Antitumor Effect of Murine Colon Carcinoma Cells Retrovirally Transduced with lnterleukin-4 and Granulocyte Macrophage-Colony Stimulating Factor Genes

Oncology (Switzerland)

Volumn 54, Issue 1, 1997, Pages 69-73

  Gunji, Yoshio ^a   Tagawa, Masatoshi ^b   Matsubara, Hisahiro ^a   Takenaga, Keizo ^d   Shimada, Hideaki ^a   Kondo, Fukuo ^c   Suzuki, Takao ^a   Nakajima, Kazuaki ^a   Sugaya, Makoto ^a   Asano, Takehide ^a   Ochiai, Takenori ^a   Isono, Kaichi ^a  

^a Chiba University   (Japan)

^b Chiba University   (Japan)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d CHIBA CANCER CENTER   (Japan)

Author keywords

Colon cancer; Cytokines; Gene therapy; Interleukin 4 GM CSF

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CELL INFILTRATION; COLON CARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE THERAPY; GENETIC TRANSDUCTION; HISTOPATHOLOGY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; TUMOR REGRESSION;

ANIMALS; COLONIC NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; RETROVIRIDAE; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0031060194     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000227664     Document Type: Article

References (29)

1. Sobol RE, Scanlon KJ: Cancer gene therapy clinical trials, Cancer Gene Ther 1995;2:5-6.
2. Carbone DP, Minna JD: In vivo gene therapy of human lung cancer using wild-type p53 delivered by retrovirus, J Natl Cancer Inst 1994; 86:1437-1438.
3. Mooltcn FL: Drug sensitivity (‘suicide’) genes for selective cancer chemotherapy, Cancer Gene Ther 1994;1:279-287.
4. Teppcr RI, Mulé JJ: Experimental and clinical studies of cytokine gene-modified tumor cells, Hum Gene Ther 1994;5:153-164.
5. Teppcr RI, Pattengale PK, Leder P: Murine interleukin-4 displays potent anti-tumor activity in vivo, Cell 1989;57:503-512.
6. Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM: T reatment of established renal cancer by tumor cells engineered to secrete interleukin-4, Science 1991;254:713-716.
7. Tepper RI, Coffman RL, Leder P: An eosinophil-dependent mechanism for the antitumor effect of interleukin-4, Science 1992,257:548-551.
8. Wei MX, Tamiya T, Hurford RK Jr, Boviatsis EJ, Tepper RI, Chiocca EA: Enhancement of interleukin-4-mcdiatcd tumor regression in athymic mice by in situ retroviral gene transfer, Hum Gene Ther 1995;6:437-443.
9. Mullen CA, Coale MM, Levy AT, Stetler-Ste-venson WG, Liotta LA, Brandt S, Blaese RM: Fibrosarcoma cells transduced with the IL-6 gene exhibit reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential, Cancer Res 1992;52:6020-6024.
10. Porgador A, Tzchoval E, Katz A, Vadai E, Revel M, Feldman M, Eiscnbach L: Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells, Cancer Res 1992;52:3679-3686.
11. Sun WH, Kreisle RA, Phillips AW, Ershlcr WB: In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells, Cancer Res 1992;52:5412-5415.
12. Sun WH, Burkholder JK, Sun J, Culp J, Turner J, Lu XG, Pugh TD, Ershler WB, Yang N-S: In vivo cytokine gene transfer by gene gun reduces tumor growth in mice, Proc Natl Acad Sci USA 1995;92:2889-2893.
13. Dranof T G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophagc colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity, Proc Natl Acad Sci USA 1993;90:3539-3543.
14. Sanda MG, Ayyagari SR, Jaffee EM, Epstein JI, Clift SL, Cohen LK, DranofT G, Pardoll DM, Mulligan RC, Simons JW: Demonstration of a rational strategy for human prostate cancer gene therapy, J Urol 1994; 151:622-628.
15. Fearon ER, Pardoll DM, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vo-gelstein B, Frost P: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response, Cell 1990;60:397-403.
16. Gastl G, Finstad CL, Guarini A, Bosl G, Gil-boa E, Bander NH, Gansbacher B: Retroviral vector-mediated lymphokine gene transfer into human renal cancer cells, Cancer Res 1992;52: 6229-6236.
17. Cignetti A, Guarini A, Carbone A, Fomi M, Cronin K, Fomi G, Gansbacher B, Foa R: Transduction of the IL2 gene into human acute leukemia cells; Induction of tumor rejection w'ithout modifying cell proliferation and IL2 receptor expression, J Natl Cancer Inst 1994; 86:785-791.
18. Corbett TH, Grinswold DP Jr, Roberts BJ, Peckham JC, Schabel FM Jr: Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure, Cancer Res 1975;35:2434-2439.
19. Brattain MG, Strobel-Stevens J, Fine D, Webb M, Sarrif AM: Establishment of mouse colonic carcinoma cell lines with different metastatic properties, Cancer Res 1980;40:2142-2146.
20. Miller AD, Rosman GJ: Improved retroviral vectors for gene transfer and expression, Bio-Techniques 1989;7:980-990.
21. Lee F, Yokota T, Otuka T, Meyerson P, Villa-ret D, Coffman R, Mosmann T, Rennick D, Roehm N, Smith C, Zlotnik A, Arai K-I: Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor I activities and T-cell- and mast-cell-stimulating activities, Proc Natl Acad Sci USA 1986;83:2061-2065.
22. Miyatake S, Otsuka T, Yokota T, Lee F, Arai K-I: Structure of the chromosomal gene for granulocyte-macrophagc colony stimulating factor: Comparison of the mouse and human genes, EMBOJ 1985;4:2561-2568.
23. Janik P, Briand P, Hartmann NR: The effect of estrcne-progesteronc treatment on cell proliferation kinetics of hormone-dependent GR mouse mammary tumors, Cancer Res 1975;35: 3698-3704.
24. Steinman RM: The dendritic cell system and its role in immunogenicity, Annu Rev Immunol 1991;9:271-296.
25. Restifo NP, Esquivel F, Kawakami Y, Yewdell JW, Mulé JJ, Rosenberg SA, Bennink JR: Identification of human cancers deficient in antigen processing, J Exp Med 1993; 117:265-272.
26. Ohe Y, Podack ER, Olsen KJ, Miyahara Y, Ohira T, Miura K, Nishio K, Saijo N: Combination effect of vaccination with IL2 and IL4 cDNA transfected cells on the induction of a therapeutic immune response against Lewis lung carcinoma cells, Int J Cancer 1993;53: 432-437.
27. Rosenthal FM, Cronin K, Bannerji R, Golde DW, Gansbacher B: Augmentation of antitumor immunity by tumor cells transduced with a relroviral vector carrying the interleukin-2 and:nterferon-y cDNAs, Blood 1994;83:1289-1298.
28. Saito S, Bannerji R, Gansbacher B, Rosenthal FM, Romanenko P, Heston WDW, Fair WR, Gilboa E: Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines, Cancer Res 1994;54:3516-3520.
29. Rajagopalan LE, Burkholder JK, Turner J, Culp J, Yang N-S, Malter JS: Granulocyte-macrophagc colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues, Blood 1995:86:2551-2558.