The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: Sequence of a new 2-exon hinge gene

Human Genetics

Volumn 99, Issue 1, 1996, Pages 138-141

  Dard, Patricia ^a   Huck, Sylvie ^b   Frippiat, Jean Pol ^b   Lefranc, Gérard ^b   Langaney, André ^a   Lefranc, Marie Paule ^b   Sanchez Mazas, Alicia ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b CNRS and University Montpellier II   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G;

ARTICLE; CASE REPORT; CONTROLLED STUDY; EXON; GENE DELETION; GENE SEQUENCE; GENE STRUCTURE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENEGAL;

EID: 0031060652     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050328     Document Type: Article

References (12)

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2. Brekke OH, Michaelsen TE, Sandin R, Sandlie I (1993) Activation of complement by an IgG molecule without a genetic hinge. Nature 363:628-630
3. Brekke OH, Michaelsen TE, Sandlie I (1995) The structural requirements for complement activation by IgG: does it hinge on the hinge? Immunol Today 2:85-90
4. Dard P, Sanchez-Mazas A, Dugoujon J-M, De Lange G, Langaney A, Huck S, Lefranc M-P, Lefranc G (1996) DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal: correlation with Gm haplotypes and hypotheses for the evolution of the Ig CH region. Hum Genet 98:36-47
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7. Huck S, Lefranc G, Lefranc M-P (1989) A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons. Immunogenetics 30:250-257
8. Ito W, Arata Y (1985) Proton nuclear magnetic resonance study on the dynamics of the conformation of the hinge segment of human G1 immunoglobulin. Biochemistry 24:6467-6474
9. Marquart M, Deisenhofer J, Huber R (1980) Crystallographic refinement and atomic models of the intact immunoglobulin molecule kol and its antigen-binding fragments at 3.0 and 1.9 Å resolution. J Mol Biol 141:369-391
10. Michaelsen TE, Brekke OH, Aase A, Sandin RH, Bremens B, Sandlie I (1994) One disulphide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge. Proc Natl Acad Sci USA 91:9243-9247
11. Schneider WI, Wensel TG, Stryer L, Oi VT (1988) Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility. Proc Natl Acad Sci USA 85:2509-2513
12. Tan LK, Shopes RJ, Oi VT, Morrison SL (1990) Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins. Proc Natl Acad Sci USA 87:162-166