antagonism of estrogen action with a new benzothiophene-derived antiestrogen. Life Sci 32: 1031-1036, 1983.
27. Gibson MK, Nemmers LA, Beckman WCJ, Davis VL, Curtis SW and Korach KS, The mechanism of ICI164.384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology 129: 2000-2010, 1991.
28. Dill JA and Howlett AC, Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs. J Pharmacol Exp Ther 244: 1157-1163, 1988.
29. Raz A and Goldman R, Effect of hashish compounds on mouse peritoneal macrophages. Lab Invest 34: 69-76, 1976.
30. 1-tetrahydrocannabinol on cyclic AMP in cultured human diploid fibroblasts. J Cyclic Nucleotide Res 5: 303-313, 1979.
31. 1 on the growth of cultured human fibroblasts. Can J Physiol Pharmacol 54: 541-545, 1976.
32. 9-tetrahydrocannabinol. J Pharm Sci 63: 1056-1064, 1974.
33. Seeman P, Chau-Wong M and Moyyen S, The membrane binding of morphine, diphenylhydantoin, and tetrahydrocannabinol. Can J Physiol Pharmacol 50: 1193-1200, 1972.
34. 9-tetrahydrocannabinol in rat brain. Biochem Pharmacol 23: 873-877, 1974.
35. 9-tetrahydrocannabinol and the effects of various solubilizers. J Pharm Pharmacol 31: 224-230, 1979.
36. McIlhenny HM, Mast RW, Johnson MR and Milne GM, Nantradol hydrochloride: Pharmacokinetics and behavioral effects after acute and chronic treatment. J Phormacol Exp Ther 219: 363-369, 1981.
37. Hewlett AC, Johnson MR, Melvin LS and Milne GM, Non-classical cannabinoid analgetics inhibit adenylate cyclase: Development of a cannabinoid receptor model. Mol Pharmacol 33: 297-302, 1988.
38. Carlini EA and Cunha JM, Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol 21: Suppl 417S-427S, 1981.
39. Hollister LE, Cannabidiol and cannabinol in man. Experientia 29: 825-826, 1973.
40. 9-tetrahydrocannabinol, cannabinol, and cannabidiol. Experientia 29: 1368-1369, 1973.
41. Raloff J, Ecocancers. Do environmental factors underlie a breast cancer epidemic? Sci News 144: 10-13, 1993.
42. Miksicek RJ, Commonly occurring plant flavonoids have estrogenic activity. J Pharmacol Exp Ther 44: 37-43, 1993.
43. Miksicek RJ, Estrogenic flavonoids: Structural requirements for biological activity. Proc Soc Exp Biol Med 208: 44-50, 1995.
44. Ruh MF, Zacharewski T, Connor K, Howell J, Chen I and Safe S, Naringenin: A weakly estrogenic bioflavonoid that exhibits antiestrogenic activity. Biochem Pharmacol 50: 1485-1493, 1995.
45. Harris LS, Carchman RA and Martin BR, Evidence for the existence of specific cannabinoid binding sites. Life Sci 22: 1131-1137, 1978.
46. Eldridge JC and Landfield PW, Cannabinoid interactions with glucocorticoid receptors in rat hippocampus. Brain Res 534: 135-141, 1990.
47. Eldridge JC, Murphy LL and Landfield PW, Cannabinoids and the hippocampal glucocorticoid receptor: Recent findings and possible significance. Steroids 56: 226-231, 1991.
48. Bidaut-Russell M, Devane WA and Howlett AC, Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain. J Neurochem 55: 21-26, 1990.
49. Howlett AC, Evans DM and Houston DB, The cannabinoid receptor. In: Marijuana/Cannabinoids: Neurobiologe and Neurophysiology (Eds. Murphy L and Bartke A), pp. 35-72. CRC Press, Boca Raton, 1992.
50. Kuster JE, Stevenson JI, Ward SJ, D'Ambra TE and Haycock DA, Aminoalkylindole binding in rat cerebellum: Selective displacement by natural and synthetic cannabinoids. J Pharmacol Exp Ther 264: 1352-1363, 1993.